Central nervous system trauma : journal of the American Paralysis Association最新文献_第8页

Fetal CNS transplants into adult spinal cord: techniques, initial effects, and caveats. 胎儿中枢神经系统移植到成人脊髓:技术，初步效果和注意事项。

Central nervous system trauma : journal of the American Paralysis Association Pub Date : 1984-01-01 DOI: 10.1089/cns.1984.1.39

J J Bernstein, D Underberger, D W Hoovler

引用次数: 12

Structural and functional impairment of adrenergic input to intraocular cerebellar grafts during thyroid hormone deficiency. 甲状腺激素缺乏对眼内小脑移植物肾上腺素能输入的结构和功能损害。

Central nervous system trauma : journal of the American Paralysis Association Pub Date : 1984-01-01 DOI: 10.1089/cns.1984.1.105

A C Granholm, M Hall, M R Palmer, A Seiger

{"title":"Structural and functional impairment of adrenergic input to intraocular cerebellar grafts during thyroid hormone deficiency.","authors":"A C Granholm, M Hall, M R Palmer, A Seiger","doi":"10.1089/cns.1984.1.105","DOIUrl":"https://doi.org/10.1089/cns.1984.1.105","url":null,"abstract":"Embryonic cerebellae were transplanted to the anterior eye chamber of normal and thyroidectomized adult rats and were left in the eye to mature for 5 weeks. The cerebellar grafts received adrenergic innervation from the sympathetic ground plexus of the host iris. The density of adrenergic fibers innervating the grafts was reduced by approximately 50% in all thyroidectomized groups, without any effect on the fluorescence intensity or the morphology of individual nerve fibers. The reduction in adrenergic ingrowth was entirely prevented in grafts raised in similarly thyroidectomized recipients, which were substituted daily with thyroxine (100 micrograms/kg, SC). Electrophysiologically, there was no difference between the groups in terms of spontaneous firing rate of Purkinje neurons, recorded extracellularly from cerebellar grafts. However, there was a 10-fold decrease in the potency of catecholamines to inhibit the spontaneous neuronal activity in thyroidectomized hosts as compared to controls when applied either locally by micropressure ejection or by superfusion. Similar to the observed histologic changes in catecholamine innervation, the abnormal responsiveness of hypothyroid cerebellar neurons to locally applied catecholamines could be prevented by daily substitution with thyroxine in these animals. It is thus concluded that there is both structural and functional impairment of the adrenergic innervation of intraocular cerebellar grafts that underwent development under conditions of thyroid hormone deficiency.","PeriodicalId":77690,"journal":{"name":"Central nervous system trauma : journal of the American Paralysis Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/cns.1984.1.105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17602600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The use of hyperbaric oxygen to modify the effects of recent contusion injury to the spinal cord. 高压氧对近期脊髓挫伤的影响。

Central nervous system trauma : journal of the American Paralysis Association Pub Date : 1984-01-01 DOI: 10.1089/cns.1984.1.161

J D Yeo

引用次数: 12

Acute spinal cord injury: a systems approach. 急性脊髓损伤:系统方法。

Central nervous system trauma : journal of the American Paralysis Association Pub Date : 1984-01-01 DOI: 10.1089/cns.1984.1.173

B A Green, F J Eismont

引用次数: 9

The vestibulospinal free fall response: a test of descending function in spinal-injured cats. 前庭脊髓自由落体反应:脊髓损伤猫的下降功能测试。

Central nervous system trauma : journal of the American Paralysis Association Pub Date : 1984-01-01 DOI: 10.1089/cns.1984.1.139

J A Gruner, W Young, V DeCrescito

{"title":"The vestibulospinal free fall response: a test of descending function in spinal-injured cats.","authors":"J A Gruner, W Young, V DeCrescito","doi":"10.1089/cns.1984.1.139","DOIUrl":"https://doi.org/10.1089/cns.1984.1.139","url":null,"abstract":"A major problem in spinal cord injury research is quantification of motor function in animals. Most investigators in the field currently use neurologic scoring systems, relying on subjective observations of complex behaviours and assigning scores based on arbitrary criteria. These scoring scales are prone to observer bias and are nonspecific. We describe here a simple, reproducible, noninvasive, and objective test of a limited aspect of spinal motor function in cats, based on a well-known involuntary response of animals to sudden free fall. Free fall responses, or FFRs, have been studied in many species, including man, and are thought to be carried in ventral and lateral column pathways, i.e., vestibulospinal, reticulospinal, and rubrospinal tracts. We recorded the FFRs from hind and forelimb muscles of 100 cats before and after thoracic spinal cord injury. Hindlimb FFRs were shown to have three quantifiable components: a fast synchronous activation (E1) followed by a short silent period during which spinal segmental reflexes are inhibited (I1) and a late desynchronized excitatory burst (E2). Thoracic spinal injury produced hindlimb FFR losses ranging from greatly reduced amplitude to complete absence of response. Residual FFRs correlated with the extent of ventral column preservation and locomotory ability. Individual FFR components can be preserved. For example, some injured cats exhibited only 11 responses. Our work suggests that FFRs are a reliable and sensitive test of motor recovery in spinal cord injury.","PeriodicalId":77690,"journal":{"name":"Central nervous system trauma : journal of the American Paralysis Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/cns.1984.1.139","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17397167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Gangliosides and their effects on rearranging peripheral and central neural pathways. 神经节苷类及其对外周和中枢神经通路重排的影响。

Central nervous system trauma : journal of the American Paralysis Association Pub Date : 1984-01-01 DOI: 10.1089/cns.1984.1.29

A Gorio, G Ferrari, M Fusco, D Janigro, R Zanoni, G Jonsson

引用次数: 13

A critical overview of spinal injury research presented at the First International Symposium on CNS Trauma. 在第一届中枢神经系统创伤国际研讨会上提出的脊髓损伤研究的关键概述。

Central nervous system trauma : journal of the American Paralysis Association Pub Date : 1984-01-01 DOI: 10.1089/cns.1984.1.75

W Young

引用次数: 1

Intracerebral grafting of neuronal cell suspensions into the adult brain. 成人脑内神经细胞悬液的脑内移植。

Central nervous system trauma : journal of the American Paralysis Association Pub Date : 1984-01-01 DOI: 10.1089/cns.1984.1.47

F H Gage, A Björklund

引用次数: 29

Changes in myelin and axonal proteins in CaCl2-induced myelopathy in rat spinal cord. cacl2诱导的大鼠脊髓脊髓病中髓磷脂和轴突蛋白的变化。

Central nervous system trauma : journal of the American Paralysis Association Pub Date : 1984-01-01 DOI: 10.1089/cns.1984.1.131

N L Banik, E L Hogan, L J Whetstine, J D Balentine

引用次数: 19

The use of functional electrical stimulation for rehabilitation of spinal cord injured patients. 功能性电刺激在脊髓损伤患者康复中的应用。

Central nervous system trauma : journal of the American Paralysis Association Pub Date : 1984-01-01 DOI: 10.1089/cns.1984.1.57

J S Petrofsky, C A Phillips

{"title":"The use of functional electrical stimulation for rehabilitation of spinal cord injured patients.","authors":"J S Petrofsky, C A Phillips","doi":"10.1089/cns.1984.1.57","DOIUrl":"https://doi.org/10.1089/cns.1984.1.57","url":null,"abstract":"Computer-directed functional electrical stimulation that employs closed-loop (feedback) technology has been used for rehabilitation of spinal cord injured (SCI) patients. This paper summarizes the most recent developments in our laboratory. First, the design of an adaptive control system is described, and its resultant controllability is reviewed. Second, our current results with the isokinetic leg trainer are summarized with respect to muscular strength and mass and cardiovascular changes in paraplegics and quadriplegics. Third, our current results with the exercise bicycle ergometer are summarized regarding muscular endurance and cardiovascular changes in control, paraplegic, and quadriplegic subjects. Fourth, impact vibration is reviewed as a potential technique to reverse disuse osteoporosis, and clinical case studies are cited. Fifth and finally, thermoregulatory studies are presented for the first time on control, paraplegic, and quadriplegic subjects. Conclusions are drawn regarding mechanisms and recommendations made for exercise of SCI subjects in hot and humid environments.","PeriodicalId":77690,"journal":{"name":"Central nervous system trauma : journal of the American Paralysis Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/cns.1984.1.57","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17458651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 84