Advances in cell biology最新文献_第3页

Innovative Methods of Archiving, Presentation and Providing Access to Histological Sections 组织切片的归档、呈现和提供访问的创新方法

Advances in cell biology Pub Date : 2011-10-01 DOI: 10.2478/v10052-011-0003-4

K. Filipiak, A. Malińska, Dariusz Krupa, M. Zabel

{"title":"Innovative Methods of Archiving, Presentation and Providing Access to Histological Sections","authors":"K. Filipiak, A. Malińska, Dariusz Krupa, M. Zabel","doi":"10.2478/v10052-011-0003-4","DOIUrl":"https://doi.org/10.2478/v10052-011-0003-4","url":null,"abstract":"Summary The dynamic development of technical sciences and informatics makes now possible acquisition of microscopic images of histological sections, not only using digital cameras, but also through specialized devices called scanners. The digitalized images stored in a computer storage device are called virtual slides and, together with special software, are known as virtual microscopy. The virtual slides can be analyzed on a computer screen by panoramic viewing or using a detailed image examination at higher magnification. In many research and education institutions in both the U.S. and Europe, the virtual microscopy is used for teaching and training purposes. In the academic year of 2009/10, Department of Histology and Embryology, University of Medical Sciences in Poznan, as one of the first in Poland, has created a virtual database for educational purposes. This database created by archiving the traditional images of histological slides in the form of digital images. So far, more than 130 virtual slides have been acquired and catalogued in 24 thematic folders, available for medical students participating in histology, embryology and cell biology courses. Telepathology is the second branch which uses virtual microscopy. Virtual microscope allows to discuss and resolve medical/diagnostic problems with the use of telecommunication systems and information technology. The existing internet platforms offer access to virtual microscopes and virtual slides. In June, 2011 the Center of Morphologic Images Archivization and Digital Database of Microscopic Pictures in the Department of Histology and Embryology, Poznan University of Medical Sciences has launched an online platform (www.caom.pl), aimed to provide the central database of scanned histological sections of physiological tissues, and pathological, rare and sporadic lesions, including tumor","PeriodicalId":77994,"journal":{"name":"Advances in cell biology","volume":"3 1","pages":"41 - 53"},"PeriodicalIF":0.0,"publicationDate":"2011-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68949942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Selected Aspects of Angiogensis in Haematological Malignancies 血液系统恶性肿瘤血管生成的若干方面

Advances in cell biology Pub Date : 2011-06-01 DOI: 10.2478/v10052-011-0002-5

Patrycja Sujka-Kordowska, A. Malińska, M. Zabel

引用次数: 1

Tilling and Fox-Hunting: New Methods for Functional Analysis of Genes 种田和猎狐:基因功能分析的新方法

Advances in cell biology Pub Date : 2011-02-01 DOI: 10.2478/v10052-011-0001-6

K. Rybka

引用次数: 2

Tyreoliberin (Trh) – The Regulatory Neuropeptide of Cns Homeostasis Tyreoliberin（Trh）——Cns稳态的调节神经肽

Advances in cell biology Pub Date : 2010-11-01 DOI: 10.2478/v10052-010-0008-4

D. Jantas

引用次数: 3

Stem Cells of Adult Organisms in Biology and Medicine 干细胞在生物和医学上的应用

Advances in cell biology Pub Date : 2010-11-01 DOI: 10.2478/v10052-010-0009-3

J. Kawiak

{"title":"Stem Cells of Adult Organisms in Biology and Medicine","authors":"J. Kawiak","doi":"10.2478/v10052-010-0009-3","DOIUrl":"https://doi.org/10.2478/v10052-010-0009-3","url":null,"abstract":"Summary The life span of adult cells is restricted, becoming senescent and eventually undergoing apoptosis. Cells are replaced by new ones which originate from a population of stem cells. An example is provided by the hemopoietic system in the bone marrow. In an adult body, stem cells may be identified by markers present in both embryonic and tissue-specific stem cells. Oct3/4, CXCR4, Nanog, CD133 and CD34 are examples of such markers. The stem cells share several properties, such as they may: 1) replicate and give rise to new stem cells, 2) differentiate into heterogenous tissue and organ specific cells and, finally, 3) stem cells are self-protected against various toxic agents and radiation. In adult tissues, stem cells reside in specialized sites (niches), for example in the bone marrow, skin, digestive tract epithelium, and skeletal muscles. Stem cells residing in these stem cell niches are anchored there by chemokines and adhesion molecules. Stroma-Derived Factor-1 (SDF-1), α-chemokine and stem-cell expressed receptor CXCR4 play an important role in the retention of stem cells in such niches. Several stress factors may attenuate the SDF-1-CXCR4 axis in the bone marrow, which leads to the release of stem cells from their niches into circulation. Another important stem cell niche-anchoring mechanism is the interaction of Wnt (a ligand) with Frizzled LRP (receptor). The recently accumulated evidence suggests that malignancy arises from an arrest in maturation and mutation of stem cells. Cancer stem cells are responsible for tumor growth, its relapse and metastasis. The first direct evidence for the existence of cancer stem cells came from observations of acute myeloblastic leukemia. Currently, cell populations enriched for cancer stem cells have been isolated from several tumors. The cancer stem cells represent less than 1% of tumor cells in the mouse models.","PeriodicalId":77994,"journal":{"name":"Advances in cell biology","volume":"2 1","pages":"155 - 166"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68949551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Role of Glutathione in the Multidrug Resistance in Cancer 谷胱甘肽在癌症多药耐药中的作用

Advances in cell biology Pub Date : 2010-04-01 DOI: 10.2478/v10052-010-0006-6

E. Karwicka

引用次数: 4

The Role of Map Kinases in Immune Response Map激酶在免疫反应中的作用

Advances in cell biology Pub Date : 2010-04-01 DOI: 10.2478/v10052-010-0007-5

M. Krzyżowska, Weronika Swiatek, Beata Fijałkowska, M. Niemiałtowski, A. Schollenberger

引用次数: 18

The Current Knowledge of Invertebrate Aquaporin Water Channels with Particular Emphasis on Insect AQPs 目前对无脊椎动物水通道蛋白的认识，特别是对昆虫AQPs的认识

Advances in cell biology Pub Date : 2010-02-01 DOI: 10.2478/v10052-010-0005-7

E. Tomkowiak, J. Pieńkowska

{"title":"The Current Knowledge of Invertebrate Aquaporin Water Channels with Particular Emphasis on Insect AQPs","authors":"E. Tomkowiak, J. Pieńkowska","doi":"10.2478/v10052-010-0005-7","DOIUrl":"https://doi.org/10.2478/v10052-010-0005-7","url":null,"abstract":"Summary Aquaporins (AQPs) or water channels are some of the most ubiquitous integral membrane proteins, and are present in all living organisms. Their presence in the lipid bilayer of cell membranes considerably increases their permeability to water and, in some cases, to other small solutes. All AQPs, identified thus far, share the same structure, comprising of six transmembrane segments and two conserved regions forming the pore. Depending on the transported solutes, AQPs can be divided into two classes: ‘classical’ aquaporins (permeable only to water) and aquaglyceroporins (permeable also to glycerol and/or other solutes). Many subtypes of AQPs coexist in a single organism. Localization of particular subtypes of AQPs is tissue-specific. AQPs have been well characterized in almost all vertebrate classes. However, little is known about their counterparts in invertebrates. Most of the water channels characterized in invertebrates are found in insects. Therefore, the knowledge of aquaporins in invertebrates is generally limited to the information concerning water channels in this class of organism. Insects are characterized by an astonishing variety of physiological adaptations, notable in their feeding strategies or survival strategies in hostile environments. An example of such, is feeding on blood, or tolerating extreme cold or drought. It is likely that many of these adaptation patterns emerged due to the expression and regulation of particular aquaporins. Here we review the current state of knowledge of invertebrate AQPs (of insects and nematodes) and compare their structure and function with mammalian water channels","PeriodicalId":77994,"journal":{"name":"Advances in cell biology","volume":"11 1","pages":"104 - 91"},"PeriodicalIF":0.0,"publicationDate":"2010-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/v10052-010-0005-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68949415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Insulin Receptor and its Relationship with Different Forms of Insulin Resistance 胰岛素受体及其与不同形式胰岛素抵抗的关系

Advances in cell biology Pub Date : 2010-02-01 DOI: 10.2478/v10052-010-0004-8

A. Rojek, M. Niedziela

引用次数: 5

Pollen Transcriptome and Proteome: Molecular and Functional Analysis 花粉转录组和蛋白质组:分子和功能分析

Advances in cell biology Pub Date : 2010-01-01 DOI: 10.2478/v10052-010-0003-9

K. Rafińska, K. Zienkiewicz, E. Bednarska

引用次数: 3