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Medical oncology and tumor pharmacotherapy最新文献

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Prevention of chemotherapy-induced leukemia and of leukemia relapses. 预防化疗性白血病及白血病复发。
Medical oncology and tumor pharmacotherapy Pub Date : 1991-01-01 DOI: 10.1007/BF02987173
E J Freireich
{"title":"Prevention of chemotherapy-induced leukemia and of leukemia relapses.","authors":"E J Freireich","doi":"10.1007/BF02987173","DOIUrl":"https://doi.org/10.1007/BF02987173","url":null,"abstract":"<p><p>Fifty percent of patients with the myelodysplastic syndrome, frequently following treatment by radiation or chemotherapy, have prognostically unfavorable deletions of the long arms of chromosomes 5 and 7, or trisomy 8, as have the 25% of patients with acute myeloblastic leukemia where remissions last 6-12 months, and where relapse cannot be prevented. In contrast, patients with prognostically favorable cytogenetics (translocation 15; 17 or 8; 21 or inversion 16) maintenance chemotherapy may prevent relapses. Of chronic myelocytic leukemia patients, 85% can achieve hematological remission with interferon alpha, and 40% a partial cytogenetic remission, which probably delays relapse.</p>","PeriodicalId":77257,"journal":{"name":"Medical oncology and tumor pharmacotherapy","volume":"8 3","pages":"155-8"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02987173","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12889092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cranial irradiation and cerebrospinal fluid levels of 6-mercaptopurine in children with acute leukemia. 急性白血病患儿颅脑照射与脑脊液6-巯基嘌呤水平的关系。
Medical oncology and tumor pharmacotherapy Pub Date : 1991-01-01 DOI: 10.1007/BF02988860
R Riccardi, A Lasorella, R L Tartaglia, A Riccardi, T Servidei, R Mastrangelo
{"title":"Cranial irradiation and cerebrospinal fluid levels of 6-mercaptopurine in children with acute leukemia.","authors":"R Riccardi,&nbsp;A Lasorella,&nbsp;R L Tartaglia,&nbsp;A Riccardi,&nbsp;T Servidei,&nbsp;R Mastrangelo","doi":"10.1007/BF02988860","DOIUrl":"https://doi.org/10.1007/BF02988860","url":null,"abstract":"<p><p>We measured 6-mercaptopurine levels in the cerebrospinal fluid and plasma of 15 children undergoing treatment for acute leukemia. Plasma and cerebrospinal fluid samples obtained by lumbar puncture were collected before, during, and after cranial irradiation in order to evaluate a possible change in blood-brain barrier permeability to orally administered 6-mercaptopurine. Considerable interpatient variability has been observed in both plasma and cerebrospinal fluid 6-mercaptopurine levels. No statistical differences in the 6-mercaptopurine cerebrospinal fluid levels under the three different conditions could be detected. Our data suggest that cranial irradiation does not significantly influence the cerebrospinal fluid levels.</p>","PeriodicalId":77257,"journal":{"name":"Medical oncology and tumor pharmacotherapy","volume":"8 2","pages":"95-8"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02988860","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12912151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Resistance of single tumor cells and their intracellular compartments to lipid peroxidation. 单个肿瘤细胞及其细胞内隔室对脂质过氧化的抗性。
Medical oncology and tumor pharmacotherapy Pub Date : 1991-01-01 DOI: 10.1007/BF02988854
P M Schwarzburd, K B Aslanidi
{"title":"Resistance of single tumor cells and their intracellular compartments to lipid peroxidation.","authors":"P M Schwarzburd,&nbsp;K B Aslanidi","doi":"10.1007/BF02988854","DOIUrl":"https://doi.org/10.1007/BF02988854","url":null,"abstract":"<p><p>An attempt was made to analyze heterogeneity of tumor populations with respect to potential stability of single cells and their intracellular compartments (lipid-containing refractory granules, RG, and cytoplasmic sites) to lipid peroxidation (LP). LP was initiated by a combined action of hypoxia and u.v.-light and measured by the level of fluorescent product of lipid peroxidation (FPLP) well distinguished from other fluorescent components of the cell. Irrespective of the cell growth stage, RG were found to make a major contribution to the total intensity of FPLP of the cell. However, this contribution was minimal (20 to 30%) in exponentially growing ascites tumor cells and maximal (70 to 90%) in the stationary growing ones. It is noteworthy that in both cases the heterogeneous tumor population has cells with a high stability to inhibitory and cytokilling action of LP. We believe that the approach suggested in this work is of potential importance for experimental and clinical practice since it is highly sensitive for detecting FPLP in single cells, which allows one to reveal various subcellular tumor populations and estimate their stability to LP.</p>","PeriodicalId":77257,"journal":{"name":"Medical oncology and tumor pharmacotherapy","volume":"8 2","pages":"57-61"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02988854","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12913088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Early detection and prevention of cutaneous malignant melanoma: emphasis on Swedish activities. 皮肤恶性黑色素瘤的早期发现和预防:瑞典活动的重点。
Medical oncology and tumor pharmacotherapy Pub Date : 1991-01-01 DOI: 10.1007/BF02987178
U Ringborg, B Lagerlöf, M Broberg, E Månsson-Brahme, A Platz, M Thörn
{"title":"Early detection and prevention of cutaneous malignant melanoma: emphasis on Swedish activities.","authors":"U Ringborg,&nbsp;B Lagerlöf,&nbsp;M Broberg,&nbsp;E Månsson-Brahme,&nbsp;A Platz,&nbsp;M Thörn","doi":"10.1007/BF02987178","DOIUrl":"https://doi.org/10.1007/BF02987178","url":null,"abstract":"<p><p>The incidence of cutaneous malignant melanoma has increased more than the incidence of any other malignant tumour disease in Sweden the last three decades. Parallel to the almost 6% annual increase in incidence there has been a 3% annual increase in mortality. The knowledge of significant risk factors for melanoma (intermittent sun exposure and phenotypic traits related to skin pigmentation and propensity for dysplastic nevi) as well as the relationship between thin tumours and a good prognosis has been used to develop strategies for primary and secondary prevention. In this paper the Swedish programs for education of physicians, nurses and the general population are presented. A nationwide program for the identification and follow-up of individuals with dysplastic nevus syndrome has been initiated. The effects of the programs are followed by population-based melanoma registries.</p>","PeriodicalId":77257,"journal":{"name":"Medical oncology and tumor pharmacotherapy","volume":"8 3","pages":"183-7"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02987178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12964868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Trends in cancer survival and mortality rates. 癌症存活率和死亡率的趋势。
Medical oncology and tumor pharmacotherapy Pub Date : 1991-01-01 DOI: 10.1007/BF02987172
J Pontén, H O Adami, P Sparén
{"title":"Trends in cancer survival and mortality rates.","authors":"J Pontén,&nbsp;H O Adami,&nbsp;P Sparén","doi":"10.1007/BF02987172","DOIUrl":"https://doi.org/10.1007/BF02987172","url":null,"abstract":"<p><p>Survival, i.e. the time from report to cancer registry to death was studied for 591,456 cases of cancer diagnosed in vivo from 1960 to 1984. Ten years survival increased from 35 to 40%. Survival rates for women were higher than for men. Since 10 years survival almost suggests cure, lead time bias is assumed not to be a major factor. Nor are relaxed histological criteria, detecting non-fatal tumors, intensified microscopic examination, changes in the relative frequency of cancer types, or increasing numbers of elderly patients assumed to be major artefacts. In contrast, improved socio-economic and health status are. Early detection also improves survival in some cancer types.</p>","PeriodicalId":77257,"journal":{"name":"Medical oncology and tumor pharmacotherapy","volume":"8 3","pages":"147-53"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02987172","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12965000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Efficacy of peptide bound m-L-sarcolysin (peptichemio) on melphalan resistant human myeloma cells in vitro. 肽结合m- l -肌溶素对体外抗melphalan人骨髓瘤细胞的作用。
Medical oncology and tumor pharmacotherapy Pub Date : 1991-01-01 DOI: 10.1007/BF02987196
R Lewensohn, J O Fernberg, H Ehrsson, G Merlini
{"title":"Efficacy of peptide bound m-L-sarcolysin (peptichemio) on melphalan resistant human myeloma cells in vitro.","authors":"R Lewensohn,&nbsp;J O Fernberg,&nbsp;H Ehrsson,&nbsp;G Merlini","doi":"10.1007/BF02987196","DOIUrl":"https://doi.org/10.1007/BF02987196","url":null,"abstract":"<p><p>Peptichemio (PTC) is a mixture of six synthetic oligopeptides, each containing the alkylating agent m-di(2-chloroethyl)amino-phenylalanine. Freshly obtained myeloma cell infiltrated human bone marrow specimens were in parallel exposed to melphalan and PTC. The cytotoxic effect of the drugs on the myeloma cells of each specimen was measured by the differential staining culture method (DISC). PTC displayed higher cytotoxicity to the myeloma cells as compared to melphalan in all 12 cases analysed. The increase of the cytotoxic effect of PTC compared to melphalan varied between different cases. In melphalan resistant cases the cytotoxic effect of PTC as compared to melphalan was clearly significant (P = 0.001).</p>","PeriodicalId":77257,"journal":{"name":"Medical oncology and tumor pharmacotherapy","volume":"8 4","pages":"265-9"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02987196","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12981372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Serum thymidine kinase in diagnosis and follow-up of the small cell carcinoma of the lung. 血清胸苷激酶在肺小细胞癌诊断及随访中的意义。
Medical oncology and tumor pharmacotherapy Pub Date : 1991-01-01 DOI: 10.1007/BF02988568
V Abbasciano, L Graziano, D Arcudi, G Felisatti, A R Cavallini, M G Reali, N Calia, S Campi, C Guglielmini
{"title":"Serum thymidine kinase in diagnosis and follow-up of the small cell carcinoma of the lung.","authors":"V Abbasciano,&nbsp;L Graziano,&nbsp;D Arcudi,&nbsp;G Felisatti,&nbsp;A R Cavallini,&nbsp;M G Reali,&nbsp;N Calia,&nbsp;S Campi,&nbsp;C Guglielmini","doi":"10.1007/BF02988568","DOIUrl":"https://doi.org/10.1007/BF02988568","url":null,"abstract":"<p><p>Serum thymidine-kinase (sTK) was assayed in 48 males affected by small cell carcinoma of the lung (SCCL) at the time of diagnosis. On the same drawing carcinoembryonic antigen (CEA) and beta 2microglobulin (beta 2 microG) were assayed in 19 of these subjects. For staging, the criterion of limited (LD) and extensive (ED) disease was used. Mean sTK and CEA values were above normal range in both the LD and ED groups, while mean beta 2 microG value remained below normal range. Thirty-two patients were subsequently submitted to therapy; sTK was assayed at the end of each treatment cycle. Mean sTK concentrations differed depending on response to therapy. From the data obtained it is concluded that sTK assay is helpful for diagnosis of SCCL; CEA to a lesser extent, above all in association with sTK, and beta microG not at all. sTK assay can also be useful for prognosis and follow-up.</p>","PeriodicalId":77257,"journal":{"name":"Medical oncology and tumor pharmacotherapy","volume":"8 1","pages":"29-34"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02988568","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12811828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Tumor markers. 肿瘤标记物。
Medical oncology and tumor pharmacotherapy Pub Date : 1991-01-01 DOI: 10.1007/BF02988564
E Munck-Wikland
{"title":"Tumor markers.","authors":"E Munck-Wikland","doi":"10.1007/BF02988564","DOIUrl":"https://doi.org/10.1007/BF02988564","url":null,"abstract":"","PeriodicalId":77257,"journal":{"name":"Medical oncology and tumor pharmacotherapy","volume":"8 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02988564","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13197709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of advanced and refractory breast cancer with doxorubicin, vincristine and continuous infusion of verapamil. A phase I-II clinical trial. 阿霉素、长春新碱联合维拉帕米持续输注治疗晚期难治性乳腺癌。I-II期临床试验。
Medical oncology and tumor pharmacotherapy Pub Date : 1991-01-01 DOI: 10.1007/BF02988570
F Ries, M Dicato
{"title":"Treatment of advanced and refractory breast cancer with doxorubicin, vincristine and continuous infusion of verapamil. A phase I-II clinical trial.","authors":"F Ries,&nbsp;M Dicato","doi":"10.1007/BF02988570","DOIUrl":"https://doi.org/10.1007/BF02988570","url":null,"abstract":"<p><p>Cancer cell resistance to several cytotoxic drugs, including doxorubicin and vincristine can be reduced in vitro by verapamil; this drug works at least in part by inhibitive competition for the multiple-drug resistance efflux-pump P-glycoprotein-170. To evaluate the clinical potential of this experimental concept we combined verapamil in continuous infusion with adriamycin and vincristine in the treatment of patients with advanced and anthracycline-refractory breast cancer. Sixteen patients were included and 55 treatment courses were given at different dose levels of chemotherapy; verapamil was given by continuous infusion of 0.003 mg kg-1 min-1 for 48 h. Overall, cardiac toxicity was low but a potentiation of neurotoxicity and hematotoxicity was observed. The objective response rate was 21% (3 partial responses in 16 patients) and the median survival was 6 months; these results are comparable to those of other second line treatment studies, using drugs not supposed to be cross-resistant.</p>","PeriodicalId":77257,"journal":{"name":"Medical oncology and tumor pharmacotherapy","volume":"8 1","pages":"39-43"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02988570","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13197711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Breast cancer: early diagnosis of precursor lesions and clinically inapparent carcinoma by fine needle aspiration. 乳腺癌:细针抽吸对早期病变及临床不明显癌的诊断。
Medical oncology and tumor pharmacotherapy Pub Date : 1991-01-01 DOI: 10.1007/BF02987176
J A Linsk
{"title":"Breast cancer: early diagnosis of precursor lesions and clinically inapparent carcinoma by fine needle aspiration.","authors":"J A Linsk","doi":"10.1007/BF02987176","DOIUrl":"https://doi.org/10.1007/BF02987176","url":null,"abstract":"<p><p>Breast cancer death rate has remained stable at 26 per 100,000 for over 50 years. This control failure is due in large part to difficulty in early diagnosis. Combined clinical evaluation, mammography and fine needle aspiration (FNA) offer the best opportunity for early diagnosis. Non-directed FNA is a useful adjunctive technique and three illustrative cases are presented. Cancer evolves from proliferative epithelial disease of ducts and lobules. Atypical duct hyperplasia in association with family history is a pertinent marker for development of cancer. Identification of hyperplastic lesions traditionally occurs after surgical biopsy and histopathologic review. FNA demonstrates patterns of both duct hyperplasia and atypical duct hyperplasia. Ploidy studies of such smears offer the possibility of selecting precancerous lesions for extirpation. A combination of directed and undirected punctures and ploidy studies may yield early diagnosis of precancerous lesions.</p>","PeriodicalId":77257,"journal":{"name":"Medical oncology and tumor pharmacotherapy","volume":"8 3","pages":"169-74"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02987176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12964866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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