Revue francaise de transfusion et d'hemobiologie : bulletin de la Societe nationale de transfusion sanguine最新文献

{"title":"Comparative study of human monoclonal anti-D antibodies of IgG and IgM classes in tests with red cells of nonhuman primates","authors":"W.W. Socha ,&nbsp;A. Blancher ,&nbsp;J. Ruffié","doi":"10.1016/S1140-4639(05)80223-0","DOIUrl":"10.1016/S1140-4639(05)80223-0","url":null,"abstract":"<div><p>Forty-nine human anti-D (Rh_o) monoclonal antibodies of the IgG and IgM classes were tested with red blood cells of various nonhuman primates, from anthropoid apes to Prosimians, and significant differences in reactivity were observed among antibodies of two classes depending on taxonomic position of primate animals. By and large, higher percentage of IgM mAbs gave positive reactions with nonhuman primate red cells and, particularly, with blood of lower monkeys : Old and New Worlds monkeys and Prosimians, than did those of IgG class. Allotypic reactions with red cells of African apes were produced by majority of IgG mAbs but by very few IgM reagents. Some of those reactions defined epitopes related to human D, such as chimpanzee R^c and gorilla D^gor. By contrast, individual differences among Old World monkey species were revealed almost exclusively in tests using anti-D mAbs of IgM class. Some of the epitopes detected by these antibodies on the red cells of macaques are related to human D alloantigen, as confirmed by absorption experiments. Differences among mAbs evidenced in tests with nonhuman primate red cells reflect the complexity of the immune reactions to the human D antigen.</p></div><div><p>Quarante-neuf anticorps monoclonaux anti-D (Rh_o) de clase IgG et IgM ont été étudiés sur des globules rouges de diverses espèces de primates non hominiens, des singes anthropoïdes aux prosimiens. Des différences significatives de réactivité apparaissent, en fonction de la classe des anticorps, et de la position taxonomique des espèces étudiées. D'une manière générale, la proportion d'anticorps de classe IgM réactifs avec les globules rouges de singes non anthropoïdes est supérieure à celle observée avec les IgG anti-D. Les réactions allotypiques observées chez les singes anthropoïdes africains sont essentiellement le fait des anti-D de classe IgG, dont certains reconnaissent des alloantigènes proches de l'antigène D tels l'antigène R^c du chimpanzé, et D^gor du gorille. Parmi les anti-D seuls ceux de classe IgM révèlent un polymorphisme chez les singes de l'ancien monde. Des expériences d'absorption ont confirmé que les antigènes reconnus par certains anti-D sur les hématies de certains macaques rhésus partagent quelques épitopes avec l'antigène D humain. Les différences de réactivité révélées par l'étude des anti-D sur un large panel d'hématies de primates non hominiens reflètent la complexité de la réponse humorale contre l'antigène D.</p></div>","PeriodicalId":77360,"journal":{"name":"Revue francaise de transfusion et d'hemobiologie : bulletin de la Societe nationale de transfusion sanguine","volume":"36 6","pages":"Pages 485-497"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1140-4639(05)80223-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19110066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymorphisme HLA-DRB1 et HLA-DQB1 dans la population algérienne originaire d'Alger","authors":"D. Reviron,&nbsp;M. André,&nbsp;J.F. Cantaloube,&nbsp;P. Biagini,&nbsp;C. Chicheportiche,&nbsp;P. Mercier","doi":"10.1016/S1140-4639(05)80225-4","DOIUrl":"10.1016/S1140-4639(05)80225-4","url":null,"abstract":"<div><p>Le polymorphisme des gènes HLA-DRB1 et HLA-DQB1 a été étudié, chez 100 Algériens non apparentés originaires d'Alger, par P.C.R et oligosondes spécifiques de séquence. Comparée aux populations d'Europe Occidentale, cette population se caractérise par une fréquence haplotypique plus élevée des DRB1*03-DQB1*0201 (21,5 %) et une fréquence moins élevée des DRB1*0101-DQB1*0501 (2 %). Deux haplotypes inattendus ont été observés: DRB1*07-DQB1*0301 et DRB1*0406-DQB1*0402. DRB1*0402 est le sous-type DRB1*04 le plus fréquent. De plus l'étude de ces sujets nous a permis de mettre en évidence un rare allèle DQB1*0305 décrit uniquement chez un sujet sarde à ce jour.</p></div><div><p>The polymorphism of HLA-DRB1 and HLA-DQB1 genes in 100 unrelated Algerians from Alger was investigated using PCR amplification and oligonucleotide typing. Compared to western Europeans, this population shows a higher haplotypic frequency of HLA DRB1*03-DQB1*0201 (21,5 %) and a lower haplotypic frequency of DRB1*0101-DQB1*0501 (2 %). Two unexpected haplotypes are observed : DRB1*07-DQB1*0301 and DRB1*0406-DQB1*0402. DRB1*0402 is the most common subtype in the DRB1*04 group. Furthermore, we detected a rare DQB1*0305 allele, only found in a Sardinian subject until today.</p></div>","PeriodicalId":77360,"journal":{"name":"Revue francaise de transfusion et d'hemobiologie : bulletin de la Societe nationale de transfusion sanguine","volume":"36 6","pages":"Pages 509-516"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1140-4639(05)80225-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19110067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diminution du risque d'hépatite C post-transfusionnelle chez les patients soumis à une allogreffe de moelle osseuse","authors":"F. Norol ,&nbsp;B. Roche ,&nbsp;M.F. Saint Marc Girardin ,&nbsp;M. Kuentz ,&nbsp;L. Desforges ,&nbsp;C. Cordonnier ,&nbsp;N. Duedari ,&nbsp;J.P. Vernant","doi":"10.1016/S1140-4639(05)80224-2","DOIUrl":"10.1016/S1140-4639(05)80224-2","url":null,"abstract":"<div><p>L'incidence de l'hépatite C post-transfusionnelle a été étudiée chez une cohorte de patients allogreffés de moelle osseuse. Le risque de séroconversion HCV a été évalué relativement à la date de la greffe et aux tests de dépistage réalisés chez les donneurs de sang à cette période. Les anticorps anti-HCV (anti-HCV) ont été dépistés à l'aide de tests Elisa de deuxième génération et confirmés par des tests Riba de deuxième génération. Les bilans hépatiques ont été analysés. Sur 181 patients consécutifs, allogreffés de janvier 1987 à décembre 1991, 120 anti-HCV négatifs avant greffe et ayant au moins 6 mois de suivi postgreffe ont été considérés évaluables en terme de séroconversion HCV. Tous ces patients avaient reçu des produits sanguins déleucocytés et la plupart d'entre eux des concentrés unitaires de plaquettes. Avant la mise en place des tests de dépistage pour l'hépatite non-A, non-B, 14 % des patients avaient séroconverti (0,44 % par produit transfusé) ; après l'introduction de la recherche des marqueurs indirects [dosage de l'alanine amino-transférase (ALT) et dépistage des anticorps dirigés contre l'antigène du core du virus de l'hépatite B (anti-HBc)] l'incidence de séroconversion était de 4 % (0,26 % par produit). Le risque actuel, depuis la mise en place du dépistage de l'anti-HCV est de 1,6 % (0,03 % par produit transfusé). 6 patients sur 7 ayant séroconverti ont développé une hépatite chronique.</p></div><div><p>Post-transfusion hepatitis C incidence was studied in a series of patients with bone marrow allograft. The risk of HCV seroconversion was evaluated according to the date of grafting and the screening tests carried out in blood donors at this time. Anti-HCV antibodies were screened using Elisa tests of 2d generation and confirmed by Riba tests of 2d generation. Results were analysed. Out of 181 allografted patients from January 1987 to December 1991, 120 patients found anti-HCV negative prior to grafting, with at least six month post-transfusion follow-up were considered as evaluable in terms of HCV seroconversion.</p><p>All these patients had received leucodepleted blood products and the most of them platelet unit concentrates.</p><p>Prior to implementation of screening tests for non-A, non-B hepatitis, 14 % of patients had seroconverted (0,44 % per transfused product) ; after introduction of the screening for indirect markers (ALAT) and for antibodies directed against the antigen of hepatitis B virus core (anti-HBc), the seroconversion incidence was 4 % (0,26 % per product). At the present time, since the implementation of anti-HCV screening tests, the risk has reached 1,6 % (0,03 % per transfused product). 6 patients out of 7 having seroconverted have been developing chronic hepatitis.</p></div>","PeriodicalId":77360,"journal":{"name":"Revue francaise de transfusion et d'hemobiologie : bulletin de la Societe nationale de transfusion sanguine","volume":"36 6","pages":"Pages 499-507"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1140-4639(05)80224-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18517095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drépanocytaire homozygote en impasse transfusionnelle : évolution favorable sous hydroxyurée","authors":"A. Monsaingeon-Lion ,&nbsp;P.Y. Le Pennec ,&nbsp;F. Bridey ,&nbsp;M. Girard ,&nbsp;R. Ricard ,&nbsp;E. Gross ,&nbsp;G. Tchernia","doi":"10.1016/S1140-4639(05)80222-9","DOIUrl":"10.1016/S1140-4639(05)80222-9","url":null,"abstract":"<div><p>L'allo-immunisation, chez les drépanocytaires homozygotes peut conduire à des situations d'impasse transfusionnelle, posant des difficultés thérapeutiques majeures. Nous présentons le cas d'une jeune femme drépanocytaire homozygote, porteuse d'ulcères de jambe invalidants, chez laquelle un programme transfusionnel régulier a été débuté, afin d'envisager des greffes cutanées. L'apparition d'une immunisation multiple, posant le problème de la sélection d'unités compatibles, a conduit à l'arrêt des transfusions.</p><p>Un traitement par l'Hydroxyurée a été entrepris dans un deuxième temps, permettant une amélioration clinique qui a persisté en l'absence de toute transfusion, un an après le début du traitement.</p></div><div><p>Alloimmunization following multiple transfusions, a frequently observed complication in sickle cell anemia patients, may make subsequent transfusion attempts extremely hazardous.</p><p>The case of a young woman with sickle-cell anemia is reported ; she was hospitalized for the treatment of extensive invalidating leg ulcers. The transfusion program that was initiated as a prerequisite to skin allografts had to be stopped, due to rapid occurrence of multiple alloimmunization.</p><p>Broad spectrum alloantibodies precluded further selection of compatible blood units.</p><p>In an attempt to get round this impossibility, a treatment with Hydroxyurea was initiated in order to boost synthesis of F-hemoglobin. After one year under this treatment, the patient's clinical status has clearly improved without requiring any new blood transfusion.</p></div>","PeriodicalId":77360,"journal":{"name":"Revue francaise de transfusion et d'hemobiologie : bulletin de la Societe nationale de transfusion sanguine","volume":"36 6","pages":"Pages 477-484"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1140-4639(05)80222-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19110065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Index thematique","authors":"","doi":"10.1016/S1140-4639(05)80228-X","DOIUrl":"https://doi.org/10.1016/S1140-4639(05)80228-X","url":null,"abstract":"","PeriodicalId":77360,"journal":{"name":"Revue francaise de transfusion et d'hemobiologie : bulletin de la Societe nationale de transfusion sanguine","volume":"36 6","pages":"Page 546"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1140-4639(05)80228-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137350336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Informations","authors":"","doi":"10.1016/S1140-4639(05)80227-8","DOIUrl":"https://doi.org/10.1016/S1140-4639(05)80227-8","url":null,"abstract":"","PeriodicalId":77360,"journal":{"name":"Revue francaise de transfusion et d'hemobiologie : bulletin de la Societe nationale de transfusion sanguine","volume":"36 6","pages":"Page 545"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1140-4639(05)80227-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136559986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunoglobulines de recombinaison","authors":"D. Goossens","doi":"10.1016/S1140-4639(05)80226-6","DOIUrl":"10.1016/S1140-4639(05)80226-6","url":null,"abstract":"","PeriodicalId":77360,"journal":{"name":"Revue francaise de transfusion et d'hemobiologie : bulletin de la Societe nationale de transfusion sanguine","volume":"36 6","pages":"Pages 517-544"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1140-4639(05)80226-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19110068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"La nomenclature des actes d'immunohématologie : pour une évolution des pratiques biologiques et médicales","authors":"Ph. Rouger","doi":"10.1016/S1140-4639(05)80221-7","DOIUrl":"10.1016/S1140-4639(05)80221-7","url":null,"abstract":"","PeriodicalId":77360,"journal":{"name":"Revue francaise de transfusion et d'hemobiologie : bulletin de la Societe nationale de transfusion sanguine","volume":"36 6","pages":"Pages 475-476"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1140-4639(05)80221-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19110064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Index des auteurs","authors":"","doi":"10.1016/S1140-4639(05)80229-1","DOIUrl":"https://doi.org/10.1016/S1140-4639(05)80229-1","url":null,"abstract":"","PeriodicalId":77360,"journal":{"name":"Revue francaise de transfusion et d'hemobiologie : bulletin de la Societe nationale de transfusion sanguine","volume":"36 6","pages":"Pages 547-548"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1140-4639(05)80229-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137350335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enseignement en transfusion sanguine : de l'obligation de formation à l'accréditation","authors":"Ph. Rouger","doi":"10.1016/S1140-4639(05)80153-4","DOIUrl":"10.1016/S1140-4639(05)80153-4","url":null,"abstract":"","PeriodicalId":77360,"journal":{"name":"Revue francaise de transfusion et d'hemobiologie : bulletin de la Societe nationale de transfusion sanguine","volume":"36 5","pages":"Pages 411-416"},"PeriodicalIF":0.0,"publicationDate":"1993-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1140-4639(05)80153-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19248104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}