Neurochemical pathology最新文献_第10页

Dexamethasone effect on free fatty acid and diacylglycerol accumulation during experimentally induced vasogenic brain edema. 地塞米松对实验性血管源性脑水肿中游离脂肪酸和二酰基甘油积累的影响。

Neurochemical pathology Pub Date : 1985-01-01

L E Politi, E B Rodriguez de Turco, N G Bazan

{"title":"Dexamethasone effect on free fatty acid and diacylglycerol accumulation during experimentally induced vasogenic brain edema.","authors":"L E Politi, E B Rodriguez de Turco, N G Bazan","doi":"","DOIUrl":"","url":null,"abstract":"Free fatty acids (FFA), diacylglycerols (DG), and water content were measured in the right and left cerebral hemispheres of rats with brain edema cryogenically induced to the right cerebral hemisphere. The effect of dexamethasone pretreatment was also studied. Twenty-four hours after lesion, maximal edema was attained concomitant with an accumulation of FFA (8.5-fold) and DG (2.9-fold). Polyunsaturated fatty acids (PUFA), primarily docosahexaenoic acid, increased greatly in both lipid pools. In the contralateral hemisphere, only DG levels increased, especially those containing stearate and arachidonate, which increased by almost 50%. By 48 h, FFA had decreased 60%, whereas DG had attained sham levels. These changes occurred prior to edema resolution. Dexamethasone decreased the degree of edema and the accumulation of PUFA-containing DG by 30% in both hemispheres. There was a complete inhibition of FFA and arachidonic acid accumulation in the lesioned side. These results suggest that dexamethasone: (1) inhibits phospholipases A2 that, in turn, decrease membrane phospholipid breakdown; and (2) has a limited effect on the enzymatic systems involved in PUFA-DG accumulation. Hence, in experimentally induced vasogenic brain edema, PUFA-containing DG, rather than FFA, may be related closely to the spreading of edema fluid.","PeriodicalId":77753,"journal":{"name":"Neurochemical pathology","volume":"3 4","pages":"249-69"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14949087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dolichols are elevated in brain tissue from Alzheimer's disease, but not in urinary sediment from Alzheimer's disease and Down's syndrome. 在阿尔茨海默病患者的脑组织中，Dolichols升高，但在阿尔茨海默病和唐氏综合症患者的尿液沉积物中，Dolichols没有升高。

Neurochemical pathology Pub Date : 1985-01-01

L S Wolfe, N M Ng Ying Kin, J Palo, C Bergeron, M Kotila, S Varonen

引用次数: 0

Fatty acid composition of ethanolamine phosphoglycerides in different areas of the gerbil brain after chronic exposure to trichloroethylene. 慢性接触三氯乙烯后沙鼠大脑不同区域乙醇胺磷酸甘油酯的脂肪酸组成。

Neurochemical pathology Pub Date : 1985-01-01 DOI: 10.1007/BF02834267

T Kyrklund, C Alling, P Kjellstrand, K G Haglid

{"title":"Fatty acid composition of ethanolamine phosphoglycerides in different areas of the gerbil brain after chronic exposure to trichloroethylene.","authors":"T Kyrklund, C Alling, P Kjellstrand, K G Haglid","doi":"10.1007/BF02834267","DOIUrl":"https://doi.org/10.1007/BF02834267","url":null,"abstract":"Exposure of Mongolian gerbils to trichloroethylene (TCE) (320 ppm) in an inhalation chamber continuously for 3 mo resulted in an altered fatty acid pattern of phospholipid in discrete areas of the brain. Lipids were extracted from four brain regions: the cerebral cortex, the hippocampus, the cerebellar vermis posterior, and the brain stem. No changes induced by TCE were found in lipid class distribution among the different regions examined. Whole brain weights and weights of the dissected pieces were also unchanged. In ethanolamine phosphoglycerides from the cerebral cortex and the hippocampus, a decrease was found among long-chain fatty acids derived from linolenic acid with a corresponding increase of the linoleic acid family. The cerebellar vermis and the brain stem were less affected. Since areas rich in gray matter were affected more than those with a high proportion of white matter, it seems reasonable to assume that the fatty acid alterations of ethanolamine phosphoglycerides occur mainly in the gray matter. Furthermore, we suggest that the alterations can be a compensatory mechanism for the membrane fluidizing properties of TCE.","PeriodicalId":77753,"journal":{"name":"Neurochemical pathology","volume":"3 3","pages":"151-8"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02834267","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15206080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Agonal status affects the metabolic activity of nerve endings isolated from postmortem human brain. Agonal状态影响死后人脑分离的神经末梢的代谢活动。

Neurochemical pathology Pub Date : 1985-01-01 DOI: 10.1007/BF02834269

P Wester, D E Bateman, P R Dodd, J A Edwardson, J A Hardy, A M Kidd, R H Perry, G B Singh

引用次数: 38

Amino acid and protein metabolism in dorsal root ganglia of rabbits with experimental allergic neuritis. 实验性变应性神经炎兔背根神经节氨基酸和蛋白质代谢。

Neurochemical pathology Pub Date : 1985-01-01 DOI: 10.1007/BF02834270

G K Molnár, E R Korpi, H Kalimo

{"title":"Amino acid and protein metabolism in dorsal root ganglia of rabbits with experimental allergic neuritis.","authors":"G K Molnár, E R Korpi, H Kalimo","doi":"10.1007/BF02834270","DOIUrl":"https://doi.org/10.1007/BF02834270","url":null,"abstract":"Amino acid and protein metabolism has been studied in the dorsal root ganglia of rabbits with experimental allergic neuritis (EAN). The concentrations of a number of nonessential amino acids (glutamine, serine, aspartate, and glutamate) were reduced in the spinal ganglia of EAN animals without any comparable change in the blood plasma. The short-term influx of glycine and GABA was decreased in EAN animals, whereas that of histidine and valine was not altered. The prolonged accumulation of all the four amino acids was unchanged. These results suggest alterations in the cell metabolism of the dorsal root ganglia, rather than unspecific changes in cellular permeability. Furthermore, incorporation of tritiated valine, histidine, and glycine into proteins of EAN-ganglia in vitro was significantly increased. Autoradiography of the protein-bound [3H]-valine indicated alterations in the protein synthesis of the ganglion neurons: A decreased grain density was found in ganglion neurons of EAN animals. The increased grain densities in the affected ganglia were observed in macrophages, and possible in activated Schwann cells, over the demyelinated spots. The results suggest intraneuronal changes in the dorsal root ganglia of amino acid and protein metabolism, possibly in response to peripheral axonal injury and/or to nonspecific cytotoxic effect of active lymphocytes and macrophages.","PeriodicalId":77753,"journal":{"name":"Neurochemical pathology","volume":"3 3","pages":"181-93"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02834270","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15206083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic galactosylceramidase deficiency (globoid cell leukodystrophy, Krabbe disease) in different mammalian species. 遗传性半乳糖神经酰胺酶缺乏症(球状细胞白质营养不良，克拉伯病)在不同哺乳动物物种。

Neurochemical pathology Pub Date : 1985-01-01 DOI: 10.1007/BF02834075

K Suzuki, K Suzuki

引用次数: 33

Decreased utilization of [2-3H]glycerol in phospholipid and neutral glyceride biosynthesis in the retina of streptozotocin-diabetic rats. 链脲佐菌素糖尿病大鼠视网膜中[2-3H]甘油在磷脂和中性甘油生物合成中的利用率降低。

Neurochemical pathology Pub Date : 1985-01-01 DOI: 10.1007/BF02834284

H E Bazan, M M Careaga, N G Bazan

引用次数: 4

Monoclonal antibodies reactive with epitopes restricted to glial fibrillary acidic proteins of several species. 单克隆抗体与局限于几种胶质原纤维酸性蛋白的表位反应。

Neurochemical pathology Pub Date : 1985-01-01 DOI: 10.1007/BF02834285

C N Pegram, L F Eng, C J Wikstrand, R D McComb, Y L Lee, D D Bigner