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[Prevention of secondary cataract by intracapsular administration of the antimitotic daunomycin]. [抗有丝分裂黄霉素囊内应用预防继发性白内障]。
Ophtalmologie : organe de la Societe francaise d'ophtalmologie Pub Date : 1990-01-01
C Hartmann, P Wiedemann, K Gothe, M Weller, K Heimann
{"title":"[Prevention of secondary cataract by intracapsular administration of the antimitotic daunomycin].","authors":"C Hartmann,&nbsp;P Wiedemann,&nbsp;K Gothe,&nbsp;M Weller,&nbsp;K Heimann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Pharmacological inhibition of capsule opacification e.g. using antimitotics such as daunomycin is a promising concept. Our own in vitro studies on cultured porcine lens epithelial cells have shown, that daunomycin penetrates the cells within at least 5 minutes. It possesses a low acute cytotoxicity and significantly inhibits epithelial cell proliferation at dose dependent concentrations ranging from 2.5 to 7.5 mg/l. In addition, in vitro studies on isolated pig corneas showed almost no corneal endothelial toxicity. After 10 resp. 30 min. exposure to 7.5 mg/l daunomycin, there was only 4.8 +/- 1.6 resp. 6.1 +/- 1.5% endothelial damage that dit not significantly differ from BSS serving as control. Encouraged by our clinical experience of good anterior segment tolerance of 7.5 mg/l daunomycin when used during vitrectomy in PVR, we started a prospective clinical trial to assess the effect to daunomycin on capsular opacification after ECCE with endo-capsular IOL implantation using the envelope technique. After agreement of the medical ethic commission we chose 6 patients with a mean age of 78 (72-83), no other ocular or general diseases and bilateral cataract of identical morphology and density. After written consent of the patients their first eye was operated using BSS as control. At least 4 weeks later the second eye was operated and received 0.5 ml of daunomycin (7.5 mg/l) applied during 5 minutes into the cleaned capsular bag, leaving the anterior capsular flap and a Healon filled anterior chamber to protect the surrounding intraocular structures. Mean postoperative control time actually is 12 (6-17) months for the controls and 10 (5-14) months for the eyes treated with daunomycin.(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":77584,"journal":{"name":"Ophtalmologie : organe de la Societe francaise d'ophtalmologie","volume":"4 1","pages":"102-6"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13403182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Differential photo-oculography of vertical and oblique movements]. [垂直和倾斜运动的微分摄影术]。
Ophtalmologie : organe de la Societe francaise d'ophtalmologie Pub Date : 1990-01-01
M A Quéré, S Toucas, C Buquet, J Charlier, F Lavenant, A Pechereau
{"title":"[Differential photo-oculography of vertical and oblique movements].","authors":"M A Quéré,&nbsp;S Toucas,&nbsp;C Buquet,&nbsp;J Charlier,&nbsp;F Lavenant,&nbsp;A Pechereau","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Up to now EOG has been the only method used to record ocular movements in daily practice. However such a mean has various drawbacks and limits. It has two main gaps: firstly for vertical movements because the interference discharges related with palpebral movements and blinkings; on the other hand for oblique movements because the unequal transmission of EOG potential towards the orbital rim. The differential photo-oculography perfected by Charlier et Buquet has been fitted and now can be easily used in clinical conditions. With this optical method, it exists a direct relation between the gaze direction and video signals of the eye. The authors point out the reliability of its results not only for horizontal movements, but also for vertical and oblique movements. This method allows a relevant analysis of all kinetic parameters whatever the moving axis may be.</p>","PeriodicalId":77584,"journal":{"name":"Ophtalmologie : organe de la Societe francaise d'ophtalmologie","volume":"4 1","pages":"109-15"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13403184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microperfusion studies of normal retinal vessels. D-glucose transport. 正常视网膜血管的微灌注研究。葡萄糖运输。
Ophtalmologie : organe de la Societe francaise d'ophtalmologie Pub Date : 1990-01-01
J N Murta, I C Andrade, J G Cunha-Vaz
{"title":"Microperfusion studies of normal retinal vessels. D-glucose transport.","authors":"J N Murta,&nbsp;I C Andrade,&nbsp;J G Cunha-Vaz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An experimental model was developed to study the permeability of individual retinal vessels in vitro using microperfusion techniques adapted from the kidney tubule studies. Inulin was used as the reference tracer and D-glucose as the test tracer. We found a concentration dependent flux of D-glucose from lumen to bath that increased as D-glucose concentrations in the lumen rose. The flattening of the hyperbolic curve at the higher D-glucose concentrations in the lumen appears consistent with the Michaelis-Menten equation (Km = 6 x 10(-3) M).</p>","PeriodicalId":77584,"journal":{"name":"Ophtalmologie : organe de la Societe francaise d'ophtalmologie","volume":"4 1","pages":"28-9"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13402314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Our experience with clinical study of the eye in the near infrared region]. [我们在近红外区域对眼睛的临床研究经验]。
Ophtalmologie : organe de la Societe francaise d'ophtalmologie Pub Date : 1990-01-01
P Bonnin, F Launay, T Fauconnier
{"title":"[Our experience with clinical study of the eye in the near infrared region].","authors":"P Bonnin,&nbsp;F Launay,&nbsp;T Fauconnier","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An instrumental setup has been developed in order to perform a quantitative clinical study of the reflectance of ocular tissues in several spectral ranges of the visible and the near infrared. The images recorded at different wavelengths are obtained nearly simultaneously from a CCD camera adapted to a retinal camera and connected to a microcomputer. The results of their analysis after processing are described. Each different type of lesion exhibits a typical spectral signature, demonstrating the value of this noninvasive extra ancillary test to help the differential diagnosis and the follow-up of choroidal tumors.</p>","PeriodicalId":77584,"journal":{"name":"Ophtalmologie : organe de la Societe francaise d'ophtalmologie","volume":"4 1","pages":"33-9"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13402315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Mitotic effect of the pigment epithelium]. [色素上皮的有丝分裂作用]。
Ophtalmologie : organe de la Societe francaise d'ophtalmologie Pub Date : 1990-01-01
R M Smets, Q R Yang, A Neetens, D Vanden Berghe
{"title":"[Mitotic effect of the pigment epithelium].","authors":"R M Smets,&nbsp;Q R Yang,&nbsp;A Neetens,&nbsp;D Vanden Berghe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors suggest the production by the cultured RPE cell of one or more angiogenic substances. This activity is highly increased when RPE are cultured in poor conditions, either due to a poor medium or after having been challenged by a high number of rod outer segments. The mitotic factor appears heat-labile and trypsine sensitive, but not dialysable which suggest their biochemical nature to be a protein.</p>","PeriodicalId":77584,"journal":{"name":"Ophtalmologie : organe de la Societe francaise d'ophtalmologie","volume":"4 1","pages":"4-7"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13402316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[In situ hybridization on tissue section: a new method for studying the amacrine cells of the retina and the centers of the visual system]. [组织切片原位杂交:研究视网膜和视觉系统中心无毛细胞的新方法]。
Ophtalmologie : organe de la Societe francaise d'ophtalmologie Pub Date : 1990-01-01
M Abitbol, S Dumas, J F Julien, T A Rhyner, J L Dufier, J Mallet
{"title":"[In situ hybridization on tissue section: a new method for studying the amacrine cells of the retina and the centers of the visual system].","authors":"M Abitbol,&nbsp;S Dumas,&nbsp;J F Julien,&nbsp;T A Rhyner,&nbsp;J L Dufier,&nbsp;J Mallet","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In situ hybridization of nucleic acid probes, encoding the key enzymes of the synthesis of neurotransmitters, with sections of retina is a new method giving complementary informations to the data obtained by immunocytochemistry and autoradiography. It will allow a better characterization of amacrin cells, whatever might be their type, and a refined understanding of their function. It is an accurate tool to investigate the mechanisms of retinal degenerations and spontaneous or experimental microphtalmia.</p>","PeriodicalId":77584,"journal":{"name":"Ophtalmologie : organe de la Societe francaise d'ophtalmologie","volume":"4 1","pages":"43-7"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13402317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Significance of the digital image in the diagnosis and classification of macular drusen]. 【数字影像在黄斑囊肿诊断与分型中的意义】。
Ophtalmologie : organe de la Societe francaise d'ophtalmologie Pub Date : 1990-01-01
G Mimoun, G Soubrane, G Coscas
{"title":"[Significance of the digital image in the diagnosis and classification of macular drusen].","authors":"G Mimoun,&nbsp;G Soubrane,&nbsp;G Coscas","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Macular drusen, hard or soft, have been often observed at the early stages of age-related macular degeneration. Clinically, it has been shown that soft drusen and macular subretinal new vessels are associated in a statistically significative manner. The question is to recognize and to determine drusen at greatest risk for developing choroidal neovascularization? To answer to this question, a method of digital images analysis of fluorescein angiography had been perfected. About ten eyes, preliminary results show, an objective and quantitative difference of the evolution of the grey level during the same angiogram between the different retinal structures. This method would bring a prognostic feature for the long term follow-up of patients with drusen.</p>","PeriodicalId":77584,"journal":{"name":"Ophtalmologie : organe de la Societe francaise d'ophtalmologie","volume":"4 1","pages":"48-50"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13402318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Immunohistologic study of the epiretinal membranes in proliferative diabetic retinopathy and retinal detachment with vitreo-retinal proliferation]. [增殖性糖尿病视网膜病变及视网膜脱离伴玻璃体视网膜增生的视网膜前膜的免疫组织学研究]。
Ophtalmologie : organe de la Societe francaise d'ophtalmologie Pub Date : 1990-01-01
C Baudouin, P Gastaud, B Gordon, P Lapalus, N G Bazan, M Righini, G A Peyman
{"title":"[Immunohistologic study of the epiretinal membranes in proliferative diabetic retinopathy and retinal detachment with vitreo-retinal proliferation].","authors":"C Baudouin,&nbsp;P Gastaud,&nbsp;B Gordon,&nbsp;P Lapalus,&nbsp;N G Bazan,&nbsp;M Righini,&nbsp;G A Peyman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An immunohistological study was performed in specimens of epiretinal membranes obtained during surgery in patients with proliferative diabetic retinopathy or retinal detachment with proliferative vitreoretinopathy. Using immunostaining procedures, these membranes were found to contain great amounts of immunoglobulins and complement, as well as a strong expression of class II antigens. These results confirm the involvement of auto-immune phenomena in intra-ocular proliferative diseases and the close relationship between the immune system and peptide growth factors.</p>","PeriodicalId":77584,"journal":{"name":"Ophtalmologie : organe de la Societe francaise d'ophtalmologie","volume":"4 1","pages":"53-5"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13402320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Selection of a herpes simplex mutant virus of weak pathogenicity, sensitive to acyclovir and not susceptible to reactivation in vivo]. [选择一种致病性弱、对无环鸟苷敏感、体内不易再激活的单纯疱疹突变病毒]。
Ophtalmologie : organe de la Societe francaise d'ophtalmologie Pub Date : 1990-01-01
J Colin, B Jouppe, A Robinet, J M Huraux, C Chastel
{"title":"[Selection of a herpes simplex mutant virus of weak pathogenicity, sensitive to acyclovir and not susceptible to reactivation in vivo].","authors":"J Colin,&nbsp;B Jouppe,&nbsp;A Robinet,&nbsp;J M Huraux,&nbsp;C Chastel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>From a KOS herpes simplex virus strain prepared in VERO cells we have been able to obtain after several exposures to increasing concentrations of trifluorothymidine, four resistant mutants. Among these strains, 31 T mutant was a TK-altered strain of low pathogenicity, sensible to acyclovir and did not induce recurrences. These properties might allow the use of such a strain as a living attenuated antiherpetic vaccine.</p>","PeriodicalId":77584,"journal":{"name":"Ophtalmologie : organe de la Societe francaise d'ophtalmologie","volume":"4 1","pages":"76-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13327865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[In vitro study of the effects of neodymium-YAG laser on silicone oil]. [钕钇铝石榴石激光对硅油影响的体外研究]。
Ophtalmologie : organe de la Societe francaise d'ophtalmologie Pub Date : 1990-01-01
P Larricart, C Pham Huy, J M Warnet, J Haut
{"title":"[In vitro study of the effects of neodymium-YAG laser on silicone oil].","authors":"P Larricart,&nbsp;C Pham Huy,&nbsp;J M Warnet,&nbsp;J Haut","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Composition of gas generated by the utilisation of Nd-Yag laser in eyes filled with silicone oil were studied by means of an in vitro optical breakdown in silicone oil. The newly formed gas were analysed by headspace gas chromatography on two separate columns. The secondary gas were mainly methane and ethylene which might be potentially harmful to the ocular tissues.</p>","PeriodicalId":77584,"journal":{"name":"Ophtalmologie : organe de la Societe francaise d'ophtalmologie","volume":"4 1","pages":"69-71"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13402199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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