Natural immunity最新文献_第2页

Andrei Sulica, MD, 1938-2000. Andrei Sulica，医学博士，1938-2000。

Natural immunity Pub Date : 1998-09-01 DOI: 10.1159/000069443

Herberman

引用次数: 0

Clinical implications of natural killer cytotoxicity in patients with squamous cell carcinoma of the penis. 自然杀伤细胞毒性在阴茎鳞状细胞癌患者中的临床意义。

Natural immunity Pub Date : 1998-01-01 DOI: 10.1159/000069451

M M Campos, M H de Souza, V Pires, M A Scheiner, E B Esteves, A A Ornellas

{"title":"Clinical implications of natural killer cytotoxicity in patients with squamous cell carcinoma of the penis.","authors":"M M Campos, M H de Souza, V Pires, M A Scheiner, E B Esteves, A A Ornellas","doi":"10.1159/000069451","DOIUrl":"https://doi.org/10.1159/000069451","url":null,"abstract":"Impairment of natural cytotoxicity mediated by natural killer (NK) cells may play a role in the pathogenesis of penile carcinoma. The aim of this study was to examine the NK activity profile and its prognostic significance in patients with squamous cell carcinoma of the penis. The NK activity was measured in peripheral blood mononuclear cells (PBMCs) from 39 patients diagnosed histologically as having invasive squamous cell penile carcinoma and 4 patients with verrucous carcinoma of the penis. Of 39 patients with invasive squamous cell carcinoma, 4 had undergone previous penile amputation. According to the prognosis, the patients with invasive squamous cell carcinoma were divided into two groups: with metastasis and without metastasis. The patients were evaluated in relation to clinicopathologic variables using univariate analyses. NK cell activity was significantly decreased in all patients with penile carcinoma when compared with the control groups (p < 0.0001). There was no statistically significant difference between the groups with and without metastasis. We conclude that there is a decrease in NK activity in PBMCs from patients with penile carcinoma and that the presence of advanced disease or metastatic involvement is not responsible for this reduction.","PeriodicalId":77279,"journal":{"name":"Natural immunity","volume":"16 5-6","pages":"256-62"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000069451","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21890354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Apoptosis induced in T cells by human neuroblastoma cells: role of Fas ligand. 人神经母细胞瘤细胞诱导T细胞凋亡:Fas配体的作用。

Natural immunity Pub Date : 1998-01-01 DOI: 10.1159/000069452

G V Shurin, V Gerein, M T Lotze, E M Barksdale

引用次数: 24

Age-associated hematopoietic alterations in the spleen of tumor-bearing hosts. 荷瘤宿主脾脏年龄相关的造血改变。

Natural immunity Pub Date : 1998-01-01 DOI: 10.1159/000069448

V Khare, S M Singh, A Sodhi

{"title":"Age-associated hematopoietic alterations in the spleen of tumor-bearing hosts.","authors":"V Khare, S M Singh, A Sodhi","doi":"10.1159/000069448","DOIUrl":"https://doi.org/10.1159/000069448","url":null,"abstract":"The present investigation was carried out to study the effect of tumor growth on the spleen of an aged host. Dalton's lymphoma (DL), a spontaneous T cell lymphoma, was grown in mice of different age groups classified as young, adult or old on the basis of their reproductive status. Splenocytes obtained from normal and tumor-bearing young, adult and old mice were checked for an in vitro blastogenic response to concanavalin A (Con A), colony-forming ability and apoptosis. There was an enhanced apoptosis of splenocytes and a concomitant inhibition of splenocyte blastogenesis and their responsiveness to the mitogenic stimulus of Con A in aged mice. The counts of granulocyte macrophage- and macrophage-colony forming units were significantly enhanced in the spleen of tumor-bearing adult mice. It is proposed that the DL-growth-dependent increase in the size of the spleen in adult mice is due to an increased blastogenesis of splenocytes, which, however, may not be applicable in the case of old tumor-bearing mice. The role of splenic macrophages in the regulation of the functions of the spleen by macrophage-derived NO is shown.","PeriodicalId":77279,"journal":{"name":"Natural immunity","volume":"16 5-6","pages":"215-27"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000069448","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21890351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

50th annual meeting of the Society for Natural Immunity. 17th International Natural Killer Cell Workshop. Warrenton, Virginia, USA. October 17-21, 1998. Abstracts. 第50届自然免疫学会年会，第17届国际自然杀伤细胞研讨会。沃伦顿，弗吉尼亚州，美国1998年10月17日至21日。摘要。

Natural immunity Pub Date : 1998-01-01

引用次数: 0

Natural killer cell levels in older adult mice are gender-dependent: thyroxin is a gender-independent natural killer cell stimulant. 老年成年小鼠的自然杀伤细胞水平是性别依赖的:甲状腺素是一种性别独立的自然杀伤细胞兴奋剂。

Natural immunity Pub Date : 1998-01-01 DOI: 10.1159/000069441

M X Mahoney, N L Currier, S C Miller

{"title":"Natural killer cell levels in older adult mice are gender-dependent: thyroxin is a gender-independent natural killer cell stimulant.","authors":"M X Mahoney, N L Currier, S C Miller","doi":"10.1159/000069441","DOIUrl":"https://doi.org/10.1159/000069441","url":null,"abstract":"The present study aimed to quantitatively analyze the effects of thyroxin on natural killer (NK) cells in the bone marrow and spleen of older adult (6 months) mice of both sexes. Five intraperitoneal injections of thyroxin were administered over 10 days in an attempt to stimulate the virtually negligible levels of NK cells in these older mice. Immunoperoxidase labeling of an NK cell surface marker, together with a tetrachrome hematologic counterstain, permitted morphological microscopic identification of mature NK cells, distinct from all other hemopoietic and immune (lymphoid) cells in the spleen and bone marrow. The results revealed that in spite of similar total cell content in both the spleen and bone marrow in both sexes at this age, there were significant, gender-based differences in NK cells and various other hemopoietic and immune cells. NK cells in the 6-month-old female mice are significantly more abundant than those of males at this age. Granulocytes in females were also significantly more numerous in both the spleen and bone marrow than in males. By contrast, monocytes and nucleated erythroid cells were significantly more numerous in males of this age. In both sexes, at this postbreeding age, the immunostimulant, thyroxin, had the common effect of significantly elevating the levels of NK cells. Our results underline the need for considering the two basic parameters of age and gender, as potentially confounding variables, prior to therapeutic administration of thyroxin, and possibly a host of hormones, cytokines and other regulators of hemopoietic and immune phenomena.","PeriodicalId":77279,"journal":{"name":"Natural immunity","volume":"16 4","pages":"165-74"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000069441","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21234453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Lack of natural killer cell precursors in fetal liver of Ikaros knockout mutant mice. Ikaros基因敲除突变小鼠胎儿肝脏缺乏自然杀伤细胞前体。

Natural immunity Pub Date : 1998-01-01 DOI: 10.1159/000069438

S S Boggs, M Trevisan, K Patrene, K Geogopoulos

引用次数: 50

Circadian secretions of IL-2, IL-12, IL-6 and IL-10 in relation to the light/dark rhythm of the pineal hormone melatonin in healthy humans. 健康人群中IL-2、IL-12、IL-6和IL-10的昼夜节律分泌与松果体褪黑激素的光/暗节律相关

Natural immunity Pub Date : 1998-01-01 DOI: 10.1159/000069464

P Lissoni, F Rovelli, F Brivio, O Brivio, L Fumagalli

{"title":"Circadian secretions of IL-2, IL-12, IL-6 and IL-10 in relation to the light/dark rhythm of the pineal hormone melatonin in healthy humans.","authors":"P Lissoni, F Rovelli, F Brivio, O Brivio, L Fumagalli","doi":"10.1159/000069464","DOIUrl":"https://doi.org/10.1159/000069464","url":null,"abstract":"It has been demonstrated that cytokine activities are under neuroendocrine control, recently mainly exerted by the pineal gland through the circadian secretion of its main hormone melatonin (MLT). It is mainly released during the night, but at present it is still unclear which relation exists between MLT and the circadian secretion of cytokines. This study was performed to evaluate the circadian secretion of IL-2, IL-6, IL-10 and IL-12 in relation to that of MLT. The study included 10 healthy volunteers whose venous blood samples were collected at 8 a.m., noon, 4 p.m., 8 p.m., 1 a.m. and 4 a.m. The mean levels of MLT were significantly higher during the night than during the light phase of the day. Similarly, IL-2 mean levels significantly increased during the night. IL-6 mean values were higher during the light period of the day without, however, any significant differences with respect to the nocturnal mean levels. Finally, no substantial circadian variation was seen in IL-10 and IL-12 mean concentrations. These results show that IL-2 secretion increases during the night, concomitantly to that of the pineal hormone MLT, whereas there is no evidence of a circadian secretion for the other cytokines. Since the pineal gland has been proven to stimulate IL-2 endogenous production, the nocturnal increase in IL-2 blood concentrations could depend at least in part on the promoting action of MLT, whose release increases during the dark period of the day.","PeriodicalId":77279,"journal":{"name":"Natural immunity","volume":"16 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000069464","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20701328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 99

CSF-1 (M-CSF) enhances the inflammatory response of fibronectin-primed macrophages: pathways involved in activation of the cytokine network. CSF-1 (M-CSF)增强了纤维连接蛋白引发的巨噬细胞的炎症反应:参与细胞因子网络激活的途径。

Natural immunity Pub Date : 1998-01-01 DOI: 10.1159/000069449

S G Kremlev, A I Chapoval, R Evans

{"title":"CSF-1 (M-CSF) enhances the inflammatory response of fibronectin-primed macrophages: pathways involved in activation of the cytokine network.","authors":"S G Kremlev, A I Chapoval, R Evans","doi":"10.1159/000069449","DOIUrl":"https://doi.org/10.1159/000069449","url":null,"abstract":"We have previously reported that the priming of thioglycollate-elicited peritoneal macrophages (PMphi), as a representative population of mononuclear phagocytes (MNP), by macrophage-colony-stimulating factor (M-CSF or CSF-1) rendered these cells more susceptible to secondary stimulation by extracellular matrix (ECM) proteins, in particular fibronectin (FN), and that at least two beta1 integrins, VLA 4 (alpha4beta1 or CD49d) and VLA 5 (alpha5beta1 or CD49e), regulate IL-6 gene expression when PMphi come into contact with FN. In this report, we focused our attention on resident PMphi, as a more mature/differentiated MNP subpopulation. By using granulocyte-macrophage colony-stimulating factor (GM-CSF)- and IL-6-knockout (null) mice, we demonstrated that the cooperative effect between CSF-1 and FN in IL-6 release was a result of a sequential stimulation of the GM-CSF, but not the TNF-alpha, gene via interaction with VLA 5. We also showed that regardless of the presence or absence of CSF-1 or FN, IL-6 inhibits GM-CSF and TNF-alpha gene expression in an autocrine manner. The observed effects were specific because CSF-1 enhanced VLA 5 expression and blocking FN-treated resident PMphi in vitro with VLA 5 monoclonal antibodies inhibited the IL-6 response. We found that treatment of resident PMphi with the protein kinase C inhibitor, staurosporine, and the activator, phorbol myristate acetate (PMA), resulted in marked modulation of either FN- or FN/CSF-1-induced cytokine release. An increased level of VLA 5 expression was observed in PMA-treated resident PMphi. We concluded that in inflammatory processes, CSF-1 drives a number of pathways involved in the regulation of the expression of several genes and renders MNP highly susceptible to stimulation by ECM proteins that transform the MNP into secretory inflammatory cells.","PeriodicalId":77279,"journal":{"name":"Natural immunity","volume":"16 5-6","pages":"228-43"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000069449","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21890352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Natural killer cell frequency and function in Yorkshire pigs selectively bred for high or low antibody and cell-mediated immune response. 高抗体或低抗体和细胞介导免疫反应的约克郡猪的自然杀伤细胞频率和功能。

Natural immunity Pub Date : 1998-01-01 DOI: 10.1159/000069437

C Raymond, B Wilkie, B Mallard, M Quinton

{"title":"Natural killer cell frequency and function in Yorkshire pigs selectively bred for high or low antibody and cell-mediated immune response.","authors":"C Raymond, B Wilkie, B Mallard, M Quinton","doi":"10.1159/000069437","DOIUrl":"https://doi.org/10.1159/000069437","url":null,"abstract":"Porcine NK cells are small to medium-size lymphocytes having a variety of functions that may include the regulation of immune response. Thus frequency and function of NK cells were examined in generations 6 and 8 (G6, G8) of pigs selectively bred for high (H) and low (L) antibody and cell-mediated immune response (CMIR). Using the monoclonal antibody 5C6 as a pan NK phenotype marker and target cell binding and lysis as assays of function, it was found that H and L immune response pigs had high and low NK cell frequency, respectively, at G6 and G8. Function of NK cells differed by line, with the control (unselected) pigs being higher (with respect to target cell binding) or similar (with respect to lytic activity) to H which were higher than the L line pigs. Frequency of NK cells after primary immunization was in significant negative correlation with antibody after secondary immunization with hen egg white lysozyme (HEWL). Therefore, simultaneous selection for antibody and CMIR altered the frequency and function of NK cells in pigs with C > or = H > L.","PeriodicalId":77279,"journal":{"name":"Natural immunity","volume":"16 4","pages":"127-36"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000069437","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21234449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10