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Natural immunity最新文献

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Prospects and advances in gene therapy. 基因治疗的前景与进展。
Natural immunity Pub Date : 1994-03-01
E Lotzová
{"title":"Prospects and advances in gene therapy.","authors":"E Lotzová","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77279,"journal":{"name":"Natural immunity","volume":"13 2-3","pages":"63-4"},"PeriodicalIF":0.0,"publicationDate":"1994-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19164163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytokine gene transduction in tumor cells: interleukin (IL)-2 or IL-4 gene transfer in human melanoma cells. 肿瘤细胞中的细胞因子基因转导:白细胞介素(IL)-2或IL-4基因在人类黑色素瘤细胞中的转移。
Natural immunity Pub Date : 1994-03-01
C Melani, C Chiodoni, F Arienti, C Maccalli, J Sule-Suso, A Anichini, M P Colombo, G Parmiani
{"title":"Cytokine gene transduction in tumor cells: interleukin (IL)-2 or IL-4 gene transfer in human melanoma cells.","authors":"C Melani,&nbsp;C Chiodoni,&nbsp;F Arienti,&nbsp;C Maccalli,&nbsp;J Sule-Suso,&nbsp;A Anichini,&nbsp;M P Colombo,&nbsp;G Parmiani","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cytokine gene transfer into mouse tumor cells has been shown to stimulate a strong immune response resulting in the rejection of the transduced tumor when injected in vivo. Therefore, retroviral vectors containing the human interleukin (IL)-2 or IL-4 gene have been constructed to transduce human melanoma cells to explore whether their immunogenicity can be increased both in vitro and in vivo. Our preliminary results indicate that retroviral vectors can efficiently transduce the IL-2 and or IL-4 gene into melanoma clones, inducing production of either cytokine in the range of 0.5-2 ng/ml/10(5) cells in 48-72 h. No modifications of the growth rate, morphology and antigenicity of the transduced tumor cells were found.</p>","PeriodicalId":77279,"journal":{"name":"Natural immunity","volume":"13 2-3","pages":"76-84"},"PeriodicalIF":0.0,"publicationDate":"1994-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19164164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antitumor potential of interferon-gamma: retroviral expression of mouse interferon-gamma cDNA in two kinds of highly metastatic mouse tumor lines reduces their tumorigenicity. 干扰素- γ的抗肿瘤潜能:在两种高度转移的小鼠肿瘤细胞系中逆转录病毒表达小鼠干扰素- γ cDNA可降低其致瘤性。
Natural immunity Pub Date : 1994-03-01
K Yanagihara, T Seyama, Y Watanabe
{"title":"Antitumor potential of interferon-gamma: retroviral expression of mouse interferon-gamma cDNA in two kinds of highly metastatic mouse tumor lines reduces their tumorigenicity.","authors":"K Yanagihara,&nbsp;T Seyama,&nbsp;Y Watanabe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The antitumor effects of interferon (IFN)-gamma were examined in two types of malignant metastatic mouse tumor cell lines following their transfection with the IFN-gamma gene by retroviral gene transfer. In both ovarian and lung tumor lines, but more markedly in the latter, subcutaneous (s.c.) tumor progression of the IFN-gamma-producing cells was profoundly suppressed in the normal syngeneic as well as in athymic nude mice. In addition, experimental metastasis via the tail vein of the IFN-gamma producers was also suppressed. Lung tumor suppression was abolished by X-irradiation of the syngeneic mice or by the administration of antiasialoganglioside GM1 antibodies into the nude mice. These results suggest that tumor suppression is due to the effect of the tumor-derived IFN-gamma on the host antitumor mechanisms including natural killer cells. Moreover, tumorigenicity of several unrelated tumor cells was significantly reduced when s.c. injected as a mixture with the apparently benign IFN-gamma-producing lung tumor cells, so that such 'non-malignant' IFN-gamma-producing cells may have therapeutic benefit against certain other malignant tumors.</p>","PeriodicalId":77279,"journal":{"name":"Natural immunity","volume":"13 2-3","pages":"102-12"},"PeriodicalIF":0.0,"publicationDate":"1994-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19164855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Natural killer cells and gene therapy: potential of gene transfection for optimizing effector cell functions and for targeting gene products into tumor metastases. 自然杀伤细胞和基因治疗:基因转染优化效应细胞功能和靶向基因产物进入肿瘤转移的潜力。
Natural immunity Pub Date : 1994-03-01
R H Goldfarb, T L Whiteside, P H Basse, W C Lin, N Vujanovic, R B Herberman
{"title":"Natural killer cells and gene therapy: potential of gene transfection for optimizing effector cell functions and for targeting gene products into tumor metastases.","authors":"R H Goldfarb,&nbsp;T L Whiteside,&nbsp;P H Basse,&nbsp;W C Lin,&nbsp;N Vujanovic,&nbsp;R B Herberman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Fluorescently labeled, adoptively transferred interleukin (IL)-2 activated natural killer (A-NK) cells have the ability to selectively accumulate within established pulmonary or hepatic metastases, binding to tumor cells and/or to microvascular endothelial cells. A-NK cells have also been shown to exert antimetastatic therapy in animal models and in the clinic. Transfection of genes for cytokines or possibly other molecules has the potential to improve the therapeutic potency and efficacy of the effector cells. Gene transfection to induce autocrine production of IL-2 and/or other cytokines is expected to augment their antimetastatic activities, while avoiding toxicity from systemic administration of high doses of cytokines. An alternative or complementary strategy for gene therapy is to transfect A-NK cells with genes for cytotoxic molecules, to selectively target them to metastatic sites.</p>","PeriodicalId":77279,"journal":{"name":"Natural immunity","volume":"13 2-3","pages":"131-40"},"PeriodicalIF":0.0,"publicationDate":"1994-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19164856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunotherapy of tumor metastasis via gene therapy. 通过基因治疗对肿瘤转移的免疫治疗。
Natural immunity Pub Date : 1994-03-01
A Porgador, M Feldman, L Eisenbach
{"title":"Immunotherapy of tumor metastasis via gene therapy.","authors":"A Porgador,&nbsp;M Feldman,&nbsp;L Eisenbach","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Active cellular immunotherapy of cancer, via gene-modified tumor cells, may develop to an effective treatment modality. Here we discuss some of the cytokines used in gene transfer, the importance of MHC class I expression on tumor cells used as vaccines, the relevance of experimental tumor systems to human tumors, and the use of live versus irradiated vaccines. Possible methods for effective gene transfer and possible protocols for immunotherapy studies are presented. Our studies in two highly metastatic murine tumors, the Lewis lung carcinoma (3LL) and the B16 melanoma, and immune mechanisms involved in immunotherapy of metastasis are summarized.</p>","PeriodicalId":77279,"journal":{"name":"Natural immunity","volume":"13 2-3","pages":"113-30"},"PeriodicalIF":0.0,"publicationDate":"1994-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19164858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nature and potential of the reactive response to mouse mammary adenocarcinoma cells engineered with interleukin-2, interleukin-4 or interferon-gamma genes. 白细胞介素-2、白细胞介素-4或干扰素- γ基因工程化小鼠乳腺腺癌细胞反应性反应的性质和潜力。
Natural immunity Pub Date : 1994-03-01
P Musiani, A Modesti, M Brunetti, A Modica, P Vitullo, A Gulino, M C Bosco, M P Colombo, P Nanni, F Cavallo
{"title":"Nature and potential of the reactive response to mouse mammary adenocarcinoma cells engineered with interleukin-2, interleukin-4 or interferon-gamma genes.","authors":"P Musiani,&nbsp;A Modesti,&nbsp;M Brunetti,&nbsp;A Modica,&nbsp;P Vitullo,&nbsp;A Gulino,&nbsp;M C Bosco,&nbsp;M P Colombo,&nbsp;P Nanni,&nbsp;F Cavallo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A spontaneous mammary adenocarcinoma of BALB/c mice was transduced with the murine interleukin (IL)-2, IL-4, and interferon (IFN)-gamma genes. The ability of clones releasing IL-2, IL-4 or IFN-gamma to form tumors after s.c. challenge was compared to the TS/A parental cells (TS/A-pc) and to cells transduced with the neomycin resistance gene alone. Cytokine-gene-transduced clones activated a strong inflammatory reaction. The elicited by IL-2 and IL-4-gene-transduced cells efficiently led to tumor rejection. This reaction depended on the activation of several cell mechanisms, those classed as nonspecific being predominant. The repertoire of reactive leukocytes recruited in the reaction varies as a function of the secreted cytokine. The growth of a secondary contralateral TS/A-pc challenge after clone rejection was significantly impaired.</p>","PeriodicalId":77279,"journal":{"name":"Natural immunity","volume":"13 2-3","pages":"93-101"},"PeriodicalIF":0.0,"publicationDate":"1994-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19164167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor-cell-targeted cytokine gene transfer in experimental models for cancer therapy. 肿瘤细胞靶向细胞因子基因转移在肿瘤治疗实验模型中的应用。
Natural immunity Pub Date : 1994-03-01
H Hock, M Dorsch, G Richter, U Kunzendorf, S Krüger-Krasagakes, T Blankenstein, Z Qin, T Diamantstein
{"title":"Tumor-cell-targeted cytokine gene transfer in experimental models for cancer therapy.","authors":"H Hock,&nbsp;M Dorsch,&nbsp;G Richter,&nbsp;U Kunzendorf,&nbsp;S Krüger-Krasagakes,&nbsp;T Blankenstein,&nbsp;Z Qin,&nbsp;T Diamantstein","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The genetic manipulation of tumor cells to express immunostimulatory molecules provides a current approach for the analysis of immune reactions against tumor cells in vivo. Experiments with multiple cytokines have demonstrated that an array of different host effector cells can be recruited by different cytokines in vivo, but more studies are necessary to distinguish cytokine-specific effects from as yet uncharacterized influences of different tumor models. A technically feasible clinical application of this approach is to be seen in the generation of vaccines by introducing such immunostimulatory genes into cancer cells and boosting systemic immune reactions against the unmodified cells. The experimental basis of these vaccination studies is critically discussed.</p>","PeriodicalId":77279,"journal":{"name":"Natural immunity","volume":"13 2-3","pages":"85-92"},"PeriodicalIF":0.0,"publicationDate":"1994-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19164165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-efficiency gene transfer employing adenovirus-polylysine-DNA complexes. 利用腺病毒-聚赖氨酸- dna复合物的高效基因转移。
Natural immunity Pub Date : 1994-03-01
D T Curiel
{"title":"High-efficiency gene transfer employing adenovirus-polylysine-DNA complexes.","authors":"D T Curiel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Gene transfer may be accomplished via the receptor-mediated endocytosis pathway employing molecular conjugate vectors. These synthetic agents consist of two covalently linked functional components: a DNA-binding domain and a domain that is a ligand for a cell surface receptor. Recognition of the ligand by its appropriate cell surface receptor allows cellular internalization of the complex via receptor-mediated endocytosis. Since conjugates are limited because they lack a specific mechanism to accomplish cell vesicle escape, and since adenoviruses possess such a mechanism, we derived conjugates that incorporate adenovirus into their functional design. The adenovirus-polylysine conjugates mediated high-efficiency gene transfer. In this configuration, the viral moiety functions both as an endosomolysis agent and also as the ligand domain of the conjugate. To determine whether the adenovirus component of the conjugate could function exclusively in the former capacity, combination conjugates were constructed containing an alternative ligand in conjugation with an incorporated adenovirus. Internalization of these conjugates via the receptor for the alternative ligand in cells lacking adenovirus receptors demonstrated that the adenovirus moiety could function to enhance conjugate entry in this context. Thus, it is possible to design highly efficient molecular conjugate vectors that possess specific and distinct mechanisms to accomplish cellular internalization and cell vesicle escape.</p>","PeriodicalId":77279,"journal":{"name":"Natural immunity","volume":"13 2-3","pages":"141-64"},"PeriodicalIF":0.0,"publicationDate":"1994-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19164857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytokine gene therapy: a new strategy for the management of cancer patients. 细胞因子基因治疗:癌症患者治疗的新策略。
Natural immunity Pub Date : 1994-03-01
R Foa, A Guarini, A Cignetti, K Cronin, F Rosenthal, B Gansbacher
{"title":"Cytokine gene therapy: a new strategy for the management of cancer patients.","authors":"R Foa,&nbsp;A Guarini,&nbsp;A Cignetti,&nbsp;K Cronin,&nbsp;F Rosenthal,&nbsp;B Gansbacher","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cytokine gene therapy has recently become a new potential prospect in the management of cancer patients. This has stemmed from clinical considerations based on the evidence that high-dose interleukin-2 (IL-2) may be effective in a proportion of patients, that foreign genetic material may be successfully inserted into the genome of normal and neoplastic cells, and by extensive studies in experimental models which have shown that cytokine-gene-transduced tumor cells may reveal a diminished or abolished tumorigenicity. Evidence has also been provided that the IL-2 released constitutively by engineered tumor cells may induce the generation of specific cytotoxic T lymphocytes and of an antitumor memory response. Here, we will review the data which have led to the activation of the first pilot vaccination protocols with IL-2 gene-transduced allogeneic cell lines for advanced-stage melanoma and renal cell carcinoma patients. New directions in delivery modalities, as well as future strategies will also be discussed.</p>","PeriodicalId":77279,"journal":{"name":"Natural immunity","volume":"13 2-3","pages":"65-75"},"PeriodicalIF":0.0,"publicationDate":"1994-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19164162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The natural killer cell and its interaction with immune and non-immune cells. 2nd Meeting of the Society for Natural Immunity. Taormina, Italy, May 25-28, 1994. Abstracts. 自然杀伤细胞及其与免疫细胞和非免疫细胞的相互作用。自然免疫学会第二次会议。1994年5月25日至28日，意大利陶尔米纳。摘要。
Natural immunity Pub Date : 1994-01-01
{"title":"The natural killer cell and its interaction with immune and non-immune cells. 2nd Meeting of the Society for Natural Immunity. Taormina, Italy, May 25-28, 1994. Abstracts.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77279,"journal":{"name":"Natural immunity","volume":"13 4","pages":"173-236"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18915608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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