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[Sensitivity and specificity of alpha-1-antitrypsin and acid alpha-1-glycoprotein in colorectal carcinoma]. [α -1抗胰蛋白酶和酸性α -1糖蛋白在结直肠癌中的敏感性和特异性]。
Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR Pub Date : 1991-01-01
H Putzki, O Hafner
{"title":"[Sensitivity and specificity of alpha-1-antitrypsin and acid alpha-1-glycoprotein in colorectal carcinoma].","authors":"H Putzki,&nbsp;O Hafner","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In a group of 80 patients with colorectal cancer and a control group of 91 persons and in 15 patients with acute diverticulitis of the sigmoid colon acid alpha-1-glycoprotein (AGP) and alpha-1-antitrypsin (AAT) were measured. The median of AAT in the carcinoma group was 3.34 g/l, in the control group 2.39 g/l. AGP was in the carcinoma group 1.19 g/l, in the control group 0.79 g/l. Both differences are significant. The sensitivities of AGP and AAT were compared with the sensitivities of CEA and CA 19/9 using ROC-curves. AAT and AGP have a distinctly lower sensitivity than CEA, but only on the basis of a high specificity of 95%. In the region of lower specificities AAT has the highest sensitivity. Therefore, the sensitivity of CEA for colorectal carcinoma is not reached by AAT and AGP, when a high specificity of the test is required. The relevance of AAT and AGP determinations is further reduced because in the diverticulitis group the levels were as high as in the carcinoma group.</p>","PeriodicalId":77539,"journal":{"name":"Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12889017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Ultrasonography studies on spontaneous and pharmacologically modified gallbladder motility]. 胆囊自发运动和药理学改变的超声研究。
Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR Pub Date : 1991-01-01
M Zillmann, M Zillmann, K U Schentke
{"title":"[Ultrasonography studies on spontaneous and pharmacologically modified gallbladder motility].","authors":"M Zillmann,&nbsp;M Zillmann,&nbsp;K U Schentke","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The intra- and interindividual variations of gallbladder motility were sonographically studied in 10 healthy subjects. We investigated the following criteria: a) the gallbladder volumes after overnight fasting on 5 consecutive days, b) the spontaneous motility under fasting over 12 or 24h at hourly intervals, c) the emptying rate and time of maximal contraction after stimulation with sorbitol, and d) the emptying rate and time (like c) after premedication with \"cholagogic\" drugs (Cholecysmon, Divalol), nifedipine, indomethacin or N-butylscopolaminiumbromide. We found a great intrapersonal and interpersonal variability in gallbladder volumes after overnight fasting in consecutive days. In subjects fasting over 24h phases of dilatation with maxima at 12 AM and 4 PM alternated with phases of contraction with maxima at 8 AM and 4 PM. After premedication with nifedipine, indomethacin and N-butylscopolaminiumbromide a significant decrease of the emptying rate was observed. The time of maximal contraction did not differ however. After premedication we found a distinct intra- and interindividual variability too. Cautious interpretation of gallbladder motility studies is necessary.</p>","PeriodicalId":77539,"journal":{"name":"Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12918656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effects of pentagastrin and somatostatin on duodenal motility in chronic experiments]. [慢性实验中胃泌素和生长抑素对十二指肠运动的影响]。
Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR Pub Date : 1991-01-01
A Petzold, J Hammer, J Walther, R Keitel, V Junhold
{"title":"[Effects of pentagastrin and somatostatin on duodenal motility in chronic experiments].","authors":"A Petzold,&nbsp;J Hammer,&nbsp;J Walther,&nbsp;R Keitel,&nbsp;V Junhold","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Electromyography of the duodenums was performed in dogs, using two bipolar electrodes placed 5 and 10 cm aborally of the pylorus on the serosa of the duodenums. 10 days after implantation and 24 hours after the last meal the duodenal motility was registered in 9 bastard dogs for 5 hours. Pentagastrin, given as a 1-hour intravenous infusion, changed the interdigestive motility to an irregular (postprandial) pattern, which continued up to the end of measurement or was followed by a prolonged phase III with return to cyclic activity. Infusion of somatostatin for 1 hour interrupted the interdigestive motility leading to a prolonged phase I pattern and to partial discoordination. After the end of infusion phase III motility returning to cyclic activity or irregular activity were registered. A standard relaparotomy 10 days after implantation was performed in 3 dogs. Up to the second day of the postoperative period interdigestive cycles of duodenal motility were not obtained.</p>","PeriodicalId":77539,"journal":{"name":"Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12852275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Changes in serotonin-containing EC-cells in the lamina epithelialis mucosae of the small intestine in young children with growth disorders caused by intestinal diseases]. [肠道疾病引起的生长障碍幼儿小肠上皮粘膜层中含血清素ec细胞的变化]。
Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR Pub Date : 1991-01-01
C Pfister, R Peuthert, M Günther, E Schön
{"title":"[Changes in serotonin-containing EC-cells in the lamina epithelialis mucosae of the small intestine in young children with growth disorders caused by intestinal diseases].","authors":"C Pfister,&nbsp;R Peuthert,&nbsp;M Günther,&nbsp;E Schön","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Duodenal jejunal biopsy material from children with growth retardation due to enteric disease was investigated. The disease dependent mucosa types were classified into three groups according to Shmerling (1970). 5-hydroxytryptamine was demonstrated with an impregnation technique and histochemically, as well, in EC-cells in the crypt epithelium. The EC-cell content in specimens with subtotal villus atrophy (type III) was higher significantly compared to normal mucosa (type I). The findings were discussed with regard to the possible role of 5-hydroxytryptamine in the pathogenesis of the growth retardation due to enteric disease in children.</p>","PeriodicalId":77539,"journal":{"name":"Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12973021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Comparison of ICG elimination with biotransformation of model substances and histological features of liver biopsy in liver diseases]. [肝病中ICG消除与模型物质生物转化及肝活检组织学特征的比较]。
Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR Pub Date : 1991-01-01
H Kraul, J Truckenbrodt, H Sigusch, M Hippius, G Machnik, A Hoffmann
{"title":"[Comparison of ICG elimination with biotransformation of model substances and histological features of liver biopsy in liver diseases].","authors":"H Kraul,&nbsp;J Truckenbrodt,&nbsp;H Sigusch,&nbsp;M Hippius,&nbsp;G Machnik,&nbsp;A Hoffmann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The elimination of indocyanine green (ICG) was measured in 45 patients with histologically proved liver disease to evaluate liver blood flow. Furthermore, the elimination of caffeine and metamizol was determined in serum as a parameter of in vivo biotransformation. In a further step the activity of 7-ethoxycoumarin O-deethylation was measured in liver biopsy samples of 30 out of 45 patients (in vitro parameter of biotransformation). The half-life of ICG was compared with the data of biotransformation by means of the calculation of correlations with special consideration of histological findings in liver biopsy samples (monocellular necrosis, intra-acinar fibrosis, structural transformation). Results demonstrate that ICG-elimination is a nonsufficient criterion of liver blood flow in patients with liver disease, because of considerable variation and many influencing factors including the function of the liver cells. Therefore, it is difficult to evaluate results.</p>","PeriodicalId":77539,"journal":{"name":"Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12973022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Influence of exogenous factors on the behavior of aminophenazone breath test in chronic liver diseases]. [外源性因素对慢性肝病氨基那酮呼气试验行为的影响]。
Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR Pub Date : 1991-01-01
J Treutler, H Sensing, K O Haustein, G Hüller
{"title":"[Influence of exogenous factors on the behavior of aminophenazone breath test in chronic liver diseases].","authors":"J Treutler,&nbsp;H Sensing,&nbsp;K O Haustein,&nbsp;G Hüller","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>230 patients with different chronic liver diseases of various severity were researched because of the influence of nicotine and alcohol on the results of the aminopyrine breath test in the modification of Haustein and Schenker (1985). Smoker with chronic liver diseases had higher 14CO2-results than nonsmoker. The difference was only significant in fatty liver disease in the first stadium (p less than 0,001) and chronic active hepatitis (p less than 0.05). Patients with chronic liver diseases of fewer severity had higher mean values of aminopyrine breath test, if they had chronic alcohol consumption. The difference between these and abstinent patients could secure only in fatty liver disease in the first stadium (p less than 0.001). Patients with severe chronic liver diseases had lower results of aminopyrine breath test, if they drink alcohol regular. These difference was significant in patients with cirrhotic liver disease (p less than 0.05).</p>","PeriodicalId":77539,"journal":{"name":"Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12973024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biochemical pattern of the ascitic fluid in liver cirrhosis and in neoplastic diseases. 肝硬化和肿瘤性疾病腹水的生化模式。
Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR Pub Date : 1991-01-01
M Boca, I Hanták, M Mikulecký, P Ondrejka
{"title":"Biochemical pattern of the ascitic fluid in liver cirrhosis and in neoplastic diseases.","authors":"M Boca,&nbsp;I Hanták,&nbsp;M Mikulecký,&nbsp;P Ondrejka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In 22 subjects with liver cirrhosis and in 18 with malignancy, both with ascites, 10 biochemical parameters have been investigated in ascitic fluid. The evaluation of data by cluster analysis, optimized with the aid of multivariate normality testing, was able to recognize correctly a majority of cases. For diagnosis of malignancy, an 89% sensitivity and 82% specificity was obtained. The described way of data collecting and processing is recommended for the clinical practice.</p>","PeriodicalId":77539,"journal":{"name":"Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12973025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The effects of verapamil and nifedipine on the biotransformation of model substances and on the indocyanine green elimination]. 维拉帕米和硝苯地平对模型物质生物转化和吲哚菁绿消除的影响。
Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR Pub Date : 1991-01-01
H Sigusch, L Henschel, A Hoffmann
{"title":"[The effects of verapamil and nifedipine on the biotransformation of model substances and on the indocyanine green elimination].","authors":"H Sigusch,&nbsp;L Henschel,&nbsp;A Hoffmann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Twelve healthy subjects received a cocktail of model substances (containing metamizol: 1000 mg, caffeine: 200 mg, sulfadimidine: 500 mg, and debrisoquine: 10 mg) alone and on the fifth day of a five day therapy of oral verapamil (3 x 80 mg) or nifedipine (3 x 20 mg) to assess the effect of verapamil and nifedipine on hepatic biotransformation. To investigate liver blood flow intravenous indocyanine green (0,5 mg/kg) was given 12 and 1 hours after oral verapamil (80 mg) or nifedipine (20 mg). In the presented study an influence of verapamil and nifedipine treatment on the hepatic drug oxidizing system was not observed. The elimination half-life of intravenous indocyanine green was only 1 hour after oral nifedipine (20 mg) significantly decreased. 12 hours after nifedipine (20 mg) or verapamil (80 mg) as well as 1 hour after verapamil (80 mg) treatment no change in indocyanine green elimination was observed. The estimated increase of liver blood flow after oral nifedipine may cause increased absorption of other oral administered drugs and may accelerate hepatic elimination of drug with high hepatic extraction rate. 6 fast an 6 slow acetylators were found. This classification did not change after nifedipine or verapamil therapy.</p>","PeriodicalId":77539,"journal":{"name":"Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13070371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effect of gastrointestinal hormones on duodenal motility in acute experiments]. [胃肠激素对急性十二指肠运动的影响]。
Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR Pub Date : 1991-01-01
A Petzold, A Ottinger, J Hammer, J Walter
{"title":"[Effect of gastrointestinal hormones on duodenal motility in acute experiments].","authors":"A Petzold,&nbsp;A Ottinger,&nbsp;J Hammer,&nbsp;J Walter","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In this study was observed the influence of Pancreozymin, Secretin, Glucagon, Pentagastrin and Somatostatin on the motility of duodenum in 256 seances in acute experiments on 12 dogs before and after truncal vagotomy and on 20 Wistar rats. As a control we used the return of the parameters of electrical and motor activity to their original levels. The reaction was registered with the help of electromyography, using bipolar electrodes and with measurement of intraluminal pressure, using open-tip catheter technique. Spike-activity was graphically presented and statistically performed. It was shown, that Secretin and Glucagon caused relaxation of duodenum, but Pentagastrin, Pancreozymin and Somatostatin stimulated duodenal motility with spastic component and gradual phasic character of a process. After truncular vagotomy the reaction to Pancreozymin and Pentagastrin was slowly, to Glucagon strongly reduced, but the reaction to Secretin was extended. We observed after TV either no reaction or a diminished reaction to Somatostatin. This study serves as experimental basis for use of gastrointestinal hormones and electromyography for diagnosis and therapy of motility disorders of duodenum in surgical practice.</p>","PeriodicalId":77539,"journal":{"name":"Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12848793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pathogenesis and therapy of ascites in liver cirrhosis]. 肝硬化腹水的发病机制及治疗
Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR Pub Date : 1991-01-01
R Nilius
{"title":"[Pathogenesis and therapy of ascites in liver cirrhosis].","authors":"R Nilius","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This paper reviews pathogenetic factors which contribute to the development of therapy-resistant ascites in liver cirrhosis. Main principles are known as \"Overfilling\"--and \"Underfilling\"-hypotheses followed by disturbances of different kinds of mediators influencing renal blood flow and natriuresis. The endpoint of a cascade is the development of a hepatorenal syndrome which is connected with therapeutic resistance against diuretics. Therefore, other therapeutic methods (paracentesis, reinfusion) must be taken in to account in order to improve prognosis of such cases.</p>","PeriodicalId":77539,"journal":{"name":"Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12972927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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