Survey of immunologic research最新文献

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Thymopentin treatment of herpes simplex infections. An open, monitored, multicenter study. 胸腺肽治疗单纯疱疹感染。一项开放、监测、多中心的研究。
Survey of immunologic research Pub Date : 1985-01-01
J DeMaubeuge, E Haneke, D Djawari, K Wolff, G Stingl, L Molin, E Schöpf, R Stengel, H Degreef, E Panconesi
{"title":"Thymopentin treatment of herpes simplex infections. An open, monitored, multicenter study.","authors":"J DeMaubeuge, E Haneke, D Djawari, K Wolff, G Stingl, L Molin, E Schöpf, R Stengel, H Degreef, E Panconesi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Twenty-seven patients suffering from long-standing, severe, recurrent herpes simplex (14 labial and 13 genital) who had not responded adequately to prior therapy were recruited for this open, monitored study. They were treated with thymopentin 50 mg subcutaneously three times weekly for a period of 6 weeks. Clinical controls were performed once a week and then again 6 weeks after cessation of therapy; laboratory investigations were done at time points 0, 3, and 6 weeks. Additionally, information was collected with regard to the clinical course during the following year. Thirteen of 14 patients with labial infection and 10 of the 13 with genital herpes improved markedly (p less than 0.05) as shown by decrease in the relapse rate of at least 50%, shorter relapse episodes, and improvement of symptoms such as pain and itching. Fourteen of these 27 patients experienced no relapse for a period longer than 4 months after cessation of therapy. These favorable results were paralleled by a statistically significant increase in the T cell helper/suppressor ratio. This finding indicates that thymopentin acts as an immunodomulator; it is assumed that the activation of T helper cells induces-presumable via interleukin 2-the proliferation of cytotoxic T lymphocytes and natural killer cells which play a major role in the natural immune defense. No serious side effects of thymopentin were recorded.</p>","PeriodicalId":77804,"journal":{"name":"Survey of immunologic research","volume":"4 Suppl 1 ","pages":"30-6"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14001383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tolerance induction and maintenance in primed lymphocytes. 诱导淋巴细胞耐受诱导和维持。
Survey of immunologic research Pub Date : 1985-01-01 DOI: 10.1007/BF02918739
J D Levich, W O Weigle
{"title":"Tolerance induction and maintenance in primed lymphocytes.","authors":"J D Levich,&nbsp;W O Weigle","doi":"10.1007/BF02918739","DOIUrl":"https://doi.org/10.1007/BF02918739","url":null,"abstract":"","PeriodicalId":77804,"journal":{"name":"Survey of immunologic research","volume":"4 4","pages":"313-8"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02918739","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13572081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The prothymocyte revisited. 再次检查胸腺原细胞。
Survey of immunologic research Pub Date : 1985-01-01 DOI: 10.1007/BF02918579
A E Silverstone
{"title":"The prothymocyte revisited.","authors":"A E Silverstone","doi":"10.1007/BF02918579","DOIUrl":"https://doi.org/10.1007/BF02918579","url":null,"abstract":"","PeriodicalId":77804,"journal":{"name":"Survey of immunologic research","volume":"4 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02918579","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14989407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Thymopentin in experimental and clinical medicine. 胸腺肽在实验和临床医学中的应用。
Survey of immunologic research Pub Date : 1985-01-01
{"title":"Thymopentin in experimental and clinical medicine.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77804,"journal":{"name":"Survey of immunologic research","volume":"4 Suppl 1 ","pages":"1-156"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15014898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor growth and evasion of immune destruction: UV-induced tumors as a model. 肿瘤生长和逃避免疫破坏:以紫外线诱导肿瘤为模型。
Survey of immunologic research Pub Date : 1985-01-01 DOI: 10.1007/BF02918734
C A Mullen, H Schreiber
{"title":"Tumor growth and evasion of immune destruction: UV-induced tumors as a model.","authors":"C A Mullen,&nbsp;H Schreiber","doi":"10.1007/BF02918734","DOIUrl":"https://doi.org/10.1007/BF02918734","url":null,"abstract":"<p><p>A number of complex interrelating mechanisms contributing to progressive growth of an immunogenic tumor and its evasion of immune destruction are exemplified in the model of the UV-induced tumor 1591 (fig. 3). The effects of (i) carcinogen-induced immune suppression, (ii) age-related changes in immune competence, (iii) generation and immunoselection of tumor cell variants which do not express target tumor antigen and (iv) tumor-induced immune suppression have been documented. The findings may help to assess the problems and the possibilities of immunotherapy of cancer. The problems reside in the many avenues of escape available to the tumor. The possibilities for immunotherapy derive from the fact that progressively growing tumors may still retain immunogenic antigens and therefore be susceptible to immune attack.</p>","PeriodicalId":77804,"journal":{"name":"Survey of immunologic research","volume":"4 4","pages":"264-70"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02918734","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14077945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Thymopentin: stability considerations and potency by various routes of administration. 胸腺喷丸素:稳定性考虑和不同给药途径的效力。
Survey of immunologic research Pub Date : 1985-01-01 DOI: 10.1007/BF02919052
T K Audhya, G Goldstein
{"title":"Thymopentin: stability considerations and potency by various routes of administration.","authors":"T K Audhya,&nbsp;G Goldstein","doi":"10.1007/BF02919052","DOIUrl":"https://doi.org/10.1007/BF02919052","url":null,"abstract":"<p><p>Thymopentin, the synthetic pentapeptide Arg-Lys-Asp-Val-Tyr corresponding to amino acids 32-36 of thymopoietin, was rapidly degraded in human plasma (T 1/2 = 30 s) and this was shown to be due to proteolytic enzymes in plasma. The biological potency of thymopentin varied greatly with the route of administration, a finding possibly related to its short half-life. Intravenous infusion provided the most potent and bolus intraperitoneal injection the least potent mode of administration. Thus the route and rate of administration are critical factors in determining the effective dose being received by the animal.</p>","PeriodicalId":77804,"journal":{"name":"Survey of immunologic research","volume":"4 Suppl 1 ","pages":"17-23"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02919052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15013963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Herpes simplex. Clinical and pathogenetic aspects. 单纯疱疹。临床和发病方面。
Survey of immunologic research Pub Date : 1985-01-01 DOI: 10.1007/BF02919053
S Lidén
{"title":"Herpes simplex. Clinical and pathogenetic aspects.","authors":"S Lidén","doi":"10.1007/BF02919053","DOIUrl":"https://doi.org/10.1007/BF02919053","url":null,"abstract":"<p><p>Primary infection with herpes simplex virus of either type 1 or type 2 occurs frequently, however, recurring disease develops in only a small fraction of the population. Circulating antibodies against the virus do not prevent relapses. The cell-mediated immunity probably is more important in determining whether triggering factors will activate the latent infection or not. Changes in the cell-mediated immunity may be one of the factors involved in the pathogenesis of the relapses. New methods for the rapid diagnosis of herpes simplex virus have been developed. These methods (immunofluorescence, enzyme-linked immunosorbent assay) have a very good specificity, but a somewhat lower sensitivity than conventional viral cultures. Topical treatment can be expected to influence the course of the actual recurrence. Systemic treatment ought to have greater potential in affecting the relapse rate as well, either by a direct effect on the virus or by means of immunomodulation, e.g., with thymopentin.</p>","PeriodicalId":77804,"journal":{"name":"Survey of immunologic research","volume":"4 Suppl 1 ","pages":"24-9"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02919053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15013964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Modification of diverse experimental immunosuppressive states by glucan. 葡聚糖对多种实验性免疫抑制状态的修饰。
Survey of immunologic research Pub Date : 1985-01-01 DOI: 10.1007/BF02918811
N R Di Luzio, D L Williams, E R Sherwood, I W Browder
{"title":"Modification of diverse experimental immunosuppressive states by glucan.","authors":"N R Di Luzio,&nbsp;D L Williams,&nbsp;E R Sherwood,&nbsp;I W Browder","doi":"10.1007/BF02918811","DOIUrl":"https://doi.org/10.1007/BF02918811","url":null,"abstract":"","PeriodicalId":77804,"journal":{"name":"Survey of immunologic research","volume":"4 2","pages":"160-7"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02918811","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15014895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
Safety of thymopentin 胸腺五肽的安全性
Survey of immunologic research Pub Date : 1985-01-01 DOI: 10.1007/BF02919071
W. P., S. H.
{"title":"Safety of thymopentin","authors":"W. P., S. H.","doi":"10.1007/BF02919071","DOIUrl":"https://doi.org/10.1007/BF02919071","url":null,"abstract":"","PeriodicalId":77804,"journal":{"name":"Survey of immunologic research","volume":"4 1","pages":"149-154"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02919071","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52661855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thymopentin treatment in a patient with pluriorificial pyoderma vegetans. 胸腺肽治疗多胎性素食性脓皮病1例。
Survey of immunologic research Pub Date : 1985-01-01 DOI: 10.1007/BF02919067
M Simon, D Djawari, O P Horstein, K Bolla
{"title":"Thymopentin treatment in a patient with pluriorificial pyoderma vegetans.","authors":"M Simon, D Djawari, O P Horstein, K Bolla","doi":"10.1007/BF02919067","DOIUrl":"10.1007/BF02919067","url":null,"abstract":"<p><p>This paper presents longitudinal clinical and immunological findings in a patient with a life-long history of pluriorificial pyoderma vegetans, a disease characterized by a distinct immunodeficiency of T lymphocytes. After treatment with thymopentin, 50 mg s.c. three times weekly for 12 weeks, the number of T lymphocytes in peripheral blood normalized, while other impaired immunological functions failed to improve, however. The most impressive observation was the significant clinical improvement of the patient's condition.</p>","PeriodicalId":77804,"journal":{"name":"Survey of immunologic research","volume":"4 Suppl 1 ","pages":"125-8"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15013958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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