Analytical Chemistry Insights最新文献_第6页

Holistic Control of Herbal Teas and Tinctures Based on Sage (Salvia officinalis L.) for Compounds with Beneficial and Adverse Effects using NMR Spectroscopy. 基于鼠尾草(Salvia officinalis L.)的草药茶和酊剂对有益和不良反应化合物的整体控制。

Analytical Chemistry Insights Pub Date : 2012-01-01 Epub Date: 2012-03-21 DOI: 10.4137/ACI.S8946

Stephan G Walch, Dirk W Lachenmeier, Thomas Kuballa, Wolf Stühlinger, Yulia B Monakhova

{"title":"Holistic Control of Herbal Teas and Tinctures Based on Sage (Salvia officinalis L.) for Compounds with Beneficial and Adverse Effects using NMR Spectroscopy.","authors":"Stephan G Walch, Dirk W Lachenmeier, Thomas Kuballa, Wolf Stühlinger, Yulia B Monakhova","doi":"10.4137/ACI.S8946","DOIUrl":"https://doi.org/10.4137/ACI.S8946","url":null,"abstract":"A methodology that utilizes (1)H-NMR spectroscopy has been developed to simultaneously analyze toxic terpenes (thujone and camphor), major polyphenolic compounds, the total antioxidant capacity (ORAC) and the Folin-Ciocalteu (FC) index in foods and medicines containing sage. The quantitative determination of rosmarinic acid (limit of detection (LOD) = 10 mg/L) and total thujone (LOD = 0.35 mg/L) was possible using direct integration of the signals. For other parameters (derivatives of rosmarinic acid, carnosol and flavone glycosides, ORAC and FC index), chemometric regression models obtained separately for alcohol-based tinctures (R(2) = 0.94-0.98) and aqueous tea infusions (R(2) = 0.79-0.99) were suitable for screening analysis. The relative standard deviations for authentic samples were below 10%. The developed methodology was applied for the analysis of a wide variety of sage products (n = 108). The total thujone content in aqueous tea infusions was found to be in the range of not detectable (nd) to 37.5 mg/L (average 9.2 mg/L), while tinctures contained higher levels (range nd-409 mg/L, average 107 mg/L). The camphor content varied from 2.1 to 43.7 mg/L in aqueous infusions and from not detectable to 748 mg/L in tinctures (averages were 14.1 and 206 mg/L, respectively). Phenolic compounds were also detected in the majority of the investigated products. (1)H-NMR spectroscopy was proven to have the ability to holistically control all important adverse and beneficial compounds in sage products in a single experiment, considerably saving time, resources and costs as NMR replaces four separate methodologies that were previously needed to analyze the same parameters.","PeriodicalId":7781,"journal":{"name":"Analytical Chemistry Insights","volume":"7 ","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/ACI.S8946","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30566138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Analysis and Confirmation of 1,3-DMAA and 1,4-DMAA in Geranium Plants Using High Performance Liquid Chromatography with Tandem Mass Spectrometry at ng/g Concentrations. 用高效液相色谱-串联质谱法测定天竺葵植物中1,3- dmaa和1,4- dmaa的含量。

Analytical Chemistry Insights Pub Date : 2012-01-01 Epub Date: 2012-11-08 DOI: 10.4137/ACI.S10445

Heather L Fleming, Patricia L Ranaivo, Paul S Simone

{"title":"Analysis and Confirmation of 1,3-DMAA and 1,4-DMAA in Geranium Plants Using High Performance Liquid Chromatography with Tandem Mass Spectrometry at ng/g Concentrations.","authors":"Heather L Fleming, Patricia L Ranaivo, Paul S Simone","doi":"10.4137/ACI.S10445","DOIUrl":"https://doi.org/10.4137/ACI.S10445","url":null,"abstract":"1,3-Dimethylamylamine (1,3-DMAA) is a stimulant commercially sold in a variety of dietary supplements as a chemical species derived from geranium plants (Pelargonium graveolens). Whether 1,3-DMAA naturally occurs in geranium plants or other dietary ingredients, it has important regulatory and commercial ramifications. However, the analysis of 1,3-DMAA in geranium plants is not trivial due to low concentrations and a complex environmental matrix, requiring high selectivity and sensitivity. An extraction method combined with high performance liquid chromatography and tandem mass spectrometry is used to determine 1,3-DMAA and 1,4-dimethylamylamine (1,4-DMAA) concentrations in geranium plants with both external calibration and standard addition method. Samples from the Changzhou, Kunming, and Guiyang regions of China during both winter and summer were analyzed for 1,3-DMAA and 1,4-DMAA. The diastereomer ratios of the 1,3-DMAA stereoisomers of a racemic standard and the extracted plant were also quantified.","PeriodicalId":7781,"journal":{"name":"Analytical Chemistry Insights","volume":"7 ","pages":"59-78"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/ACI.S10445","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31107971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Identification and quantification of dimethylamylamine in geranium by liquid chromatography tandem mass spectrometry. 液相色谱串联质谱法测定天竺葵中二甲胺的含量。

Analytical Chemistry Insights Pub Date : 2012-01-01 Epub Date: 2012-08-06 DOI: 10.4137/ACI.S9969

J S Li, M Chen, Z C Li

{"title":"Identification and quantification of dimethylamylamine in geranium by liquid chromatography tandem mass spectrometry.","authors":"J S Li, M Chen, Z C Li","doi":"10.4137/ACI.S9969","DOIUrl":"https://doi.org/10.4137/ACI.S9969","url":null,"abstract":"A sensitive and reliable method of liquid chromatography-electrospray ionization/tandem mass spectrometry (LC-ESI/MS/ MS) was developed and validated for determining 1,3-dimethylamylamine (1,3-DMAA) and 1,4-dimethylamylamine (1,4-DMAA) in geranium plants (Pelargonium graveolens). The sample was extracted with 0.5 M HCl and purified by liquid-liquid partition with hexane. The parameters for reverse-phase (C18) LC and positive ESI/MS/MS were optimized. The matrix effect, specificity, linearity, precision, accuracy and reproducibility of the method were determined and evaluated. The method was linear over a range of 0.10-10.00 ng/mL examined, with R(2) of 0.99 for both 1,3-DMAA and 1,4-DMAA. The recoveries from spiked concentrations between 5.00-40.00 ng/g were 85.1%-104.9% for 1,3-DMAA, with relative standard deviation (RSD) of 2.9%-11.0%, and 82.9%-101.8% for 1,4-DMAA, with RSD of 3.2%-11.7%. The instrument detection limit was 1-2 pg for both DMAAs. The quantification limit was estimated to be 1-2 ng/g for the plant sample. This method was successfully applied to the quantitative determination of 1,3- and 1,4-DMAA in both geranium plant and geranium oil.","PeriodicalId":7781,"journal":{"name":"Analytical Chemistry Insights","volume":"7 ","pages":"47-58"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/ACI.S9969","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30853451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Evaluation of matrix-assisted laser desorption/ionization mass spectrometry for second-generation lignin analysis. 第二代木质素基质辅助激光解吸/电离质谱分析的评价。

Analytical Chemistry Insights Pub Date : 2012-01-01 Epub Date: 2012-12-13 DOI: 10.4137/ACI.S10799

Aurore Richel, Caroline Vanderghem, Mathilde Simon, Bernard Wathelet, Michel Paquot

{"title":"Evaluation of matrix-assisted laser desorption/ionization mass spectrometry for second-generation lignin analysis.","authors":"Aurore Richel, Caroline Vanderghem, Mathilde Simon, Bernard Wathelet, Michel Paquot","doi":"10.4137/ACI.S10799","DOIUrl":"https://doi.org/10.4137/ACI.S10799","url":null,"abstract":"Matrix-Assisted Laser Desorption/Ionization time-of-flight (MALDI-TOF) mass spectrometry is evaluated as an elucidation tool for structural features and molecular weights estimation of some extracted herbaceous lignins. Optimization of analysis conditions, using a typical organic matrix, namely α-cyano-4-hydroxycinnamic acid (CHCA), in combination with α-cyclodextrin, allows efficient ionization of poorly soluble lignin materials and suppression of matrix-related ions background. Analysis of low-mass fragments ions (m/z 100–600) in the positive ion mode offers a “fingerprint” of starting lignins that could be a fine strategy to qualitatively identify principal inter-unit linkages between phenylpropanoid units. The molecular weights of lignins are estimated using size exclusion chromatography and compared to MALDI-TOF-MS profiles. Miscanthus (Miscanthus x giganteus) and Switchgrass (Panicum Virgatum L.) lignins, recovered after a formic acid/acetic acid/water process or aqueous ammonia soaking, are selected as benchmarks for this study.","PeriodicalId":7781,"journal":{"name":"Analytical Chemistry Insights","volume":" ","pages":"79-89"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/ACI.S10799","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40221856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 40

Simultaneous determination of sitagliptin and metformin in pharmaceutical preparations by capillary zone electrophoresis and its application to human plasma analysis. 毛细管区带电泳同时测定药物制剂中的西格列汀和二甲双胍及其在人血浆分析中的应用。

Analytical Chemistry Insights Pub Date : 2012-01-01 Epub Date: 2012-07-30 DOI: 10.4137/ACI.S9940

Mohamed Salim, Nahed El-Enany, Fathallah Belal, Mohamed Walash, Gabor Patonay

{"title":"Simultaneous determination of sitagliptin and metformin in pharmaceutical preparations by capillary zone electrophoresis and its application to human plasma analysis.","authors":"Mohamed Salim, Nahed El-Enany, Fathallah Belal, Mohamed Walash, Gabor Patonay","doi":"10.4137/ACI.S9940","DOIUrl":"https://doi.org/10.4137/ACI.S9940","url":null,"abstract":"A novel, quick, reliable and simple capillary zone electrophoresis CZE method was developed and validated for the simultaneous determination of sitagliptin (SG) and metformin (MF) in pharmaceutical preparations. Separation was carried out in fused silica capillary (50.0 cm total length and 43.0 cm effective length, 49 μm i.d.) by applying a potential of 15 KV (positive polarity) and a running buffer containing 60 mM phosphate buffer at pH 4.0 with UV detection at 203 nm. The samples were injected hydrodynamically for 3 s at 0.5 psi and the temperature of the capillary cartridge was kept at 25 °C. Phenformin was used as internal standard (IS). The method was suitably validated with respect to specificity, linearity, limit of detection and quantitation, accuracy, precision, and robustness. The method showed good linearity in the ranges of 10-100 μg/mL and 50-500 μg/mL with limits of detection of 0.49, 2.11 μg/mL and limits of quantification of 1.48, 6.39 μg/mL for SG and MF, respectively. The proposed method was successfully applied for the analysis of the studied drugs in their synthetic mixtures and co-formulated tablets without interfering peaks due to the excipients present in the pharmaceutical tablets. The method was further extended to the in-vitro determination of the two drugs in spiked human plasma. The estimated amounts of SG/MF were almost identical with the certified values, and their percentage relative standard deviation values (% R.S.D.) were found to be ≤1.50% (n = 3). The results were compared to a reference method reported in the literature and no significant difference was found statistically.","PeriodicalId":7781,"journal":{"name":"Analytical Chemistry Insights","volume":"7 ","pages":"31-46"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/ACI.S9940","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30843827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 53

Two chromatographic methods for the determination of some antimigraine drugs. 两种色谱法测定抗偏头痛药物的含量。

Analytical Chemistry Insights Pub Date : 2012-01-01 Epub Date: 2012-05-14 DOI: 10.4137/ACI.S8864

Ramzia I El-Bagary, Nashwah G Mohammed, Heba A Nasr

{"title":"Two chromatographic methods for the determination of some antimigraine drugs.","authors":"Ramzia I El-Bagary, Nashwah G Mohammed, Heba A Nasr","doi":"10.4137/ACI.S8864","DOIUrl":"https://doi.org/10.4137/ACI.S8864","url":null,"abstract":"Two stability indicating chromatographic methods were proposed for the determination of almotriptan, eletriptan, and rizatriptan, in presence of their acid degradation products. The first method is a quantitative densitometric thin layer chromatography. The developing systems were; acetonitrile: methanol: dichloromethane: ammonia (10:6:3:1 v/v), ethyl acetate: methanol: ammonia (15:4:1 v/v), and methanol: acetonitrile: ammonia (9:4:1 v/v) for almotriptan, eletriptan and rizatriptan respectively. The TLC plates were scanned at 235 nm. Linear relationships were obtained over concentration ranges (5-50 μg/spot) for almotriptan and rizatriptan, and (5-60 μg/spot) for eletriptan. The second method based on the separation and determination of the studied drugs, using RP-HPLC technique. The separation was achieved on C18 Hypersil column, elution was carried out using phosphate buffer pH 3: methanol: acetonitrile (2: 1:1 v/v) at flow rate 2 mL/min and UV detection at 235 nm. Linear relationships were obtained over concentration ranges (10-200 μg/mL) for almotriptan and eletriptan, and (10-180 μg/mL) for rizatriptan. The chromatographic methods were successfully applied for the determination of each of the studied drugs in pure form, tablet form, and in laboratory prepared mixtures with their acid degradation products.","PeriodicalId":7781,"journal":{"name":"Analytical Chemistry Insights","volume":"7 ","pages":"13-21"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/ACI.S8864","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30659010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Erratum for “Determination of Trace Amounts of Lead Using the Flotation-spectrophotometric method” 用浮选-分光光度法测定痕量铅的勘误

Analytical Chemistry Insights Pub Date : 2011-06-06 DOI: 10.4137/ACI.S7674

S. Shiri, A. Delpisheh, A. Haeri, A. Poornajaf, Babakgolzadeh, Sina Shiri

引用次数: 2

Determination of Trace Amounts of Lead Using the Flotation-spectrophotometric method. 用浮选-分光光度法测定微量铅。

Analytical Chemistry Insights Pub Date : 2011-03-01 eCollection Date: 2011-01-01 DOI: 10.4137/ACI.S5948

Sabah Shiri, Ali Delpisheh, Ali Haeri, Abdolhossein Poornajaf, Babak Golzadeh, Sina Shiri

{"title":"Determination of Trace Amounts of Lead Using the Flotation-spectrophotometric method.","authors":"Sabah Shiri, Ali Delpisheh, Ali Haeri, Abdolhossein Poornajaf, Babak Golzadeh, Sina Shiri","doi":"10.4137/ACI.S5948","DOIUrl":"https://doi.org/10.4137/ACI.S5948","url":null,"abstract":"The present study describes a simple and highly selective method for separation, preconcentration and spectrophotometric determination of extremely low concentrations of lead. It is based on flotation of a complex of Pb2+ ions and Alizarin yellow between aqueous and n-hexane interface at pH = 6. The proposed procedure is also applied for determination of lead in both tap water and prepared sea water samples. Beer's Law was obeyed over the concentration range of 3.86 × 10-8 To 8.20 × 10-7 molL-1 (8-170 ngmL-1) with an apparent molar absorptivity of 1.33 × 106 molL-1 cm-1 for a 100 mL aliquot of the water sample. The detection limit (n = 10) was 8.7 × 10-9 molL-1 (1.0 ngmL-1) and the Relative standard deviation (R.S.D), (n = 10) for 7.2 × 10-7 molL-1 (150 ngmL-1) of Pb (II) was 4.36%. A notable advantage of the method is that the determination of Pb (II) is free from the interference of almost all cations and ions found in the environment and waste water samples. The determination of Pb (II) in tap and synthetic seawater samples was also carried out by the present method. The results were satisfactorily comparable so that the applicability of the proposed method was confirmed to the real samples.","PeriodicalId":7781,"journal":{"name":"Analytical Chemistry Insights","volume":"6 ","pages":"15-20"},"PeriodicalIF":0.0,"publicationDate":"2011-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/ACI.S5948","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36821410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Floatation-spectrophotometric Determination of Thorium, Using Complex Formation with Eriochrome Cyanine R. 利用与 Eriochrome Cyanine R 形成的络合物进行浮游-分光光度法钍测定

Analytical Chemistry Insights Pub Date : 2011-01-23 DOI: 10.4137/ACI.S5949

Sabah Shiri, Ali Delpisheh, Ali Haeri, Abdolhossein Poornajaf, Tahereh Khezeli, Nadie Badkiu

{"title":"Floatation-spectrophotometric Determination of Thorium, Using Complex Formation with Eriochrome Cyanine R.","authors":"Sabah Shiri, Ali Delpisheh, Ali Haeri, Abdolhossein Poornajaf, Tahereh Khezeli, Nadie Badkiu","doi":"10.4137/ACI.S5949","DOIUrl":"10.4137/ACI.S5949","url":null,"abstract":"A novel and sensitive floatation-spectrophotometric method is presented for determination of trace amounts of thorium in water samples. The method is based on the ion-associated formation between thorium, Eriochrome cyanine R and Brij-35 at pH = 4 media. The complex was floated in the interface of the aqueous phase and n-hexane by vigorous shaking. After removing the aqueous phase the floated particles were dissolved in methanol and the absorbance was measured at 607 nm. The influence of different important parameters such as Eriochrome cyanine R and surfactants concentration, pH, volume of n-hexane, standing time and interfering ions were evaluated. Under optimized conditions the calibration graph was linear in the range of 6-230 ng mL(-1) of thorium with a correlation coefficient of 0.9985. The limit of detections (LOD), based on signal to noise ratio (S/N) of 3 was 1.7 ng mL(-1). The relative standard deviations for determination of 150 and 30 ng ml(-1) of thorium were 3.26 and 4.41%, respectively (n = 10). The method showed a good linearity, recoveries, as well as some advantages such as sensitivity, simplicity, affordability and a high feasibility. The method was successfully applied to determine thorium in different water and urine samples.","PeriodicalId":7781,"journal":{"name":"Analytical Chemistry Insights","volume":"6 ","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2011-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29688738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of varying short-chain alkyl substitution on the molar absorptivity and quantum yield of cyanine dyes. 不同短链烷基取代对菁染料摩尔吸收率和量子产率的影响。

Analytical Chemistry Insights Pub Date : 2011-01-01 Epub Date: 2011-03-23 DOI: 10.4137/ACI.S6568

Gala Chapman, Maged Henary, Gabor Patonay

引用次数: 31