S Paranos, N Despotović, M Vidanović, I Bojović, M Milovanović, V Dmitrović
{"title":"[The effect of ranitidine on theophylline pharmacokinetics in patients with obstructive lung disease].","authors":"S Paranos, N Despotović, M Vidanović, I Bojović, M Milovanović, V Dmitrović","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The study was performed in 20 patients with mild and moderately severe forms of bronchial asthma or chronic obstructive bronchitis. Theophylline for oral use (sustained release form) and ranitidine was used in the first group of patients (7 females and 3 males, mean years of age 37.9). Dosage of theophylline from patients' sera was monitored prior and at 3, 6, and 12 hours beginning with the initial morning dose. The second group of patients (9 females and 1 male, mean age 46.3 years) were on ranitidine therapy along with 250 mg intravenous theophylline-ethylene-diamine. Fractionated dosage of theophylline was made within 12 hours. Pharmacokinetic parameters were calculated according to the concentration of theophylline in the sera of patients in the second group. In the sera of patients in the first group significantly higher concentrations of theophylline were found at 3 and 6 hour of the initial morning dose (p less than 0.05). In the second group a significant difference was not registered for the assessed pharmacokinetic parameters. This investigation indicates that there are individual differences of the metabolism of theophylline drugs with concommitant use of ranitidine.</p>","PeriodicalId":77589,"journal":{"name":"Plucne bolesti : casopis Udruzenja pneumoftiziologa Jugoslavije = the journal of Yugoslav Association of Phthisiology and Pneumology","volume":"43 1-2","pages":"89-93"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12929606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Pulmonary adiaspiromycosis].","authors":"Z Eri, I Klem, B Durić, M Durić, S Pavlović","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 54-yr old male patient with a history of dyspnea and cough is presented. Due to the clinical course of disease and the radiological changes in the chest a diagnosis of sarcoidosis was established. However, the open lung biopsy revealed the true nature of the pulmonary disease: pulmonary adiaspiromycosis, only secondary to asbestosis, siderosis and silicosis as due to the well known occupational exposure to asbestos and other dusts.</p>","PeriodicalId":77589,"journal":{"name":"Plucne bolesti : casopis Udruzenja pneumoftiziologa Jugoslavije = the journal of Yugoslav Association of Phthisiology and Pneumology","volume":"43 1-2","pages":"69-71"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12929789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Evaluation of the results of radiotherapy in planocellular bronchial carcinoma].","authors":"L Nagorni-Obradović","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The analysis comprised 23 patients with planocellular bronchial carcinoma in whom monoradiotherapy was used. Stage III dominated in the studied group (56.6%). Positive response to therapy was achieved in 60.9% of the patients. The effect was maintained for 9 months and after that the disease continued to progress. In 17.4% of the patients the findings remained unchanged, while in 21.7% uninterrupted progression of the disease was noted. Therapeutical doses of 45 Gy and 60 Gy were applied in 52.2% and 47.8% patients, respectively. Survival of one year was achieved in 26.1% while 4.3% survived for two years. Advanced stage of the disease dominating in the studied group could be the reason for the low survival rate. The results presented as well as the referential ones suggest the better response to therapy and longer survival of patients with planocellular bronchial carcinoma in whom higher therapeutical irradiation dose was applied (60 Gy).</p>","PeriodicalId":77589,"journal":{"name":"Plucne bolesti : casopis Udruzenja pneumoftiziologa Jugoslavije = the journal of Yugoslav Association of Phthisiology and Pneumology","volume":"43 1-2","pages":"26-9"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12930654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Biological standardization of the allergenic extract of Ambrosia elatior].","authors":"D Petrović, N Delimar, A Trescec, E Arslanagić","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Allergenic activity of allergen extract Ambrosia elatior (AE) was tested in fifteen volunteers extremely sensitive to the allergen. The research was performed by using the quantitative prick (P) and the intradermal (ID) test. The results were analyzed by the parallel line assay method. Allergenic activity of the specimen was estimated: by the number of the allergen units (AU) in 1 ml of the undiluted specimen according to the results of the P (prick) test; by the number of the allergen units (AU) in 1 ml of the undiluted specimen according to the results of the I. D. test, and by the in vitro standardized method of the RAST inhibition. These preliminary results show that allergen extract Ambrosio elatior has 100,000-130,000 Bu/ml and ca 1000 AU/ml while allergenic activity of the extract measured by the RAST inhibition method has ca 57,000 IU/ml.</p>","PeriodicalId":77589,"journal":{"name":"Plucne bolesti : casopis Udruzenja pneumoftiziologa Jugoslavije = the journal of Yugoslav Association of Phthisiology and Pneumology","volume":"43 1-2","pages":"98-100"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12929568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Planocellular bronchial carcinoma--patho-anatomic characteristics, tumor growth rate and possibilities of modern diagnosis].","authors":"L Nagorni-Obradović","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Basic features of squamous cell bronchial carcinoma are reviewed since this is one of the most common histologic forms of this malignoma. Referential data reveal pathoanatomic features of squamous cell bronchial carcinoma and classification according to degree of differentiation to well, moderately and poorly differentiated histologic type. Data on the growth rate of squamous cell bronchial carcinoma are presented and correlated to other histologic groups of bronchial carcinoma. The most commonly applied diagnostic measures and their efficacy have also been discussed.</p>","PeriodicalId":77589,"journal":{"name":"Plucne bolesti : casopis Udruzenja pneumoftiziologa Jugoslavije = the journal of Yugoslav Association of Phthisiology and Pneumology","volume":"43 1-2","pages":"30-4"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12930653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Effect of vitamin C on exercise-induced bronchoconstriction].","authors":"M Mirić, M A Haxhiu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of vitamin C on exercise-induced airway constriction was studied. Pretreatment with ascorbic acid prevented the significant alteration in airway geometry induced by exercise asthmatic patients. These results suggest that vitamin C deficiency might augment airway responses to exercise and other bronchospasmogenic factors, and treatment with vitamin C may decrease airway hyperresponsiveness.</p>","PeriodicalId":77589,"journal":{"name":"Plucne bolesti : casopis Udruzenja pneumoftiziologa Jugoslavije = the journal of Yugoslav Association of Phthisiology and Pneumology","volume":"43 1-2","pages":"94-7"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12929608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V Popović, M Arandelović, J Jovanović, E Veselić, A Popović, O Momcilović, D Ilić
{"title":"[The effect of occupational exposure to respiratory noxae in the tobacco industry on the status of pulmonary ventilation].","authors":"V Popović, M Arandelović, J Jovanović, E Veselić, A Popović, O Momcilović, D Ilić","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The study from the working environment prevailing in two departments of tobacco factory (DIN) Nis together with the study of the employees (95) working in these departments were carried out. The workers were divided into two sub-groups: smokers (62) and non-smokers (33) and the results of the lung function tests were compared to normal values. The results found point out to the presence of the tobacco dust in these departments and the values exceeding MAC might have caused the obstructive changes of airways in the workers exposed.</p>","PeriodicalId":77589,"journal":{"name":"Plucne bolesti : casopis Udruzenja pneumoftiziologa Jugoslavije = the journal of Yugoslav Association of Phthisiology and Pneumology","volume":"43 1-2","pages":"51-4"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12929781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T Kolevska, V Jagić, B Cvoriscec, I Palecek, Z Tudman, A Stipić-Marković
{"title":"[Procollagen type 111 peptide levels in patients with bronchial asthma and COPD].","authors":"T Kolevska, V Jagić, B Cvoriscec, I Palecek, Z Tudman, A Stipić-Marković","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of these study was to evaluate if the inflammatory injury of parenchymal cells can lead to proliferation of fibroblasts and deposition of increased amounts of collagen, measured by the increased concentration of procollagen in blood, in patients with asthma and COPD. We evaluated 22 patients with asthma that has lasted more than 5 years, 18 patients with COPD and 20 healthy subjects. RIA-gnost method (Behring) was used to measure the procollagen peptide concentrations in blood. Our results showed that the concentration of procollagen peptide in blood samples from patients with asthma was 5.8 +/- 2.4, 4.9 +/- 1.8 in patients with COPD and 11.1 +/- 3.6 in healthy subjects. There was no significant difference between patients with asthma, COPD and healthy subjects (p less than 0.01). It can be concluded that there is no increased deposition of collagen in patients with long lasting asthma and COPD. Further studies of active collagen deposition in the early acute forms of these diseases are in progress.</p>","PeriodicalId":77589,"journal":{"name":"Plucne bolesti : casopis Udruzenja pneumoftiziologa Jugoslavije = the journal of Yugoslav Association of Phthisiology and Pneumology","volume":"43 1-2","pages":"59-61"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12929785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Abramović, Z Hadzimurtezić, I Jokić, D Milosavljević, S Zarić
{"title":"[Personal experience in the treatment of pulmonary tuberculosis in mentally retarded persons].","authors":"M Abramović, Z Hadzimurtezić, I Jokić, D Milosavljević, S Zarić","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The results of the therapy of pulmonary tuberculosis in 90 mentally retarded patients in various forms and degrees of retardation are presented. General and clinical condition of 62 patients was very bad prior to the onset of antituberculotic therapy and most of them were immobile due to the mental retardation and dissemination of pulmonary tuberculosis. In 30 patients advanced form of tuberculosis, in 54 patients mild form and in 6 patients a minimal degree of tuberculosis were found. In hospitalized patients all clinical forms of pulmonary tuberculosis were found. The therapy started with triplicate antituberculotic therapy and the patients were also administered other drugs due to their mental retardation. During the first two months of antituberculotic therapy a high mortality rate was registered (27 or 30%) especially in younger patients. The reason for such high rate cannot be attributed only to pulmonary tuberculosis but also to the primary disease as was the main reason of patients' hospitalization at the institute for mentally retarded persons. Many complications in antituberculotic use could not be registered since many of the basic data could not be obtained from mentally retarded subjects. The complete recovery or improvement of pulmonary tuberculosis was achieved in 63 patients.</p>","PeriodicalId":77589,"journal":{"name":"Plucne bolesti : casopis Udruzenja pneumoftiziologa Jugoslavije = the journal of Yugoslav Association of Phthisiology and Pneumology","volume":"42 3-4","pages":"234-8"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13257091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Modern approach to the classification and diagnosis of pneumonia].","authors":"E Ajanović","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>New classification of pneumonia is pragmatic since a significant criterion is a condition in which an infection may develop: inflammations of the lungs in the home environment, immunodeficient patients, hospital infections, as a result of iatrogen complication, epidemics, etc. The principle of etiologic differentiation is reasonable when the therapy is indicated with certainty. Due to the difficulties in isolation and identification of sputum as well as the disappearance of the agent on onset of treatment because of specific therapy, the pathogenetic evolution and morphologic definition of the process is of great importance in the diagnostics and classification of pneumonia. In most patients the pneumonia has a clear course and the diagnosis is mostly established either by epidemiologic and clinical finding, laboratory testing and radiographically or by the response on empiric therapy. In some cases the invasive methods of diagnostics should be applied (BAL, transtracheal biopsy) in order to avoid false positive findings from the upper respiratory tract.</p>","PeriodicalId":77589,"journal":{"name":"Plucne bolesti : casopis Udruzenja pneumoftiziologa Jugoslavije = the journal of Yugoslav Association of Phthisiology and Pneumology","volume":"42 3-4","pages":"239-44"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13257095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}