Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ)最新文献_第3页

Large scale collection of viable infective larvae of Loa loa. 大规模采集罗阿鱼有活力的侵染幼虫。

Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ) Pub Date : 1995-09-01

G Wahl, R Moukagni, F Toure, A J Georges

引用次数: 0

Human pharmacokinetics of chloroquine and proguanil delivered in a single capsule for malaria chemoprophylaxis. 用于疟疾化学预防的氯喹和proguanil单胶囊的人体药代动力学。

Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ) Pub Date : 1995-09-01

J E Touze, A Keundjian, T Fusai, J C Doury

引用次数: 0

Changes in malaria associated morbidity in children using insecticide treated mosquito nets in the Bagamoyo district of coastal Tanzania. 坦桑尼亚沿海巴加莫约地区使用经杀虫剂处理的蚊帐的儿童疟疾相关发病率的变化。

Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ) Pub Date : 1995-09-01

Z Premji, P Lubega, Y Hamisi, E Mchopa, J Minjas, W Checkley, C Shiff

{"title":"Changes in malaria associated morbidity in children using insecticide treated mosquito nets in the Bagamoyo district of coastal Tanzania.","authors":"Z Premji, P Lubega, Y Hamisi, E Mchopa, J Minjas, W Checkley, C Shiff","doi":"","DOIUrl":"","url":null,"abstract":"A community based malaria control intervention using insecticide treated mosquito nets (IMN) has been implemented and tested in 13 villages of the Yombo Division, Bagamoyo District in the Coastal Region, Tanzania, an area holoendemic for P. falciparum malaria. Following extensive sociological research into local perceptions of malaria, the programme was implemented. It wa decided by consensus that village mosquito net committees would be the appropriate local level implementors. These were formed and provided with IMN's which were sold to villagers at subsidised cost. The income was invested for use by the committees for sustaining the activity. Use patterns were determined and high coverages were obtained among the community, particularly after promotions e.g. plays, school meetings etc. Malaria morbidity was measured among children 6-40 months of age in 7 index villages prior to the intervention in 1992 and in a comparison study between 3 villages using nets and 4 villages not using nets in 1993. Examination of the 7 cohorts of children was done from June to October each year covering the period of most severe transmission. The children using nets showed marked improvement in several malariometric indices. Following an initial clearance of parasitaemia with sulphadoxine/pyrimethamine, when compared with unprotected children, those with nets were slower to become re-infected (Relative Risk 0.45), had lower parasitaemias and showed marked improvement in anaemia (RR 0.47). Use of IMN's produced a 54% reduction in the prevalence of anaemia among young children. Attempts are being made to ensure that the programme is locally sustained.","PeriodicalId":77449,"journal":{"name":"Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ)","volume":"46 3","pages":"147-53"},"PeriodicalIF":0.0,"publicationDate":"1995-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19515303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stand-by treatment of suspected malaria in travellers. 为旅行者提供疑似疟疾的备用治疗。

Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ) Pub Date : 1995-09-01

H D Nothdurft, T Jelinek, S M Pechel, F Hess, H Maiwald, A Marschang, F von Sonnenburg, T Weinke, T Löscher

引用次数: 0

Babesia canis: evidence for genetic diversity among isolates revealed by restriction fragment length polymorphism analysis. 犬巴贝斯虫:限制性片段长度多态性分析揭示的分离株间遗传多样性的证据。

Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ) Pub Date : 1995-09-01

T Citard, P Mähl, H J Boulouis, C Chavigny, P Druilhe

引用次数: 0

Innate lack of susceptibility of Ugandan Trypanosoma brucei rhodesiense to DL-alpha-difluoromethylornithine (DFMO). 乌干达布氏罗得西亚锥虫对dl - α -二氟甲基鸟氨酸(DFMO)先天缺乏易感性。

Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ) Pub Date : 1995-09-01

M Iten, E Matovu, R Brun, R Kaminsky

{"title":"Innate lack of susceptibility of Ugandan Trypanosoma brucei rhodesiense to DL-alpha-difluoromethylornithine (DFMO).","authors":"M Iten, E Matovu, R Brun, R Kaminsky","doi":"","DOIUrl":"","url":null,"abstract":"Trypanosoma brucei rhodesiense isolates from South East Uganda were characterized for susceptibility to the drugs suramin, nifurtimox, melarsoprol and DL-alpha-difluoromethylornithine (DFMO). Two different assays were used to determine the drug susceptibility of the field isolates: the [3H]hypoxanthine incorporation assay (24 hours) and the long term viability assay (10 days). All trypanosome stocks were susceptible to suramin and nifurtimox. Differences in the susceptibility to melarsoprol were observed in the [3H]hypoxanthine incorporation assay, but could not be confirmed in the long term viability assay. All T. b. rhodesiense stocks were found in vitro to have innate tolerance to DFMO, under conditions where T. b. gambiense stocks from West Africa were susceptible to the drug. Ugandan T. b. rhodesiense stocks did respond to 25-100 micrograms/ml after 10 days of drug exposure, but the DFMO level reached in cerebrospinal fluid during treatment is only 16.3 +/- 7.8 micrograms/ml. Therefore, DFMO is not an appropriate alternative or backup drug for treatment of Rhodesian sleeping sickness in Uganda.","PeriodicalId":77449,"journal":{"name":"Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ)","volume":"46 3","pages":"190-4"},"PeriodicalIF":0.0,"publicationDate":"1995-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19513089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of Paraguayan Trypanosoma cruzi strains isolated from acute patients of Chagas disease. 急性恰加斯病患者分离的巴拉圭克氏锥虫菌株的特征。

Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ) Pub Date : 1995-09-01

N Acosta, M Maldonado, L Sanabria, G Yaluff, S Fuentes, S Torres, M E Ferreira, A Rojas de Arias, T Shozawa

引用次数: 0

Vectorial capacity and entomological inoculation rates of Anopheles gambiae in a high rainfall forested area of southern Sierra Leone. 塞拉利昂南部高降雨量林区冈比亚按蚊的媒介能力和昆虫学接种率。

Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ) Pub Date : 1995-09-01

M J Bockarie, M W Service, G Barnish, Y T Touré

{"title":"Vectorial capacity and entomological inoculation rates of Anopheles gambiae in a high rainfall forested area of southern Sierra Leone.","authors":"M J Bockarie, M W Service, G Barnish, Y T Touré","doi":"","DOIUrl":"","url":null,"abstract":"We report the first study of gonotrophic cycle duration, survival rates, pre-gravid rates, vectorial capacity and chromosomal polymorphism of Anopheles gambiae s.s. in Sierra Leone. In the village of Bayama in the Southern Province, An. gambiae was the only species found to be naturally infected with Plasmodium falciparum and it constituted 99.7% of 22,541 anopheline mosquitoes caught. Chromosomal studies revealed only An. gambiae s.s. out of 66 females examined for chromosomal polymorphism, 61 (92.4%) had the 2LA inversion in the standard arrangement. Other inversions observed in low frequencies included 2Rcu and 2Ru. We estimated a gonotrophic cycle length of three days and survival rate per gonotrophic cycle of 0.59 for this species. The mean daily survival rate of An. gambiae was 0.85 and the entomological inoculation rate was 1,235 infective bites/person/year. Blood-meal ELISA tests showed that the species was very anthropophagic and that there were an estimated 35.4 daily inoculations per infective case. The epidemiological significance of these entomological parameters is discussed in the light of parasitological results for nearby villages.","PeriodicalId":77449,"journal":{"name":"Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ)","volume":"46 3","pages":"164-71"},"PeriodicalIF":0.0,"publicationDate":"1995-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19515307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of circumsporozoite antibody testing as a sero-epidemiological tool for the detection of Plasmodium falciparum infection in non-immune travelers. 环孢子子抗体检测在无免疫旅行者中作为检测恶性疟原虫感染血清流行病学工具的评价。

Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ) Pub Date : 1995-09-01

T Jelinek, H D Nothdurft, T Löscher

{"title":"Evaluation of circumsporozoite antibody testing as a sero-epidemiological tool for the detection of Plasmodium falciparum infection in non-immune travelers.","authors":"T Jelinek, H D Nothdurft, T Löscher","doi":"","DOIUrl":"","url":null,"abstract":"The objective of this investigation was to collect data concerning CS-antibody levels and duration of the immunological response to exposure of non-immune persons to a single malaria infection. For this purpose 156 specimens from 98 patients with confirmed falciparum malaria, 76 specimen derived from 64 patients with vivax malaria and sera from 32 patients who had not been previously to malarious areas were investigated by use of a commercially available ELISA testkit. All specimens from patients with falciparum malaria were also tested for merozoite-antibodies by an indirect fluorescence antibody test (IFAT). Positive levels of merozoite-antibodies were detectable in 89.1% of the specimen in this panel during the period between days 8 and 90 after onset of symptoms and decreased steadily thereafter. The test results were positive for CS-antibodies in 36.4% of the specimens from patients with falciparum malaria during the first 7 days after onset of symptoms. This figure increased to 55.8% during days 8-90 after onset and decreased to 38.9% in specimens which were tested later (91-1898 days). 11 specimens reacted positively to CS-antibody testing but negative in the IFAT. Therefore, the percentage of specimen detected by either IFAT or CS-ELISA was at 51.9% during days 0 and 7 (p < 0.001), 95.3% during days 8 and 90 (p = 0.039) and 44.4% for testing performed later (p < 0.001). CS-antibodies could also be detected in 5.3% of specimen from patients with vivax malaria while none of the sera from the malaria-negative control-group tested positive for CS-antibodies.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":77449,"journal":{"name":"Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ)","volume":"46 3","pages":"154-7"},"PeriodicalIF":0.0,"publicationDate":"1995-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19515304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The chemotherapeutic efficacy of diminazene aceturate and lithium chloride against relapse infection of Trypanosoma brucei brucei in rats. 醋酸二硝基萘和氯化锂对大鼠布氏锥虫复发的化疗疗效。

Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ) Pub Date : 1995-06-01

I E Odika, I U Asuzu, S M Anika

{"title":"The chemotherapeutic efficacy of diminazene aceturate and lithium chloride against relapse infection of Trypanosoma brucei brucei in rats.","authors":"I E Odika, I U Asuzu, S M Anika","doi":"","DOIUrl":"","url":null,"abstract":"The chemotherapeutic efficacy of diminazene aceturate (Berenil) and lithium chloride (LiCl) in relapse infection of trypanosomiasis was investigated in rats experimentally infected with Trypanosoma brucei brucei. The study showed that the combination of diminazene aceturate at (7 mg/kg) and LiCl (10 micrograms/kg) appeared more effective therapeutically than diminazene aceturate, or diminazene aceturate and LiCl and dexamethasone group, as more of the rats in the diminazene aceturate and LiCl treated-group remained aparasitaemic for longer days (60 days). Relapse parasitaemia occurred on days 10 and 12 in diminazene aceturate (7 mg/kg); diminazene aceturate (7 mg/kg) and LiCl (10 micrograms/kg) plus dexamethasone (1 mg/kg) treated group respectively, while relapse parasitaemia did not occur in the diminazene aceturate and LiCl treated group until day 20. Histopathological examination of the brain did not show any signs of inflammatory reaction in the diminazene aceturate and LiCl and dexamethasone treated group. However lesions associated with meningoencephalitis, such as cellular infiltration of mononuclear cells, perivascular cuffings and perivascular congestion and oedema were observed in the diminazene aceturate; diminazene aceturate and LiCl treated groups.","PeriodicalId":77449,"journal":{"name":"Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ)","volume":"46 2","pages":"99-102"},"PeriodicalIF":0.0,"publicationDate":"1995-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19506032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0