{"title":"Functional Analysis of Genes","authors":"D. Sitnicka, K. Figurska, S. Orzechowski","doi":"10.2478/v10052-010-0001-y","DOIUrl":"https://doi.org/10.2478/v10052-010-0001-y","url":null,"abstract":"Summary The aim of this article is to present the current literature concerning the expression analysis and methods of functional characteristics of genes. The progress in the analysis of gene expression within cells or whole tissues is undisputed and leads to a constant improvement of our understanding of the function of particular gene. The traditional methods of the functional characteristics of genes such as homology, inactivation and overexpression are more frequently being replaced by microarray and DNA chip analysis, which are extensively supported by bioinformatics tools. Knowledge of the functions and changes in gene expression has applications in medical diagnostics, the pharmaceutical industry and in plant and animal biotechnology.","PeriodicalId":77994,"journal":{"name":"Advances in cell biology","volume":"51 1","pages":"1 - 16"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/v10052-010-0001-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68949778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Małgorzata Witkowska-Zimny, E. Wróbel, J. Przybylski
{"title":"The Most Important Transcriptional Factors of Osteoblastogenesis","authors":"Małgorzata Witkowska-Zimny, E. Wróbel, J. Przybylski","doi":"10.2478/v10052-010-0002-x","DOIUrl":"https://doi.org/10.2478/v10052-010-0002-x","url":null,"abstract":"Summary One of the key issues of organogenesis is the understanding of mechanisms underlying the differentiation of progenitor cells into more specialized cells of individual tissues. Recent transcriptomic and proteomic approaches of molecular biology have led to the identification of several factors and mechanisms regulating morphogenesis at the genetic level which affect the function of already differentiated cells. In the last few years, several reports about osteoblastogenesis have been published. This review presents recent findings on the role of the most important transcription factors supporting bone formation.","PeriodicalId":77994,"journal":{"name":"Advances in cell biology","volume":"2 1","pages":"17 - 28"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68949807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Sakowicz, Marek Gadzalski, Wiktor Pszczółkowski
{"title":"Short Interspersed Elements (SINEs) in plant genomes","authors":"T. Sakowicz, Marek Gadzalski, Wiktor Pszczółkowski","doi":"10.2478/V10052-009-0002-X","DOIUrl":"https://doi.org/10.2478/V10052-009-0002-X","url":null,"abstract":"","PeriodicalId":77994,"journal":{"name":"Advances in cell biology","volume":"-1 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2009-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/V10052-009-0002-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68949751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Immunity Without Antibodies","authors":"M. Cytryńska","doi":"10.2478/V10052-009-0003-9","DOIUrl":"https://doi.org/10.2478/V10052-009-0003-9","url":null,"abstract":"","PeriodicalId":77994,"journal":{"name":"Advances in cell biology","volume":"-1 1","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2009-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/V10052-009-0003-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68949765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Kwiatkowska, K. Popłońska, D. Stępiński, A. Wojtczak
{"title":"Lipotubuloids - Domains of Cytoplasm Rich in Lipid Bodies, Entwined by the Microtubule System, and Active in Lipid Synthesis","authors":"M. Kwiatkowska, K. Popłońska, D. Stępiński, A. Wojtczak","doi":"10.2478/V10052-009-0001-Y","DOIUrl":"https://doi.org/10.2478/V10052-009-0001-Y","url":null,"abstract":"","PeriodicalId":77994,"journal":{"name":"Advances in cell biology","volume":"-1 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2009-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68949715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"S100B Protein, Astrocytes and Memory","authors":"M. Kielbinski, Z. Soltys","doi":"10.2478/V100052-008-0005","DOIUrl":"https://doi.org/10.2478/V100052-008-0005","url":null,"abstract":"Streszczenie: SI00 to występująca u kręgowców rodzina małych, wiążących wapń białek. Jednym z nich jest S100B, białko występujące głównie w astrocytach. Komórki te są również źródłem S100B uwalnia nego do przestrzeni międzykomórkowej. Białko S100B uczestniczy w regulacji wielu procesów, takich jak: fosforylacja białek cytoszkieletowych, namnażanie się i różnicowanie komórek. Prowadzone od ponad 40 lat badania dowodzą, że S100B ma dodatni wpływ na procesy uczenia się. Są jednak również dowody wskazujące na to, że nadmiar S100B może prowadzić do zaburzeń pamięci. Jest możliwe, że zwiększone wydzielanie S100B przez astrocyty może być współodpowiedzialne za deficyty pamięci obserwowane we wczesnych stadiach choroby Alzheimera.","PeriodicalId":77994,"journal":{"name":"Advances in cell biology","volume":"-1 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2009-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68925505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Role of Connective Tissue Growth Factor (CTGF) in Fibroproliferative Processes and Tissues Fibrosis","authors":"K. Gojniczek, M. Jurzak, A. Garncarczyk","doi":"10.2478/V10052-008-0004-0","DOIUrl":"https://doi.org/10.2478/V10052-008-0004-0","url":null,"abstract":"","PeriodicalId":77994,"journal":{"name":"Advances in cell biology","volume":"8 1","pages":"1-17"},"PeriodicalIF":0.0,"publicationDate":"2008-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68949702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cytosolic Phospholipase A2 and its Role in Parkinson's Disease","authors":"Anna Stolecka, M. Chalimoniuk","doi":"10.2478/V10052-008-0002-2","DOIUrl":"https://doi.org/10.2478/V10052-008-0002-2","url":null,"abstract":"","PeriodicalId":77994,"journal":{"name":"Advances in cell biology","volume":"-1 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2008-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68949637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sines – Interspersed Elements of Eukaryote Genomes","authors":"Marek Gadzalski, T. Sakowicz","doi":"10.2478/V10052-008-0001-3","DOIUrl":"https://doi.org/10.2478/V10052-008-0001-3","url":null,"abstract":"SINEs (Short INterspersed Elements or Short Interspersed Nuclear Elements) are a class of dispersed and mobile DNA sequences (less than 500 basepairs (bp) in length) that are propagated through a replicative mechanism called retrotransposition, in which a RNA intermediate is reverse-transcribed into a cDNA that can integrate into the genome. As nonautonomous elements with no coding capability SINEs must use the enzymatic machinery of an autonomous LINE (Long INterspersed Element) partner for retroposition [20]. This SINE-LINE partnership is based on common 3' terminal regions or polyadenylated tails. These interspersed elements are found in essentially all eukaryotic nuclear genomes [5, 17, 19, 22, 23]. Interestingly, SINEs are particularly abundant in mammals accounting for more than 15% of the human genome. All currently known SINEs are derived from tRNA (major classes), 7SL RNA or 5S rRNA (for several mammalian and zebrafish families) genes, and exploit their type 1 or 2 internal polymerase III promoters. Conservation in tRNA-related regions and the internal promoter (composed of A and B motifs) allows recognition by the RNA polymerase III machinery [8]. SINEs are probably mobilized by the retroposition activity of autonomous long interspersed elements (LINEs) and upon integration usually generate a duplication of the genomic target sites. The most extensively characterized SINE families are the human Alu family (the most abundant SINE in the human genome that is amplified to a copy","PeriodicalId":77994,"journal":{"name":"Advances in cell biology","volume":"-1 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2008-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68949591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nucleolin – Characteristics of Protein and its Role in Biology of Cancers and Viral Infections","authors":"M. Masiuk","doi":"10.2478/V10052-008-0003-1","DOIUrl":"https://doi.org/10.2478/V10052-008-0003-1","url":null,"abstract":"","PeriodicalId":77994,"journal":{"name":"Advances in cell biology","volume":"-1 1","pages":"1-19"},"PeriodicalIF":0.0,"publicationDate":"2008-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/V10052-008-0003-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68949654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}