{"title":"Immunomodulation by interferons: recent developments.","authors":"J De Maeyer-Guignard, E De Maeyer","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77727,"journal":{"name":"Interferon","volume":"6 ","pages":"69-91"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15042208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mechanisms of antiviral action of interferon.","authors":"C Baglioni, T W Nilsen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77727,"journal":{"name":"Interferon","volume":"5 ","pages":"23-42"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17267396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Interferon induction by viruses: one molecule of dsRNA as the threshold for interferon induction.","authors":"P I Marcus","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The studies chronicled in this chapter were chosen largely because they contained data amenable to the quantitative analysis of interferon induction dose-response curves and the IFP activity they represented. The interpretation of the data was predicated on the assumption that a single molecule of dsRNA, when properly introduced into a cell, either as a preformed entity or formed therein following some synthetic event, can induce a quantum yield of interferon. This novel view of interferon induction by viruses has provided an explanation for many seemingly discordant results and offers a unifying hypothesis regarding the nature of the interferon inducer moiety for viruses from widely different families. If we note the reluctance of some to accept dsRNA as a common interferon inducer molecule ( McKimm and Rapp , 1977; Kowal and Youngner , 1978; Joklik , 1980) but recognize that the threshold for activating the interferon induction system is one molecule per cell, many aspects of interferon induction heretofore enigmatic are rendered offerpretable . Furthermore, one molecule of dsRNA per cell suffices to induce a quantum yield of interferon, an apparent expression of the \"one-shot affair\" of interferon production recognized by Ho (1964). In some cases of induction (the r = 1 type dose-response curve) there is an exquisitely responsive modulation of production when a second molecule of dsRNA is simultaneously introduced into the cell. The experimental approach and concepts discussed herein offer a new perspective on the mechanism of interferon induction by viruses and its regulation, and point out the incredible biological potency of a dsRNA molecule--a molecule found to play a key role in viral infection and host defence (Carter and De Clercq , 1974), regulation of the immune system (Johnson, 1980), and perhaps some yet to be defined function in cell growth (Taylor- Papadimitriou , 1980) and differentiation ( Grossberg and Sabran , 1981-2) through its capacity to activate the interferon system.</p>","PeriodicalId":77727,"journal":{"name":"Interferon","volume":"5 ","pages":"115-80"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17267395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The toxic effects of interferon in man.","authors":"G M Scott","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77727,"journal":{"name":"Interferon","volume":"5 ","pages":"85-114"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17731029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Interferons and cancer: how the promise is being kept.","authors":"E C Borden","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77727,"journal":{"name":"Interferon","volume":"5 ","pages":"43-83"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17267397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Genetic and functional diversity of interferons in man.","authors":"M Revel","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77727,"journal":{"name":"Interferon","volume":"5 ","pages":"205-39"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17388986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}