The Prostate. Supplement最新文献

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Complete androgen blockade in prostate cancer: an overview of randomized trials. 完全雄激素阻断前列腺癌:随机试验综述。
The Prostate. Supplement Pub Date : 1992-01-01 DOI: 10.1002/pros.2990210517
O Dalesio
{"title":"Complete androgen blockade in prostate cancer: an overview of randomized trials.","authors":"O Dalesio","doi":"10.1002/pros.2990210517","DOIUrl":"https://doi.org/10.1002/pros.2990210517","url":null,"abstract":"<p><p>The role of the addition of anti-androgen therapy to surgical or chemical castration in metastatic prostate cancer is still unclear. The impact on time to progression and mortality of this treatment modality is, however, likely to be moderate at most. Is this therapeutic approach of real benefit? A reliable answer to this question requires the study of large numbers of patients. Several randomized studies are currently being performed and results are becoming available. Consideration of data available from all studies might make it possible to estimate the true value of this therapeutic approach.</p>","PeriodicalId":77436,"journal":{"name":"The Prostate. Supplement","volume":"4 ","pages":"111-4"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/pros.2990210517","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12701973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
DNA content/ploidy as prognostic factors in prostate cancer. DNA含量/倍体作为前列腺癌的预后因素。
The Prostate. Supplement Pub Date : 1992-01-01 DOI: 10.1002/pros.2990210519
M M Lieber
{"title":"DNA content/ploidy as prognostic factors in prostate cancer.","authors":"M M Lieber","doi":"10.1002/pros.2990210519","DOIUrl":"https://doi.org/10.1002/pros.2990210519","url":null,"abstract":"Modern electronic analytic instruments and computers make determination of DNA content/ploidy from individual tumor cells an efficient, accurate, and economical process. Both flow-cytometric, singlecell DNA content measurements and static image cytometry, using histologic sections stained by the Feulgen process are commonly used methodologies. DNA content/ploidy can now be reliably measured by flow cytometry, either from fresh tissues or, using theHedley methodology, from formalin-fixed, paraffin-embedded tissues. Cytologic needle aspirates of the prostate and prostate tissue specimens obtained by radical prostatectomy, transurethral resection, or needle biopsy can be studied effectively by either flow or static image cytometry. In certain countries, particularly the USA, DNA content/ploidy is a routinely available laboratory test that can be obtained at about the same price as standard histologic analysis; there is every reason to believe that DNA content/ploidy measurement of human prostate cancer is a more objective, accurate, and reproducible method of grading such tumors than is human microscopic grading, particularly for intermediate grade (Gleason 5-7) tumors.","PeriodicalId":77436,"journal":{"name":"The Prostate. Supplement","volume":"4 ","pages":"119-24"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/pros.2990210519","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12741557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The TNM classification of prostate cancer. 前列腺癌的TNM分类。
The Prostate. Supplement Pub Date : 1992-01-01 DOI: 10.1002/pros.2990210521
F H Schröder, P Hermanek, L Denis, W R Fair, M K Gospodarowicz, M Pavone-Macaluso
{"title":"The TNM classification of prostate cancer.","authors":"F H Schröder,&nbsp;P Hermanek,&nbsp;L Denis,&nbsp;W R Fair,&nbsp;M K Gospodarowicz,&nbsp;M Pavone-Macaluso","doi":"10.1002/pros.2990210521","DOIUrl":"https://doi.org/10.1002/pros.2990210521","url":null,"abstract":"Department of Urology, Erasmus University and Academic Hospital Dijkzigt, Rotterdam, The Netherlands (F.H.S.); Department of Pathology, University of Erlangen, Germany (P.H.); Department of Urology, A. Z. Middelheim, Antwelp, Belgium (L. 0.); Department of Urology, Memorial Sloan-Kettering Cancer Center, New York (W. R. F.); The Princess Margaret Hospital, Toronto, Canada (M. K.G.); and Institute of Urology, University of Palermo, Palermo, Italy (M. P. -M.J","PeriodicalId":77436,"journal":{"name":"The Prostate. Supplement","volume":"4 ","pages":"129-38"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/pros.2990210521","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12741558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 460
Preliminary results of three-dimensional reconstruction of previously imaged prostates. 先前成像前列腺三维重建的初步结果。
The Prostate. Supplement Pub Date : 1992-01-01 DOI: 10.1002/pros.2990210506
I A Sesterhenn, F K Mostofi, R R Mattrey, J P Sands, C J Davis, W F McCarthy
{"title":"Preliminary results of three-dimensional reconstruction of previously imaged prostates.","authors":"I A Sesterhenn,&nbsp;F K Mostofi,&nbsp;R R Mattrey,&nbsp;J P Sands,&nbsp;C J Davis,&nbsp;W F McCarthy","doi":"10.1002/pros.2990210506","DOIUrl":"https://doi.org/10.1002/pros.2990210506","url":null,"abstract":"<p><p>In patients with biopsy proven prostate cancer, preoperative transrectal magnetic resonance imaging (MRI) and ultrasound were performed, followed by total prostatectomy. Generally, the findings with MRI correlated well with the histopathologic findings, including infiltration of and extension through the capsule into periprostatic tissue and the seminal vesicles. False negative results with MRI included centrally located tumors and small tumors. False positive results with MRI included lobular atrophy, cystic hyperplasia, cystic atrophy, florid glandular hyperplasia and scars with chronic inflammation.</p>","PeriodicalId":77436,"journal":{"name":"The Prostate. Supplement","volume":"4 ","pages":"33-41"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/pros.2990210506","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12741565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Magnetic resonance spectroscopy in prostate disease: diagnostic possibilities and future developments. 磁共振波谱在前列腺疾病:诊断的可能性和未来的发展。
The Prostate. Supplement Pub Date : 1992-01-01 DOI: 10.1002/pros.2990210507
P Narayan, J Kurhanewicz
{"title":"Magnetic resonance spectroscopy in prostate disease: diagnostic possibilities and future developments.","authors":"P Narayan,&nbsp;J Kurhanewicz","doi":"10.1002/pros.2990210507","DOIUrl":"https://doi.org/10.1002/pros.2990210507","url":null,"abstract":"<p><p>Magnetic resonance spectroscopy (MRS) is a relatively new technique for studying membrane and intracellular metabolic events occurring in cancer. A series of transrectal probes were used for performing MRS and subsequently for integrated MRS/magnetic resonance imaging (MRI) of the prostate. Studies using transrectal 31P/1H MRS showed that it can characterize metabolic differences between normal and malignant prostates. Specifically, malignant prostates are characterized by low levels of phosphocreatine and citrate and high levels of phosphomonoesters relative to normal glands. These findings were verified in biochemical studies of prostate biopsies. The images obtained by transrectal coil techniques were superior to images obtained by the conventional body coil technique. In the future, the integration of 1H imaging and multi-volume localization techniques (spectroscopic imaging) will allow the acquisition of metabolic maps of the prostate which may eventually be useful in diagnosis and in management of patients with prostate cancer.</p>","PeriodicalId":77436,"journal":{"name":"The Prostate. Supplement","volume":"4 ","pages":"43-50"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/pros.2990210507","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12546849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 35
The management of bladder outlet obstruction due to prostate cancer, untreated and after endocrine treatment. 前列腺癌所致膀胱出口梗阻,未经治疗及经内分泌治疗后的处理。
The Prostate. Supplement Pub Date : 1992-01-01 DOI: 10.1002/pros.2990210525
J E Montie
{"title":"The management of bladder outlet obstruction due to prostate cancer, untreated and after endocrine treatment.","authors":"J E Montie","doi":"10.1002/pros.2990210525","DOIUrl":"https://doi.org/10.1002/pros.2990210525","url":null,"abstract":"Symptoms of bladder outlet obstruction are commonly seen with locally advanced prostate cancer though the incidence is poorly defined, ranging from 18% [ 13 to 72% [2]. Symptoms may have abenigncause, as benignprostatic hyperplasia (BPH) often occurs concurrently with prostate cancer and can also produce obstructive symptoms [3]. Three therapeutic options, surgery, radiation therapy (RT) or endocrine treatment, can be used either sequentially or in combination earlier in the course of the disease. In general, a relapsing cancer is more difficult to control and additional morbidity is common.","PeriodicalId":77436,"journal":{"name":"The Prostate. Supplement","volume":"4 ","pages":"153-7"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/pros.2990210525","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12741562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
To screen or not to screen? 筛选还是不筛选?
The Prostate. Supplement Pub Date : 1992-01-01 DOI: 10.1002/pros.2990210510
L J Denis
{"title":"To screen or not to screen?","authors":"L J Denis","doi":"10.1002/pros.2990210510","DOIUrl":"https://doi.org/10.1002/pros.2990210510","url":null,"abstract":"<p><p>This paper aims to present a case for screening for prostate cancer, though medical committees from many countries have recently decided against it. It is clear that prostate cancer fails many of the criteria for an effective screening program. There is certainly no single test that can be used reliably to detect prostate cancer. All the available tests have advantages and disadvantages. The sensitivities of the three widely used screening tests--digital rectal examination (DRE), prostate specific antigen (PSA), and transrectal ultrasound (TRUS)--vary from 50% to 85% in a number of studies, but the positive predictive value fluctuates around 30%. The use of all three tests must improve the detection rate. The European Cancer Programme is funding a pilot study in Antwerp and Rotterdam on screening for prostatic diseases. In Rotterdam, a pre-screen PSA is performed and then patients are randomized to no screening or DRE with TRUS. The Antwerp section of the study includes screening for benign prostatic hyperplasia and employs a questionnaire on urinary symptoms as a pre-screen test. Patients are then randomized to controls or DRE with TRUS and, if results are suspicious, PSA measurement. It will be about 8 years before it becomes clear whether there is a resulting drop in mortality from prostate cancer.</p>","PeriodicalId":77436,"journal":{"name":"The Prostate. Supplement","volume":"4 ","pages":"63-70"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/pros.2990210510","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12742207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Indications and techniques of prostate biopsies. 前列腺活检的适应症和技术。
The Prostate. Supplement Pub Date : 1992-01-01 DOI: 10.1002/pros.2990210518
L Andersson
{"title":"Indications and techniques of prostate biopsies.","authors":"L Andersson","doi":"10.1002/pros.2990210518","DOIUrl":"https://doi.org/10.1002/pros.2990210518","url":null,"abstract":"Of 77 patients with non-nodular but abnormally fm prostates investigated at Stanford, 36% had prostate cancer [l]. In another study of patients with abnormal transrectalultrasonography(TRUS) findings, 65.6%ofthose withaPSAabove 10 ng/ ml had cancer [2]. Furthermore, cancer was also found in 3 1% of patients who had a normal digital rectal examination @RE). Inthegroup ofpatients withanormalDREandaPSAleve1 intherange4-10 ng/ ml, it is debatable whether or not biopsy should be pedormed In a comparatively young man, who may receive radical surgery if findings are positive, a more active approach is likely to be taken than in an elderly man to whom radical treatment will presumably not be offered","PeriodicalId":77436,"journal":{"name":"The Prostate. Supplement","volume":"4 ","pages":"115-8"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/pros.2990210518","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12741556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What is 'progression' in prostate cancer? 什么是前列腺癌的“进展”?
The Prostate. Supplement Pub Date : 1992-01-01 DOI: 10.1002/pros.2990210522
D W Newling
{"title":"What is 'progression' in prostate cancer?","authors":"D W Newling","doi":"10.1002/pros.2990210522","DOIUrl":"https://doi.org/10.1002/pros.2990210522","url":null,"abstract":"If progression can be defined at an early stage, a change in treatment may significantly improve the length and quality of apatient's survival. In this seminar, involving 35 participants, the assessment of progression in phase I1 and phase 111 studies was discussed, against the background of papers prepared by the invited participants, and an analysis of progression in a recent EORTC phase 111 study prepared by Dr. Sylvester.","PeriodicalId":77436,"journal":{"name":"The Prostate. Supplement","volume":"4 ","pages":"139-43"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/pros.2990210522","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12741559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Casodex: a pure non-steroidal anti-androgen used as monotherapy in advanced prostate cancer. Casodex:一种纯非甾体抗雄激素,用于晚期前列腺癌的单药治疗。
The Prostate. Supplement Pub Date : 1992-01-01 DOI: 10.1002/pros.2990210515
C J Tyrrell
{"title":"Casodex: a pure non-steroidal anti-androgen used as monotherapy in advanced prostate cancer.","authors":"C J Tyrrell","doi":"10.1002/pros.2990210515","DOIUrl":"https://doi.org/10.1002/pros.2990210515","url":null,"abstract":"<p><p>Casodex, a pure potent non-steroidal anti-androgen, has been shown in a phase II clinical trial program to be very well tolerated and to have fewer side-effects compared with other anti-androgens. The most commonly reported side-effects (prompted by direct questioning) were breast tenderness (63.4%), breast swelling (52.5%), and hot flashes (23.6%). Gastrointestinal disturbances, hepatic impairment, alcohol intolerance, and problems with light adaptation are not associated with Casodex treatment. In this study, Casodex (50 mg once daily) was evaluated in 267 patients, 130 of whom have received it for more than 1 year. On assessment of best objective response, 55.5% of patients showed partial regression, 15.6% stable disease, 17.1% progression, and 11.8% were not assessable. These results are comparable with other standard hormonal therapies for advanced prostate cancer.</p>","PeriodicalId":77436,"journal":{"name":"The Prostate. Supplement","volume":"4 ","pages":"97-104"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/pros.2990210515","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12742210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 38
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