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[Metoclopramide antagonizes dopamine-induced inhibition of lower esophageal sphincter pressure in the awake beagle]. 在清醒的小猎犬中，甲氧氯普胺可拮抗多巴胺诱导的食管下括约肌压力抑制。
Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR Pub Date : 1990-01-01
P Thies, H D Janisch, D H von Kleist, K U Wolf, K E Hampel
{"title":"[Metoclopramide antagonizes dopamine-induced inhibition of lower esophageal sphincter pressure in the awake beagle].","authors":"P Thies,&nbsp;H D Janisch,&nbsp;D H von Kleist,&nbsp;K U Wolf,&nbsp;K E Hampel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Different contradictory results, even in the same species of the DOP-effect on LESP have been reported. The aim of the present studies was to evaluate the effect of DOP on LES in purebread male beagles and whether in could be antagonised by the DOP-antagonist MCP. The LESP in beagles is sensitive to dopamine (DOP) and its \"antagonist\", metoclopramide (MCP). MCP raised the inhibited LESP after DOP-infusion in vivo, while it failed to change DOP-induced relaxation of opossum LES in vitro [1]. Data obtained after monotherapie with MCP did not exceed LESP-response to MCP after DOP-pretreatment. DOP applied as background counter-inhibition could be used to correct interdigestive phasic changements of LESP in order to reach a stable starting-point to investigate the action of LESP-stimulating compounds pharmacomanometrically. Due to DOP reflux-facilitating side effect via its decrease of LESP, large doses of DOP, as used in the intensiv care unit, should be administered together with sphincter-strengthening agents or antacid compounds.</p>","PeriodicalId":77539,"journal":{"name":"Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13374933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Lymph drainage disorder as a pathogenetic co-factor in acute pancreatitis?]. [淋巴引流障碍是急性胰腺炎的致病因子?]。
Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR Pub Date : 1990-01-01
H P Putzke, M Müller, E Siegmund, W Dummler
{"title":"[Lymph drainage disorder as a pathogenetic co-factor in acute pancreatitis?].","authors":"H P Putzke,&nbsp;M Müller,&nbsp;E Siegmund,&nbsp;W Dummler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Experiments performed on 71 Wistar rats confirm that preexisting interruption of lymph drainage by ligation of the ductus thoracicus can have a major influence on the development of pancreatitis. The effect of a ductus hepatopancreaticus blockade in experimental group A (32 animals) was greatly exacerbated by previous ligation of the ductus thoracicus (experimental group B; 34 animals). Edema of the interstitial pancreatic tissue led to lipolytic necrotizing pancreatitis with a slight hemorrhagic component, increasing ascites after the 12 th hour of the experiment, and numerous abdominal fat necroses after about 19 hours, but only relatively minor necroses of acinar parenchyma cells in the pancreas. Fat tissue necroses were only found in almost 20% of the animals in group A, and these probably resulted from manipulation of the duodenum during the implantation of a shunt to divert the bile, whereas they were found in all animals of group B after the 19th hour of the experiment, usually in large numbers. The sometimes considerable increases in serum amylase and particularly lipase activity were caused by obstruction of the efferent ducts, but did not increase appreciably after disturbance of the lymph drainage systems. On the contrary, under these circumstances, drainage of the salivary edema via the peritoneal mesothelium and into retroperitoneal fat tissue must be considered responsible for ascites and the initiation of fat cell necroses by lipase and other enzymes.</p>","PeriodicalId":77539,"journal":{"name":"Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13441312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Individualized sulfasalazine treatment of ulcerative colitis and monitoring of patient compliance by determining sulfapyridine serum concentration]. [磺胺吡啶个体化治疗溃疡性结肠炎及通过测定磺胺吡啶血清浓度监测患者依从性]。
Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR Pub Date : 1990-01-01
H J Klugmann, B Giehler, D Lohmann, W Schiedewitz
{"title":"[Individualized sulfasalazine treatment of ulcerative colitis and monitoring of patient compliance by determining sulfapyridine serum concentration].","authors":"H J Klugmann,&nbsp;B Giehler,&nbsp;D Lohmann,&nbsp;W Schiedewitz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Sulphasalazine (SASP) is the drug of choice in the treatment of ulcerative colitis (UC). But there are adverse effects in 20-30% dependent on the serum-level of the resorbed SASP-metabolite sulphapyridine (SP). Relapses during treatment may have their cause in an under-dosage or patient's non-compliance. In 19 patients with UC the possibility of an individualized most effective treatment and the patient's compliance by the simple practicable analysis of SP-serum-level were checked. The results show that it is necessary to dose the SASP in dependence of the genetically determined type of acetylation. The SASP-dosage must be decreased in patients with slow acetylation and vice versa consequently. After rectal SASP-application - in opposite to the oral treatment - significant lower serum levels of SP were analyzed. In 63.1% of the patients we found an insufficient of non-compliance.</p>","PeriodicalId":77539,"journal":{"name":"Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13129305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The serum activities of AP, gamma-GT, GlDH and GPT after bile duct obstruction and ethionine in the rat. 胆管梗阻后大鼠血清AP、γ - gt、GlDH、GPT及蛋氨酸的活性。
Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR Pub Date : 1990-01-01
H Putzki, B Reichert
{"title":"The serum activities of AP, gamma-GT, GlDH and GPT after bile duct obstruction and ethionine in the rat.","authors":"H Putzki,&nbsp;B Reichert","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The increase of activity of the enzymes AP, Gamma-GT, GlDH and GPT was investigated in this study with regard to its pathomechanism. The increase of AP is known to be caused by a de novo-protein synthesis in the liver, as several investigators have demonstrated using protein synthesis inhibitors. In this study female Wistar rats were partly sham-operated, partly bile duct-obstructed. One half of each group received the protein synthesis inhibitor ethionine, 24 h after bile duct obstruction in the group with ethionine the following enzyme activities were measured in the serum: AP 216 +/- 80 U/l; gamma-GT 4.5 +/- 1.9 U/l; GlDH 85 +/- 26 U/l; GPT 375 +/- 163 U/l. In the group without ethionine the activities were: AP 459 +/- 69 U/l; gamma-GT 4 +/- 0.9 U/l; GlDH 120 +/- 81 U/l; GPT 417 +/- 191 U/l. Because the differences between the groups with and without ethionine were not significant with the exception of AP, it is concluded that in the early phase of bile duct obstruction up to 24 h no influence of de novo-protein synthesis can be demonstrated in the elevation of the activities of gamma-GT, GlDH and GPT.</p>","PeriodicalId":77539,"journal":{"name":"Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13133580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Simultaneous administration of various model substances for characterizing in vivo biotransformation in chronic liver diseases]. [同时给药多种模型物质表征慢性肝病的体内生物转化]。
Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR Pub Date : 1990-01-01
J Truckenbrodt, H Kraul, A Huster, R Töpfer, L Henschel, A Hoffmann, M Reinhardt, D Jorke
{"title":"[Simultaneous administration of various model substances for characterizing in vivo biotransformation in chronic liver diseases].","authors":"J Truckenbrodt,&nbsp;H Kraul,&nbsp;A Huster,&nbsp;R Töpfer,&nbsp;L Henschel,&nbsp;A Hoffmann,&nbsp;M Reinhardt,&nbsp;D Jorke","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>16 patients with different chronic liver diseases were given single doses of the model substances caffeine, metamizol, sufamethacine and debrisoquine. This was followed by the simultaneous administration of all these substances as a \"cocktail\". A comparison between the single and the \"cocktail\" dosage did not reveal any significant differences in the pharmacokinetic parameters. So the \"cocktail\" administration is even possible in chronic liver diseases. Requiring relatively little time, it makes statements possible concerning various cytochrome P450 enzymes including the types of hydroxylation and acetylation. Intraindividual variations can be ruled out.</p>","PeriodicalId":77539,"journal":{"name":"Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13247500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Complications of hepatic coma in liver cirrhosis]. [肝硬化肝昏迷的并发症]。
Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR Pub Date : 1990-01-01
K Grüngreiff
{"title":"[Complications of hepatic coma in liver cirrhosis].","authors":"K Grüngreiff","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>59 patients with exogenous liver coma in state III-IV were treated from 1980 to 1989 in our clinic. Incidence and complications in these patients were evaluated retrospectively. The most frequent eliciting factors were gastrointestinal bleeding, infections and acute alcohol excess, more than 2/3 of them having severe portal hypertension with ascites and esophageal varices at the time. Altogether 55 of the 59 liver coma patients died. The most important complications were, beside bleeding and infections, disturbances of the renal function and of the coagulation. Severe acute or chronic liver injury is often associated with multiorgan failure.</p>","PeriodicalId":77539,"journal":{"name":"Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13374931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Clinically unrecognized colorectal cancers? An autopsy study]. 临床未被识别的结直肠癌?尸检研究]。
Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR Pub Date : 1989-01-01
A Schneider, G Machnik, U Friedrich, O Löw
{"title":"[Clinically unrecognized colorectal cancers? An autopsy study].","authors":"A Schneider,&nbsp;G Machnik,&nbsp;U Friedrich,&nbsp;O Löw","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of our study was to discover pathomorphological features of clinically undetected colorectal carcinomas in autopsy material. Out of 400 colorectal carcinomas from the periods of 1960 to 1966 and 1981 to 1983 126 (32%) of all carcinomas remained clinically undetected during lifetime of the patients. In 1/3 of these cases the clinician did not suggest a malign neoplasm, in the other 2/3 a malignant neoplasm of unknown or false origin was assigned. 44% of the right-sided colon carcinomas, 36% of the left-sided colon carcinomas and 22% of the rectal carcinomas remained clinically undetected. At the time of autopsy in 10 cases (13%) a second malignant neoplasm far from the colorectal region could be demonstrated. In 104 cases (82%) the colorectal carcinoma was the cause of death. 18% of the colorectal carcinomas were an additional finding at autopsy, independent of the cause of death.</p>","PeriodicalId":77539,"journal":{"name":"Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13927992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Differential diagnosis of drug-induced liver damage. Problems and conclusions from the viewpoint of the clinician]. 药物性肝损害的鉴别诊断。从临床医生的角度看问题与结论]。
Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR Pub Date : 1989-01-01
M Wiese, R Haupt
{"title":"[Differential diagnosis of drug-induced liver damage. Problems and conclusions from the viewpoint of the clinician].","authors":"M Wiese,&nbsp;R Haupt","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Our analysis showed that in of more than 80% of the patients admitted to the infection hospital because of suspicion of viral hepatitis there is also an anamnesis of one or several drugs. Among 2944 patients, admitted with being suspect of having viral hepatitis, there were 128 patients (adequate to 4.4%) with a drug-induced liver injury diagnosed in the result of all clinical, serological, histological and immunological findings. Inducing noxes were - in accordance to the frequency of ordination - ovulation inhibitors followed by Berlocombin, Ketazon, Depressan and Obsidan. In view of a clinic for infectious diseases it has to be pointed to the necessity of a high degree of security in the differential diagnosis of the drug-induced liver injury in relation to the viral hepatitis and one has to consider the great responsibility of the clinician. Often a decision may only be taken in close interdisciplinary collaboration of gastroenterologists, pathologists, epidemiologists and immunologists.</p>","PeriodicalId":77539,"journal":{"name":"Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13772833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A rapid urease test in Campylobacter pylori colonization of the gastric mucosa]. [胃粘膜幽门弯曲杆菌定植的快速脲酶试验]。
Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR Pub Date : 1989-01-01
W Bornschein, A Bauernfeind, K L Heilmann
{"title":"[A rapid urease test in Campylobacter pylori colonization of the gastric mucosa].","authors":"W Bornschein,&nbsp;A Bauernfeind,&nbsp;K L Heilmann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Biopsies from the gastric mucosa (antrum, corpus) of 145 patients investigated by endoscopy were analysed for Campylobacter pylori. The results of bacteriological, histological, enzymatic and chemical methods were compared. Urease activity was determined both in biopsies (CLO-test) and in gastric secretion. Furthermore, the concentration of urea was measured in gastric secretion. 71% of gastritis, 86% of ulcus duodeni and 83% of ulcus ventriculi diagnosed by endoscopy produced positive histological and/or cultural results, while 100% of control persons exhibited negative for both parameters. The sensitivity of the CLO-test (n = 112) was 95% and its specificity 78% when compared with bacteriological and histological results. The majority of false positive results was due to delayed and incomplete reactions. However, when compared with endoscopic-histological results the specificity of the CLO-test was 100%. The results of a modification of CLO-test (without culture medium) were up to 5 hours comparable. There was no positive correlation between the concentration of urea in gastric secretion and the histological or cultural identification of Campylobacter pylori. However, the measurement of ammonia turned out to be promising (sensitivity 80%). None of the tests was sufficiently specific on its own, whereas a 100% specificity was achieved when both the CLO-test and the determination of ammonia in gastric secretion were performed.</p>","PeriodicalId":77539,"journal":{"name":"Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13821843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The importance of liver changes in workers with chronic benzene exposure]. [慢性苯暴露工人肝脏变化的重要性]。
Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR Pub Date : 1989-01-01
J Damrau, C Skodzik
{"title":"[The importance of liver changes in workers with chronic benzene exposure].","authors":"J Damrau,&nbsp;C Skodzik","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Essential parameters of hepatic functioning in 84 labourers, whose exposition to benzene is differing in assimilation as well as length of time is discussed.--45 persons from the same county without contact to benzene or hepatotoxic agents served as control-group. Neither long-term exposure to benzene nor its size were of any influence on the hepatic data controlled.--Correlations became evident in non-occupational factors such as alcoholism and overweight.--Any damaging effect of benzene on the liver can be excluded.</p>","PeriodicalId":77539,"journal":{"name":"Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13905464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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