{"title":"衰老和药物引起的视神经副作用。","authors":"M T Dorigo, R Altafini","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>In this review the authors attempt to explain how aging can determine optic nerve neuropathy and modify the pharmacodynamics and pharmacokinetics of a drug. The major causes of increased drug toxicity in the elderly are discussed. The most frequently used drugs that can cause optic nerve side effects are reported. The authors stress problems related to drug administration in the elderly and push towards the study of this aspect of geriatric ophthalmology.</p>","PeriodicalId":77261,"journal":{"name":"Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)","volume":"12 1-3","pages":"24-7"},"PeriodicalIF":0.0000,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Aging and drug-induced optic nerve side effects.\",\"authors\":\"M T Dorigo, R Altafini\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In this review the authors attempt to explain how aging can determine optic nerve neuropathy and modify the pharmacodynamics and pharmacokinetics of a drug. The major causes of increased drug toxicity in the elderly are discussed. The most frequently used drugs that can cause optic nerve side effects are reported. The authors stress problems related to drug administration in the elderly and push towards the study of this aspect of geriatric ophthalmology.</p>\",\"PeriodicalId\":77261,\"journal\":{\"name\":\"Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)\",\"volume\":\"12 1-3\",\"pages\":\"24-7\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1989-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
In this review the authors attempt to explain how aging can determine optic nerve neuropathy and modify the pharmacodynamics and pharmacokinetics of a drug. The major causes of increased drug toxicity in the elderly are discussed. The most frequently used drugs that can cause optic nerve side effects are reported. The authors stress problems related to drug administration in the elderly and push towards the study of this aspect of geriatric ophthalmology.