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Evolution of human papillomavirus infections in the uterine cervix during a long-term prospective follow-up. 人乳头瘤病毒感染在宫颈的演变在长期的前瞻性随访。
Applied pathology Pub Date : 1987-01-01
K Syrjänen, R Mäntyjärvi, M Väyrynen, S Syrjänen, S Parkkinen, M Yliskoski, S Saarikoski, O Castrén
{"title":"Evolution of human papillomavirus infections in the uterine cervix during a long-term prospective follow-up.","authors":"K Syrjänen,&nbsp;R Mäntyjärvi,&nbsp;M Väyrynen,&nbsp;S Syrjänen,&nbsp;S Parkkinen,&nbsp;M Yliskoski,&nbsp;S Saarikoski,&nbsp;O Castrén","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A series of 513 women presented with cervical human papillomavirus (HPV) infections (with or without cervical intraepithelial neoplasia; CIN) have been prospectively followed up since 1981 (mean 25.6 months), at 6-month intervals, by colposcopy with PAP smears and/or punch biopsies. The latter were analyzed by light microscopy, as well as immunohistochemically for HPV structural proteins. HPV DNA typing was accomplished by Southern blot, spot, and in situ hybridization techniques using the DNA probes for HPV 6, 11, 16, 18 and 31. Of the 513 lesions, 24.8% regressed, 59.8% persisted, and 14.1% progressed, 11.9% having been coned due to progression to carcinoma in situ (CIS). So far, 1.1% of lesions have recurred after such a treatment. The natural history was significantly associated with the grade of CIN (HPV-NCIN versus HPV-CIN, p less than 0.01). The progression rate was highest (33.3%) and regression lowest (5.6%) in HPV 16 lesions. All the recurrent lesions disclosed HPV 16 DNA, this type being found most frequently in the severest lesions (CIN III). Depending on the hybridization technique used, changes in HPV type were found in 11-17% of the lesions during the follow-up. Noteworthy is the discovery of all the HPV types also in biopsies with no signs of HPV infection on light microscopy, suggesting a latent HPV infection in these 'regressor' lesions. The results confirm that cervical HPV infections show a natural history comparable to that of classical CIN. Although the high-risk character of HPV 16 (and HPV 18) was clearly established, the inherent potential for progression (25.6%) of the HPV 6/11 lesions should not be neglected in therapeutic considerations.</p>","PeriodicalId":77670,"journal":{"name":"Applied pathology","volume":"5 2","pages":"121-35"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13958202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of lymphocyte-associated antigens on neoplastic angioendotheliomatosis. 淋巴细胞相关抗原在肿瘤血管内皮瘤病中的表达。
Applied pathology Pub Date : 1987-01-01
N Maruyama, Y Ishida, H Sato, T Koike, K Nagao
{"title":"Expression of lymphocyte-associated antigens on neoplastic angioendotheliomatosis.","authors":"N Maruyama,&nbsp;Y Ishida,&nbsp;H Sato,&nbsp;T Koike,&nbsp;K Nagao","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Neoplastic angioendotheliomatosis (NAE) is a rare and fatal disorder and has been regarded as a multifocal in situ neoplastic change of endothelial cells. This report describes a case of NAE from whom a biopsy specimen was obtained and studied immunohistologically using several monoclonal antibodies against lymphocyte-associated antigens. The tumor cells occluding luminal space express both T and B cell markers such as Leu-1, Leu-3, Leu-10, Leu-M3, HLA-DR, and HLA-DQ, whereas they do not express Leu-2, Leu-4, lymphocyte-common antigen, and immunoglobulins. Factor VIII as a marker of vascular endothelial cell is false positive in the present case. Since immunoglobulins as a definitive B lymphocyte marker are negative in this case, there is no direct evidence indicating that NAE is a tumor of B lymphocytic lineage as previously reported. These results suggest the two possibilities that NAE is a unique variant of T cell lymphoma or true vascular endothelial tumor sharing the common histogenesis with malignant lymphoma. As it stands the former possibility is more likely than the latter in our case.</p>","PeriodicalId":77670,"journal":{"name":"Applied pathology","volume":"5 4","pages":"246-52"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14447223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current concepts of intraepithelial neoplasia in the uterine cervix (CIN). 当前宫颈上皮内瘤变(CIN)的概念。
Applied pathology Pub Date : 1987-01-01
L G Koss
{"title":"Current concepts of intraepithelial neoplasia in the uterine cervix (CIN).","authors":"L G Koss","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The unifying concept of precancerous events in the epithelia of the uterine cervix is reviewed in the light of epidemiologic and morphologic observations. The role of human papillomavirus (HPV) infection as a factor in the genesis of precancerous states and carcinoma of the uterine cervix is assessed. Although cytologic, histologic, ultrastructural and molecular biologic data support the concept of HPV as an oncogenic virus, the precise mechanisms linking the infection with cancer are not known at this time. A hypothesis of the presumed sequence of events is presented.</p>","PeriodicalId":77670,"journal":{"name":"Applied pathology","volume":"5 1","pages":"7-18"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14172469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The spectrum of pathology in osteomalacia. 骨软化症的病理谱。
Applied pathology Pub Date : 1987-01-01
H E Gruber, F R Singer
{"title":"The spectrum of pathology in osteomalacia.","authors":"H E Gruber,&nbsp;F R Singer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A classification and discussion of the histology of osteomalacia and the current histological techniques used in its identification are presented. Three categories of histologic features of osteomalacic bone are proposed: (1) increased osteoid, elevated osteoblast and osteoclast numbers and marrow fibrosis; (2) increased osteoid and osteoblast numbers, and (3) increased osteoid associated with few osteoblasts. Clinical conditions for which quantitative bone histomorphometric data are available are presented and related to the three categories. The consistency of clinical pathophysiology and histologic bone features is emphasized.</p>","PeriodicalId":77670,"journal":{"name":"Applied pathology","volume":"5 3","pages":"160-71"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14430599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiological data on cervical carcinoma relevant to cytopathology. 宫颈癌与细胞病理学相关的流行病学资料。
Applied pathology Pub Date : 1987-01-01
C La Vecchia, A Decarli, G Gallus
{"title":"Epidemiological data on cervical carcinoma relevant to cytopathology.","authors":"C La Vecchia,&nbsp;A Decarli,&nbsp;G Gallus","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Epidemiological studies based on cervical cytopathology have aroused widespread interest since it was realized that they could be a useful tool for measuring the effectiveness of screening programs and defining practical measures for the prevention of invasive neoplasms and deaths. In the present article, published evidence from screening programs, cohort investigations and case-control studies is reviewed, and possibilities for further analyses and applications are discussed. In particular, when estimates of the relative protections conveyed by Pap smear from various case-control studies conducted on different populations and using different criteria of selection were pooled, a surprisingly close concordance emerged, with overall risk estimates of invasive cervical cancer of 0.42 for women reporting one smear, and of 0.20 for two or more smears in the past. This protection appeared to be long-lasting in a considerable proportion of cases, since the major determinant of invasive cancer risk was the number of previous smears rather than the interval since last smear, and a noticeable residual effect was evident even more than 10 years after the last smear. Besides providing a measure of the effectiveness of cytological screening and helping define the optimal frequency of screening using the limited resources available, case-control studies should permit accurate estimates of the sensitivity of the test and quantify the probability of transition and the duration of various stages of the neoplastic process, i.e., permit a better understanding of the natural history of the disease.</p>","PeriodicalId":77670,"journal":{"name":"Applied pathology","volume":"5 1","pages":"25-32"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14740412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrastructural glomerular findings in cryoglobulinemic glomerulonephritis. 低温球蛋白血症性肾小球肾炎的超微结构表现。
Applied pathology Pub Date : 1987-01-01
G Monga, G Mazzucco, S Casanova, R Boero, L Cagnoli, G Barbiano di Belgiojoso, R Confalonieri
{"title":"Ultrastructural glomerular findings in cryoglobulinemic glomerulonephritis.","authors":"G Monga,&nbsp;G Mazzucco,&nbsp;S Casanova,&nbsp;R Boero,&nbsp;L Cagnoli,&nbsp;G Barbiano di Belgiojoso,&nbsp;R Confalonieri","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Thirty-three renal biopsies of patients affected by cryoglobulinemic glomerulonephritis (CRYGN) were investigated by electron microscopy, paying particular attention to the nature of cells responsible of glomerular hypercellularity, the presence and site of electron-dense deposits and their ultrastructural characteristics. Personal as well as literature data suggest (a) diffuse glomerular hypercellularity found in most cases of CRYGN is mainly due to polymorphonuclear leukocytes and even more to monocyte exudation; (b) the interposition of the latter cell type in the glomerular capillary wall is the main responsible cause of the frequent occurrence of the membranoproliferative pattern in CRYGN, and (c) peculiar structures found in the electron dense deposits are characteristic of CRYGN and related to cryoglobulin composition. Electron microscopy therefore seems to be a valuable diagnostic procedure for this type of glomerulonephritis.</p>","PeriodicalId":77670,"journal":{"name":"Applied pathology","volume":"5 2","pages":"108-15"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14435051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cervical neoplasia. 宫颈肿瘤。
Applied pathology Pub Date : 1987-01-01
{"title":"Cervical neoplasia.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77670,"journal":{"name":"Applied pathology","volume":"5 1","pages":"1-75"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14740411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic problems of in situ and invasive adenocarcinomas of the uterine cervix. 宫颈原位腺癌和浸润性腺癌的诊断问题。
Applied pathology Pub Date : 1987-01-01
Y S Fu, J S Berek, L H Hilborne
{"title":"Diagnostic problems of in situ and invasive adenocarcinomas of the uterine cervix.","authors":"Y S Fu,&nbsp;J S Berek,&nbsp;L H Hilborne","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In this study of 58 cervical in situ and invasive adenocarcinomas, the diagnostic accuracy of cervical biopsies was found to be closely related to the extent and the degree of differentiation of the neoplasm. Biopsies of in situ and early, well-differentiated adenocarcinomas were often limited in amount, precluding an accurate assessment of stromal invasion. In such cases, a comprehensive sample, e.g., by conization, was required to establish the diagnosis. Invasive adenocarcinoma could be distinguished from the in situ change by the loss of branching pattern of normal endocervical glands, a marked variation in the size and shape of the glands, and a complex papillary or solid growth pattern. The presence of a desmoplastic reaction further supported the invasive nature of the neoplasm.</p>","PeriodicalId":77670,"journal":{"name":"Applied pathology","volume":"5 1","pages":"47-56"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14740415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adult osteopetrosis: study of two brothers. 成人骨质疏松症:两兄弟的研究。
Applied pathology Pub Date : 1987-01-01
G Silvestrini, G F Ferraccioli, F Quaini, E Palummeri, E Bonucci
{"title":"Adult osteopetrosis: study of two brothers.","authors":"G Silvestrini,&nbsp;G F Ferraccioli,&nbsp;F Quaini,&nbsp;E Palummeri,&nbsp;E Bonucci","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Bone biopsies from 2 adult cases of benign osteopetrosis have been studied histologically and under the electron microscope. The most important findings were a high degree of osteosclerosis, narrowing and fibrosis of medullary spaces, and the presence of abundant uncalcified osteoid tissue with an osteomalacia-like appearance. The osteoclasts were not numerous. All of them lacked the brush border and many showed wide cytoplasmic vacuoles containing amorphous and filamentous material. This picture, which is not different from that found in cases of fetal osteopetrosis, has not been modified by ethydronate therapy.</p>","PeriodicalId":77670,"journal":{"name":"Applied pathology","volume":"5 3","pages":"184-9"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14740422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Osteopetrosis--multiple pathways for the interception of osteoclast function. 骨质疏松——破骨细胞功能被阻断的多种途径。
Applied pathology Pub Date : 1987-01-01
S C Marks
{"title":"Osteopetrosis--multiple pathways for the interception of osteoclast function.","authors":"S C Marks","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Osteopetrosis is a metabolic bone disease inherited in a number of species including human beings and characterized by a generalized increase in skeletal density detected radiographically. This condition results primarily from reduced osteoclast function which produces partial or complete absence of marrow spaces, a variable compensatory hepatosplenomegaly, interferences with tooth eruption and certain neurological complications. Experimental investigations of some mutations have shown that restoration of bone resorption and recovery from the disease follow bone marrow transplantation. These data indicate that in these mutations, including some children, the defect is intrinsic to osteoclasts or their stem cells. In other mutations in animals and children, bone marrow transplants do not restore bone resorption and the defect is believed to be one of local environmental products or signals whose importance in cell differentiation and regulation is becoming increasingly appreciated. These data, reviewed with respect to the emerging cell biology of the osteoclast, indicate that osteopetrotic mutations have much to teach us about the regulation of bone metabolism.</p>","PeriodicalId":77670,"journal":{"name":"Applied pathology","volume":"5 3","pages":"172-83"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14430600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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