The Canadian journal of infection control : the official journal of the Community & Hospital Infection Control Association-Canada = Revue canadienne de prevention des infections最新文献

{"title":"Catheter salvage strategies in children with central venous catheter-related or -associated bloodstream infections: a systematic review and meta-analysis.","authors":"D Buonsenso, G Salerno, G Sodero, F Mariani, L Pisapia, C Gelormini, M Di Nardo, P Valentini, G Scoppettuolo, D G Biasucci","doi":"10.1016/j.jhin.2022.03.010","DOIUrl":"10.1016/j.jhin.2022.03.010","url":null,"abstract":"<p><strong>Background: </strong>Optimal management of central venous catheter-related, or -associated, bloodstream infections (CRBSI or CLABSI) in children is not established.</p><p><strong>Aim: </strong>To evaluate success of catheter salvage strategies in paediatric patients.</p><p><strong>Methods: </strong>Studies were retrieved from medical databases and article reference lists. Data were collected relating to clinical outcomes of two treatments: systemic antibiotics alone or in association with antimicrobial lock therapy (ALT). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated from a mixed logistic effects model. Heterogeneity was summarized using I² statistics. Publication bias was investigated by Egger's regression test and funnel plots.</p><p><strong>Findings: </strong>From 345 identified publications, 19 met inclusion criteria (total of 914 attempted salvage strategies). To achieve successful catheter salvage, in CRBSI the addition of ALT was superior to systemic antibiotics alone (OR: -0.40; 95% CI: -1.41, 0.62): 77% (95% CI: 69, 85; I² = 42.5%; P = 0.12) and 68% of success (95% CI: 59, 77; I² = 0; P < 0.05), respectively. CRBSI recurrence was less common in studies that used ALT compared with systemic antibiotics alone: 5% (95% CI: 0, 13; I² = 59.7%; P = 0.03) and 18% of recurrence (95% CI: 9, 28; I² = 0; P < 0.05), respectively. Recurrences were low with both antibiotic locks and ethanol lock. No clear benefits of ALT addition compared to systemic antibiotic only were found in CLABSI (OR: -0.81; 95% CI: -0.80, 2.43).</p><p><strong>Conclusion: </strong>The addition of an antimicrobial lock solution to systemic antibiotic may be beneficial for successful catheter salvage in paediatric patients with CRBSI, depending on aetiology, whereas no statistically significant difference between systemic antibiotic with or without addition of an antimicrobial lock solution was found regarding CLABSI.</p>","PeriodicalId":77413,"journal":{"name":"The Canadian journal of infection control : the official journal of the Community & Hospital Infection Control Association-Canada = Revue canadienne de prevention des infections","volume":"50 1","pages":"1-20"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91049282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A fatal outbreak of neonatal sepsis caused by mcr-10-carrying Enterobacter kobei in a tertiary care hospital in Nepal.","authors":"S Manandhar, Q Nguyen, D T Pham, P Amatya, M Rabaa, S Dongol, B Basnyat, S M Dixit, S Baker, A Karkey","doi":"10.1016/j.jhin.2022.03.015","DOIUrl":"10.1016/j.jhin.2022.03.015","url":null,"abstract":"<p><strong>Background: </strong>Enterobacter kobei is an emerging cause of outbreak of nosocomial infections in neonatal intensive care units (NICUs). Between July and September 2016, a NICU in a tertiary care hospital of Nepal observed an abrupt increase in the number of neonatal sepsis cases caused by Enterobacter spp. infecting 11 out of 23 admitted neonates, five of whom died of an exacerbated sepsis.</p><p><strong>Aim: </strong>To confirm the suspected outbreak, identify environmental source of infection, and characterize genetic determinants of antimicrobial resistance (AMR) and virulence of the pathogen.</p><p><strong>Methods: </strong>Whole-genome sequencing of all Enterobacter spp. isolated from blood cultures of septic neonates admitted to NICU between May 2016 and December 2017 was performed. Also, an environmental sampling was intensified from fortnightly to weekly during the outbreak.</p><p><strong>Findings: </strong>The genomic analysis revealed that 10 out of 11 non-duplicated E. kobei isolated from neonatal blood cultures between July and September 2016 were clonal, confirming the outbreak. The isolates carried AMR genes including bla_AmpC and mcr-10 conferring reduced susceptibility to carbapenem and colistin respectively. The environmental sampling, however, failed to isolate any Enterobacter spp. Reinforcement of aseptic protocols in invasive procedures, hand hygiene, environmental decontamination, fumigation, and secluded care of culture-positive cases successfully terminated the outbreak.</p><p><strong>Conclusion: </strong>Our study underscored the need to implement stringent infection control measures to prevent infection outbreaks. For the first time, we report the emergence of carbapenem and colistin non-susceptible E. kobei carrying mcr-10 gene as a cause of nosocomial neonatal sepsis in a NICU.</p>","PeriodicalId":77413,"journal":{"name":"The Canadian journal of infection control : the official journal of the Community & Hospital Infection Control Association-Canada = Revue canadienne de prevention des infections","volume":"71 1","pages":"60-66"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7619562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78722436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-cell RNA sequencing analysis of liver reveals the enhanced entry and release abilities of human adenovirus F41, partially explaining acute hepatitis in children","authors":"Junwen Luan, Yixuan Zhou, Xiao Wang, Annan Ming, Yuwen Liu, Yupei Yuan, Junhan Liang, Leiliang Zhang","doi":"10.1016/j.jinf.2022.06.007","DOIUrl":"https://doi.org/10.1016/j.jinf.2022.06.007","url":null,"abstract":"","PeriodicalId":77413,"journal":{"name":"The Canadian journal of infection control : the official journal of the Community & Hospital Infection Control Association-Canada = Revue canadienne de prevention des infections","volume":"214 1","pages":"334 - 363"},"PeriodicalIF":0.0,"publicationDate":"2022-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75751817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geographical distribution of cystic fibrosis carriers as population genetic determinant of COVID-19 spread and fatality in 37 countries","authors":"C. Gabbi, A. Renieri, B. Strandvik","doi":"10.1016/j.jinf.2022.06.006","DOIUrl":"https://doi.org/10.1016/j.jinf.2022.06.006","url":null,"abstract":"","PeriodicalId":77413,"journal":{"name":"The Canadian journal of infection control : the official journal of the Community & Hospital Infection Control Association-Canada = Revue canadienne de prevention des infections","volume":"139 1","pages":"318 - 321"},"PeriodicalIF":0.0,"publicationDate":"2022-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81762160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High efficacy of Glecaprevir/Pibrentasvir for HCV-Infected individuals with active drug use.","authors":"A. Gonzalez-Serna, J. Macías, A. Corma‐Gómez, F. Téllez, J. Cucurull, L. Real, R. Granados, A. Rivero-Juarez, J. Hernández-Quero, D. Merino, R. Palacios, M. Ríos, A. Collado, J. Pineda","doi":"10.1016/j.jinf.2022.06.005","DOIUrl":"https://doi.org/10.1016/j.jinf.2022.06.005","url":null,"abstract":"","PeriodicalId":77413,"journal":{"name":"The Canadian journal of infection control : the official journal of the Community & Hospital Infection Control Association-Canada = Revue canadienne de prevention des infections","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88678630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing changes in stethoscope hygiene during COVID-19: a multi-centre cross-sectional study","authors":"R. Vasudevan, M. Nedjat-Haiem, A. Mahadevan, M.S. Herbert, L. Lander, T. Warsi, U. Shaikh, C. Harding, M. Savoia","doi":"10.1016/j.jhin.2022.05.019","DOIUrl":"https://doi.org/10.1016/j.jhin.2022.05.019","url":null,"abstract":"","PeriodicalId":77413,"journal":{"name":"The Canadian journal of infection control : the official journal of the Community & Hospital Infection Control Association-Canada = Revue canadienne de prevention des infections","volume":"29 1","pages":"1 - 6"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90697004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-acting HIV fusion inhibitor albuvirtide combined with ritonavir-boosted lopinavir for HIV-1-infected patients after failing the first-line antiretroviral therapy: 48-week randomized, controlled, phase 3 non-inferiority TALENT study.","authors":"B. Su, Cheng Yao, Qing-xia Zhao, W. Cai, Min Wang, Hong Zhou Lu, Ting-Ting Mu, Yuan Chen, Li Liu, Hui Wang, Yun He, Yu-huang Zheng, Ling-hua Li, Jin-feng Chen, Jianhua Yu, B. Zhu, Min Zhao, Yong-tao Sun, W. Lun, Yihang Zhang, Hu Wang, Wei Xia, Li-jun Sun, Lili Dai, T. Jiang, Meixia Wang, Qing-shan Zheng, Hai-Yan Peng, Yao Wang, M. Hu, Xia Liu, Rongjian Lu, Jian-hua Hu, Chengzhu Sun, Hui-Qin Xing, Yinghai Shao, D. Xie, Tong Zhang, Fuhua Zhang, Hao Wu","doi":"10.1016/j.jinf.2022.05.034","DOIUrl":"https://doi.org/10.1016/j.jinf.2022.05.034","url":null,"abstract":"","PeriodicalId":77413,"journal":{"name":"The Canadian journal of infection control : the official journal of the Community & Hospital Infection Control Association-Canada = Revue canadienne de prevention des infections","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77073667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The resurgence of wild poliovirus in Pakistan and Afghanistan: A new setback for polio eradication","authors":"M. Rana, R. Asghar, M. Usman, A. Ikram, M. Salman, M. Umair, S. Zaidi, Muhammad Anas, N. Khan","doi":"10.1016/j.jinf.2022.05.038","DOIUrl":"https://doi.org/10.1016/j.jinf.2022.05.038","url":null,"abstract":"","PeriodicalId":77413,"journal":{"name":"The Canadian journal of infection control : the official journal of the Community & Hospital Infection Control Association-Canada = Revue canadienne de prevention des infections","volume":"102 1","pages":"334 - 363"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85505151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The dangers of reused personal protective equipment: healthcare workers and workstation contamination","authors":"D. Doos, P. Barach, N. J. Alves, L. Falvo, A. Bona, M. Moore, D. Cooper, R. Lefort, R. Ahmed","doi":"10.1016/j.jhin.2022.05.016","DOIUrl":"https://doi.org/10.1016/j.jhin.2022.05.016","url":null,"abstract":"","PeriodicalId":77413,"journal":{"name":"The Canadian journal of infection control : the official journal of the Community & Hospital Infection Control Association-Canada = Revue canadienne de prevention des infections","volume":"23 1","pages":"59 - 68"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81757569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is the fourth COVID-19 vaccine dose urgently needed? Revelation from a prospective cohort study","authors":"Qiu-Yan Xu, Qiuying Li, Zhi-Juan Jia, Meng-Juan Wu, Yan-Yun Liu, Li-Rong Lin, Li-Li Liu, Tian-ci Yang","doi":"10.1016/j.jinf.2022.06.003","DOIUrl":"https://doi.org/10.1016/j.jinf.2022.06.003","url":null,"abstract":"","PeriodicalId":77413,"journal":{"name":"The Canadian journal of infection control : the official journal of the Community & Hospital Infection Control Association-Canada = Revue canadienne de prevention des infections","volume":"67 1","pages":"e66 - e68"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72639759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}