Archives of gerontology and geriatrics. Supplement最新文献

Experimental dissociation of memory systems in mice: behavioral and neurochemical aspects. 小鼠记忆系统的实验分离:行为和神经化学方面。

Archives of gerontology and geriatrics. Supplement Pub Date : 1989-01-01

R Jaffard, T Durkin, A Toumane, A Marighetto, C Lebrun

引用次数: 0

Memory processes and aging: a defect of automatic rather than controlled processes? 记忆过程与衰老:是一种自动而非受控过程的缺陷?

Archives of gerontology and geriatrics. Supplement Pub Date : 1989-01-01

J Delbecq-Derouesné, M F Beauvois

{"title":"Memory processes and aging: a defect of automatic rather than controlled processes?","authors":"J Delbecq-Derouesné, M F Beauvois","doi":"","DOIUrl":"","url":null,"abstract":"The effect of age (20-86) and/or cultural level is investigated from the point of view of Cognitive Psychology. The study was carried out with 75 subjects distributed into 5 age-ranges and 3 cultural levels. It involved the following memory tests: forced choice recognition of faces (Warrington, 1984) and of abstract paintings; Rey Figure; immediate free recall; final free recall; learning and retention of paired associates; learning with AB-AC-AB design to test for interference; Selective Reminding test of Buschke (1973); repeated free recall. Data where analysed, taking into account dozens of variables. As far as age is concerned, all the analyses converge toward the same conclusion: short-term memory is not significantly affected by age, while a clear distinction appears between two kinds of secondary memory. Secondary memory involved in the course of learning or in the retention of learning is unaffected by age. By contrast, secondary memory involved in the retention of an initial or single confrontation with test material is very much affected by age. Age might, therefore, differentially affect two kinds of secondary memory. It is suggested that, contrary to the view of certain authors, age mainly affects automatic secondary memory, whereas voluntary, conscious, controlled and effortful secondary memory, which could require a greater amount of 'mental energy' or attentional resource, is relatively well preserved with age.","PeriodicalId":77833,"journal":{"name":"Archives of gerontology and geriatrics. Supplement","volume":"1 ","pages":"121-50"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13896425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A logical approach to the clinical assessment of cerebro-active drugs. 脑活性药物临床评价的逻辑方法。

Archives of gerontology and geriatrics. Supplement Pub Date : 1989-01-01

J Wertheimer

引用次数: 0

How to evaluate a drug efficacy at the behavioural level? 如何在行为层面评估药物的疗效?

Archives of gerontology and geriatrics. Supplement Pub Date : 1989-01-01

J P Aquino, J Poitrenaud

引用次数: 0

Animal studies of brain acetylcholine and memory. 脑乙酰胆碱和记忆的动物研究。

Archives of gerontology and geriatrics. Supplement Pub Date : 1989-01-01

R J Beninger, B A Wirsching, K Jhamandas, R J Boegman

{"title":"Animal studies of brain acetylcholine and memory.","authors":"R J Beninger, B A Wirsching, K Jhamandas, R J Boegman","doi":"","DOIUrl":"","url":null,"abstract":"Memory loss is a common feature of aging in the human but not all memories are equally lost. Usually the loss is more severe for the memory of recent events and information rather than the memory of remote events and information. Associated with memory losses of this type is a reduction in levels of cortical acetylcholine and a loss of cholinergic cells of the nucleus basalis magnocellularis. In the rat it is possible to assess two types of memory analogous to recent and remote memories in humans. Reference memory would refer to information concerning the task that is invariant from trial to trial. Working memory would refer to information that changes from trial to trial. In support of the hypothesis that decreases in cholinergic function lead to a differential impairment of working memory, rats trained in this task and given scopolamine showed a specific increase in working memory errors. In more recent studies rats have been trained in a task and then given unilateral neurotoxic lesions of the NBM. These results raise the intriguing possibility that degeneration of the NBM and associated memory impairment seen in aging and in Alzheimer's disease may be related to a change in the ratio of these or related endogenous tryptophan metabolites.","PeriodicalId":77833,"journal":{"name":"Archives of gerontology and geriatrics. Supplement","volume":"1 ","pages":"71-89"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13712118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Positron emission tomographic study in Alzheimer's disease and Pick's disease. 阿尔茨海默病和匹克病的正电子发射断层扫描研究。

Archives of gerontology and geriatrics. Supplement Pub Date : 1989-01-01

E Salmon, G Franck

引用次数: 0

Neuropathology of amnesic syndromes. 失忆综合征的神经病理学。

Archives of gerontology and geriatrics. Supplement Pub Date : 1989-01-01

C Duyckaerts

引用次数: 0

Drug development in age-related memory disorders. 与年龄有关的记忆障碍的药物开发。

Archives of gerontology and geriatrics. Supplement Pub Date : 1989-01-01

D Guez