American Journal of Hematology最新文献

{"title":"Cryoablation for unresectable unicentric Castleman disease","authors":"Yoshito Nishimura, Thomas Atwell, Matthew Callstrom, Patrick McGarrah, Matthew Howard, Rebecca L. King, Angela Dispenzieri","doi":"10.1002/ajh.27507","DOIUrl":"https://doi.org/10.1002/ajh.27507","url":null,"abstract":"Laboratory findings and timeline of treatments. Day 0 is the day of the initial consult at our institution. CRP, C-reactive protein; IgG, immunoglobulin G.","PeriodicalId":7724,"journal":{"name":"American Journal of Hematology","volume":"7 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142440373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LLM 2024 Abstracts","authors":"","doi":"10.1002/ajh.27491","DOIUrl":"https://doi.org/10.1002/ajh.27491","url":null,"abstract":"","PeriodicalId":7724,"journal":{"name":"American Journal of Hematology","volume":"99 S2","pages":"S3-S64"},"PeriodicalIF":10.1,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajh.27491","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142443531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing coagulation responses in humans and nonhuman primates following kidney xenotransplantation—A narrative review","authors":"Ali Zidan, Adham H. El-Sherbini, Abdelrahman Noureldin, David K. C. Cooper, Maha Othman","doi":"10.1002/ajh.27506","DOIUrl":"https://doi.org/10.1002/ajh.27506","url":null,"abstract":"The recent report of the first pig kidney transplant in a living human brings hope to thousands of people with end-stage kidney failure. The scientific community views this early success with caution as kidney xenotransplantation exhibits many challenges and barriers. One of these is coagulation dysregulation. This includes (i) pig von Willebrand Factor (vWF) interaction with human platelets, which can induce abnormal clotting responses, heightening the risk of graft failure, (ii) the inefficiency of pig thrombomodulin in activating human protein C, which emphasizes the species-specific variations that aggravate coagulation challenges, and (iii) the development of thrombotic microangiopathy in the pig grafts and the occurrence of systemic consumptive coagulopathy in the recipients. Indeed, coagulation dysregulation largely results from differences in endothelial cell response and incompatibilities between pig and human coagulation–anticoagulation pathways. These barriers can be resolved by modifications to pig vWF and the expression of human thrombomodulin and endothelial protein C receptors in pig cells, serving as strategic interventions to align the coagulation systems of the two species more closely. These coagulation challenges have clinical implications in how they affect graft survival and patient outcome. Genetic engineering of the organ-source pig and the administration of various drugs have assisted in correcting this coagulation dysregulation. Hence, comprehending and controlling coagulation dysregulation is crucial for progress in xenotransplantation as a viable option for treating patients with terminal kidney disease.","PeriodicalId":7724,"journal":{"name":"American Journal of Hematology","volume":"78 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142436453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hereditary stomatocytosis in the general population: A genetically based prevalence estimate from a 109 039 individual Danish cohort","authors":"Mathis Mottelson, Jens Helby, Jesper Petersen, Børge Grønne Nordestgaard, Stig Egil Bojesen, Selma Kofoed Bendtsen, Maria Rossing, Andreas Ørslev Rasmussen, Andreas Glenthøj","doi":"10.1002/ajh.27508","DOIUrl":"https://doi.org/10.1002/ajh.27508","url":null,"abstract":"<p>Hereditary spherocytosis (HS) is caused by mutations in genes such as <i>ANK1</i>, <i>EPB42</i>, <i>SLC4A1</i>, <i>SPTA1</i>, or <i>SPTB</i>,<span><sup>1</sup></span> leading to altered red blood cell (RBC) membrane proteins, reduced deformability, and decreased RBC lifespan. Dehydrated hereditary stomatocytosis (xerocytosis) is caused by variants in the <i>PIEZO1</i> gene and, less commonly, <i>KCNN4</i> variants, affecting RBC hydration and stability.<span><sup>2</sup></span></p>\u0000<p>The prevalence of HS is generally reported around 1:2000, while dehydrated hereditary stomatocytosis estimates range from 1:10 000 to 1:50 000, though mostly based on sporadic cases or older studies lacking comprehensive diagnostic methods.<span><sup>1, 2</sup></span> Current prevalence estimates may be inaccurate due to underdiagnosis, referral bias, and the lack of systematic population-based testing. A study analyzing complete blood counts of 48 million North American patients suggested that up to 1:8000 individuals could potentially have dehydrated hereditary stomatocytosis based on specific biochemical markers, although definitive confirmation through genetic or specialized testing was not feasible.<span><sup>3</sup></span> Interestingly, a study identified a gain-of-function <i>PIEZO1</i> allele in one-third of African Americans, which, in a mouse model, induced a phenotype resembling dehydrated hereditary stomatocytosis and provided significant resistance to malaria.<span><sup>4</sup></span></p>\u0000<p>We tested the hypothesis that both hereditary spherocytosis and dehydrated hereditary stomatocytosis are more frequent in the white general population than previously estimated. For this purpose, we studied 109 039 white individuals of Danish descent from the Copenhagen General Population Study(H-KF 01-144/01) examined between 2003 and 2015.<span><sup>5</sup></span> All individuals had hemoglobin, red cell distribution width (RDW), and MCHC measured, and all individuals had DNA obtained for further genetic analysis. Individuals with biochemical signs of hemolysis were genetically tested for the most frequent causes of hereditary hemolysis. All individuals aged 40–100 years and 25% of inhabitants aged 20–39 years living in a suburban part of the Capital Region of Denmark were invited, of these 43% participated. All participating individuals underwent a physical examination, had blood samples drawn, and completed a questionnaire on lifestyle and health on the day of enrollment. Blood samples for hemoglobin, mean corpuscular volume, and MCHC were drawn at enrollment and analyzed fresh on an ADVIA 120 Hematology System. RDW was calculated as standard deviation of mean corpuscular volume divided by mean corpuscular volume multiplied by 100. As previously proposed by Kaufman et al.<span><sup>3</sup></span> potential hemolysis was considered in individuals with RBC indices suggesting hemolysis: increased MCHC and high RDW (as a sign of reticulocytosis), or increased MC","PeriodicalId":7724,"journal":{"name":"American Journal of Hematology","volume":"43 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142431727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and outcomes of incidentally diagnosed diffuse large B-cell lymphoma and implications for cancer screening","authors":"Suheil Albert Atallah-Yunes, Matthew J. Rees, Raphael Mwangi, Robyn L. Kuchler, Grzegorz S. Nowakowski, Thomas M. Habermann, Yucai Wang, Carrie A. Thompson, Andrew L. Feldman, Matthew J. Maurer, James R. Cerhan, Stephen M. Ansell, Thomas E. Witzig","doi":"10.1002/ajh.27504","DOIUrl":"https://doi.org/10.1002/ajh.27504","url":null,"abstract":"Differences in characteristics and outcomes between incidental and symptomatic presentations of Large B-Cell Lymphoma.","PeriodicalId":7724,"journal":{"name":"American Journal of Hematology","volume":"57 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142431710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypercoagulability in hemoglobinopathies: Decoding the thrombotic threat","authors":"Rayan Bou-Fakhredin, Maria Domenica Cappellini, Ali T. Taher, Lucia De Franceschi","doi":"10.1002/ajh.27500","DOIUrl":"https://doi.org/10.1002/ajh.27500","url":null,"abstract":"Beta (β)-thalassemia and sickle cell disease (SCD) are characterized by a hypercoagulable state, which can significantly influence organ complication and disease severity. While red blood cells (RBCs) and erythroblasts continue to play a central role in the pathogenesis of thrombosis in β-thalassemia and SCD, additional factors such as free heme, inflammatory vasculopathy, splenectomy, among other factors further contribute to the complexity of thrombotic risk. Thus, understanding the role of the numerous factors driving this hypercoagulable state will enable healthcare practitioners to enhance preventive and treatment strategies and develop novel therapies for the future. We herein describe the pathogenesis of thrombosis in patients with β-thalassemia and SCD. We also identify common mechanisms underlying the procoagulant profile of hemoglobinopathies translating into thrombotic events. Finally, we review the currently available prevention and clinical management of thrombosis in these patient populations.","PeriodicalId":7724,"journal":{"name":"American Journal of Hematology","volume":"193 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142431709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avatrombopag in immune thrombocytopenia: A real-world study of the Spanish ITP Group (GEPTI)","authors":"Cristina Pascual-Izquierdo,&nbsp;Blanca Sánchez-González,&nbsp;Mariana-Isabel Canaro-Hirnyk,&nbsp;Gloria García-Donas,&nbsp;María Menor-Gómez,&nbsp;Juan-José Gil-Fernández,&nbsp;Silvia Monsalvo-Saornil,&nbsp;Almudena de-Laiglesia,&nbsp;María-Teresa Álvarez-Román,&nbsp;Isidro Jarque-Ramos,&nbsp;María-José Llácer,&nbsp;Begoña Pedrote-Amador,&nbsp;Denis Zafra-Torres,&nbsp;Isabel Caparrós-Miranda,&nbsp;Ariana Ortúzar-Pasalodos,&nbsp;Nuria Revilla-Calvo,&nbsp;José-María Bastida,&nbsp;Esther Chica-Gullón,&nbsp;Montserrat Alvarellos,&nbsp;Reyes Jiménez-Bárcenas,&nbsp;Silvia Bernat,&nbsp;Daniel Martínez-Carballeira,&nbsp;Sunil Lakhwani,&nbsp;Elsa López-Ansoar,&nbsp;María-Esperanza Moreno-Beltrán,&nbsp;Álvaro Lorenzo-Vizcaya,&nbsp;María-Aránzazu Aguirre,&nbsp;Maialen Lasa-Eguialde,&nbsp;Marta Canet,&nbsp;Isabel-Teresa González-Gascón-y-Marín,&nbsp;Gonzalo Caballero-Navarro,&nbsp;Amalia Cuesta,&nbsp;Marta Díaz-López,&nbsp;Teresa Arquero,&nbsp;Marta Moreno-Carbonell,&nbsp;María-Eva Mingot-Castellano,&nbsp;the Spanish ITP Group (GEPTI) of the Spanish Society of Hematology and Hemotherapy (SEHH)","doi":"10.1002/ajh.27498","DOIUrl":"10.1002/ajh.27498","url":null,"abstract":"<p>Avatrombopag is the newest thrombopoietin receptor agonist (TPO-RA) approved to treat immune thrombocytopenia (ITP). Real-world evidence regarding effectiveness/safety is limited. The Spanish ITP Group (GEPTI) performed a retrospective study with patients starting avatrombopag for the first time. A total of 268 ITP patients were recruited. The median (interquartile range [IQR]) follow-up time was 47.5 (30.4–58.9) weeks. Among the 193 patients with baseline platelet counts &lt;50 × 10⁹/L, 174 (90.1%) of them achieved response (PC ≥50 × 10⁹/L), and 113 (87.6%) of the 129 who persisted on avatrombopag at last visit had platelet levels above such threshold. Results were similar when only those patients switching to avatrombopag due to previous treatment failure were considered (<i>n</i> = 104). Patients reached response in 13 (7–21) days. Among patients with baseline levels ≥50 × 10⁹/L, 73/75 (97.3%) reported response, which was maintained by 53 (94.6%) of the 56 who continued on avatrombopag at the end of the study. Loss-of-response was always &lt;10%. ITP duration did not influence response. Approximately 79% (34/43) of heavily pretreated (≥4 lines) patients with baseline platelet counts &lt;50 × 10⁹/L switching after previous failure achieved PC ≥50 × 10⁹/L. Previous use of eltrombopag and/or romiplostim did not influence response, regardless of whether previous TPO-RA(s) succeeded or failed. Avatrombopag allowed dose-reduction/suspension of corticosteroids in 40/50 (80.0%) patients with baseline platelet counts &lt;50 × 10⁹/L. Overall, 40/268 (14.9%) thrombocytosis and 12/268 (4.5%) thromboembolic events were reported. Our real-world cohort supports the use of avatrombopag to manage ITP, regardless of disease severity and treatment history.</p>","PeriodicalId":7724,"journal":{"name":"American Journal of Hematology","volume":"99 12","pages":"2328-2339"},"PeriodicalIF":10.1,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajh.27498","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142415779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Massive hemolysis in paroxysmal nocturnal hemoglobinuria after switching from proximal complement inhibitor to anti‐C5 therapy: A lesson not to be forgotten","authors":"Antonio M. Risitano, Camilla Frieri, Luana Marano, Eleonora Urciuoli, Ada Sanseverino, Caterina Nannelli, Rosario Notaro","doi":"10.1002/ajh.27502","DOIUrl":"https://doi.org/10.1002/ajh.27502","url":null,"abstract":"","PeriodicalId":7724,"journal":{"name":"American Journal of Hematology","volume":"27 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142430486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The spectrum of hematologic neoplasms in patients with Li-Fraumeni syndrome","authors":"Yiannis Petros Dimopoulos,&nbsp;Wei Wang,&nbsp;Sa A. Wang,&nbsp;Sanam Loghavi,&nbsp;Courtney D. DiNardo,&nbsp;Yoheved Gerstein,&nbsp;Shimin Hu,&nbsp;Zhenya Tang,&nbsp;Charmaine Joyce Lim Ilagan,&nbsp;Beenu Thakral,&nbsp;Siba El Hussein,&nbsp;Jie Xu,&nbsp;Shaoying Li,&nbsp;Pei Lin,&nbsp;Keyur P. Patel,&nbsp;Chi Young Ok,&nbsp;L. Jeffrey Medeiros,&nbsp;Hong Fang","doi":"10.1002/ajh.27497","DOIUrl":"10.1002/ajh.27497","url":null,"abstract":"&lt;p&gt;Li-Fraumeni syndrome (LFS) is a rare inherited disorder associated with germline pathogenic &lt;i&gt;TP53&lt;/i&gt; variants. The absence of the functional gene product, p53 protein, results in failure to activate programmed cell death in the appropriate context and leads to uncontrolled cell proliferation. LFS patients present with a high incidence of various malignancies, often at young ages. In contrast to the high occurrence rate of solid tumors, hematologic neoplasms in LFS patients are relatively rare and not systemically described. A few previous studies showed that leukemias developed in about 2%–4% of LFS patients, whereas lymphomas are less frequent, seen in approximately 2% of LFS patients.&lt;span&gt;&lt;sup&gt;1-3&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;This study explored the clinicopathologic spectrum of hematologic neoplasms in LFS patients. Eighteen patients with a well-established clinical diagnosis of LFS and confirmatory &lt;i&gt;TP53&lt;/i&gt; genetic testing as well as a hematologic neoplasm were included, spanning the time interval from 1/1/2000 through 8/5/2023. Their LFS diagnosis was further confirmed by our LFS Progeny Database and/or Clinical Cancer Genetics (CCG) team that runs the LFS program in our institution. Four previously reported patients (cases #1, 2, 6, 7 in that cohort)&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; were included in this study. To the best of our knowledge, this is the largest cohort described to date.&lt;/p&gt;&lt;p&gt;The cohort included 12 (67%) women and 6 (33%) men. Their clinical history and hematologic diagnoses are presented in Table 1. All patients had a confirmed germline pathogenic variant of &lt;i&gt;TP53&lt;/i&gt; at MD Anderson Cancer Center and/or an outside institution, although the detailed nomenclature of &lt;i&gt;TP53&lt;/i&gt; germline mutation in 4 patients (cases #1, 8, 14, 18) tested at an outside institution was not available. All 18 patients had an extensive family history of malignancies (Supplementary Table 1). Seventeen (94%) patients had other malignant or pre-malignant neoplasms in additional to hematologic malignancy; 7 (39%) patients had one neoplasm and 10 (56%) patients had ≥2 neoplasms. The most common non-hematologic malignancies were breast cancer (9/18, 50%), sarcoma (8/18, 44%), and gastrointestinal tumors (5/18, 28%). The only patient without any other neoplasm (case #18) was diagnosed with B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) at the age of 11 years and died 4 years later.&lt;/p&gt;&lt;p&gt;The median age at diagnosis of the first malignancy was 32 years (range, 1–54 years) and the median age at diagnosis of hematologic neoplasm was 41 years (range, 11–73 years). The initial presenting hematologic neoplasms included myelodysplastic syndrome (MDS) (&lt;i&gt;n&lt;/i&gt; = 10, 56%), “de novo” acute myeloid leukemia (AML) developing in patients without a prior history of MDS or other hematologic neoplasms (&lt;i&gt;n&lt;/i&gt; = 2, 11%), B-ALL/LBL (&lt;i&gt;n&lt;/i&gt; = 2, 11%), plasma cell neoplasms (PCN) (&lt;i&gt;n&lt;/i&gt; = 2, 11%), T-lymphoblastic leukemia/lymphoma (T-ALL/LBL) (&lt;i&gt;n&lt;/i&gt; = 1, 6%), and myelop","PeriodicalId":7724,"journal":{"name":"American Journal of Hematology","volume":"99 12","pages":"2416-2419"},"PeriodicalIF":10.1,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajh.27497","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endogenous retroelements in hematological malignancies: From epigenetic dysregulation to therapeutic targeting","authors":"Mohamed Chour, Françoise Porteu, Stéphane Depil, Vincent Alcazer","doi":"10.1002/ajh.27501","DOIUrl":"https://doi.org/10.1002/ajh.27501","url":null,"abstract":"Endogenous retroelements (EREs), which comprise half of the human genome, play a pivotal role in genome dynamics. Some EREs retained the ability to encode proteins, although most degenerated or served as a source for novel genes and regulatory elements during evolution. Despite ERE repression mechanisms developed to maintain genome stability, widespread pervasive ERE activation is observed in cancer including hematological malignancies. Challenging the perception of noncoding DNA as “junk,” EREs are underestimated contributors to cancer driver mechanisms as well as antitumoral immunity by providing innate immune ligands and tumor antigens. This review highlights recent progress in understanding ERE co-option events in cancer and focuses on the controversial debate surrounding their causal role in shaping malignant phenotype. We provide insights into the rapidly evolving landscape of ERE research in hematological malignancies and their clinical implications in these cancers.","PeriodicalId":7724,"journal":{"name":"American Journal of Hematology","volume":"8 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142405257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}