Kroc Foundation series最新文献

{"title":"Radial distribution of white cells in tube flow.","authors":"H L Goldsmith, S Spain","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77744,"journal":{"name":"Kroc Foundation series","volume":"16 ","pages":"131-46"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17642206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyphosphoinositides as regulators of membrane skeletal stability.","authors":"M P Sheetz,&nbsp;W P Wang,&nbsp;D L Kreutzer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The membrane skeleton is a two-dimensional complex of actin, spectrinlike, and associated proteins which lies on the cytoplasmic face of most plasma membranes. Components of this complex are believed to control the lateral mobility of integral membrane proteins as well as influence cell shape and motility. In earlier studies we observed that the addition of polyphosphorylated inositol lipids could increased membrane skeleton dissociation. In preliminary studies of leukocyte function we have observed that increased chemotaxis with Trental addition is correlated with increased polyphosphoinositide levels. Consequently, we suggest that polyphosphoinositides contribute to, if not are requisite for, cellular mobility.</p>","PeriodicalId":77744,"journal":{"name":"Kroc Foundation series","volume":"16 ","pages":"87-94"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17386908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro transformation of human cord blood and bone marrow T lymphocytes by HTLV.","authors":"P D Markham,&nbsp;R C Gallo,&nbsp;S Z Salahuddin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77744,"journal":{"name":"Kroc Foundation series","volume":"18 ","pages":"323-35"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17165965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adhesion and locomotion of neutrophil leucocytes on 2-D substrata and in 3-D matrices.","authors":"J M Lackie,&nbsp;P C Wilkinson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77744,"journal":{"name":"Kroc Foundation series","volume":"16 ","pages":"237-54"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17295956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relative roles of interleukins 1, 2, and 3 in the regulation of T cell differentiation.","authors":"J N Ihle,&nbsp;J Keller","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The initial description and purification of IL 3 was based on its potential relevance in early T cell differentiation. Although the data do not provide conclusive evidence for a role of IL 3 in T cell differentiation, a number of observations provide some indications that a relationship exists. The most intriguing aspects are concerned with the distribution and regulation of expression of 20 alpha SDH. This particular marker is interesting since it may allow studies of aspects of T cell differentiation that have not been possible with more conventional approaches. The available data are consistent with the hypothesis that in the bone marrow there exists a stem cell that in response to IL 3 is induced to differentiate including the induction of expression of 20 alpha SDH and Thy 1+. Phenotypically this induced cell is similar to a medullary thymocyte, although the cells derived in vitro clearly do not have the functional characteristics of medullary thymocytes. It can be rationalized that a bone marrow-induced prothymocyte may require the thymic microenvironment for continued maturation. Irrespective of this, it now becomes necessary to further explore the possibilities by extending the approaches used to define and study early bone marrow-localized pre-T cell populations as well as continuing to define the necessary components of the thymus in the differentiation pathway for T cells. In these areas of research the experience and systems derived from studies of long-term bone marrow cultures will be of considerable value. In addition to the proposed role that IL 3 plays in early T cell differentiation, it is apparent that the stem cell that is induced to differentiate may have considerably more potentials than the T cell lineage. The ability of IL 3 to induce the differentiation of 20 alpha SDH-positive mastlike cells in vitro is the most demonstrable functional phenotype. The absolute requirement of Il 3 throughout the differentiation of such cells indicates that in vivo, where IL 3 is generally not detectable, the frequency with which such progeny are obtained may be quite low and restricted to unique immunological situations in which high levels of IL 3 are produced. In addition, it appears likely that IL 3 induces the differentiation of a cell that in the presence of erythropoietin can be induced to differentiate along an erythroid pathway. Last, IL 3 may induce the differentiation of promyeloblasts that can differentiate in the presence of CSF-2 [unpublished data].(ABSTRACT TRUNCATED AT 400 WORDS)</p>","PeriodicalId":77744,"journal":{"name":"Kroc Foundation series","volume":"18 ","pages":"399-421"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17500066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of cell egress in bone marrow.","authors":"R E Waugh,&nbsp;L L Hsu,&nbsp;P Clark,&nbsp;A Clark","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77744,"journal":{"name":"Kroc Foundation series","volume":"16 ","pages":"221-36"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17642116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphocyte recognition of lymph node high endothelium: adhesive interactions determining entry into lymph nodes.","authors":"J J Woodruff,&nbsp;Y H Chin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Our interpretation of these results is that lymphocyte surface HEBF is composed of high endothelial adhesion molecules which mediate cell-cell interactions that result in lymphocyte entry from blood into lymph nodes. The evidence that anti-HEBF antibody does not interfere with lymphocyte entry into PP is intriguing, since migration into this tissue as well as LN, occurs via HEV. This suggests that high endothelial cells differ in LN and PP at least with respect to the specificity of surface molecules involved in lymphocyte adherence. It could be that separate lymphocyte subpopulations express receptors for these two types of high endothelium. If this explanation is correct, then cells negatively selected using this antibody should be capable of binding to HEV of PP but not HEV of LN. However, if receptors for both high endothelial types are present on the same lymphocyte, then it is unlikely that such selection would yield cells exhibiting tissue specificity. Our observations are consistent with previous findings which suggested that high endothelial cells of mouse LN and PP exhibit differences in lymphocyte binding properties. For example, it has been reported that certain murine lymphomas bind to HEV of either peripheral LN or PP and that, to a limited degree, this preference is a property of most B and T cells [Butcher et al, 1980; Stevens et al, 1982]. Thymus and bone marrow cells show only low levels of HEV binding and less than 10% of such cells react with anti-HEBF antibody. During differentiation lymphocytes appear to acquire surface components which mediate high endothelial adhesion and this event is associated with the appearance of surface molecules recognized by anti-HEBF antibody. This suggests that it is the expression of these surface molecules during differentiation which confers high endothelial recognition properties on lymphocytes and that this mechanism plays a role in adhesive interactions leading to entry of both T and B cells into LN.</p>","PeriodicalId":77744,"journal":{"name":"Kroc Foundation series","volume":"16 ","pages":"255-68"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17642117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leukocyte rheology in cardiac ischemia.","authors":"M D Dahlgren,&nbsp;M A Peterson,&nbsp;R L Engler,&nbsp;G W Schmid-Schönbein","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77744,"journal":{"name":"Kroc Foundation series","volume":"16 ","pages":"271-83"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17642118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coupled NaCl transport: cotransport or parallel ion exchange?","authors":"D W Powell,&nbsp;C C Fan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In recent years it has become apparent that at least part of the transcellular movements of Na and Cl are linked by a process or processes which couple the entry of Na to Cl across the apical cell membrane of the intestinal cell. In some tissues, eg, gallbladder and renal tubule, this coupled transport of Na and Cl may be the predominant electrolyte-transporting mechanism. Studies in rabbit ileal brush-border membrane vesicles present evidence for a coupled NaCl process that has the same ionic specificities and similar kinetics as the processes demonstrated by influx techniques across the apical membrane of the intact epithelium. However, the vesicles also exhibit Na:H and Cl:HCO3 exchange processes and the inhibitors thought to be specific for either the NaCl cotransport system (loop diuretics), for the Na:H exchange (high-dose amiloride), or for the Cl:HCO3 exchange (disulfonic stilbenes such as SITS or DIDS), do not prove to be so. It is possible that all three processes could be present in intestinal brush-border membranes. Furthermore, the techniques of isolating vesicles could uncouple or otherwise inhibit the coupled NaCl process. Nonetheless, the preponderance of evidence at this time indicates that parallel ion exchangers of Na:H and Cl:HCO3, as initially suggested by Turnberg et al [4], account for coupled NaCl transport in rabbit ileum. Additional studies will be necessary to determine if this is the only mechanism in the intestinal apical membrane and whether this conclusion applies to other tissues such as gallbladder and renal tubule.</p>","PeriodicalId":77744,"journal":{"name":"Kroc Foundation series","volume":"17 ","pages":"13-26"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17651291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of intestinal electrolyte transport and regulation by calcium. Proceedings of a conference, Santa Ynez Valley, California, September 26-30, 1983.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77744,"journal":{"name":"Kroc Foundation series","volume":"17 ","pages":"1-374"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17651289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}