{"title":"Decreased utilization of [2-3H]glycerol in phospholipid and neutral glyceride biosynthesis in the retina of streptozotocin-diabetic rats.","authors":"H E Bazan, M M Careaga, N G Bazan","doi":"10.1007/BF02834284","DOIUrl":null,"url":null,"abstract":"<p><p>The effect of streptozotocin (STZ)-induced diabetes on lipid uptake was studied in the rat retina. The intravitreal incorporation of [2-3H]glycerol was followed in retinal lipids from the first day of diabetes (acute state) up to 20 wk (chronic state). Total lipid incorporation decreased 50% 2 d after injection of STZ; the labeling remained lower than the control values throughout the 20 wk period studied. In the chronic state of diabetes, the time-course of the incorporation of [2-3H]glycerol during the first 2 h after its injection displayed a pattern of incorporation similar to that of the controls. The possibility that the decreased utilization of [2-3H]glycerol in the lipid pathway results from a competition between the injected [3H]glycerol and the glycolytic pathway during diabetes in rat retina in vivo is discussed.</p>","PeriodicalId":77753,"journal":{"name":"Neurochemical pathology","volume":"3 2","pages":"109-18"},"PeriodicalIF":0.0000,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02834284","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurochemical pathology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/BF02834284","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4
Abstract
The effect of streptozotocin (STZ)-induced diabetes on lipid uptake was studied in the rat retina. The intravitreal incorporation of [2-3H]glycerol was followed in retinal lipids from the first day of diabetes (acute state) up to 20 wk (chronic state). Total lipid incorporation decreased 50% 2 d after injection of STZ; the labeling remained lower than the control values throughout the 20 wk period studied. In the chronic state of diabetes, the time-course of the incorporation of [2-3H]glycerol during the first 2 h after its injection displayed a pattern of incorporation similar to that of the controls. The possibility that the decreased utilization of [2-3H]glycerol in the lipid pathway results from a competition between the injected [3H]glycerol and the glycolytic pathway during diabetes in rat retina in vivo is discussed.
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