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The American journal of cardiovascular pathology最新文献

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Netrin-1 overexpression induces polycystic kidney disease - a novel mechanism contributing cystogenesis in ADPKD. Netrin-1过表达诱导多囊肾病——ADPKD中促进囊形成的新机制
The American journal of cardiovascular pathology Pub Date : 2022-03-01 DOI: 10.1016/j.ajpath.2022.03.004
Riyaz Mohamed, Yang Liu, A. Kistler, P. Harris, M. Thangaraju
{"title":"Netrin-1 overexpression induces polycystic kidney disease - a novel mechanism contributing cystogenesis in ADPKD.","authors":"Riyaz Mohamed, Yang Liu, A. Kistler, P. Harris, M. Thangaraju","doi":"10.1016/j.ajpath.2022.03.004","DOIUrl":"https://doi.org/10.1016/j.ajpath.2022.03.004","url":null,"abstract":"","PeriodicalId":77408,"journal":{"name":"The American journal of cardiovascular pathology","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73867721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Periprostatic adipose tissue displays a chronic hypoxic state that limits its expandability. 前列腺周围脂肪组织表现为慢性缺氧状态，限制了其可扩展性。
The American journal of cardiovascular pathology Pub Date : 2022-03-01 DOI: 10.1016/j.ajpath.2022.03.008
M. Roumiguié, D. Estève, C. Manceau, A. Toulet, J. Gilleron, C. Belles, Y. Jia, Cynthia Houël, S. Péricart, S. LeGonidec, P. Valet, M. Cormont, J. Tanti, B. Malavaud, A. Bouloumié, D. Milhas, C. Muller
{"title":"Periprostatic adipose tissue displays a chronic hypoxic state that limits its expandability.","authors":"M. Roumiguié, D. Estève, C. Manceau, A. Toulet, J. Gilleron, C. Belles, Y. Jia, Cynthia Houël, S. Péricart, S. LeGonidec, P. Valet, M. Cormont, J. Tanti, B. Malavaud, A. Bouloumié, D. Milhas, C. Muller","doi":"10.1016/j.ajpath.2022.03.008","DOIUrl":"https://doi.org/10.1016/j.ajpath.2022.03.008","url":null,"abstract":"","PeriodicalId":77408,"journal":{"name":"The American journal of cardiovascular pathology","volume":"197 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72828853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Tensor Decomposition of Largest Convolutional Eigenvalues Reveals Pathological Predictive Power of RhoB in Rectal Cancer Biopsy. 最大卷积特征值张量分解揭示RhoB在直肠癌活检中的病理预测能力。
The American journal of cardiovascular pathology Pub Date : 2021-10-13 DOI: 10.21203/rs.3.rs-957359/v1
T. Pham, Vinayakumar Ravi, Chuanwen Fan, B. Luo, Xiao-Feng Sun
{"title":"Tensor Decomposition of Largest Convolutional Eigenvalues Reveals Pathological Predictive Power of RhoB in Rectal Cancer Biopsy.","authors":"T. Pham, Vinayakumar Ravi, Chuanwen Fan, B. Luo, Xiao-Feng Sun","doi":"10.21203/rs.3.rs-957359/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-957359/v1","url":null,"abstract":"RhoB protein belongs to the Rho GTPase family, which plays an important role in governing cell signaling and tissue morphology. RhoB expression is known to have implications in pathological processes of diseases. Investigation in the regulation and communication of this protein detected by immunohistochemical staining on the microscope is worth exploring to gain insightful information that may lead to identifying optimal disease treatment options. In particular, the role of RhoB in rectal cancer is not well-discovered. Here, we report that methods of deep learning-based image analysis and the decomposition of multiway arrays discover the predictive factor of RhoB in two cohorts of rectal cancer patients having survival rates of less and more than 5 years. The analysis results show distinctions between the tensor decomposition factors of the two cohorts.","PeriodicalId":77408,"journal":{"name":"The American journal of cardiovascular pathology","volume":"150 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75766087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Long Intervening Noncoding 00467 RNA Contributes to Tumorigenesis by Acting as a Competing Endogenous RNA against miR-107 in Cervical Cancer Cells. 长时间介入的非编码00467 RNA通过作为对抗miR-107的内源性RNA参与宫颈癌细胞的肿瘤发生
The American journal of cardiovascular pathology Pub Date : 2019-11-01 DOI: 10.1016/j.ajpath.2019.07.012
Guang-Cai Li, L. Xin, Yong-Sheng Wang, Ying Chen
{"title":"Long Intervening Noncoding 00467 RNA Contributes to Tumorigenesis by Acting as a Competing Endogenous RNA against miR-107 in Cervical Cancer Cells.","authors":"Guang-Cai Li, L. Xin, Yong-Sheng Wang, Ying Chen","doi":"10.1016/j.ajpath.2019.07.012","DOIUrl":"https://doi.org/10.1016/j.ajpath.2019.07.012","url":null,"abstract":"","PeriodicalId":77408,"journal":{"name":"The American journal of cardiovascular pathology","volume":"13 1","pages":"2293-2310"},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79366288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
A new role for the spleen: aggravation of the systemic inflammatory response in rats with severe acute pancreatitis. 脾的新作用:加重严重急性胰腺炎大鼠全身炎症反应。
The American journal of cardiovascular pathology Pub Date : 2019-11-01 DOI: 10.1016/j.ajpath.2019.07.008
Rui Zhou, Jian Zhang, W. Bu, Wei Zhang, Baojun Duan, Xianwei Wang, L. Yao, Zongfang Li, Jun Li
{"title":"A new role for the spleen: aggravation of the systemic inflammatory response in rats with severe acute pancreatitis.","authors":"Rui Zhou, Jian Zhang, W. Bu, Wei Zhang, Baojun Duan, Xianwei Wang, L. Yao, Zongfang Li, Jun Li","doi":"10.1016/j.ajpath.2019.07.008","DOIUrl":"https://doi.org/10.1016/j.ajpath.2019.07.008","url":null,"abstract":"","PeriodicalId":77408,"journal":{"name":"The American journal of cardiovascular pathology","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76656733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
The Inability of the Choroid to Revascularize in Oxygen-Induced Retinopathy Results from Increased P53/mir-Let-7b Activity. P53/mir-Let-7b活性升高导致氧诱导视网膜病变脉络膜血运重建能力的丧失。
The American journal of cardiovascular pathology Pub Date : 2019-11-01 DOI: 10.1016/j.ajpath.2019.07.009
T. Zhou, T. Zhu, J. Rivera, S. Omri, H. Tahiri, I. Lahaie, R. Rouget, M. Wirth, S. Nattel, G. Lodygensky, G. Ferbeyre, M. Nezhady, Michel Desjarlais, P. Hamel, S. Chemtob
{"title":"The Inability of the Choroid to Revascularize in Oxygen-Induced Retinopathy Results from Increased P53/mir-Let-7b Activity.","authors":"T. Zhou, T. Zhu, J. Rivera, S. Omri, H. Tahiri, I. Lahaie, R. Rouget, M. Wirth, S. Nattel, G. Lodygensky, G. Ferbeyre, M. Nezhady, Michel Desjarlais, P. Hamel, S. Chemtob","doi":"10.1016/j.ajpath.2019.07.009","DOIUrl":"https://doi.org/10.1016/j.ajpath.2019.07.009","url":null,"abstract":"","PeriodicalId":77408,"journal":{"name":"The American journal of cardiovascular pathology","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82046054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Myeloid-Derived Lymphatic Endothelial Cell Progenitors Significantly Contribute to Lymphatic Metastasis in Clinical Breast Cancer. 骨髓源性淋巴内皮细胞祖细胞在乳腺癌淋巴转移中的作用
The American journal of cardiovascular pathology Pub Date : 2019-11-01 DOI: 10.1016/j.ajpath.2019.07.006
Lisa D. Volk-Draper, Radhika A. Patel, Nihit Bhattarai, Jie Yang, A. Wilber, D. DeNardo, S. Ran
{"title":"Myeloid-Derived Lymphatic Endothelial Cell Progenitors Significantly Contribute to Lymphatic Metastasis in Clinical Breast Cancer.","authors":"Lisa D. Volk-Draper, Radhika A. Patel, Nihit Bhattarai, Jie Yang, A. Wilber, D. DeNardo, S. Ran","doi":"10.1016/j.ajpath.2019.07.006","DOIUrl":"https://doi.org/10.1016/j.ajpath.2019.07.006","url":null,"abstract":"","PeriodicalId":77408,"journal":{"name":"The American journal of cardiovascular pathology","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73366571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
Neutrophil-derived reactive oxygen orchestrates epithelial cell signaling events during intestinal repair. 中性粒细胞衍生的活性氧在肠修复过程中协调上皮细胞信号事件。
The American journal of cardiovascular pathology Pub Date : 2019-11-01 DOI: 10.1016/j.ajpath.2019.07.017
J. Matthews, Joshua A. Owens, C. Naudin, B. Saeedi, Ashfaqul Alam, April R. Reedy, B. Hinrichs, R. Sumagin, A. Neish, Rheinallt M. Jones
{"title":"Neutrophil-derived reactive oxygen orchestrates epithelial cell signaling events during intestinal repair.","authors":"J. Matthews, Joshua A. Owens, C. Naudin, B. Saeedi, Ashfaqul Alam, April R. Reedy, B. Hinrichs, R. Sumagin, A. Neish, Rheinallt M. Jones","doi":"10.1016/j.ajpath.2019.07.017","DOIUrl":"https://doi.org/10.1016/j.ajpath.2019.07.017","url":null,"abstract":"","PeriodicalId":77408,"journal":{"name":"The American journal of cardiovascular pathology","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88070893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Tissue Iron Promotes Wound Repair via M2 Macrophage Polarization and the Chemokine (C-C Motif) Ligands 17 and 22. 组织铁通过M2巨噬细胞极化和趋化因子（C-C Motif）配体17和22促进伤口修复。
The American journal of cardiovascular pathology Pub Date : 2019-11-01 Epub Date: 2019-08-27 DOI: 10.1016/j.ajpath.2019.07.015
Holly N Wilkinson, Elizabeth R Roberts, Amber R Stafford, Kayleigh L Banyard, Paolo Matteucci, Kimberly A Mace, Matthew J Hardman
{"title":"Tissue Iron Promotes Wound Repair via M2 Macrophage Polarization and the Chemokine (C-C Motif) Ligands 17 and 22.","authors":"Holly N Wilkinson, Elizabeth R Roberts, Amber R Stafford, Kayleigh L Banyard, Paolo Matteucci, Kimberly A Mace, Matthew J Hardman","doi":"10.1016/j.ajpath.2019.07.015","DOIUrl":"10.1016/j.ajpath.2019.07.015","url":null,"abstract":"<p><p>Macrophages are important for effective iron recycling and erythropoiesis, but they also play a crucial role in wound healing, orchestrating tissue repair. Recently, we demonstrated a significant accumulation of iron in healing wounds and a requirement of iron for effective repair. Herein, we sought to determine the influence of iron on macrophage function in the context of wound healing. Interestingly, wound macrophages extensively sequestered iron throughout healing, associated with a prohealing M2 phenotype. In delayed healing diabetic mouse wounds, both macrophage polarization and iron sequestration were impaired. In vitro studies revealed that iron promotes differentiation, while skewing macrophages toward a hypersecretory M2-like polarization state. These macrophages produced high levels of chemokine (C-C motif) ligands 17 and 22, promoting wound reepithelialization and extracellular matrix deposition in a human ex vivo wound healing model. Together, these findings reveal a novel, unappreciated role for iron in modulating macrophage behavior to promote subsequent wound repair. These findings support therapeutic evaluation of iron use to promote wound healing in the clinic.</p>","PeriodicalId":77408,"journal":{"name":"The American journal of cardiovascular pathology","volume":"2 1","pages":"2196-2208"},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73314042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The MHC II-CD4 Immunologic Synapse in Alcoholic Hepatitis and Autoimmune Liver Pathology: The Role of Aberrant MHC II in Hepatocytes. 酒精性肝炎中MHC II- cd4免疫突触与自身免疫性肝脏病理:异常MHC II在肝细胞中的作用
The American journal of cardiovascular pathology Pub Date : 2019-10-25 DOI: 10.1016/j.ajpath.2019.09.019
JiaJie Lu, P. Ji, S. French
{"title":"The MHC II-CD4 Immunologic Synapse in Alcoholic Hepatitis and Autoimmune Liver Pathology: The Role of Aberrant MHC II in Hepatocytes.","authors":"JiaJie Lu, P. Ji, S. French","doi":"10.1016/j.ajpath.2019.09.019","DOIUrl":"https://doi.org/10.1016/j.ajpath.2019.09.019","url":null,"abstract":"","PeriodicalId":77408,"journal":{"name":"The American journal of cardiovascular pathology","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74123665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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