Pediatric pharmacology (New York, N.Y.)最新文献_第7页

Precursor prothrombin status in two mother-infant pairs following gestational anticonvulsant therapy. 妊娠期抗惊厥治疗后两对母婴凝血酶前体原状态。

Pediatric pharmacology (New York, N.Y.) Pub Date : 1984-01-01

A C Argent, A D Rothberg, N Pienaar

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The assessment of pulmonary vascular tone: a review of experimental methodologies. 肺血管张力的评估:实验方法综述。

Pediatric pharmacology (New York, N.Y.) Pub Date : 1984-01-01

T J Kulik, J E Lock

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Pharmacokinetics and metabolism of trimethoprim in neonatal and young pigs. 甲氧苄啶在新生猪和幼猪体内的药代动力学和代谢。

Pediatric pharmacology (New York, N.Y.) Pub Date : 1984-01-01

C Friis, N Gyrd-Hansen, P Nielsen, L Nordholm, F Rasmussen

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Circulatory effects of tolazoline and prostacyclin (PGI2) in chronically instrumented lambs. 长期使用托唑啉和前列环素(PGI2)对羔羊循环的影响。

Pediatric pharmacology (New York, N.Y.) Pub Date : 1984-01-01

W H Drummond, B J Williams, I B Webb

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Polymorphic acetylation of 7-amino-clonazepam in human liver cytosol. 7-氨基氯硝西泮在人肝细胞质中的多态乙酰化。

Pediatric pharmacology (New York, N.Y.) Pub Date : 1984-01-01

D R Peng, C Birgersson, C von Bahr, A Rane

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Evaluation of adverse renal reactions to prolonged indomethacin therapy in preterm infants with persistent ductus arteriosus. 长期吲哚美辛治疗顽固性动脉导管早产儿肾脏不良反应的评价。

Pediatric pharmacology (New York, N.Y.) Pub Date : 1983-01-01

H W Seyberth, W Rascher, L Wille, E Hackenthal, H E Ulmer

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Ontogeny of ovarian glutathione and sensitivity to primordial oocyte destruction by cyclophosphamide. 卵巢谷胱甘肽的个体发生及对环磷酰胺破坏原始卵母细胞的敏感性。

Pediatric pharmacology (New York, N.Y.) Pub Date : 1983-01-01

D R Mattison, K Shiromizu, J A Pendergrass, S S Thorgeirsson

{"title":"Ontogeny of ovarian glutathione and sensitivity to primordial oocyte destruction by cyclophosphamide.","authors":"D R Mattison, K Shiromizu, J A Pendergrass, S S Thorgeirsson","doi":"","DOIUrl":"","url":null,"abstract":"Ovarian reduced glutathione concentration (microgram/mg wet ovarian weight) develops from levels of less than 0.2 microgram/mg in newborn Osborn Mendel rats to plateau at 0.7 microgram/mg between the ages of 3-7 weeks of age, finally reaching mature levels of approximately 1.0 microgram/mg between 7-8 weeks of age. Ovarian reduced glutathione concentration matures somewhat faster in Sprague Dawley rats, reaching mature levels of 1.0 microgram/mg between 4-6 weeks of age. The development of ovarian glutathione from immature (less than 0.2 microgram/mg) to mature levels (1.0 microgram/mg) was also observed over similar developmental time spans in DBA/2N and C57BL/6N mice. The sensitivity of primordial oocytes to destruction by cyclophosphamide in C57BL/6N mice was considerably different at 4 and 6 weeks of age. The ED50 for primordial oocyte destruction at 4 weeks of age in C57BL/6N mice was 140 mg/kg while at 6 weeks of age the ED50 was 260 mg/kg. The increase in ovarian reduced glutathione with age and the increasing resistance to primordial oocyte destruction over the same time period are consistent with the hypothesis that glutathione plays a major role in the modulation of primordial oocyte destruction.","PeriodicalId":77932,"journal":{"name":"Pediatric pharmacology (New York, N.Y.)","volume":"3 1","pages":"49-55"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17702180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of phenobarbital treatment on erythrocyte glucose-6-phosphate dehydrogenase in human newborns. 苯巴比妥治疗对新生儿红细胞葡萄糖-6-磷酸脱氢酶的影响。

Pediatric pharmacology (New York, N.Y.) Pub Date : 1983-01-01

E Laconi, S Dessì, B Batetta, P Pani, L Pirisi, C Andria, A Macciotta

引用次数: 0

Aortic flow velocity curves in the diagnosis and the followup of symptomatic patent ductus arteriosus in preterm infants during therapeutic interventions. 治疗干预期间早产儿症状性动脉导管未闭的主动脉血流速度曲线诊断及随访。

Pediatric pharmacology (New York, N.Y.) Pub Date : 1983-01-01

H E Ulmer, G Knapp, D Wolf, L Wille, H W Seyberth

{"title":"Aortic flow velocity curves in the diagnosis and the followup of symptomatic patent ductus arteriosus in preterm infants during therapeutic interventions.","authors":"H E Ulmer, G Knapp, D Wolf, L Wille, H W Seyberth","doi":"","DOIUrl":"","url":null,"abstract":"In preterm infants, persistent ductus arteriosus (PDA) fails to close soon after birth and becomes symptomatic (sPDA) in about 40% of the infants, causing cardio-respiratory deterioration by a left-to-right shunt across the PDA. Aortic run-off of blood, predominantly occurring during ventricular diastole, causes an abnormal diastolic retrograde aortic blood flow. This aortic reverse flow can be assessed semi-quantitatively in a noninvasive way, using continuous-wave Doppler-ultrasonography. An increased ratio (R/F ratio) of the abnormal retrograde aortic blood flow (R) related to the normal forward flow (F) in the aorta indicates presence of sPDA in preterm infants. The R/F ratio was assessed in 30 premature infants, including 13 cases without sPDA, and 17 infants with sPDA--in 12 of them before and after surgical ligation of PDA, in five concomitantly to pharmacological closure of PDA by the application of indomethacin. The R/F ratio was low in all infants without sPDA and in infants following surgical ligation of PDA. On the other hand, a high R/F ratio was found in all patients with sPDA before specific treatment. During indomethacin-induced closure of PDA the R/F ratio decreased continuously, whereas it remained high in infants with sPDA not responding to indomethacin treatment.","PeriodicalId":77932,"journal":{"name":"Pediatric pharmacology (New York, N.Y.)","volume":"3 3-4","pages":"167-74"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17732401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epoxide hydrolase and aryl hydrocarbon hydroxylase in human fetal tissues: activities in nuclear and microsomal fractions and in isolated hepatocytes. 人胎儿组织中的环氧化物水解酶和芳烃羟化酶:核和微粒体部分和分离肝细胞的活性。

Pediatric pharmacology (New York, N.Y.) Pub Date : 1983-01-01

G M Pacifici, D Peng, A Rane

{"title":"Epoxide hydrolase and aryl hydrocarbon hydroxylase in human fetal tissues: activities in nuclear and microsomal fractions and in isolated hepatocytes.","authors":"G M Pacifici, D Peng, A Rane","doi":"","DOIUrl":"","url":null,"abstract":"Epoxide formation from drugs, chemicals, food additives and environmental pollutants is catalyzed by cytochrome P-450 dependent monooxygenase(s). Epoxides are converted to glycols or dihydrodiols by epoxide hydrolase (EH). These enzymes are known to be present in the microsomes of different mammalian tissues and in the hepatic nuclei from rats and humans. The balance between the epoxide forming (AHH) and metabolizing (EH) enzyme activities may provide information about the \"epoxide exposure\" of a tissue. We thus investigated AHH and EH in the nuclear and microsomal fractions from six livers, four kidneys, four lungs, and two adrenals from human fetuses (gestational age between 15 and 24 weeks). Tissues were obtained at legal abortion for sociomedical reasons. AHH activity was measured according to van Cantfort et al (Biochem Biophys Res Commun 79: 505, 1977) using beno (a)pyrene as substrate. EH was measured as described by Jerina et al (Mol Pharmacol 13:342, 1977) using both styrene oxide (SO) and benzo(a)pyrene-4,5-oxide (BPO) as substrate. The nuclear fraction was isolated by a multistep procedure including centrifugation in high density sucrose ( Pacifici et al, unpublished). The hepatic AHH activity (pmole/min/mg; mean +/- SEM) was 11.5 +/- 2.2 in the nuclear fraction and 34.7 +/- 1.7 in the microsomes. In adrenals it was 6.0 (nuclei) and 4.4 (microsomes). The nuclear fraction from kidneys and lungs did not catalyze this reaction at a measurable rate, whereas microsomal AHH activity was 1.3 +/- 0.3 and 5.3 +/- 1.1, respectively, in these tissues.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":77932,"journal":{"name":"Pediatric pharmacology (New York, N.Y.)","volume":"3 3-4","pages":"189-97"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17732403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0