American Journal of Hematology最新文献_第4页

Lymphoma, Leukemia & Myeloma Congress 2026 Abstracts 淋巴瘤，白血病和骨髓瘤大会2026摘要

IF 9.4 1区医学

American Journal of Hematology Pub Date : 2026-10-11 DOI: 10.1002/ajh.70508

引用次数: 0

Oral Azacitidine Maintenance After CPX-351 in Transplant-Ineligible Patients With Therapy-Related or Myelodysplasia-Related Acute Myeloid Leukemia. 治疗相关或骨髓增生异常相关的急性髓系白血病不适合移植患者在CPX-351后口服阿扎胞苷维持

IF 9.4 1区医学

American Journal of Hematology Pub Date : 2026-10-09 DOI: 10.1002/ajh.70521

Caroline Fileni, Edmond Chiche, David Swoboda, Alexander Coltoff, Rami Komrokji, Geoffrey Uy, Sarah Bertoli, Lenaig Le Clech, Mael Heiblig, Ludovic Gabellier, Patrick Lawrence, Lydia Kretschmer, Christoph Röllig, A H Wei, Fabio Guolo, Roberto Massimo Lemoli, Jeffrey Lancet, David Sallman, Thomas Cluzeau

引用次数: 0

A Pooled CRISPR Screen Reveals Genes Critical for Erythroblast Enucleation CRISPR筛选揭示红母细胞去核的关键基因

IF 12.8 1区医学

American Journal of Hematology Pub Date : 2026-10-06 DOI: 10.1002/ajh.70520

Marilou Tetard,Tianjian Lin,Nana A. Peterson,Rebekah C. Gullberg,Yann Le Guen,Jasmine Moshiri,John G. Doench,Elizabeth S. Egan

{"title":"A Pooled\u0000 CRISPR\u0000 Screen Reveals Genes Critical for Erythroblast Enucleation","authors":"Marilou Tetard,Tianjian Lin,Nana A. Peterson,Rebekah C. Gullberg,Yann Le Guen,Jasmine Moshiri,John G. Doench,Elizabeth S. Egan","doi":"10.1002/ajh.70520","DOIUrl":"https://doi.org/10.1002/ajh.70520","url":null,"abstract":"ABSTRACT Terminal erythroid differentiation involves dramatic cellular remodeling that culminates in the expulsion of the nucleus, a process known as enucleation. While enucleation is conserved across mammals and is crucial for the generation of fully functional erythrocytes, the mechanisms governing this process have remained largely unknown, in part because the absence of genetic material in mature, enucleated red blood cells hinders genetic experimentation. Here, we performed a pooled, forward‐genetic CRISPR‐Cas9 screen in enucleated red blood cells derived from primary human hematopoietic stem/progenitor cells to identify genes required for enucleation. We found that Chloride Intracellular Channel 3 (CLIC3) and Vesicle‐associated membrane protein 8 (VAMP8) are both necessary for terminal erythroid differentiation, yet likely act through different mechanisms. Knockdown of CLIC3 led to a delay in erythroblast differentiation, culminating in impaired enucleation. We found that the knockdown cells had increased p53 and p21 and exhibited cell cycle alterations, suggesting CLIC3 plays a crucial role in coordinating cell cycle progression during erythropoiesis. In comparison, VAMP8‐depleted cells accumulated at the orthochromatic erythroblast stage and displayed a specific defect in enucleation. Transcriptional analysis of the VAMP8‐knockdown cells suggested dysregulation of pathways for vesicle trafficking and actin binding, and imaging of late‐stage erythroblasts revealed impaired nuclear polarization and disorganized actin. This work provides a new approach for functional genomics in enucleated cells and reveals novel factors important for terminal erythroid differentiation and enucleation.","PeriodicalId":7724,"journal":{"name":"American Journal of Hematology","volume":"1 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chromosomal Abnormalities, Drug Sensitivity and Resistance in Hematological Malignancies: A Comprehensive Overview by the Francophone Group of Hematological Cytogenetics ( GFCH ) 血液学恶性肿瘤的染色体异常、药物敏感性和耐药性：法语国家血液学细胞遗传学（GFCH）的综合综述

IF 12.8 1区医学

American Journal of Hematology Pub Date : 2026-10-05 DOI: 10.1002/ajh.70499

Florence Nguyen‐Khac, Audrey Bidet, Elise Chapiro, Nathalie Douet‐Guilbert, Jean‐Baptiste Gaillard, Nada Assaf, Nathalie Auger, Hend Chaker, Jasmine Chauzeix, Inge Govaerts, Hippolyte Guérineau, Christine Lefebvre, Pauline Roynard, Hélène Guermouche, Lucienne Michaux, Marie‐Bérengère Troadec, Lauren Véronèse

{"title":"Chromosomal Abnormalities, Drug Sensitivity and Resistance in Hematological Malignancies: A Comprehensive Overview by the Francophone Group of Hematological Cytogenetics ( GFCH )","authors":"Florence Nguyen‐Khac, Audrey Bidet, Elise Chapiro, Nathalie Douet‐Guilbert, Jean‐Baptiste Gaillard, Nada Assaf, Nathalie Auger, Hend Chaker, Jasmine Chauzeix, Inge Govaerts, Hippolyte Guérineau, Christine Lefebvre, Pauline Roynard, Hélène Guermouche, Lucienne Michaux, Marie‐Bérengère Troadec, Lauren Véronèse","doi":"10.1002/ajh.70499","DOIUrl":"https://doi.org/10.1002/ajh.70499","url":null,"abstract":"Chromosomal abnormalities have a major clinical impact on hematological malignancies, particularly with regard to treatment strategies. To preserve and consolidate fundamental knowledge in this rapidly evolving field, the Francophone Group of Hematological Cytogenetics (Groupe Francophone de Cytogénétique Hématologique, GFCH) conducted a comprehensive review of chromosomal abnormalities associated with drug sensitivity and resistance in hematological disorders. This work highlights the emergence of alteration‐driven therapy, with certain agents (e.g., tyrosine kinase inhibitors, menin inhibitors, venetoclax) used across entities sharing common molecular lesions, while others remain disease‐specific, such as in Helicobacter pylori –associated lymphomas.","PeriodicalId":7724,"journal":{"name":"American Journal of Hematology","volume":"11 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149086754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary Alveolar Proteinosis After Allogeneic Stem Cell Transplant in a Patient Undergoing Multiagent Chronic Graft‐Versus‐Host‐Disease Treatment Including Axatilimab 一名接受包括阿替利单抗在内的多药慢性移植物抗宿主病治疗的患者的异基因干细胞移植后肺泡蛋白沉积

IF 12.8 1区医学

American Journal of Hematology Pub Date : 2026-10-04 DOI: 10.1002/ajh.70517

Cydney Nichols, Noelle Frey, Saar Gill, Elizabeth Hexner, Rebecca L. Hirsh, Nasheed M. Hossain, Alison Loren, Mary Ellen Martin, Shannon R. McCurdy, Pashna Munshi, Linda Perry, Jacqueline Smith, Leslie Litzky, Sujani Madabhushi, Emily Baumrin, Vivek N. Ahya, David L. Porter

引用次数: 0

Exploring the Patient Perspective of Gene Therapy for Sickle Cell Disease 探索镰状细胞病基因治疗的患者视角

IF 12.8 1区医学

American Journal of Hematology Pub Date : 2026-10-03 DOI: 10.1002/ajh.70518

Clare Nimura, Lisbel Gonzalez, Sharl Azar, Alexander Boucher, Seethal A. Jacob, Kristine Karkoska, Layla Van Doren, Maayan Leroy‐Melamed, Patrick T. McGann

引用次数: 0

Radiation‐Free Haploidentical Transplantation With PTCy and Extended Abatacept in Pediatric Nonmalignant Disorders PTCy和扩展Abatacept治疗儿童非恶性疾病的无辐射单倍体移植

IF 12.8 1区医学

American Journal of Hematology Pub Date : 2026-10-02 DOI: 10.1002/ajh.70514

Thomas Pfeiffer, Alexander Ngwube, Rachel E. Granberg, Ian Snyder, Ginny Schulz, Allison A. King, Melissa Mavers, Robert J. Hayashi, Jeffrey J. Bednarski, Yvonne Suessmuth, Emi Caywood, Troy C. Quigg, Rebecca A. Marsh, Leslie S. Kean, Shalini Shenoy

引用次数: 0

Schistocytes Are a Clue, Not a Gatekeeper in Thrombotic Microangiopathy 血吸虫细胞是血栓性微血管病的线索，而不是看门人

IF 12.8 1区医学

American Journal of Hematology Pub Date : 2026-10-02 DOI: 10.1002/ajh.70519

Akiyoshi Takami, Shingo Sugawara

引用次数: 0

Soluble Transferrin Receptor and the sTfR /Log Ferritin Index May Not Be Better Than Ferritin Alone for Diagnosis of Anemia of Chronic Disease and Iron Deficiency Anemia 可溶性转铁蛋白受体和sTfR /Log铁蛋白指数对慢性贫血和缺铁性贫血的诊断可能不如单独使用铁蛋白

IF 12.8 1区医学

American Journal of Hematology Pub Date : 2026-10-01 DOI: 10.1002/ajh.70513

Brett G. Fischer, Jay Canarick

引用次数: 0

Proteomic Profiling of Nodal T‐Follicular Helper Cell Lymphoma Reveals Distinct Biological Signatures and Improves Prognostic Stratification Beyond the IPI 淋巴结T -滤泡辅助细胞淋巴瘤的蛋白质组学分析揭示了不同的生物学特征，并改善了IPI以外的预后分层

IF 12.8 1区医学

American Journal of Hematology Pub Date : 2026-10-01 DOI: 10.1002/ajh.70502

David Beauvais, Yanis Zirem, Tristan Cardon, Soulaimane Aboulouard, Romain Dubois, Isabelle Fournier, Franck Morschhauser, Michel Salzet, Ibrahim Yakoub‐Agha, Marie Duhamel

{"title":"Proteomic Profiling of Nodal T‐Follicular Helper Cell Lymphoma Reveals Distinct Biological Signatures and Improves Prognostic Stratification Beyond the IPI","authors":"David Beauvais, Yanis Zirem, Tristan Cardon, Soulaimane Aboulouard, Romain Dubois, Isabelle Fournier, Franck Morschhauser, Michel Salzet, Ibrahim Yakoub‐Agha, Marie Duhamel","doi":"10.1002/ajh.70502","DOIUrl":"https://doi.org/10.1002/ajh.70502","url":null,"abstract":"Nodal T‐follicular helper cell lymphoma (nTFHL), most commonly of angioimmunoblastic type, exhibits heterogeneous clinical outcomes that are not fully explained by current clinical and biological variables. While genetic alterations have been extensively investigated, its proteomic landscape remains largely unexplored. Here, in a discovery cohort, the classical and alternative proteome of 63 nTFHL patients at diagnosis was profiled by mass spectrometry and analyzed using unsupervised k‐means clustering. Two nTFHL signatures with distinct pathway enrichment and significantly different overall survival ( p = 0.02) were identified: the nTFHL‐stromal profile, characterized by a complex microenvironment, and the nTFHL‐translational profile, enriched in protein biosynthesis and cell proliferation pathways. Profile discrimination was confirmed across multiple supervised learning algorithms, enabling selection of a 10‐protein biomarker panel validated by immunofluorescence. In an independent validation cohort including 31 nTFHL patients, the 10‐protein panel accurately predicted the proteomic profiles, reproducing the observed difference in overall survival. In multivariable Cox regression, the nTFHL‐translational profile remained associated with poorer OS (HR = 1.92, p = 0.01), independently of the International Prognostic Index (IPI). Integration of the proteomic profile with the IPI generated the IPI‐P score, which refined risk stratification and identified three groups with significantly different overall survival ( p < 0.001). Overall, these findings reveal distinct proteomic programs underlying nTFHL heterogeneity and provide a clinically applicable framework for proteome‐based prognostic stratification.","PeriodicalId":7724,"journal":{"name":"American Journal of Hematology","volume":"22 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149085968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0