Journal of trace elements and electrolytes in health and disease最新文献_第8页

On the capacity of the rat intestine to excrete lithium ions at therapeutic and toxic plasma lithium concentrations. 治疗性和毒性血浆锂浓度对大鼠肠道锂离子排泄能力的影响。

Journal of trace elements and electrolytes in health and disease Pub Date : 1993-06-01

Y Erbil, L Eroglu, W Forth, G Schmolke, B Elsenhans, K Schümann

{"title":"On the capacity of the rat intestine to excrete lithium ions at therapeutic and toxic plasma lithium concentrations.","authors":"Y Erbil, L Eroglu, W Forth, G Schmolke, B Elsenhans, K Schümann","doi":"","DOIUrl":"","url":null,"abstract":"Lithium (Li) excretion into the intestinal lumen was quantitated in rats in situ by use of a pendular perfusion technique. Male Sprague-Dawley rats were injected daily (7-10 days) i.p. with 1, 3, and 6 mmol LiCl per kg body weight (n = 9-12). Jejunal as well as ileal and colonic segments were perfused with isotonic saline containing 3H-PEG-4000. Perfusate samples were taken after 0, 5, 10, 20, and 60 min. At the highest dose toxic symptoms were observed. At 6 mmol Li per kg the plasma Li concentrations were higher than those linearly extrapolated from the lower-dose groups, which may be due to inappropriate renal excretion. The Li concentration in the perfusate increased linearly over time and was not significantly different between jejunal and colonic segments. The same ratio between the Li concentration in the plasma and in the luminal perfusate was observed in all groups. Intestinal Li excretion is not impaired by high plasma concentrations. The intestinal capacity to excrete Li is considerable: 45 cm of jejunum is able to excrete the intire plasma Li content in 30-40 min, when Li is not resupplemented from intracellular stores. The renal clearance of lithium (Li) decreases when toxic Li plasma concentrations are reached. Therefore, if it were possible to trap Li in the intestinal lumen, this excretion route might be of therapeutic interest in cases of Li intoxication with impaired renal Li-excretion.","PeriodicalId":77233,"journal":{"name":"Journal of trace elements and electrolytes in health and disease","volume":"7 2","pages":"95-9"},"PeriodicalIF":0.0,"publicationDate":"1993-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19210908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selected papers of the 3rd ISTERH 92 and the 4th NTES on Trace Elements in Health and Disease. Stockholm, Sweden, May 24-29, 1992. 第3届ISTERH 92和第4届NTES微量元素与健康和疾病的论文选集。1992年5月24日至29日，瑞典斯德哥尔摩。

Journal of trace elements and electrolytes in health and disease Pub Date : 1993-06-01

引用次数: 0

Ischemic heart disease: nutrition or pharmacotherapy? 缺血性心脏病:营养还是药物治疗?

Journal of trace elements and electrolytes in health and disease Pub Date : 1993-06-01

L M Klevay

引用次数: 0

Calcium uptake and ATPase activity of sarcoplasmic reticulum vesicles isolated from control and selenium deficient lambs. 对照和缺硒羔羊肌浆网囊泡的钙摄取和atp酶活性。

Journal of trace elements and electrolytes in health and disease Pub Date : 1993-06-01

M J Tripp, P D Whanger, J A Schmitz

{"title":"Calcium uptake and ATPase activity of sarcoplasmic reticulum vesicles isolated from control and selenium deficient lambs.","authors":"M J Tripp, P D Whanger, J A Schmitz","doi":"","DOIUrl":"","url":null,"abstract":"The calcium uptake and ATPase activity were studied using fragmented sarcoplasmic reticulum (FSR) vesicles from normal and selenium (vitamin E)--deficient lambs. The latter group was suffering from white muscle disease (WMD). The calcium uptake of FSR vesicles from muscle of WMD lambs was reduced 10-fold as compared to those from normal lambs. An inverse relationship was found with the calcium uptake ability of the FSR vesicles and the severity of WMD. ATPase activity was nonsignificantly lower in vesicles from WMD lambs. The most active FSR vesicles from both normal and WMD lambs banded at 27% when purified on linear sucrose density gradients. The number of protein bands appearing in acrylamide gels of the purified vesicles appeared to be directly proportional to the severity of WMD. The 75Se cosedimented with the calcium uptake and ATPase activity when FSR vesicles from a lamb injected with 75Se-selenite were subjected to linear sucrose density gradient centrifugation, suggesting that selenium is incorporated into these vesicles. Injection of selenium into WMD lambs resulted in significantly greater calcium uptake activity in vesicles 18 and 38 days later as compared with untreated WMD lambs. Injection of selenium in WMD lambs resulted in a marked decrease in plasma CPK activity and a significant increase of glutathione peroxidase activity in the blood.","PeriodicalId":77233,"journal":{"name":"Journal of trace elements and electrolytes in health and disease","volume":"7 2","pages":"75-82"},"PeriodicalIF":0.0,"publicationDate":"1993-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19210905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors that influence the distribution of trace element-containing chemical species in living systems before and after sample collection. 样品采集前后影响生命系统中微量元素化学物质分布的因素。