[Comparison of ICG elimination with biotransformation of model substances and histological features of liver biopsy in liver diseases].

Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR Pub Date : 1991-01-01

H Kraul, J Truckenbrodt, H Sigusch, M Hippius, G Machnik, A Hoffmann

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Abstract

The elimination of indocyanine green (ICG) was measured in 45 patients with histologically proved liver disease to evaluate liver blood flow. Furthermore, the elimination of caffeine and metamizol was determined in serum as a parameter of in vivo biotransformation. In a further step the activity of 7-ethoxycoumarin O-deethylation was measured in liver biopsy samples of 30 out of 45 patients (in vitro parameter of biotransformation). The half-life of ICG was compared with the data of biotransformation by means of the calculation of correlations with special consideration of histological findings in liver biopsy samples (monocellular necrosis, intra-acinar fibrosis, structural transformation). Results demonstrate that ICG-elimination is a nonsufficient criterion of liver blood flow in patients with liver disease, because of considerable variation and many influencing factors including the function of the liver cells. Therefore, it is difficult to evaluate results.

本刊更多论文

[肝病中ICG消除与模型物质生物转化及肝活检组织学特征的比较]。

在45例组织学证实的肝病患者中测量了吲哚菁绿(ICG)的消除，以评估肝血流。此外，作为体内生物转化的参数，测定了血清中咖啡因和metamizol的消除。在进一步的步骤中，在45名患者中的30名患者的肝脏活检样本中测量了7-乙氧基香豆素o -去甲基化的活性(体外生物转化参数)。通过计算与肝活检标本组织学表现(单细胞坏死、腺泡内纤维化、结构转化)的相关性，比较ICG的半衰期与生物转化数据。结果表明，由于肝细胞功能等多种因素的影响，icg消除是肝病患者肝血流的一个不充分标准。因此，很难评价结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR

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