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Berberine Attenuated Aging-Accelerating Effect of High Temperature in Drosophila Model. 小檗碱在果蝇高温模型中的延缓衰老作用。

American Journal of Plant Sciences Pub Date : 2014-02-01 DOI: 10.4236/ajps.2014.53037

Valeriya Navrotskaya, Gregory Oxenkrug, Lyudmila Vorobyova, Paul Summergrad

{"title":"Berberine Attenuated Aging-Accelerating Effect of High Temperature in Drosophila Model.","authors":"Valeriya Navrotskaya, Gregory Oxenkrug, Lyudmila Vorobyova, Paul Summergrad","doi":"10.4236/ajps.2014.53037","DOIUrl":"https://doi.org/10.4236/ajps.2014.53037","url":null,"abstract":"We have observed that berberine prolonged life span and improved viability of pupae and climbing activity of imagoes of wild-type Drosophila melanogaster maintained at 23°C. As a continuation of our studies of berberine effect on life span, we were interested to evaluate the effect of berberine of life span in flies maintained at a higher temperature (28°C) known to accelerate aging in wild type flies. Considering that genetically or pharmacologically induced deficiency of TRP conversion into KYN prolonged life span in a Drosophila model, we compared the effects of berberine, a powerful inhibitor of kynurenine (KYN) formation from tryptophan (TRP), on life span in wild type and in Drosophila melanogaster mutants (vermilion) with deficient TRP-KYN metabolism maintained at 23°C and 28°C. High (28°C) ambient temperature decreased life span in both wild type and vermilion flies. Aging accelerating effect of high temperature was more pronounced in Oregon than in vermilion flies (-60% vs. -40% decrease of mean life span, resp). Berberine attenuated the aging-accelerating effect of high temperature. Effect of berberine was more pronounced in Oregon (+46%) than in vermilion (+22%) flies. The obtained data suggested the possible involvement of TRP-KYN metabolism in the aging-acceleration effect of the high temperature and in protective effect of berberine.","PeriodicalId":7726,"journal":{"name":"American Journal of Plant Sciences","volume":"5 3","pages":"275-278"},"PeriodicalIF":0.0,"publicationDate":"2014-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33898358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Berberine Prolongs Life Span and Stimulates Locomotor Activity of Drosophila melanogaster. 小檗碱延长果蝇寿命并刺激果蝇运动活动。

American Journal of Plant Sciences Pub Date : 2012-07-01 DOI: 10.4236/ajps.2012.327123

V V Navrotskaya, G Oxenkrug, L I Vorobyova, P Summergrad

{"title":"Berberine Prolongs Life Span and Stimulates Locomotor Activity of Drosophila melanogaster.","authors":"V V Navrotskaya, G Oxenkrug, L I Vorobyova, P Summergrad","doi":"10.4236/ajps.2012.327123","DOIUrl":"https://doi.org/10.4236/ajps.2012.327123","url":null,"abstract":"Drosophila melanogaster mutants with deficient kynurenine (KYN) formation from tryptophan (TRP) have longer life span than wild type flies. Administration of alpha-methyl-TRP and 5-methyl-TRY, the inhibitors of TRP-KYN metabolism, prolonged life span in wild-type flies. Both inhibitors are not available for human use. Berberine, an isoquinoline alkaloid isolated from Berberis aristata, is known as the herb widely used in traditional Chinese and Indian medicine. Berberin is a strong inhibitor of the enzyme catalyzing TRP conversion into KYN. Considering this particular feature we investigated the effect of berberine on life- and health-span in wild-type Drosophila melanogaster. The results of our study showed that Berberine extended mean, median and maximum life span of female flies. Berberine did not affect the number of pupae of filial generation and decreased their lethality. Berberine increased locomotor activity (vertical climbing). The results of the study suggest that berberine prolongs life- and improves health-span of Drosophila melanogaster. Berberine might be a candidate drug for prevention and treatment of aging and aging-associated medical and psychiatric disorders.","PeriodicalId":7726,"journal":{"name":"American Journal of Plant Sciences","volume":"3 7A","pages":"1037-1040"},"PeriodicalIF":0.0,"publicationDate":"2012-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4236/ajps.2012.327123","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33898357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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