Alcohol Research : Current Reviews最新文献_第7页

Advances in Substance Abuse Prevention and Treatment Interventions Among Racial, Ethnic, and Sexual Minority Populations. 种族、民族和性少数群体药物滥用预防和治疗干预措施的进展。

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2016-01-01

Arthur W Blume

{"title":"Advances in Substance Abuse Prevention and Treatment Interventions Among Racial, Ethnic, and Sexual Minority Populations.","authors":"Arthur W Blume","doi":"","DOIUrl":"","url":null,"abstract":"Substance abuse research among racial, ethnic, and sexual minority populations historically has lagged behind that conducted with majority samples. However, interesting and potentially important advances in prevention, brief interventions, and treatment have been made in the last few years, at least among some minority populations, such as American Indian youth. New prevention efforts have focused on point-of-sale interventions for alcohol, as well as on family-unit interventions designed with subpopulation cultural values in mind. In addition, previously established evidence-based and culturally relevant interventions are being combined with computer technology. Empirical data support using brief interventions with patients of color in medical settings, capitalizing on teachable and reachable moments during a physical trauma or other health crisis. Finally, use of empirically supported treatment may be helpful, with a caveat that these interventions must appropriately match cultural traditions and respect the values of the clients. More research clearly is needed, especially among certain minority populations in the United States. A greater emphasis should be placed on developing novel, culturally grounded interventions in partnership with communities, in addition to adapting existing mainstream interventions for use by other cultures.","PeriodicalId":7736,"journal":{"name":"Alcohol Research : Current Reviews","volume":"38 1","pages":"47-54"},"PeriodicalIF":9.4,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10292392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Medications and Tailoring Treatment for Alcohol Use Disorder. 酒精使用障碍的药物治疗和针对性治疗进展

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2015-01-01

Chamindi Seneviratne, Bankole A Johnson

{"title":"Advances in Medications and Tailoring Treatment for Alcohol Use Disorder.","authors":"Chamindi Seneviratne, Bankole A Johnson","doi":"","DOIUrl":"","url":null,"abstract":"Alcohol use disorder (AUD) is a chronic heritable brain disorder with a variable clinical presentation. This variability, or heterogeneity, in clinical presentation suggests complex interactions between environmental and biological factors, resulting in several underlying pathophysiological mechanisms in the development and progression of AUD. Classifying AUD into subgroups of common clinical or pathological characteristics would ease the complexity of teasing apart underlying molecular mechanisms. Genetic association analyses have revealed several polymorphisms-small differences in DNA-that increase a person's vulnerability to develop AUD and other alcohol-related intermediate characteristics, such as severity of drinking, age of AUD onset, or measures of craving. They also have identified polymorphisms associated with reduced drinking. Researchers have begun utilizing these genetic polymorphisms to identify alcoholics who might respond best to various treatments, thereby enhancing the effectiveness of currently tested medications for treating AUD. This review compares the efficacy of medications tested for treatment of AUD with and without incorporating genetics. It then discusses advances in pre-clinical genetic and genomic studies that potentially could be adapted to clinical trials to improve treatment efficacy. Although a pharmacogenetic approach is promising, it is relatively new and will need to overcome many challenges, including inadequate scientific knowledge and social and logistic constraints, to be utilized in clinical practice. ","PeriodicalId":7736,"journal":{"name":"Alcohol Research : Current Reviews","volume":"37 1","pages":"15-28"},"PeriodicalIF":9.4,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33976989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Human Neuroconnectivity Research: Applications for Understanding Familial History Risk for Alcoholism. 人类神经连通性研究进展:用于了解酗酒家族史风险的应用。

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2015-01-01

Anita Cservenka, Gabriela Alarcón, Scott A Jones, Bonnie J Nagel

引用次数: 0

Advances in Diagnosis and Treatment of Fetal Alcohol Spectrum Disorders: From Animal Models to Human Studies. 胎儿酒精谱系障碍的诊断和治疗进展:从动物模型到人类研究

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2015-01-01

Nathen J Murawski, Eileen M Moore, Jennifer D Thomas, Edward P Riley

{"title":"Advances in Diagnosis and Treatment of Fetal Alcohol Spectrum Disorders: From Animal Models to Human Studies.","authors":"Nathen J Murawski, Eileen M Moore, Jennifer D Thomas, Edward P Riley","doi":"","DOIUrl":"","url":null,"abstract":"Prenatal alcohol exposure can cause a number of physical, behavioral, cognitive, and neural impairments, collectively known as fetal alcohol spectrum disorders (FASD). This article examines basic research that has been or could be translated into practical applications for the diagnosis or treatment of FASD. Diagnosing FASD continues to be a challenge, but advances are being made at both basic science and clinical levels. These include identification of biomarkers, recognition of subtle facial characteristics of exposure, and examination of the relation between face, brain, and behavior. Basic research also is pointing toward potential new interventions for FASD involving pharmacotherapies, nutritional therapies, and exercise interventions. Although researchers have assessed the majority of these treatments in animal models of FASD, a limited number of recent clinical studies exist. An assessment of this literature suggests that targeted interventions can improve some impairments resulting from developmental alcohol exposure. However, combining interventions may prove more efficacious. Ultimately, advances in basic and clinical sciences may translate to clinical care, improving both diagnosis and treatment. ","PeriodicalId":7736,"journal":{"name":"Alcohol Research : Current Reviews","volume":"37 1","pages":"97-108"},"PeriodicalIF":9.4,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33976992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Electrophysiological Research. 电生理研究进展。

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2015-01-01

Chella Kamarajan, Bernice Porjesz

引用次数: 0

Translating Alcohol Research: Opportunities and Challenges. 翻译酒精研究:机遇与挑战。

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2015-01-01

Angela M Batman, Michael F Miles

{"title":"Translating Alcohol Research: Opportunities and Challenges.","authors":"Angela M Batman, Michael F Miles","doi":"","DOIUrl":"","url":null,"abstract":"Alcohol use disorder (AUD) and its sequelae impose a major burden on the public health of the United States, and adequate long-term control of this disorder has not been achieved. Molecular and behavioral basic science research findings are providing the groundwork for understanding the mechanisms underlying AUD and have identified multiple candidate targets for ongoing clinical trials. However, the translation of basic research or clinical findings into improved therapeutic approaches for AUD must become more efficient. Translational research is a multistage process of stream-lining the movement of basic biomedical research findings into clinical research and then to the clinical target populations. This process demands efficient bidirectional communication across basic, applied, and clinical science as well as with clinical practitioners. Ongoing work suggests rapid progress is being made with an evolving translational framework within the alcohol research field. This is helped by multiple interdisciplinary collaborative research structures that have been developed to advance translational work on AUD. Moreover, the integration of systems biology approaches with collaborative clinical studies may yield novel insights for future translational success. Finally, appreciation of genetic variation in pharmacological or behavioral treatment responses and optimal communication from bench to bedside and back may strengthen the success of translational research applications to AUD. ","PeriodicalId":7736,"journal":{"name":"Alcohol Research : Current Reviews","volume":"37 1","pages":"7-14"},"PeriodicalIF":9.4,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33976987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utilization of Magnetic Resonance Imaging in Research Involving Animal Models of Fetal Alcohol Spectrum Disorders. 磁共振成像在胎儿酒精谱系障碍动物模型研究中的应用。

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2015-01-01

Xiaojie Wang, Christopher D Kroenke

{"title":"Utilization of Magnetic Resonance Imaging in Research Involving Animal Models of Fetal Alcohol Spectrum Disorders.","authors":"Xiaojie Wang, Christopher D Kroenke","doi":"","DOIUrl":"","url":null,"abstract":"It is well recognized that fetal alcohol exposure can profoundly damage the developing brain. The term fetal alcohol spectrum disorder (FASD) describes the range of deficits that result from prenatal alcohol exposure. Over the past two decades, researchers have used magnetic resonance imaging (MRI) as a noninvasive technique to characterize anatomical, physiological, and metabolic changes in the human brain that are part of FASD. As using animal models can circumvent many of the complications inherent to human studies, researchers have established and explored a number of models involving a range of species. Using MRI-based modalities, the FASD animal models have demonstrated decreased brain volume and abnormal brain shape, disrupted cellular morphology differentiation, altered neurochemistry, and blood perfusion. These animal studies have facilitated characterization of the direct effects of ethanol; in many cases identifying specific sequelae related to the timing and dose of exposure. Further, as a result of the ability to perform traditional (such as histological) analyses on animal brains following neuroimaging experiments, this work leads to improvements in the accuracy of our interpretations of neuroimaging findings in human studies. ","PeriodicalId":7736,"journal":{"name":"Alcohol Research : Current Reviews","volume":"37 1","pages":"39-51"},"PeriodicalIF":9.4,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33976990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroplasticity in Human Alcoholism: Studies of Extended Abstinence with Potential Treatment Implications. 人类酒精中毒的神经可塑性:长期戒酒与潜在治疗意义的研究。

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2015-01-01

George Fein, Valerie A Cardenas

{"title":"Neuroplasticity in Human Alcoholism: Studies of Extended Abstinence with Potential Treatment Implications.","authors":"George Fein, Valerie A Cardenas","doi":"","DOIUrl":"","url":null,"abstract":"Alcoholism is characterized by a lack of control over excessive alcohol consumption despite significant negative consequences. This impulsive and compulsive behavior may be related to functional abnormalities within networks of brain regions responsible for how we make decisions. The abnormalities may result in strengthened networks related to appetitive drive-or the need to fulfill desires-and simultaneously weakened networks that exercise control over behaviors. Studies using functional magnetic resonance imaging (fMRI) in abstinent alcoholics suggest that abstinence is associated with changes in the tone of such networks, decreasing resting tone in appetitive drive networks, and increasing resting tone in inhibitory control networks to support continued abstinence. Identifying electroencephalographic (EEG) measures of resting tone in these networks initially identified using fMRI, and establishing in longitudinal studies that these abstinence-related changes in network tone are progressive would motivate treatment initiatives to facilitate these changes in network tone, thereby supporting successful ongoing abstinence. ","PeriodicalId":7736,"journal":{"name":"Alcohol Research : Current Reviews","volume":"37 1","pages":"125-41"},"PeriodicalIF":9.4,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33976993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroplasticity and Predictors of Alcohol Recovery. 神经可塑性和酒精恢复的预测因子。

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2015-01-01

Dongju Seo, Rajita Sinha

引用次数: 0

Cognitive Neuroscience Approaches to Understanding Behavior Change in Alcohol Use Disorder Treatments. 认知神经科学方法理解酒精使用障碍治疗中的行为改变。

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2015-01-01

Nasir H Naqvi, Jon Morgenstern

{"title":"Cognitive Neuroscience Approaches to Understanding Behavior Change in Alcohol Use Disorder Treatments.","authors":"Nasir H Naqvi, Jon Morgenstern","doi":"","DOIUrl":"","url":null,"abstract":"Researchers have begun to apply cognitive neuroscience concepts and methods to study behavior change mechanisms in alcohol use disorder (AUD) treatments. This review begins with an examination of the current state of treatment mechanisms research using clinical and social psychological approaches. It then summarizes what is currently understood about the pathophysiology of addiction from a cognitive neuroscience perspective. Finally, it reviews recent efforts to use cognitive neuroscience approaches to understand the neural mechanisms of behavior change in AUD, including studies that use neural functioning to predict relapse and abstinence; studies examining neural mechanisms that operate in current evidence-based behavioral interventions for AUD; as well as research on novel behavioral interventions that are being derived from our emerging understanding of the neural and cognitive mechanisms of behavior change in AUD. The article highlights how the regulation of subcortical regions involved in alcohol incentive motivation by prefrontal cortical regions involved in cognitive control may be a core mechanism that plays a role in these varied forms of behavior change in AUD. We also lay out a multilevel framework for integrating cognitive neuroscience approaches with more traditional methods for examining AUD treatment mechanisms. ","PeriodicalId":7736,"journal":{"name":"Alcohol Research : Current Reviews","volume":"37 1","pages":"29-38"},"PeriodicalIF":9.4,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33976988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0