Detection of flutamide in pharmaceutical dosage using higher electrospray ionization mass spectrometry (ESI-MS) tandem mass coupled with Soxhlet apparatus
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引用次数: 36
Abstract
Flutamide (2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-propanamide) is a non-steroidal drug that has a specific anti-androgenic activity so that it is used in the treatment of prostate cancer. A simple method for extraction and detection of flutamide from pharmaceutical forms are reported using Soxhlet apparatus combined electrospray ionization tandem mass spectrometry (ESI(−)-MSn, n = 1−4) in negative ion mode. Spectra show a fingerprint peaks corresponding to flutamide. Propanamide moiety plays important role in structure elucidation. The diagnostic ions produced a useful fingerprint maps to identify flutamide in unknown samples. Furthermore, the proposed ions may help in the metabolite studies of the drug. The method proposed here is easy, cheap and applicable for large quantity.
氟他胺(2-甲基-n -[4-硝基-3-(三氟甲基)苯基]-丙酰胺)是一种非甾体类药物，具有特定的抗雄激素活性，因此用于治疗前列腺癌。报道了一种在负离子模式下用索氏装置联合电喷雾串联质谱法(ESI(−)-MSn, n = 1−4)从药物中提取和检测氟他胺的简单方法。光谱显示与氟他胺对应的指纹峰。丙酰胺部分在结构解析中起着重要作用。诊断离子产生了有用的指纹图谱，以识别未知样品中的氟他胺。此外，所提出的离子可能有助于药物的代谢物研究。该方法简便、经济、适用于大批量生产。
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