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Targeted diagnosis and therapy最新文献

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Genetically engineered toxins. 基因工程毒素。
Targeted diagnosis and therapy Pub Date : 1992-01-01
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引用次数: 0
Structural characteristics and regulation of the asialoglycoprotein receptor. asialal糖蛋白受体的结构特征及调控。
Targeted diagnosis and therapy Pub Date : 1991-01-01
R J Stockert, A G Morell, G Ashwell
{"title":"Structural characteristics and regulation of the asialoglycoprotein receptor.","authors":"R J Stockert, A G Morell, G Ashwell","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77632,"journal":{"name":"Targeted diagnosis and therapy","volume":"4 ","pages":"41-64"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12958360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Receptor-mediated radiopharmaceutical imaging of the liver. 受体介导的肝脏放射药物显像。
Targeted diagnosis and therapy Pub Date : 1991-01-01
R P Spencer
{"title":"Receptor-mediated radiopharmaceutical imaging of the liver.","authors":"R P Spencer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Receptor imaging of the liver has not yet evolved into a routinely employed tool. However, the vast array of intrahepatic receptors (in terms of both variety and number) holds promise of potential use in defining otherwise difficult to assess liver functions.</p>","PeriodicalId":77632,"journal":{"name":"Targeted diagnosis and therapy","volume":"4 ","pages":"321-38"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12831079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Receptor-mediated protection of normal hepatocytes during chemotherapy for hepatocellular carcinoma. 受体介导的肝癌化疗期间正常肝细胞的保护作用。
Targeted diagnosis and therapy Pub Date : 1991-01-01
V Keegan-Rogers, C H Wu, G Y Wu
{"title":"Receptor-mediated protection of normal hepatocytes during chemotherapy for hepatocellular carcinoma.","authors":"V Keegan-Rogers,&nbsp;C H Wu,&nbsp;G Y Wu","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77632,"journal":{"name":"Targeted diagnosis and therapy","volume":"4 ","pages":"105-25"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12831075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trafficking of the transferrin receptor. 转运转运蛋白受体。
Targeted diagnosis and therapy Pub Date : 1991-01-01
W Stoorvogel, G J Strous, A Ciechanover, A L Schwartz
{"title":"Trafficking of the transferrin receptor.","authors":"W Stoorvogel,&nbsp;G J Strous,&nbsp;A Ciechanover,&nbsp;A L Schwartz","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77632,"journal":{"name":"Targeted diagnosis and therapy","volume":"4 ","pages":"267-304"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12958355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting of liposomes to hepatocytes. 脂质体靶向肝细胞。
Targeted diagnosis and therapy Pub Date : 1991-01-01
P C Ghosh, B K Bachhawat
{"title":"Targeting of liposomes to hepatocytes.","authors":"P C Ghosh,&nbsp;B K Bachhawat","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We began our investigations about 15 years ago with the concept that it should be possible to deliver drugs or enzymes intracellularly into lysosomes for diseases associated with lysosomal enzymes (e.g., sphingolipidosis). The results have been very gratifying. It now has been possible to extend our in vitro studies on the kinetics of lectin-liposome interaction to the targeting of glycolipid liposomes to specific liver cell types in vivo by simply varying the sugar residue on the surface of liposome. Nevertheless, much remains to be done to ascertain the stability of the external enzyme and the expression of its activity after the delivery into the lysosomes.</p>","PeriodicalId":77632,"journal":{"name":"Targeted diagnosis and therapy","volume":"4 ","pages":"87-103"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12888055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Key issues in the delivery of pharmacological agents using lipoproteins: design of a synthetic apoprotein-lipid carrier. 利用脂蛋白递送药物的关键问题:设计一种合成载脂蛋白-脂质载体。
Targeted diagnosis and therapy Pub Date : 1991-01-01 DOI: 10.1201/9780203748831-11
J M Shaw, K V Shaw
{"title":"Key issues in the delivery of pharmacological agents using lipoproteins: design of a synthetic apoprotein-lipid carrier.","authors":"J M Shaw,&nbsp;K V Shaw","doi":"10.1201/9780203748831-11","DOIUrl":"https://doi.org/10.1201/9780203748831-11","url":null,"abstract":"","PeriodicalId":77632,"journal":{"name":"Targeted diagnosis and therapy","volume":"5 ","pages":"351-83"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12831604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Targeted delivery and expression of foreign genes in hepatocytes. 外源基因在肝细胞中的靶向传递和表达。
Targeted diagnosis and therapy Pub Date : 1991-01-01
G Y Wu, C H Wu
{"title":"Targeted delivery and expression of foreign genes in hepatocytes.","authors":"G Y Wu,&nbsp;C H Wu","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77632,"journal":{"name":"Targeted diagnosis and therapy","volume":"4 ","pages":"127-49"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12958348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trafficking of asialoglycoproteins and the asialoglycoprotein receptor. asialal糖蛋白和asialal糖蛋白受体的转运。
Targeted diagnosis and therapy Pub Date : 1991-01-01
A L Schwartz
{"title":"Trafficking of asialoglycoproteins and the asialoglycoprotein receptor.","authors":"A L Schwartz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Thus, the ASGP-R, a liver parenchymal cell-specific receptor, directs the receptor-mediated endocytosis of galactose-terminal glycoprotein ligands from the circulation into the liver cell, as seen in Figure 3. Following binding at the cell surface and internalization, the major pathway of ligand and receptor movement in the cell involves trafficking to CURL. Here acidification dissociates ligand from receptor, allowing the receptor to recycle back to the cell surface and directing ligand on to lysosomal degradation. Alternative routes of ligand movement, such as the slow ligand-recycling pathway, have recently been observed, and it is tempting to speculate that this occurs by the TGR. There is now ample biochemical, kinetic, and morphological evidence to support both rapid receptor recycling as well as slow receptor recycling associated with ligand recycling. The importance of CURL in the dissociation and segregation of ligand and receptors as well as in receptor recycling and of the recently described TGR are now evident. In addition, the ASGP-R of the hepatocyte has provided interesting parallels and contrasts to other receptor systems that participate in receptor-mediated endocytosis in liver parenchymal cells (155).</p>","PeriodicalId":77632,"journal":{"name":"Targeted diagnosis and therapy","volume":"4 ","pages":"3-39"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12958358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanism and clinical significance of soluble hepatic cell-surface receptors. 可溶性肝细胞表面受体的作用机制及临床意义。
Targeted diagnosis and therapy Pub Date : 1991-01-01
Y Kohgo, H Kondo, Y Mogi, Y Niitsu
{"title":"Mechanism and clinical significance of soluble hepatic cell-surface receptors.","authors":"Y Kohgo,&nbsp;H Kondo,&nbsp;Y Mogi,&nbsp;Y Niitsu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Transferrin receptors take up transferrin-iron complexes into hepatic cells. Although the receptor is not highly expressed in normal liver cells, malignant transformation of the cells increases its expression. As part of the expressed receptors are released into blood, a significant increase of serum receptors are observed in cases of hepatoma. Therefore, measurement of transferrin receptors in blood from patients with hepatoma may be useful for estimating the tumor burden and determinating therapeutic effects. Asialoglycoprotein receptors are expressed strongly in normal liver cells, whereas the expression is decreased in various chronic liver diseases and hepatoma. Although the active shedding of the receptors clearly occurs in vitro, as does that of the transferrin receptor, determination of the significance of these shed receptors in blood will require further studies.</p>","PeriodicalId":77632,"journal":{"name":"Targeted diagnosis and therapy","volume":"4 ","pages":"305-19"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12958359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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