American journal of reproductive immunology and microbiology : AJRIM最新文献_第2页

Genetic and immunological factors in human recurrent abortion. 人复发性流产的遗传和免疫因素。

American journal of reproductive immunology and microbiology : AJRIM Pub Date : 1987-12-01

J F Mowbray

{"title":"Genetic and immunological factors in human recurrent abortion.","authors":"J F Mowbray","doi":"","DOIUrl":"","url":null,"abstract":"The theoretical causes of recurrent spontaneous abortion may be several. Gill and others have suggested that the human disease may be mimicked by the rodent genetic diseases, as exemplified by the T locus in mice. He would suggest that there may be lethal recessive gene phenomena which may cause repeated abortion, or if the abortion is prevented by immunological means the birth of genetically defective individuals. The evidence presented here shows that prevention of abortion by immunological treatment, that is immunisation of the wife with paternal lymphocytes, is associated with a very high success rate, and the children born do not have more than the normal incidence of birth defects. Thus far, over the 7 years of study, the children also appear to develop normally. Probably the reason for this is that the methods of selection for treatment tend to exclude quite effectively those couples with pure genetic problems. In particular, the the exclusion of women who have had more than one live child removes a group of women who might have lethal recessive problems which would only affect 25-50% of the offspring. The interactive gene products that may produce abortion of all pregnancies, suggested as a theoretical concept by Gill, would be expected to show an incidence no more than the square root of the frequency of the recessive disease, and are probably too few to be seen even in the more than 1,500 couples we have studied.","PeriodicalId":77662,"journal":{"name":"American journal of reproductive immunology and microbiology : AJRIM","volume":"15 4","pages":"138-40"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14559510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of maternal-fetal histoincompatibility on the weight of the feto-placental unit in mice: the role of minor histocompatibility antigens. 母胎组织不相容性对小鼠胎胎盘单位重量的影响:次要组织相容性抗原的作用。

American journal of reproductive immunology and microbiology : AJRIM Pub Date : 1987-12-01

B L Hamilton, M S Hamilton

引用次数: 0

Zona pellucida: current status as a candidate antigen for contraceptive vaccine development. 透明带:作为避孕疫苗开发候选抗原的现状。

American journal of reproductive immunology and microbiology : AJRIM Pub Date : 1987-12-01

A G Sacco

引用次数: 0

Histopathological changes in decidua in human spontaneous abortion. 人自然流产时蜕膜的组织病理学改变。

American journal of reproductive immunology and microbiology : AJRIM Pub Date : 1987-08-01

J N Bulmer

引用次数: 0

Detection of early pregnancy factor-like activity in women with gestational trophoblastic tumors. 妊娠滋养细胞肿瘤患者早期妊娠因子样活性的检测。

American journal of reproductive immunology and microbiology : AJRIM Pub Date : 1987-07-01 DOI: 10.1111/j.1600-0897.1987.tb00122.x

A R Mehta, S K Shahani

引用次数: 9

The role of spermine in the cytotoxic effects of seminal plasma. 精胺在精浆细胞毒性作用中的作用。

American journal of reproductive immunology and microbiology : AJRIM Pub Date : 1987-07-01

P Quinn

引用次数: 0

Antigens of human trophoblast: trophoblast-lymphocyte cross-reactive antigens on platelets. 人滋养细胞抗原:血小板上的滋养细胞-淋巴细胞交叉反应抗原。

American journal of reproductive immunology and microbiology : AJRIM Pub Date : 1987-07-01 DOI: 10.1111/j.1600-0897.1987.tb00123.x

T Kajino, W P Faulk, J A McIntyre

{"title":"Antigens of human trophoblast: trophoblast-lymphocyte cross-reactive antigens on platelets.","authors":"T Kajino, W P Faulk, J A McIntyre","doi":"10.1111/j.1600-0897.1987.tb00123.x","DOIUrl":"https://doi.org/10.1111/j.1600-0897.1987.tb00123.x","url":null,"abstract":"Human and rabbit antibodies to trophoblast-lymphocyte cross-reactive (TLX) antigens were employed in an enzyme-linked immunosorbent assay (ELISA) to identify and characterize the TLX alloantigen system on human platelets. Neither washing nor extraction in chaotrope or acid altered platelet TLX. The antigen was significantly changed by pronase and trypsin digestion, but Folch extraction yielded antigen in the hydrophilic interface, suggesting carbohydrate. Rabbit antibodies prepared to HLA-negative human syncytiotrophoblast TLX antigens were shown by platelet ELISA to have the same specificity and similar allotypy as anti-TLX antibodies from secondary (2 degrees) spontaneously aborting women. Patients with normal pregnancies before becoming 2 degrees aborters had both IgG and IgM antibodies to TLX. Anti-TLX in patients who never had a normal pregnancy were predominantly IgG. ELISA reactions performed with different concentrations of protein in the buffers detected anti-TLX activity in buffers containing high protein concentrations. This has been observed in studies of blocking antibodies in graft-versus-host disease and immune responses to tumor cells. Platelet TLX offers a new genetic and immunological approach to study similarities of the host-parasite relationships in pregnancy, transplantation, and cancer.","PeriodicalId":77662,"journal":{"name":"American journal of reproductive immunology and microbiology : AJRIM","volume":"14 3","pages":"70-8"},"PeriodicalIF":0.0,"publicationDate":"1987-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0897.1987.tb00123.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14794424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Investigation of the expression of amnion antigens by spiral arteries in human utero-placental tissues. 螺旋动脉在人子宫-胎盘组织中羊膜抗原表达的研究。

American journal of reproductive immunology and microbiology : AJRIM Pub Date : 1987-07-01 DOI: 10.1111/j.1600-0897.1987.tb00124.x

J N Bulmer, M Wells, D P Lunny, C J Yeh, B L Hsi

{"title":"Investigation of the expression of amnion antigens by spiral arteries in human utero-placental tissues.","authors":"J N Bulmer, M Wells, D P Lunny, C J Yeh, B L Hsi","doi":"10.1111/j.1600-0897.1987.tb00124.x","DOIUrl":"https://doi.org/10.1111/j.1600-0897.1987.tb00124.x","url":null,"abstract":"Two monoclonal antibodies raised against human amnion, GB3 and GB5, were used in an indirect immunoperoxidase method to investigate the expression of amnion antigens by spiral arteries in pregnant and nonpregnant uterine tissues. GB3 showed focal reactivity with occasional spiral arteries in the placental bed throughout pregnancy, but no GB3-staining was observed in nonpregnant endometrium. In contrast, GB5 showed bandlike circumferential reactivity with spiral arteries at all gestational ages examined. GB5-positivity showed no relation to the presence of endovascular or perivascular trophoblast. In nonpregnant endometrium, GB5 labeled rare spiral arteries. However, in a premenstrual specimen showing pseudodecidual change, there was circumferential reactivity with GB5 resembling that in pregnancy. The reaction patterns of GB3 or GB5 were not similar to those for two other basement-membrane components, fibronectin and type IV collagen. The results suggest that expression of the GB5 antigen may in part be regulated by hormones.","PeriodicalId":77662,"journal":{"name":"American journal of reproductive immunology and microbiology : AJRIM","volume":"14 3","pages":"79-83"},"PeriodicalIF":0.0,"publicationDate":"1987-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0897.1987.tb00124.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14794425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

A potential anti-pregnancy vaccine built by conjugation of the beta-subunit of human chorionic gonadotropin to adjuvant-active muramyl peptide. 人绒毛膜促性腺激素β亚基与佐剂活性muramyl肽结合构建的潜在抗妊娠疫苗。

American journal of reproductive immunology and microbiology : AJRIM Pub Date : 1987-07-01 DOI: 10.1111/j.1600-0897.1987.tb00125.x

M P Schutze, C LeClerc, M Jolivet, E Deriaud, F Audibert, C C Chang, L Chedid

{"title":"A potential anti-pregnancy vaccine built by conjugation of the beta-subunit of human chorionic gonadotropin to adjuvant-active muramyl peptide.","authors":"M P Schutze, C LeClerc, M Jolivet, E Deriaud, F Audibert, C C Chang, L Chedid","doi":"10.1111/j.1600-0897.1987.tb00125.x","DOIUrl":"https://doi.org/10.1111/j.1600-0897.1987.tb00125.x","url":null,"abstract":"The beta-subunit of human chorionic gonadotropin (hCG) conjugated to tetanus toxoid is being investigated as a vaccine for human fertility control. Initial clinical trials indicated that the level of antibody response induced by such an immunogen was not always sufficient to prevent pregnancy. Therefore, efforts are being made to evaluate new carriers for the beta-subunit and to select adjuvants to yield a more efficient vaccine. In the present report, we demonstrate that conjugates of the beta-subunit of hCG with muramyl dipeptide (MDP), or its nonpyrogenic derivative murabutide, may have potential as an effective antipregnancy vaccine. The copolymer of beta hCG and MDP administered with Al(OH)3 to mice induced a high anti-beta hCG response, better than that induced by the conjugate of beta hCG to tetanus toxoid given with Al(OH)3. Moreover, the antibodies induced by such an immunogen were competent for neutralizing the biological activity of hCG in vivo. Even more interesting, a copolymer of beta hCG and of murabutide induced high levels of biologically active antibodies. This immunogen may represent a promising candidate for the development of an efficient vaccine for human fertility control.","PeriodicalId":77662,"journal":{"name":"American journal of reproductive immunology and microbiology : AJRIM","volume":"14 3","pages":"84-90"},"PeriodicalIF":0.0,"publicationDate":"1987-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0897.1987.tb00125.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13592830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Effect of bovine virus diarrhoea virus on pregnancy in the ewe monitored by ultrasound scanning and levels of 15-keto-13,14-dihydro-PGF2 alpha and progesterone. 牛病毒腹泻病毒对母羊妊娠的影响通过超声扫描和15-酮-13,14-二氢- pgf2 α和孕酮水平监测。

American journal of reproductive immunology and microbiology : AJRIM Pub Date : 1987-07-01 DOI: 10.1111/j.1600-0897.1987.tb00126.x

U Carlsson, G Fredriksson, H Kindahl, S Alenius

引用次数: 10