Journal of free radicals in biology & medicine最新文献_第8页

Peroxidation of liposomes promoted by human polymorphonuclear leucocytes 人多形核白细胞促进脂质体的过氧化

Journal of free radicals in biology & medicine Pub Date : 1985-01-01 DOI: 10.1016/0748-5514(85)90158-8

Gunnar Carlin , Karl E. Arfors

引用次数: 23

Post resuscitation iron delocalization and malondialdehyde production in the brain following prolonged cardiac arrest 长时间心脏骤停后复苏后脑内铁的脱位和丙二醛的产生

Journal of free radicals in biology & medicine Pub Date : 1985-01-01 DOI: 10.1016/0748-5514(85)90014-5

Narsimha R. Nayini Ph.D. , Blaine C. White M.D. , Steven D. Aust Ph.D. , Raywin R. Huang Ph.D. , Richard J. Indrieri D.V.M. , A.Thomas Evans D.V.M. , Howard Bialek M.D. , William A. Jacobs M.D. , James Komara D.O.

{"title":"Post resuscitation iron delocalization and malondialdehyde production in the brain following prolonged cardiac arrest","authors":"Narsimha R. Nayini Ph.D. , Blaine C. White M.D. , Steven D. Aust Ph.D. , Raywin R. Huang Ph.D. , Richard J. Indrieri D.V.M. , A.Thomas Evans D.V.M. , Howard Bialek M.D. , William A. Jacobs M.D. , James Komara D.O.","doi":"10.1016/0748-5514(85)90014-5","DOIUrl":"10.1016/0748-5514(85)90014-5","url":null,"abstract":"<div><p>Assays for brain tissue malondialdehyde (MDA) and low molecular weight chelated (LMWC) iron were used to examine samples of the cerebral cortex obtained from dogs 2 h after resuscitation from a 15-min cardiac arrest. The effect of post-resuscitation treatment with lidoflazine and/or desferrioxamine was similarly examined. Non-ischemic brain samples had LMWC iron levels (in nmol/100 mg tissue) of 12.32 + 2.60 and MDA levels (in nmol/100 mg tissue) of 8.46 + 1.35. Animals subjected to cardiac arrest and resuscitation and standard intensive care (SIC) had LMWC iron levels of 37.04 +_4.58 (<em>p</em> < .01 against non-ischemic controls) and MDA levels of 12.24 + 1.9 (<em>p</em> < .05 against non-ischemic controls). All treatment interventions significantly reduced the LMWC iron (<em>p</em> < .05), but only treatment with desferrioxamine alone significantly reduced MDA (<em>p</em> < .05), although a trend toward reduction of the MDA was also evident in animals treated with both desferrioxamine and lidoflazine. LMWC iron levels are increased in the post-ischemic brain, and this increase may be related to lipid peroxidation in the brain following resuscitation from cardiac arrest. These changes are probably pathologic and are amenable to pharmacologic intervention.</p></div>","PeriodicalId":77737,"journal":{"name":"Journal of free radicals in biology & medicine","volume":"1 2","pages":"Pages 111-116"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0748-5514(85)90014-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14951593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 78

Repair of tryptophan radicals by antioxidants 抗氧化剂修复色氨酸自由基

Journal of free radicals in biology & medicine Pub Date : 1985-01-01 DOI: 10.1016/0748-5514(85)90016-9

Slobodan V. Jovanovic, Michael G. Simic

引用次数: 51

Initial observations on the role of glutathione peroxidases in Euglena 谷胱甘肽过氧化物酶在菊苣中作用的初步观察

Journal of free radicals in biology & medicine Pub Date : 1985-01-01 DOI: 10.1016/0748-5514(85)90117-5

Julie M. Overbaugh

引用次数: 6

Antipsoriatic drug action of anthralin: Oxidation reactions with peroxidizing lipids 抗银屑病药物蒽醌的作用:与过氧化脂质的氧化反应

Journal of free radicals in biology & medicine Pub Date : 1985-01-01 DOI: 10.1016/0748-5514(85)90135-7

F. Ducret, P. Lambelet, J. Löliger, M.-C. Savoy

{"title":"Antipsoriatic drug action of anthralin: Oxidation reactions with peroxidizing lipids","authors":"F. Ducret, P. Lambelet, J. Löliger, M.-C. Savoy","doi":"10.1016/0748-5514(85)90135-7","DOIUrl":"10.1016/0748-5514(85)90135-7","url":null,"abstract":"<div><p>Reactions of anthralin with peroxidizing lipid were investigated. Using ESR spectroscopy and quantitative HPLC analysis radical species and decomposition products respectively were analysed in the reaction mixture as a function of time. Directly after mixing anthralin with peroxidized lipids, the 1,8-dihydroxy-9-anthron-10-yl radicals (primary radical) and small amounts of 1,8-dihydroxy-anthraquinone (AQ) were formed. After a few days of reaction, two secondary radicals were observed in addition to the primary radical. At the same time, 1,8,1′8′-tetrahydroxy-10,10′-bis-9(10H)-anthrone (DI) and an increasing amount of AO and other nonidentified decomposition products were found. As the reaction proceeded further on the amount of AQ and the nonidentified decomposition products increased, the primary radical disappeared (within about 40 d) and the concentration of DI decreased to zero (within 1 yr). Nonidentified decomposition products are tentatively assigned to polymeric degradation product (anthralin brown) formed from DI via the observed secondary radical species. These radical reactions of anthralin with peroxidized lipids help to elucidate speculations on radical type reactions of anthralin in psoriasis indications, e.g., the role of peroxidized skin lipids as radical reaction initiators.</p></div>","PeriodicalId":77737,"journal":{"name":"Journal of free radicals in biology & medicine","volume":"1 4","pages":"Pages 301-306"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0748-5514(85)90135-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14952585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Cutaneous thermal burn and oxidant-mediated acute lung injury: Appearance in serum of lung-related LDH isoenzyme 皮肤热烧伤和氧化介导的急性肺损伤:肺相关LDH同工酶的血清表现

Journal of free radicals in biology & medicine Pub Date : 1985-01-01 DOI: 10.1016/0748-5514(85)90154-0

Thomas M. Annesley, Gerd O. Till, Peter A. Ward

{"title":"Cutaneous thermal burn and oxidant-mediated acute lung injury: Appearance in serum of lung-related LDH isoenzyme","authors":"Thomas M. Annesley, Gerd O. Till, Peter A. Ward","doi":"10.1016/0748-5514(85)90154-0","DOIUrl":"10.1016/0748-5514(85)90154-0","url":null,"abstract":"<div><p>Previous studies from our laboratory have demonstrated that thermal injury to the skin of rats is associated with the production of oxygen radicals by complement-activated blood neutrophils, resulting in acute lung injury as demonstrated by increases in lung vascular permeability and morphological evidence of vascular endothelial cell damage, interstitial edema, and alveolar hemorrhage. In the present study, the analysis of sera from thermally injured rats reveals an isoenzyme profile for lactate dehydrogenase (LDH;EC 1.1.1.27) that is compatible with origin from lung. The appearance of LDH-4 isoenzyme in serum of thermally injured rats correlates linearly with indices of lung damage, supporting the results of previous studies suggesting that thermal trauma to the skin can cause oxygen radical production by complement-activated blood neutrophils with resultant acute microvascular injury in the lung interstitium. Furthermore, interventions that protect from oxidant-mediated lung injury (catase, scavengers of hydroxyl radical, iron chelators or neutrophil depletion) result in significant reductions in serum levels of the LDH-4 isoenzyme following thermal injury to the skin. Thus, measurements of LDH isoenzyme patterns in serum to be useful in monitoring tissue damage such as oxygen radical-mediated acute lung injury.</p></div>","PeriodicalId":77737,"journal":{"name":"Journal of free radicals in biology & medicine","volume":"1 5","pages":"Pages 409-414"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0748-5514(85)90154-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15053759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Oxygen radicals in complement and neutrophil-mediated acute lung injury 补体和中性粒细胞介导的急性肺损伤中的氧自由基

Journal of free radicals in biology & medicine Pub Date : 1985-01-01 DOI: 10.1016/0748-5514(85)90021-2

Gerd O. Till, Peter A. Ward

引用次数: 21

Inhibition of the proteolytic contaminant in commercial xanthine oxidase preparations by serum protein fractions 血清蛋白组分对商用黄嘌呤氧化酶制剂中蛋白水解污染物的抑制作用

Journal of free radicals in biology & medicine Pub Date : 1985-01-01 DOI: 10.1016/0748-5514(85)90160-6

Robert A. Greenwald, Susan A. Moak, Steven E. Carsons, Scott Rush

引用次数: 6

Contents Volume 1, 1985/86 目录第1卷，1985/86

Journal of free radicals in biology & medicine Pub Date : 1985-01-01 DOI: 10.1016/0748-5514(85)90165-5

引用次数: 0

Forthcoming articles for volume 2, number1 第2卷第1号即将发表的文章

Journal of free radicals in biology & medicine Pub Date : 1985-01-01 DOI: 10.1016/0748-5514(85)90168-0

引用次数: 0