A P Tormene, D Doro, E Mantovani, S Fabris, F Moro
{"title":"Electrophysiological findings in anterior ischemic optic neuropathy.","authors":"A P Tormene, D Doro, E Mantovani, S Fabris, F Moro","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Electroretinograms (ERG), oscillatory potentials (OP) and pattern reversal visual evoked potentials (VEP) were performed in nine patients (mean age 66 years) with unilateral long-standing anterior ischemic optic neuropathy (AION) and in an age matched control group. Normal ERGs but bilateral impaired OPs were observed in virtually all AION affected patients. Regardless of visual acuity, VEP amplitude reduction was found in all eyes with AION and in controlateral eyes of patients with associated systemic conditions such as diabetes mellitus, arterial hypertension and atherosclerosis. A normal latency of VEP was found bilaterally in AION affected patients; however no correlation between VEP latency and visual acuity or fields could be established. Our results seem to indicate moderate ischemic damage to the retina and to the axons of the optic pathways in patients with AION.</p>","PeriodicalId":77261,"journal":{"name":"Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)","volume":"12 1-3","pages":"76-9"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13909214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anatomy of the optic nerve in elderly men.","authors":"P F Munari, R De Caro, D Colletti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The microscopic and ultrastructural modifications of glial and mesenchymal components of the optic nerve in the physiologic aging were studied in 182 human optic nerves. According to the age of subjects, a modification of topography of astrocytes was observed. In the 7th-8th decade, the axons of the optic nerve showed some phenomena of swelling and axonal degeneration. During the years, the central artery of retina showed an evident hyperplasia of intima and an increase of collagen of the media. While the connective tissue was good represented by the end of the 1st decade in the central vein of retina, the muscular tissue was almost absent. The interfascicular connective tissue increased considerably in the aging.</p>","PeriodicalId":77261,"journal":{"name":"Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)","volume":"12 1-3","pages":"13-6"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13910067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Aging and drug-induced optic nerve side effects.","authors":"M T Dorigo, R Altafini","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In this review the authors attempt to explain how aging can determine optic nerve neuropathy and modify the pharmacodynamics and pharmacokinetics of a drug. The major causes of increased drug toxicity in the elderly are discussed. The most frequently used drugs that can cause optic nerve side effects are reported. The authors stress problems related to drug administration in the elderly and push towards the study of this aspect of geriatric ophthalmology.</p>","PeriodicalId":77261,"journal":{"name":"Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)","volume":"12 1-3","pages":"24-7"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13812297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anterior ischemic optic neuropathy and aging.","authors":"F Moro, D Doro, E Mantovani","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The records of 293 patients admitted to Padua University Eye Clinic with diagnosis of optic neuropathy were reviewed. Age and sex distribution of different types of optic neuropathies were analyzed. 84 patients (28.7%) with a mean age of 61.9 years had anterior ischemic optic neuropathy (AION). The mean follow up of these patients was 3 years. In less than 30% of patients stabilized visual acuity of the first affected eye was better than 20/200; however, patients younger than 65 showed a significantly (p less than 0.01) better visual acuity than patients older than 64. Involvement of the second eye was found in 26 patients with AION (30.9%), of whom only five were considered idiopathic. The latency before controlateral eye involvement was significantly (p less than 0.05) shorter in patients over 64 years of age than in the younger group. Commonly known associated conditions such as giant cell arteritis (3.6%), arterial hypertension (34.5%), diabetes mellitus (10.7%), both arterial hypertension and diabetes (8.3%), migraine (7.2%) or intracapsular cataract extraction (1.2%) were considered. The frequency of a number of risk factors was found out in patients with arterial hypertension and/or diabetes and in patients with idiopathic AION. Symptoms or signs of ischemic cardiopathy and/or peripheral nonarteritic vascular disease, TIAs prior to AION onset, elevated plasma cholesterol or triglyceride levels, excessive smoking were considered. These risk factors were not found in 11.1% of diabetic patients with AION, in 37.9% of hypertensives, in 14.2% of both diabetic and hypertensive patients and in 31% of patients with idiopathic AION. Our data seem to indicate that the onset of AION may be influenced more strongly from these risk factors than aging.</p>","PeriodicalId":77261,"journal":{"name":"Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)","volume":"12 1-3","pages":"46-57"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13909209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The optic neuropathy of Alzheimer's disease.","authors":"A A Sadun","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Patients with Alzheimer's disease, or more often their families, frequently complain of problems with vision. Nonetheless, clinicians have tended to attribute these symptoms to impaired cognitive functions. Alzheimer patients have been ascribed to disease in the cerebral cortex. However, we have demonstrated that patients with Alzheimer's disease also have a primary optic neuropathy. Degeneration is noted in the retinal ganglion cell layer of the retina and among axons of the optic nerve. In particular, there appears to be a predilection in early Alzheimer's disease for injury to the largest retinal ganglion cell axons. Clinical assessments of patients with Alzheimer's disease demonstrated that patients with only mild dementia have excellent visual acuity. However, they demonstrate deficits in eye movements, visual evoked responses, and contrast sensitivity functions. Patients with more severe Alzheimer's disease are hard to evaluate but they demonstrate severe impairments of vision of many types including visual acuity. The differential involvement of various types of retinal ganglion cells and of different visual functions in early Alzheimer's disease further emphasizes the nature of parallel processing in human vision.</p>","PeriodicalId":77261,"journal":{"name":"Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)","volume":"12 1-3","pages":"64-8"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13909211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A P Schachat, P J McDonnell, B G Petty, H D Jampel, A Patel, J R Wittpenn, P A Rapoza
{"title":"Ophthalmology consultations at a large teaching hospital.","authors":"A P Schachat, P J McDonnell, B G Petty, H D Jampel, A Patel, J R Wittpenn, P A Rapoza","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We reviewed 100 consecutive ophthalmology consultations performed on inpatients at a large teaching hospital to help identify areas that may require greater emphasis in the medical school and housestaff curriculum. Nonophthalmologists rarely record visual acuities or perform dilated fundus examinations. If visual acuity determination were more consistently made a part of routine physical examinations, it is possible that more pathology would be detected and non-productive consultations could be minimized. We plan to emphasize these observations in our school's curriculum more than in the past.</p>","PeriodicalId":77261,"journal":{"name":"Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)","volume":"12 4","pages":"105-9"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13770281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Electrophysiology in optic nerve development.","authors":"P Steindler, A P Tormene","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>After an examination of the anatomical modifications of the retina and optic nerve during the early phases of development, the authors consider variations in some electrofunctional responses: PEV--PERG--ERG and retinocortical time.</p>","PeriodicalId":77261,"journal":{"name":"Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)","volume":"12 1-3","pages":"34-6"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13812300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Late onset multiple sclerosis: clinical pattern of optic nerve involvement.","authors":"A B Safran","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Multiple sclerosis presenting after age 50 is not rare as previously thought; it is associated with specific diagnostic difficulties, related to the age of the patient, and to the characteristically chronic progressive form of this condition. Therefore, diagnosis of MS related optic neuropathy should be considered in patients with unexplained loss of vision, even when apparent onset occurs after the age of 50.</p>","PeriodicalId":77261,"journal":{"name":"Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)","volume":"12 1-3","pages":"58-60"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13812302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V Porciatti, B Falsini, A Fadda, M Neroni, A Minnella, G Scalia
{"title":"Changes in spatial tuning of the pattern electroretinogram with age.","authors":"V Porciatti, B Falsini, A Fadda, M Neroni, A Minnella, G Scalia","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Experimental and clinical studies have demonstrated that the electroretinogram in response to periodical patterns alternating in contrast at constant mean luminance (pattern reversal ERG, P-ERG), is correlated with ganglion cell activity. Senile functional changes of these neurons might be therefore investigated by the P-ERG technique. Steady-state P-ERGs (8 Hz) in response to sinusoidal gratings of different spatial frequencies (0.6-6.8 c/d) were recorded in normal subjects ranging over 50 year age span. The P-ERG amplitude as a function of stimulus spatial frequency shows a maximum between 1.2-1.7 c/d and attenuation at higher and lower spatial frequencies (spatial tuning). The P-ERGs of the older subjects are reduced in amplitute, as compared to those of the younger ones, over the whole range of spatial frequency. This reduction is more marked at intermediate spatial frequencies resulting in a shallower tuning.</p>","PeriodicalId":77261,"journal":{"name":"Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)","volume":"12 1-3","pages":"74-5"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13909213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neuroophthalmological implications of the radiological finding of the transverse sinus.","authors":"P Puddo, R Lodi, A Mularoni, C Molinotti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Visualization of transverse intracranial sinuses by means of standard radiograms of the skill is a rather unusual finding. In order to detect the radiological evidence of this important intracranial venous collector, the authors examined 5.638 radiograms, collected since January 1982 until December 1986 at the Neuroradiological Ophtalmic Centre of the University of Bologna. 87 cases (1.54%) resulted positive, with a prevalence of young (mean age 23 years) and female (88%) patients. Among these, an involvement of the optic nerve was the most consistent finding. In fact, it was observed in 47 cases (54%) suffering from: retrobulbar optic neuritis (25 cases), papillitis (13 cases), optic disk edema (6 cases), optic chiasma syndrome (2 cases) and stasis papilla (1 case). Moreover, the report of headache in 20 further cases may have significative implications with respect to the pathogenetic hypothesis about the accentuation of the transverse sinus. Our data suggest that a primitive inflammatory disorder, such as asymptomatic meningitis or meningoencephalitis--early developed in the life--, can induce a persistent local damage also with the radiological alteration. Thus, we presumed that this sign may represent a significant marker of a compromised anatomofunctional condition predisposing to relapsing inflammatory processes. A very interesting possible clinical correlation with demyelinating disorders is also discussed for its pathogenetic implications.</p>","PeriodicalId":77261,"journal":{"name":"Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)","volume":"12 1-3","pages":"85-7"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13909835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}