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Targeted diagnosis and therapy最新文献

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Acetylated low density lipoprotein and the delivery of immunomodulators to macrophages. 乙酰化低密度脂蛋白和免疫调节剂向巨噬细胞的传递。
Targeted diagnosis and therapy Pub Date : 1991-01-01 DOI: 10.1201/9780203748831-7
M S Rutherford, W S Futch, L B Schook
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引用次数: 0
Lipoproteins as carriers for organ-imaging radiopharmaceuticals. 脂蛋白作为器官成像放射性药物的载体。
Targeted diagnosis and therapy Pub Date : 1991-01-01 DOI: 10.1201/9780203748831-9
R E Counsell, S W Schwendner, L E DeForge, M R DeGalan, R S Newton
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引用次数: 0
Effect of ethanol on asialoglycoprotein receptor function. 乙醇对asialal糖蛋白受体功能的影响。
Targeted diagnosis and therapy Pub Date : 1991-01-01
C A Casey, M F Sorrell, D J Tuma
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引用次数: 0
Lipoproteins as carriers of pharmacological agents 作为药理学载体的脂蛋白
Targeted diagnosis and therapy Pub Date : 1991-01-01 DOI: 10.1201/9780203748831
J. Shaw
{"title":"Lipoproteins as carriers of pharmacological agents","authors":"J. Shaw","doi":"10.1201/9780203748831","DOIUrl":"https://doi.org/10.1201/9780203748831","url":null,"abstract":"Explores endogenous lipoprotein particles and their interaction with pharmacological agents. Among the topics are receptor-dependent interactions of lipoproteins with tissues and cell types, their uptake and transport with the vascular endothelium, therapeutic and chemical agents that associate in v","PeriodicalId":77632,"journal":{"name":"Targeted diagnosis and therapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65937696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Receptor-dependent targeting of lipoproteins to specific cell types of the liver. 受体依赖性脂蛋白靶向肝脏特定细胞类型。
Targeted diagnosis and therapy Pub Date : 1991-01-01
T J Van Berkel, J K Kruijt, P C De Smidt, M K Bijsterbosch
{"title":"Receptor-dependent targeting of lipoproteins to specific cell types of the liver.","authors":"T J Van Berkel, J K Kruijt, P C De Smidt, M K Bijsterbosch","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77632,"journal":{"name":"Targeted diagnosis and therapy","volume":"5 ","pages":"225-49"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12888056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanism and clinical relevance of elevated levels of circulating asialoglycoproteins. 循环asial糖蛋白水平升高的机制和临床意义。
Targeted diagnosis and therapy Pub Date : 1991-01-01
T Sawamura, Y Shiozaki
{"title":"Mechanism and clinical relevance of elevated levels of circulating asialoglycoproteins.","authors":"T Sawamura, Y Shiozaki","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77632,"journal":{"name":"Targeted diagnosis and therapy","volume":"4 ","pages":"215-34"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12958351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Liver diseases: targeted diagnosis and therapy using specific receptors and ligands. 肝脏疾病:使用特异性受体和配体的靶向诊断和治疗。
Targeted diagnosis and therapy Pub Date : 1991-01-01
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引用次数: 0
Cellular interactions of lipoproteins with the vascular endothelium: endocytosis and transcytosis. 脂蛋白与血管内皮的细胞相互作用:内吞作用和胞吞作用。
Targeted diagnosis and therapy Pub Date : 1991-01-01 DOI: 10.1201/9780203748831-3
N Simionescu, M Simionescu
{"title":"Cellular interactions of lipoproteins with the vascular endothelium: endocytosis and transcytosis.","authors":"N Simionescu, M Simionescu","doi":"10.1201/9780203748831-3","DOIUrl":"https://doi.org/10.1201/9780203748831-3","url":null,"abstract":"","PeriodicalId":77632,"journal":{"name":"Targeted diagnosis and therapy","volume":"5 ","pages":"45-95"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12960255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asialoglycoproteins as radiodiagnostic agents for detection of hepatic masses and evaluation of liver function. 亚洲糖蛋白作为肝脏肿块检测和肝功能评价的放射诊断试剂。
Targeted diagnosis and therapy Pub Date : 1991-01-01
W F Makdisi, M R Versland
{"title":"Asialoglycoproteins as radiodiagnostic agents for detection of hepatic masses and evaluation of liver function.","authors":"W F Makdisi,&nbsp;M R Versland","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The use of targeted radiopharmaceuticals in the diagnosis of hepatic structural and functional defects seems to be a promising new field. Two agents, 99mTc-neogalactoalbumin and 99mTc-asialoorosomucoid, have been used with some success in recent studies. More data, however, needs to be obtained on the kinetics of uptake in various disease states. Comparison studies will also need to be done as new agents are developed.</p>","PeriodicalId":77632,"journal":{"name":"Targeted diagnosis and therapy","volume":"4 ","pages":"151-62"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12831076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulatory agency concerns in the manufacturing and testing of monoclonal antibodies for therapeutic use. 监管机构对治疗用单克隆抗体生产和检测的关注。
Targeted diagnosis and therapy Pub Date : 1990-01-01
D A Baker, W S Harkonen
{"title":"Regulatory agency concerns in the manufacturing and testing of monoclonal antibodies for therapeutic use.","authors":"D A Baker,&nbsp;W S Harkonen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Monoclonal antibody-based therapeutic products are subject to the same regulatory review procedures and submissions requirements as more traditional pharmaceutical agents. In addition, the FDA often asks for specific information on the unique aspects of the manufacture, characterization, and testing of these products. Agency concern begins with the origin of the hybridoma cell line and continues through preclinical safety testing and clinical trials. Specific regulatory issues are often decided on a case-by-case basis with the FDA reviewers. Implementing an effective strategy for identifying and addressing these issues and concerns is a critical part of the development process.</p>","PeriodicalId":77632,"journal":{"name":"Targeted diagnosis and therapy","volume":"3 ","pages":"75-98"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13286176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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