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Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model. 在灵长类动物模型中，血管内皮生长因子/血管通透性因子在时间和空间上与眼部血管生成相关。
The American journal of cardiovascular pathology Pub Date : 1994-09-01 DOI: 10.1097/00006982-199515020-00021
Joan W. Miller, A. Adamis, David T. Shima, Patricia A. D'Amore, Rachel S. Moulton, Michael S. O'Reilly, Judah Folkman, Harold F. Dvorak, L. Brown, B. Berse, T. Yeo, K. Yeo
{"title":"Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model.","authors":"Joan W. Miller, A. Adamis, David T. Shima, Patricia A. D'Amore, Rachel S. Moulton, Michael S. O'Reilly, Judah Folkman, Harold F. Dvorak, L. Brown, B. Berse, T. Yeo, K. Yeo","doi":"10.1097/00006982-199515020-00021","DOIUrl":"https://doi.org/10.1097/00006982-199515020-00021","url":null,"abstract":"Ischemia often precedes neovascularization. In ocular neovascularization, such as occurs in diabetic retinopathy, a diffusible angiogenic factor has been postulated to be produced by ischemic retina and to lead to neovascularization of the retina, optic nerve, or iris. However, no angiogenic factor has been conclusively identified that satisfies this hypothesis. Vascular endothelial growth factor/vascular permeability factor, hereafter referred to as VEGF, is a likely candidate for an ocular angiogenic factor because it is a secreted mitogen, specific for endothelial cells, and is upregulated by hypoxia. We investigated the association of VEGF with the development of experimental iris neovascularization in the cynomolgus monkey. Following the production of retinal ischemia by laser occlusion of all branch retinal veins, VEGF was increased in the aqueous fluid, and the aqueous VEGF levels changed synchronously and proportionally with the severity of iris neovascularization. Northern analysis and in situ hybridization revealed that VEGF messenger RNA is upregulated in the ischemic retina. These observations support the hypothesis that ocular neovascularization is regulated by a diffusible factor and identify VEGF as a likely candidate for a retina-derived vascular permeability and angiogenesis factor in vivo.","PeriodicalId":77408,"journal":{"name":"The American journal of cardiovascular pathology","volume":"13 1","pages":"574-84"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78368026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 794
Index of Subjects 科目索引
The American journal of cardiovascular pathology Pub Date : 1994-06-01 DOI: 10.1079/BJN19940201
Angel Abbud-Madrid
{"title":"Index of Subjects","authors":"Angel Abbud-Madrid","doi":"10.1079/BJN19940201","DOIUrl":"https://doi.org/10.1079/BJN19940201","url":null,"abstract":"Comparison of the ileal and faecal digestibility of dietary amino acids in adult humans and evaluation of the pig as a model animal for digestion studies in man. 71, 29, 1994 Use of guanidinated dietary protein to measure losses of endogenous amino acids in poultry. 71, 515, 1994 Utilization of ileal digestible amino acids by growing pigs: isoleucine. 71, 531, 1994 Absorption of lysine and methionine from the proximal colon of the piglet. 71, 739, 1994","PeriodicalId":77408,"journal":{"name":"The American journal of cardiovascular pathology","volume":"18 1","pages":"2183 - 2195"},"PeriodicalIF":0.0,"publicationDate":"1994-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83633812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of monocyte chemotactic protein-1 by monocytes and endothelial cells exposed to thrombin. 凝血酶作用下单核细胞和内皮细胞趋化蛋白-1的表达。
The American journal of cardiovascular pathology Pub Date : 1994-05-01 DOI: 10.1007/978-1-4615-2952-1_30
F. Colotta, F. Sciacca, M. Sironi, W. Luini, M. Rabiet, A. Mantovani
{"title":"Expression of monocyte chemotactic protein-1 by monocytes and endothelial cells exposed to thrombin.","authors":"F. Colotta, F. Sciacca, M. Sironi, W. Luini, M. Rabiet, A. Mantovani","doi":"10.1007/978-1-4615-2952-1_30","DOIUrl":"https://doi.org/10.1007/978-1-4615-2952-1_30","url":null,"abstract":"","PeriodicalId":77408,"journal":{"name":"The American journal of cardiovascular pathology","volume":"1 1","pages":"975-85"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89202852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 230
c-k-ras and p53 mutations occur very early in adenocarcinoma of the lung. C-k-ras和p53突变在肺腺癌中很早就发生。
The American journal of cardiovascular pathology Pub Date : 1994-02-01 DOI: 10.1016/0169-5002(95)96453-3
Zhihua Li, Jian Zheng, Weiss Lm, Darryl Shibata
{"title":"c-k-ras and p53 mutations occur very early in adenocarcinoma of the lung.","authors":"Zhihua Li, Jian Zheng, Weiss Lm, Darryl Shibata","doi":"10.1016/0169-5002(95)96453-3","DOIUrl":"https://doi.org/10.1016/0169-5002(95)96453-3","url":null,"abstract":"","PeriodicalId":77408,"journal":{"name":"The American journal of cardiovascular pathology","volume":"55 1","pages":"303-9"},"PeriodicalIF":0.0,"publicationDate":"1994-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76968790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 139
The lining of textured surfaces in implantable left ventricular assist devices. An immunocytochemical and electronmicroscopic study. 植入式左心室辅助装置中纹理表面的衬里。免疫细胞化学和电子显微镜研究。
The American journal of cardiovascular pathology Pub Date : 1993-01-01
V Salih, T R Graham, C L Berry, A Coumbe, S C Smith, K Dasse, O H Frazier
{"title":"The lining of textured surfaces in implantable left ventricular assist devices. An immunocytochemical and electronmicroscopic study.","authors":"V Salih,&nbsp;T R Graham,&nbsp;C L Berry,&nbsp;A Coumbe,&nbsp;S C Smith,&nbsp;K Dasse,&nbsp;O H Frazier","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>The aim was to examine and identify some components of biological linings developed upon the textured surfaces of a circulatory assist device. The development of biological linings upon a textured surface circulatory assist device was evaluated in patients implanted for periods ranging from 84 to 132 days.</p><p><strong>Methods: </strong>Explanted devices were examined macroscopically. Light microscopy, transmission electron microscopy and immunocytochemistry techniques were employed to evaluate the histogenesis of the tissue deposits upon the device surfaces. Visible material was essentially limited to focal areas upon the static housing and the periphery of the pusher-plate diaphragm (Biomer).</p><p><strong>Results: </strong>Microscopy of the linings showed fibrin-rich areas with platelets, monocytes and few spindle-shaped surface cells. Central areas were composed of multiple layers of spindle-shaped cells separated, mainly, by collagen. Giant-cell foreign-body reaction to Biomer fibrils was seen.</p><p><strong>Conclusion: </strong>Transmission electron microscopy and immunocytochemistry indicated the presence of at least two cell populations: fibroblasts and smooth muscle-like cells, or 'myofibroblasts'. There was no evidence of endothelial cell presence.</p>","PeriodicalId":77408,"journal":{"name":"The American journal of cardiovascular pathology","volume":"4 4","pages":"317-25"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19292729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary aortoduodenal fistula caused by severe atherosclerosis, not by aneurysm. 原发性主动脉十二指肠瘘是由严重动脉粥样硬化引起的，而不是由动脉瘤引起的。
The American journal of cardiovascular pathology Pub Date : 1993-01-01
D M Gallagher, T Mendelson, W C Krupski, W E Finkbeiner
{"title":"Primary aortoduodenal fistula caused by severe atherosclerosis, not by aneurysm.","authors":"D M Gallagher,&nbsp;T Mendelson,&nbsp;W C Krupski,&nbsp;W E Finkbeiner","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Primary aortoduodenal fistula is an uncommon cause of massive upper gastrointestinal hemorrhage usually due to pressure erosion of an abdominal aortic aneurysm into the third portion of the duodenum. This report describes a case of a 59-year-old man who died of massive gastrointestinal hemorrhage due to a primary aortoduodenal fistula. This case is unique in that the fistula formed as a result of complex atherosclerotic disease of the abdominal aorta, with adventitial chronic inflammation and foreign body reaction against atheromatous plaque, and not from an aneurysm. We were unable to identify any other reports of aortoduodenal fistulas developing spontaneously in the absence of aneurysmal disease of the aorta.</p>","PeriodicalId":77408,"journal":{"name":"The American journal of cardiovascular pathology","volume":"4 4","pages":"281-5"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19291343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitral valve anomalies associated with Ebstein's malformation of the tricuspid valve. 二尖瓣畸形与Ebstein三尖瓣畸形有关。
The American journal of cardiovascular pathology Pub Date : 1993-01-01
L M Gerlis, S Y Ho, A E Sweeney
{"title":"Mitral valve anomalies associated with Ebstein's malformation of the tricuspid valve.","authors":"L M Gerlis,&nbsp;S Y Ho,&nbsp;A E Sweeney","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The original description of Ebstein's anomaly mentioned a mild deformity of the mitral valve. Reviews of large series of cases with Ebstein's malformation have, however, tended to omit reference to accompanying mitral valve malformations. We have compared the mitral valves in 19 specimens with Ebstein's malformation with those in 30 age-matched controls in order to determine the prevalence and nature of these anomalies. In the Ebstein's group the mitral valve was abnormal in 14 hearts with orificial anomalies in four, leaflet anomalies in 11, cord anomalies in 11 and papillary muscle anomalies in 13. In the control group, five cases showed mild shortening of the tendinous cords. Half of the changes found in the Ebstein's group were of moderate or significant degree suggesting a primary involvement of the mitral valve. In time, dynamic alterations within the left ventricle might become superimposed and contribute to the development of clinically significant lesions.</p>","PeriodicalId":77408,"journal":{"name":"The American journal of cardiovascular pathology","volume":"4 4","pages":"294-301"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19292727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diastolic dysfunction of stunned myocardium. 休克心肌舒张功能障碍。
The American journal of cardiovascular pathology Pub Date : 1993-01-01
T Ehring, R Schulz, J D Schipke, G Heusch
{"title":"Diastolic dysfunction of stunned myocardium.","authors":"T Ehring,&nbsp;R Schulz,&nbsp;J D Schipke,&nbsp;G Heusch","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The prolonged regional contractile failure of reperfused myocardium has usually been characterized in terms of systolic function, while only few reports on its diastolic function are available. None of these studies considered changes in the isovolumic diastole and the subsequent filling phase separately. Therefore, in the present study, the velocities of wall excursion during systole (Vsys), isovolumic diastole (Viso) and filling phase (Vfill) were determined in 12 anesthetized dogs. Additionally, post-ejection thickening (Pejt), a marker of left ventricular asynchrony, was determined. Measurements were performed under control conditions, during a 15 minute left circumflex (LCX) coronary artery occlusion (CAO) and at 10 minutes, 4 and 8 hours reperfusion. Heart rate, left ventricular pressure, and Vsys, Viso, Vfill, and Pejt of the anterior myocardium remained unchanged throughout the experiments. During CAO, systolic wall-thickening of the posterior wall was reversed to systolic wall-thinning. Upon reperfusion, Vsys started to recover (2.5 +/- 3.2 mm/s at 10 minutes) and gradually improved over 8 hours of reperfusion (4.6 +/- 3.2 mm/s at 4 hours, 6.4 +/- 1.5 mm/s at 8 hours). Viso became positive during CAO (9.4 +/- 7.1 mm/s vs. -5.6 +/- 3.9 mm/s under control conditions) and was unchanged at 10 minutes reperfusion (7.9 +/- 5.2 mm/s). After 4 hours and 8 hours of reperfusion, Viso recovered to 1.2 +/- 9.2 mm/s and -0.3 +/- 10.7 mm/s, respectively. Vfill also became positive during CAO (1.5 +/- 6.2 mm/s vs. -18 +/- 8.7 mm/s under control conditions). There was a quick recovery of Vfill (-9.4 +/- 7.5 mm/s) with the onset of reperfusion.(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":77408,"journal":{"name":"The American journal of cardiovascular pathology","volume":"4 4","pages":"358-66"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19292734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolated right-sided endocarditis in Hong Kong Chinese. 香港华人孤立性右侧心内膜炎。
The American journal of cardiovascular pathology Pub Date : 1993-01-01
P Dickens, A C Chan, K Y Lam
{"title":"Isolated right-sided endocarditis in Hong Kong Chinese.","authors":"P Dickens,&nbsp;A C Chan,&nbsp;K Y Lam","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Thirteen histologically-proven cases of endocarditis confined to the right side of the heart were found in 9406 consecutive autopsies. Eleven cases involved the tricuspid valve and two the atrial endocardium. Nine cases were in males and 4 in females. Only one case showed underlying valvular/endocardial disease. Eight cases were infective, with Staphylococcus aureus being the predominant organism, and 5 non-infective. For the infective cases, intravenous drug abuse was the commonest predisposing factor, and malignancy the commonest association for the non-infective. The commonest overall complication was lung abscess due to septic emboli in the 3 drug addicts, a common association in other reported series. These latter cases are particularly important to recognize, being generally more responsive to treatment than left-sided infective endocarditis.</p>","PeriodicalId":77408,"journal":{"name":"The American journal of cardiovascular pathology","volume":"4 4","pages":"367-70"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19293256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determination of regional myocardial blood flow using fluorescent microspheres. 荧光微球法测定局部心肌血流。
The American journal of cardiovascular pathology Pub Date : 1993-01-01
G E Austin, M B Tuvlin, D Martino-Salzman, R L Hunter, A G Justicz, N K Thompson, A C Brooks
{"title":"Determination of regional myocardial blood flow using fluorescent microspheres.","authors":"G E Austin,&nbsp;M B Tuvlin,&nbsp;D Martino-Salzman,&nbsp;R L Hunter,&nbsp;A G Justicz,&nbsp;N K Thompson,&nbsp;A C Brooks","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Determination of blood flow in tissues at risk for infarction is necessary for in vivo studies of the pathologic effects of vascular occlusion. Such blood flow measurements are traditionally carried out using radioactive microspheres. These are expensive and may pose a significant hazard to laboratory personnel. In addition, disposal of radioactive wastes, especially radioactive carcasses, is an increasingly expensive and inconvenient process. To avoid these problems, we have developed a modified procedure using fluorescent microspheres. To measure blood flow, spheres are injected intravenously and a blood sample is taken. Following cardiectomy, appropriate segments of left ventricular myocardium are digested with proteases to release the spheres, which are then purified through sucrose gradients. The spheres may be counted manually using an epifluorescence microscope, or by flow cytometry. Comparison of this method with the traditional radioactive microsphere procedure reveals similar results for the two methods. Fluorescent microspheres should provide a useful and accurate alternative method for measuring blood flow in studies of vascular disease.</p>","PeriodicalId":77408,"journal":{"name":"The American journal of cardiovascular pathology","volume":"4 4","pages":"352-7"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19292733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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