J DeMaubeuge, E Haneke, D Djawari, K Wolff, G Stingl, L Molin, E Schöpf, R Stengel, H Degreef, E Panconesi
{"title":"Thymopentin treatment of herpes simplex infections. An open, monitored, multicenter study.","authors":"J DeMaubeuge, E Haneke, D Djawari, K Wolff, G Stingl, L Molin, E Schöpf, R Stengel, H Degreef, E Panconesi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Twenty-seven patients suffering from long-standing, severe, recurrent herpes simplex (14 labial and 13 genital) who had not responded adequately to prior therapy were recruited for this open, monitored study. They were treated with thymopentin 50 mg subcutaneously three times weekly for a period of 6 weeks. Clinical controls were performed once a week and then again 6 weeks after cessation of therapy; laboratory investigations were done at time points 0, 3, and 6 weeks. Additionally, information was collected with regard to the clinical course during the following year. Thirteen of 14 patients with labial infection and 10 of the 13 with genital herpes improved markedly (p less than 0.05) as shown by decrease in the relapse rate of at least 50%, shorter relapse episodes, and improvement of symptoms such as pain and itching. Fourteen of these 27 patients experienced no relapse for a period longer than 4 months after cessation of therapy. These favorable results were paralleled by a statistically significant increase in the T cell helper/suppressor ratio. This finding indicates that thymopentin acts as an immunodomulator; it is assumed that the activation of T helper cells induces-presumable via interleukin 2-the proliferation of cytotoxic T lymphocytes and natural killer cells which play a major role in the natural immune defense. No serious side effects of thymopentin were recorded.</p>","PeriodicalId":77804,"journal":{"name":"Survey of immunologic research","volume":"4 Suppl 1 ","pages":"30-6"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14001383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tolerance induction and maintenance in primed lymphocytes.","authors":"J D Levich, W O Weigle","doi":"10.1007/BF02918739","DOIUrl":"https://doi.org/10.1007/BF02918739","url":null,"abstract":"","PeriodicalId":77804,"journal":{"name":"Survey of immunologic research","volume":"4 4","pages":"313-8"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02918739","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13572081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The prothymocyte revisited.","authors":"A E Silverstone","doi":"10.1007/BF02918579","DOIUrl":"https://doi.org/10.1007/BF02918579","url":null,"abstract":"","PeriodicalId":77804,"journal":{"name":"Survey of immunologic research","volume":"4 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02918579","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14989407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Thymopentin in experimental and clinical medicine.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77804,"journal":{"name":"Survey of immunologic research","volume":"4 Suppl 1 ","pages":"1-156"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15014898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tumor growth and evasion of immune destruction: UV-induced tumors as a model.","authors":"C A Mullen, H Schreiber","doi":"10.1007/BF02918734","DOIUrl":"https://doi.org/10.1007/BF02918734","url":null,"abstract":"<p><p>A number of complex interrelating mechanisms contributing to progressive growth of an immunogenic tumor and its evasion of immune destruction are exemplified in the model of the UV-induced tumor 1591 (fig. 3). The effects of (i) carcinogen-induced immune suppression, (ii) age-related changes in immune competence, (iii) generation and immunoselection of tumor cell variants which do not express target tumor antigen and (iv) tumor-induced immune suppression have been documented. The findings may help to assess the problems and the possibilities of immunotherapy of cancer. The problems reside in the many avenues of escape available to the tumor. The possibilities for immunotherapy derive from the fact that progressively growing tumors may still retain immunogenic antigens and therefore be susceptible to immune attack.</p>","PeriodicalId":77804,"journal":{"name":"Survey of immunologic research","volume":"4 4","pages":"264-70"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02918734","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14077945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Thymopentin: stability considerations and potency by various routes of administration.","authors":"T K Audhya, G Goldstein","doi":"10.1007/BF02919052","DOIUrl":"https://doi.org/10.1007/BF02919052","url":null,"abstract":"<p><p>Thymopentin, the synthetic pentapeptide Arg-Lys-Asp-Val-Tyr corresponding to amino acids 32-36 of thymopoietin, was rapidly degraded in human plasma (T 1/2 = 30 s) and this was shown to be due to proteolytic enzymes in plasma. The biological potency of thymopentin varied greatly with the route of administration, a finding possibly related to its short half-life. Intravenous infusion provided the most potent and bolus intraperitoneal injection the least potent mode of administration. Thus the route and rate of administration are critical factors in determining the effective dose being received by the animal.</p>","PeriodicalId":77804,"journal":{"name":"Survey of immunologic research","volume":"4 Suppl 1 ","pages":"17-23"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02919052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15013963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Herpes simplex. Clinical and pathogenetic aspects.","authors":"S Lidén","doi":"10.1007/BF02919053","DOIUrl":"https://doi.org/10.1007/BF02919053","url":null,"abstract":"<p><p>Primary infection with herpes simplex virus of either type 1 or type 2 occurs frequently, however, recurring disease develops in only a small fraction of the population. Circulating antibodies against the virus do not prevent relapses. The cell-mediated immunity probably is more important in determining whether triggering factors will activate the latent infection or not. Changes in the cell-mediated immunity may be one of the factors involved in the pathogenesis of the relapses. New methods for the rapid diagnosis of herpes simplex virus have been developed. These methods (immunofluorescence, enzyme-linked immunosorbent assay) have a very good specificity, but a somewhat lower sensitivity than conventional viral cultures. Topical treatment can be expected to influence the course of the actual recurrence. Systemic treatment ought to have greater potential in affecting the relapse rate as well, either by a direct effect on the virus or by means of immunomodulation, e.g., with thymopentin.</p>","PeriodicalId":77804,"journal":{"name":"Survey of immunologic research","volume":"4 Suppl 1 ","pages":"24-9"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02919053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15013964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N R Di Luzio, D L Williams, E R Sherwood, I W Browder
{"title":"Modification of diverse experimental immunosuppressive states by glucan.","authors":"N R Di Luzio, D L Williams, E R Sherwood, I W Browder","doi":"10.1007/BF02918811","DOIUrl":"https://doi.org/10.1007/BF02918811","url":null,"abstract":"","PeriodicalId":77804,"journal":{"name":"Survey of immunologic research","volume":"4 2","pages":"160-7"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02918811","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15014895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Safety of thymopentin","authors":"W. P., S. H.","doi":"10.1007/BF02919071","DOIUrl":"https://doi.org/10.1007/BF02919071","url":null,"abstract":"","PeriodicalId":77804,"journal":{"name":"Survey of immunologic research","volume":"4 1","pages":"149-154"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02919071","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52661855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Thymopentin treatment in a patient with pluriorificial pyoderma vegetans.","authors":"M Simon, D Djawari, O P Horstein, K Bolla","doi":"10.1007/BF02919067","DOIUrl":"10.1007/BF02919067","url":null,"abstract":"<p><p>This paper presents longitudinal clinical and immunological findings in a patient with a life-long history of pluriorificial pyoderma vegetans, a disease characterized by a distinct immunodeficiency of T lymphocytes. After treatment with thymopentin, 50 mg s.c. three times weekly for 12 weeks, the number of T lymphocytes in peripheral blood normalized, while other impaired immunological functions failed to improve, however. The most impressive observation was the significant clinical improvement of the patient's condition.</p>","PeriodicalId":77804,"journal":{"name":"Survey of immunologic research","volume":"4 Suppl 1 ","pages":"125-8"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15013958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}