Analytical Chemistry Letters最新文献_第3页

A stability-indicating liquid chromatography - diode array detection method for quantification of febuxostat in pharmaceuticals: a recent application to chemometrics based method development and comparative greenness assessment 用于定量检测药品中非布司他的稳定性指示液相色谱-二极管阵列检测方法：基于化学计量学的方法开发和绿色性比较评估的最新应用

Analytical Chemistry Letters Pub Date : 2024-02-20 DOI: 10.1080/22297928.2024.2314529

S. Panda, Anup Kumar Patra, R. Panda

引用次数: 0

Phytochemical profile, cytotoxic assay, antibacterial activity and In-silico evaluation of essential oil extracted from Nepeta nervosa , blue moon catmint 从蓝月猫薄荷（Nepeta nervosa）中提取的精油的植物化学成分、细胞毒性试验、抗菌活性和硅学评价

Analytical Chemistry Letters Pub Date : 2024-01-02 DOI: 10.1080/22297928.2023.2288032

Shariqah Hijazi, I. A. Nawchoo, S. Wani, Iqbal Zargar, W. A. Shah

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Harmonizing water quality: Integrating indices and chemo-metrics for sustainable management in the Ramganga river watershed 协调水质：整合拉姆甘加河流域可持续管理指数和化学计量指标

Analytical Chemistry Letters Pub Date : 2024-01-02 DOI: 10.1080/22297928.2024.2310636

Pawan Kumar, G. Matta, Amit Kumar

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Assessment of heavy metal concentrations in industrial samples near Byrnihat, Meghalaya: Implications for human health 梅加拉亚邦 Byrnihat 附近工业样本中重金属浓度的评估：对人类健康的影响

Analytical Chemistry Letters Pub Date : 2024-01-02 DOI: 10.1080/22297928.2024.2318298

Thangsim K Sangma, Nokman G Momin, Sengprang R Marak, Gamrik S Sangma, Hari Prasad Jaishi

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DoE based development and validation of HPTLC method for simultaneous estimation of Curcumin and Naringin in topical gel formulation 基于 DoE 的 HPTLC 方法的开发与验证，用于同时估测外用凝胶配方中的姜黄素和柚皮苷含量

Analytical Chemistry Letters Pub Date : 2024-01-02 DOI: 10.1080/22297928.2024.2314527

Vijaykumar K. Parmar, Dipali Mistry, Meghal D. Patel, Dharati Saradhara

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One-step electrodeposition of silver nanoparticles on multi-walled carbon nanotubes to fabricate an Ag-NPs@MWNTC&CPE sensor for the detection of the toxic antibiotic ronidazole in doped chicken liver and muscle 在多壁碳纳米管上一步电沉积纳米银制备Ag-NPs@MWNTC&CPE传感器，用于检测鸡肝脏和肌肉中掺杂的有毒抗生素ronidazole

Analytical Chemistry Letters Pub Date : 2023-11-09 DOI: 10.1080/22297928.2023.2263761

Jallal Zoubir, Yassine Elkhotfi, Samir Qourzal, Malika Tamimi, Abdessamad Tounsi, Ali Assabbane, Idriss Bakas

{"title":"One-step electrodeposition of silver nanoparticles on multi-walled carbon nanotubes to fabricate an Ag-NPs@MWNTC&CPE sensor for the detection of the toxic antibiotic ronidazole in doped chicken liver and muscle","authors":"Jallal Zoubir, Yassine Elkhotfi, Samir Qourzal, Malika Tamimi, Abdessamad Tounsi, Ali Assabbane, Idriss Bakas","doi":"10.1080/22297928.2023.2263761","DOIUrl":"https://doi.org/10.1080/22297928.2023.2263761","url":null,"abstract":"AbstractIn this work, a simple and innovative fabrication strategy was developed by electrodeposition procedures to combine a film of deposited silver nanoparticles (Ag- NPs) on multi-walled carbon nanotubes to fabricate an Ag- NPs@MWNTC&CPE sensor to detect the active principle of Ronidazole. The physicochemical nature of Ag- NPs@MWNTC&CPE nanocomposite, their texture and morphology were characterized by XRD and SEM. The electrochemical results were performed using cyclic voltammetry, ESI and differential pulse voltammetry techniques. Under optimal experimental conditions, a highly electrocatalytic activity is observed, the reduction reaction of Ronidazole is controlled by a diffusion process with the participation of four electrons and four protons, and a strong potential shift of the reduction peak was measured at -0.58 V/ Ag- NPs@MWNTC&CPE vs Ag/AgCl. The developed sensor shows good selectivity in the presence of metal ions, biomolecules and similar nitro-containing drugs. The results showed that the cathodic current peak was linearly proportional to the concentration of Ronidazole in the range of 1.0×10−4 to 1 ×10−7 M with a detection limit of LOD=2.01×10−8M. To analyze the practicality of the technique for the determination of Ronidazole in real samples of spiked chicken liver and muscle with satisfactory recoveries.Keywords: Multiwalled carbon nanotubeSilver nanoparticlesRonidazoleDifferential pulse voltammetryChicken liverChicken muscle","PeriodicalId":7793,"journal":{"name":"Analytical Chemistry Letters","volume":" 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135290540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nitrate-mediated kinetic leaching for rare earth elements recovery from phosphogypsum 硝酸盐介导的动力学浸出法从磷石膏中回收稀土元素

Analytical Chemistry Letters Pub Date : 2023-09-03 DOI: 10.1080/22297928.2023.2277744

A. Orabi, Ahmed H. Ismail, K. Abou El-Nour, Bahig M. Atia, M. Gado, M. Cheira

{"title":"Nitrate-mediated kinetic leaching for rare earth elements recovery from phosphogypsum","authors":"A. Orabi, Ahmed H. Ismail, K. Abou El-Nour, Bahig M. Atia, M. Gado, M. Cheira","doi":"10.1080/22297928.2023.2277744","DOIUrl":"https://doi.org/10.1080/22297928.2023.2277744","url":null,"abstract":"Abstract Phosphogypsum (PG) is a byproduct of the decomposition of phosphate rock with sulfuric acid during phosphoric acid synthesis. Various techniques such as X-ray diffraction (XRD), Scan electron microscope with electron dispersive spectroscopy (SEM-EDS), Fourier-transform infrared spectroscopy (FTIR), and Thermal gravimetric analysis (TGA) are utilized to characterize PG and rare earth concentrate. Heir, both nitric acid (HNO3) and ammonium nitrate (NH4NO3), are used as leaching agents for rare earth elements (REEs) from Egyptian PG. The ideal working conditions for leaching about 85% of REEs from PG are 350 mg/kg REEs in PG, 149 μm grain size, 0.5M NH4NO3, 2M HNO3, 1/4 S/L, 30 minutes leaching time, 300 rpm, and 80°C. The data on the kinetic REEs leaching are matched to the diffusion control model. The kinetics of the applicable leaching activity and the reaction mechanism between the mixture of nitric acid and ammonium nitrate with REEs have been explored in detail. After concentration by vaporization to one liter, a final concentration of REEs reached ≈ 300 mg/L with a leachability of 85%. The REEs were precipitated using 20% oxalic acid at pH 2.5 as oxalate, and then the precipitate was calcined at 900°C in an electric oven, given a mixture of REEs oxides and CaO. GRAPHICAL ABSTRACT","PeriodicalId":7793,"journal":{"name":"Analytical Chemistry Letters","volume":"33 1","pages":"561 - 580"},"PeriodicalIF":0.0,"publicationDate":"2023-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139343033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of human monoclonal antibodies nivolumab and relatlimab in opdualag by using the RP-UPLC technique: method development and validation 利用 RP-UPLC 技术测定 opdualag 中的人单克隆抗体 nivolumab 和 relatlimab：方法开发与验证

Analytical Chemistry Letters Pub Date : 2023-09-03 DOI: 10.1080/22297928.2023.2289515

Sridhar Bonam, T. Siva Rao, K. Rama Srinivas, Suman Pallapati

{"title":"Determination of human monoclonal antibodies nivolumab and relatlimab in opdualag by using the RP-UPLC technique: method development and validation","authors":"Sridhar Bonam, T. Siva Rao, K. Rama Srinivas, Suman Pallapati","doi":"10.1080/22297928.2023.2289515","DOIUrl":"https://doi.org/10.1080/22297928.2023.2289515","url":null,"abstract":"Abstract A fixed combination of Nivolumab and Relatlimab (OPDUALAG) are human monoclonal antibodies (mAb) that are extensively used to treat skin cancer melanoma. The current investigation is to develop a robust, stability-indicating, and rapid method for the simultaneous determination of these two drugs by using the RP-UPLC technique. By utilizing this technique, the final chromatographic conditions were achieved with a Luna C18 column (50 x 2.1 mm, 1.6 μm), and a mobile phase made with acetonitrile and 0.1% formic acid, 6:4 ratio, respectively (Diluted 1.0 mL of Formic acid in 1000 mL of HPLC grade water) by adapting isocratic elution. Both Nivolumab and Relatlimab were detected at 229 nm, and a satisfactory separation was achieved in 3.0 minutes of run time with a flow rate of 0.2 mL/min. The method is linear from 15 - 90 μg/mL for Nivolumab (R2 = 0.9996) and 5 - 30 μg/mL for Relatlimab (R2 = 0.9997). Results of method repeatability for Nivolumab (% RSD=1.3 %) and Relatlimab (% RSD=0.48 %) and intermediate precision Nivolumab (% RSD=1.1 %) and Relatlimab (% RSD=0.48%) were found within acceptable limits. Also, the forced degradation study results show that it is discernible; the degradation products of both drugs were separated from the main peak, which demonstrates the efficiency of the stability-indicating method. So this method works well for routine analysis and stability studies. GRAPHICAL ABSTRACT","PeriodicalId":7793,"journal":{"name":"Analytical Chemistry Letters","volume":"26 1","pages":"528 - 538"},"PeriodicalIF":0.0,"publicationDate":"2023-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139343072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality by design approach in the formulation of vaginal tablet of fluconazole solid dispersion 氟康唑固体分散剂阴道片剂配方中的质量设计方法

Analytical Chemistry Letters Pub Date : 2023-09-03 DOI: 10.1080/22297928.2023.2271024

Pranita S. Kanojiya, Rita Wadetwar, Amit Godbole, Nilesh P. Gawande, Samiksha S. Dadmal, Adesh L. Fasate, Chandu B. Karad

{"title":"Quality by design approach in the formulation of vaginal tablet of fluconazole solid dispersion","authors":"Pranita S. Kanojiya, Rita Wadetwar, Amit Godbole, Nilesh P. Gawande, Samiksha S. Dadmal, Adesh L. Fasate, Chandu B. Karad","doi":"10.1080/22297928.2023.2271024","DOIUrl":"https://doi.org/10.1080/22297928.2023.2271024","url":null,"abstract":"Abstract Vaginal Candidiasis had caused quite frequent gynecological medical consultations. Fluconazole is an antifungal drug that has poor solubility that hinders dissolution and antifungal activity. The study aimed to formulate the sustained release vaginal tablet of Fluconazole solid dispersion through the Design of Experiment approach to guarantee no compromise with the quality. In the first step, Plackett Burman Design was employed for the preliminary screening of the essential factors that would affect the tablet’s property. The significant factors were used further in applying the 32 factorial design and the responses were studied. The drug release, bioadhesive strength and swelling index were taken as the responses and considered as the vital critical quality attributes of the vaginal tablet. The design space was determined through the contour and response surface plots. The tablet was prepared within the design space with the drug release (99.97±0.1%), bioadhesive strength (1671.62±43.23 dynes/cm2), and swelling index (342.47±5 %) that suggested the values lie within the quality target product profile determined previously. The antifungal activity against C. albicans resulted in a larger inhibition zone for the solid dispersion-based tablet (51±3 mm) than the plain drug-based tablet (36±2 mm). GRAPHICAL ABSTRACT","PeriodicalId":7793,"journal":{"name":"Analytical Chemistry Letters","volume":"69 1","pages":"505 - 527"},"PeriodicalIF":0.0,"publicationDate":"2023-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139343075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological and computational studies of novel scaffolds of gallic acid: insight from density functional theory and molecular docking studies 没食子酸新型支架的生物学和计算研究：密度泛函理论和分子对接研究的启示

Analytical Chemistry Letters Pub Date : 2023-09-03 DOI: 10.1080/22297928.2023.2283451

Shariqah Hijazi, Nayeem Ahmed, H. Louis, Imojara Anna, W. A. Shah

{"title":"Biological and computational studies of novel scaffolds of gallic acid: insight from density functional theory and molecular docking studies","authors":"Shariqah Hijazi, Nayeem Ahmed, H. Louis, Imojara Anna, W. A. Shah","doi":"10.1080/22297928.2023.2283451","DOIUrl":"https://doi.org/10.1080/22297928.2023.2283451","url":null,"abstract":"Abstract In this study, we carried out the isolation of gallic acid from Hippophae rhamnoides plant followed by synthetic modification by using Dicyclohexyl carbodimide (DCC) as a coupling reagent. The synthetic modification involves the amidation of Gallic acid by a one-step protocol, converting gallic acid to its corresponding amide derivatives. The reactions involve a simple one-pot procedure with the formation of a chain of scaffolds of various beneficial amides in good to outstanding yields. The synthesized amides were characterized by several spectroscopic techniques like FTIR, HNMR, and Mass spectrometry. The synthetic derivatives were theoretically studied by Density Functional Theory (DFT) and their biological structural feasibility was studied by docking studies. Moreover, the antibacterial activities of the derivatives were also evaluated, and it is worthwhile to mention that all compounds have shown good antibacterial activity with the highest inhibition zone of 21 mm (A2) against strains of gram-positive and gram-negative bacteria with MIC value of 40 mg/mL. GRAPHICAL ABSTRACT","PeriodicalId":7793,"journal":{"name":"Analytical Chemistry Letters","volume":"48 1","pages":"487 - 504"},"PeriodicalIF":0.0,"publicationDate":"2023-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139343102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0