Renal physiology最新文献_第4页

Diabetes insipidus with renal resistance to vasopressin in the desoxycorticosterone-treated dog: a possible role for prostaglandins. 去氧皮质酮治疗犬尿崩症伴肾抗利尿素:前列腺素的可能作用。

Renal physiology Pub Date : 1987-01-01 DOI: 10.1159/000173112

H G Gullner, D West, J R Gill, G L Robertson

{"title":"Diabetes insipidus with renal resistance to vasopressin in the desoxycorticosterone-treated dog: a possible role for prostaglandins.","authors":"H G Gullner, D West, J R Gill, G L Robertson","doi":"10.1159/000173112","DOIUrl":"https://doi.org/10.1159/000173112","url":null,"abstract":"We examined the release of vasopressin and the renal response to exogenous vasopressin before and during desoxycorticosterone acetate (DOCA) administration in the dog. As treatment with DOCA produced potassium loss, urine volume increased, urinary osmolality decreased, and urinary PGE2 tended to increase. The increase in urine volume was accompanied by increases in serum sodium, in plasma osmolality and in plasma arginine vasopressin. The threshold for vasopressin release measured during polyuria was higher than control but the rate of vasopressin release was unchanged. The DOCA-induced polyuria was not affected by treatment with vasopressin which further increased plasma vasopressin. Treatment with indomethacin which corrected the increase in urinary PGE2 excretion but not the hypokalemia, restored the renal responsiveness to vasopressin, decreased the secretion of vasopressin, and corrected the polyuria and the hypernatremia. These findings suggest that DOCA-induced polyuria is attributable to a decrease in renal responsiveness to vasopressin which may be mediated in part by an increase in the renal synthesis of prostaglandins.","PeriodicalId":77779,"journal":{"name":"Renal physiology","volume":"10 1","pages":"40-6"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000173112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14603886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Intranephron distribution of epidermal growth factor immunoreactivity in the mouse. 小鼠表皮生长因子免疫反应性在肾内膜内的分布。

Renal physiology Pub Date : 1987-01-01 DOI: 10.1159/000173136

Y Oka, K Fujiwara, H Endou

引用次数: 2

Effect of phenylisopropyladenosine on vasopressin-dependent cyclic AMP generation in defined nephron segments from rat. 苯基异丙腺苷对大鼠肾单位节段抗利尿激素依赖性环AMP生成的影响。

Renal physiology Pub Date : 1987-01-01 DOI: 10.1159/000173111

S Torikai

引用次数: 13

Changes in lysosome populations in the rat kidney cortex induced by passive Heymann glomerulonephritis. 被动海曼肾小球肾炎所致大鼠肾皮质溶酶体数量的变化。

Renal physiology Pub Date : 1987-01-01 DOI: 10.1159/000173133

H J Haga, K J Andersen, B M Iversen, J Ofstad, M Dobrota, R Matre

{"title":"Changes in lysosome populations in the rat kidney cortex induced by passive Heymann glomerulonephritis.","authors":"H J Haga, K J Andersen, B M Iversen, J Ofstad, M Dobrota, R Matre","doi":"10.1159/000173133","DOIUrl":"https://doi.org/10.1159/000173133","url":null,"abstract":"Acute passive Heymann glomerulonephritis in rats induced heavy proteinuria and highly increased urinary activity of N-acetyl-beta-D-glucosaminidase, acid beta-galactosidase and acid phosphatase. The cortical activity of these acid hydrolases was increased essentially in the large lysosomes as demonstrated by subfractionation of the lysosome-rich mitochondrial-lysosomal fraction, by rate zonal centrifugation. Banding density of small lysosomes shifted or reduced to slightly lower value (1.225 g/ml), which is between the banding densities of small 'light' (1.20 g/ml) and small 'dense' lysosomes (1.235 g/ml) in normal rat kidney cortex. Labelled protein reabsorbed in the proximal tubule is recovered in these populations of small lysosomes as well as in the large lysosomes or 'protein droplets'. Glomerulonephritis also induced a new population of small 'light' lysosomes (density 1.185-1.195 g/ml) enriched in cathepsin D. The previously demonstrated morphological, biochemical, and physiological heterogeneity of renal lysosomes was confirmed and emphasized in the kidney cortex of glomerulonephritic rats. The main changes in the lysosomal populations appear to reflect the increased protein reabsorption as confirmed by the proteinuria.","PeriodicalId":77779,"journal":{"name":"Renal physiology","volume":"10 5","pages":"249-60"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000173133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14267143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Effects of PGE2 infusion on renal function in normal man before and after angiotensin II inhibition by captopril. 卡托普利抑制血管紧张素II前后PGE2输注对正常人肾功能的影响。

Renal physiology Pub Date : 1987-01-01 DOI: 10.1159/000173137

M Usberti, B Cianciaruso, G Di Minno, A Auciello, G Ardillo, D Bonanno, G Conte, V E Andreucci

引用次数: 2

Renin granules isolated from rat kidney cortex by continuous colloidal silica (Percoll) density gradient centrifugation. 用连续硅胶胶体(Percoll)密度梯度离心分离大鼠肾皮质肾素颗粒。

Renal physiology Pub Date : 1986-01-01 DOI: 10.1159/000173088

Y Matsumura, M Takeshita, N Miyawaki, T Iwamoto, S Morimoto

引用次数: 1

Effective hydraulic permeability of the glomerular capillary wall in rats after uninephrectomy. 肾切除术后大鼠肾小球毛细血管壁的有效水渗透性。

Renal physiology Pub Date : 1986-01-01 DOI: 10.1159/000173091

K H Neumann, H J Schurek, C Kellner, K Kühn, B Aeikens

引用次数: 6

Acute effect of cisplatin on renal hemodynamics and tubular function in dog kidneys. 顺铂对犬肾血流动力学和肾小管功能的急性影响。

Renal physiology Pub Date : 1986-01-01 DOI: 10.1159/000173095

G Daugaard, U Abildgaard, N H Holstein-Rathlou, P P Leyssac, O Amtorp, T G Dikhoff

{"title":"Acute effect of cisplatin on renal hemodynamics and tubular function in dog kidneys.","authors":"G Daugaard, U Abildgaard, N H Holstein-Rathlou, P P Leyssac, O Amtorp, T G Dikhoff","doi":"10.1159/000173095","DOIUrl":"https://doi.org/10.1159/000173095","url":null,"abstract":"The present study was designed to investigate the early hemodynamic and tubular effects of cisplatin administration on dogs. To localize the nephrotoxic actions of cisplatin, we have taken advantage of the lithium clearance method. After infusion of 5 mg of cisplatin per kg, an immediate and significant increase in urinary flow rate (from 0.39 +/- 0.07 ml/min to 0.73 +/- 0.12 ml/min), sodium clearance (from 0.33 +/- 0.11 ml/min to 0.65 +/- 0.14 ml/min), potassium clearance (from 9.23 +/- 0.48 ml/min to 10.77 +/- 0.95 ml/min), lithium clearance (from 15.55 +/- 2.21 ml/min to 23.76 +/- 4.00 ml/min) and fractional lithium clearance (from 0.31 +/- 0.03 to 0.44 +/- 0.04) was seen. This occurred without measurable changes in glomerular filtration rate and renal blood flow. The calculated fractional as well as absolute rates of proximal reabsorption of sodium decreased significantly from 0.68 +/- 0.03 to 0.56 +/- 0.04 and from 4.76 +/- 0.32 mmol/min to 3.92 +/- 0.23 mmol/min, respectively. The results show that administration of cisplatin causes an acute, mainly proximal tubular impairment in dogs without alterations in renal hemodynamics.","PeriodicalId":77779,"journal":{"name":"Renal physiology","volume":"9 5","pages":"308-16"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000173095","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14926357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Single nephron hyperfiltration and proteinuria in a newly selected rat strain with superficial glomeruli. 新选择的浅表性肾小球大鼠品系的单肾元高滤过和蛋白尿。

Renal physiology Pub Date : 1986-01-01 DOI: 10.1159/000173097

G Rovira-Halbach, J M Alt, R Brunkhorst, U Frei, K Kühn, H Stolte

{"title":"Single nephron hyperfiltration and proteinuria in a newly selected rat strain with superficial glomeruli.","authors":"G Rovira-Halbach, J M Alt, R Brunkhorst, U Frei, K Kühn, H Stolte","doi":"10.1159/000173097","DOIUrl":"https://doi.org/10.1159/000173097","url":null,"abstract":"Alterations in glomerular permeability were studied in female MWF/Ztm rats, newly selected from the Munich Wistar rats with a high number of superficial glomeruli. This strain is characterized by a diminished number of functioning nephrons, an elevated arterial blood pressure and a high proteinuria averaging 24 mg/24 h. Samples of Bowman capsular space (BCS) obtained by free-flow renal micropuncture techniques with pressure control were analyzed for albumin and high-molecular-weight (HMW) proteins by ultramicrodisc electrophoresis. The measured mean albumin and HMW protein concentration in BCS were 1.72 g/l and 0.66 g/l, respectively. The glomerular filtration rate (GFR) averaged 0.74 ml/min/g kidney weight and the single nephron GFR (SNGFR) 48 nl/min. Ultrastructural studies revealed focal bleb-like alterations of the podocytes as has been observed in hyperfiltration states. We suggest that the reduced number of functioning nephrons in the kidneys of these rats could induce glomerular hyperfiltration and permselectivity changes, which cause a high glomerular protein leakage.","PeriodicalId":77779,"journal":{"name":"Renal physiology","volume":"9 6","pages":"317-25"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000173097","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14723281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Interaction between laminin, fibronectin and the light chain of the H2 complex. Attachment of glomerular cells to basement membranes by linking the endoskeleton to the exoskeleton by a transmembrane protein. 层粘连蛋白、纤维连接蛋白与H2复合物轻链的相互作用。通过跨膜蛋白连接内骨骼和外骨骼，肾小球细胞附着在基底膜上。

Renal physiology Pub Date : 1986-01-01 DOI: 10.1159/000173071

G. Lubec

{"title":"Interaction between laminin, fibronectin and the light chain of the H2 complex. Attachment of glomerular cells to basement membranes by linking the endoskeleton to the exoskeleton by a transmembrane protein.","authors":"G. Lubec","doi":"10.1159/000173071","DOIUrl":"https://doi.org/10.1159/000173071","url":null,"abstract":"At present the detailed mechanism for transmembrane interactions is not known and a protein linked to the endoskeleton as well as to the exoskeleton has not been described as yet. The H2 complex, a transmembrane protein, consists of heavy and light chains, the latter is named beta-2-microglobulin. In order to look for an association of beta-2-microglobulin with an exoskeleton protein, we examined the extracellular matrix proteins, collagen type I, type IV, fibronectin, amyloid P, the solubilized glomerular basement membrane and laminin in respect to their interaction with the light chain. The heavy chain is known to bind strongly to the endoskeleton protein actin. Only laminin and the glomerular basement membrane bound firmly to the beta-2-microglobulin; 3 M urea was necessary to dissociate the formed complex. Incubation with beta-2-microglobulin antibody prevented binding of beta-2-microglobulin to laminin and the glomerular basement membrane on affinity chromatography columns. Antiserum to the glomerular basement membrane in turn prevented binding of beta-2-microglobulin to the glomerular basement membrane, whereas antibodies against the basement membrane collagen type IV failed to inhibit this binding to the glomerular basement membrane. Beta-2-microglobulin also bound to fibronectin but this complex was dissociated with 1 M urea. In a rosette assay beta-2-microglobulin antibody and antiserum to the glomerular basement membrane reduced attachment of glomerular cells to beads coupled with laminin and solubilized glomerular cells to beads coupled with laminin and solubilized glomerular basement membrane.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":77779,"journal":{"name":"Renal physiology","volume":"9 1-2 1","pages":"9-17"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000173071","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65092642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1