Journal of spinal disorders最新文献

Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions. 增强子α和β（FAM150）是受体酪氨酸激酶ALK和LTK的配体：配体与受体相互作用的层次性和特异性。

Journal of spinal disorders Pub Date : 2015-12-29 Epub Date: 2015-11-16 DOI: 10.1073/pnas.1520099112

Andrey V Reshetnyak, Phillip B Murray, Xiarong Shi, Elizabeth S Mo, Jyotidarsini Mohanty, Francisco Tome, Hanwen Bai, Murat Gunel, Irit Lax, Joseph Schlessinger

{"title":"Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions.","authors":"Andrey V Reshetnyak, Phillip B Murray, Xiarong Shi, Elizabeth S Mo, Jyotidarsini Mohanty, Francisco Tome, Hanwen Bai, Murat Gunel, Irit Lax, Joseph Schlessinger","doi":"10.1073/pnas.1520099112","DOIUrl":"10.1073/pnas.1520099112","url":null,"abstract":"<p><p>Receptor tyrosine kinases (RTKs) are a class of cell surface receptors that, upon ligand binding, stimulate a variety of critical cellular functions. The orphan receptor anaplastic lymphoma kinase (ALK) is one of very few RTKs that remain without a firmly established protein ligand. Here we present a novel cytokine, FAM150B, which we propose naming augmentor-α (AUG-α), as a ligand for ALK. AUG-α binds ALK with high affinity and activates ALK in cells with subnanomolar potency. Detailed binding experiments using cells expressing ALK or the related receptor leukocyte tyrosine kinase (LTK) demonstrate that AUG-α binds and robustly activates both ALK and LTK. We show that the previously established LTK ligand FAM150A (AUG-β) is specific for LTK and only weakly binds to ALK. Furthermore, expression of AUG-α stimulates transformation of NIH/3T3 cells expressing ALK, induces IL-3 independent growth of Ba/F3 cells expressing ALK, and is expressed in neuroblastoma, a cancer partly driven by ALK. These experiments reveal the hierarchy and specificity of two cytokines as ligands for ALK and LTK and set the stage for elucidating their roles in development and disease states. </p>","PeriodicalId":77226,"journal":{"name":"Journal of spinal disorders","volume":"7 3 1","pages":"15862-7"},"PeriodicalIF":0.0,"publicationDate":"2015-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83404562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphologic and radiologic anatomy of the occipital bone. 枕骨的形态学和放射学解剖。

Journal of spinal disorders Pub Date : 2001-12-01 DOI: 10.1097/00002517-200112000-00006

S. Naderi, C. Usal, A. Tural, E. Korman, T. Mertol, M. Arda

{"title":"Morphologic and radiologic anatomy of the occipital bone.","authors":"S. Naderi, C. Usal, A. Tural, E. Korman, T. Mertol, M. Arda","doi":"10.1097/00002517-200112000-00006","DOIUrl":"https://doi.org/10.1097/00002517-200112000-00006","url":null,"abstract":"Several diseases may cause craniovertebral instability warranting occiput-cervical fusion. As occipital screw and rod constructs are becoming more popular, requiring that screws be placed either medially or laterally in the occipital bone, the need for clearer anatomical and computed tomography (CT)-confirmed data regarding the relative thickness of the occiput in its various localities has become more critical. In 18 cadaveric specimens, the occipital bone was divided into 35 measurable segments. Transversely, the occipital bone was divided into five lines starting at the level of the inion; horizontal lines then proceeded inferiorly in 1-cm segments, 1, 2, 3, and 4 cm below the level of inion. In a comparable fashion, the occipital bone was divided vertically, starting at the midline, and proceeding laterally also in 1-, 2-, and 3-cm segments. Anatomical measurements of thickness were directly performed using a Vernier caliper. Results were directly correlated with axial CT measurements of bony thickness. Anatomical and CT measurements closely correlated within the same specimen, but there was significant interspecimen variability. The marked differences in the occipital bone anatomy noted between specimens indicates that patients undergoing occipital screw placement for cranial-cervical instability would benefit from preoperative occipital CT evaluations.","PeriodicalId":77226,"journal":{"name":"Journal of spinal disorders","volume":"14 6 1","pages":"500-3"},"PeriodicalIF":0.0,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00002517-200112000-00006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61370507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Radiographic characteristics on conventional radiographs after posterior lumbar interbody fusion: comparative study between radiotranslucent and radiopaque cages. 后路腰椎椎体间融合术后常规x线片的影像学特征:放射性透明与不透明椎体间融合器的比较研究。

Journal of spinal disorders Pub Date : 2001-12-01 DOI: 10.1097/00002517-200112000-00012

O. Diedrich, L. Perlick, O. Schmitt, C. Kraft

{"title":"Radiographic characteristics on conventional radiographs after posterior lumbar interbody fusion: comparative study between radiotranslucent and radiopaque cages.","authors":"O. Diedrich, L. Perlick, O. Schmitt, C. Kraft","doi":"10.1097/00002517-200112000-00012","DOIUrl":"https://doi.org/10.1097/00002517-200112000-00012","url":null,"abstract":"The problem of determining solidity of a fused spinal segment still remains. Our purpose is to evaluate radiographic findings after posterior lumbar interbody fusion (PLIF) with cages and estimate their relative value in judging fusion status. Radiographic follow-up was performed in patients after PLIF with cages of either radiotranslucent or radiopaque material. Conventional radiographs were obtained 6 weeks, 3 and 6 months, and then yearly after surgery for spinal instability for 64 patients. We differentiated between uncertain (increased density within the cage, increase of sclerotic endplates, and posterolateral fusion) and definite (trabecular continuous bone bridging within the implant and periimplant new bone formation with bridging of the intervertebral space) fusion signs. A fusion rate of 51.5% after 12 months, 61.4% after 24 months, 66.7% after 36 months, and 77.8% after 48 months postoperatively was found. We found only a slight, nonsignificant correlation between radiographic fusion and patient-assessed clinical outcome. There is evidence that radiographic fusion criteria occur in a specific chronologic order. The interpretation of fusion status is notably impaired by the use of radiopaque cages. Criteria to standardize the interpretation and evaluation of radiographic findings after PLIF are discussed.","PeriodicalId":77226,"journal":{"name":"Journal of spinal disorders","volume":"60 1","pages":"522-32"},"PeriodicalIF":0.0,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00002517-200112000-00012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61370600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 47

Does the method of injection alter the outcome of epidural injections? 注射方式是否会改变硬膜外注射的结果?

Journal of spinal disorders Pub Date : 2001-12-01 DOI: 10.1097/00002517-200112000-00008

A. Mcgregor, N. Anjarwalla, T. Stambach

引用次数: 37

Occipital fixation: effect of inner occipital protuberance alignment on screw position. 枕内固定:枕内凸对准对螺钉位置的影响。

Journal of spinal disorders Pub Date : 2001-12-01 DOI: 10.1097/00002517-200112000-00007

J. Mullett, P. McCarthy, D. O'Keefe, J. McCabe

引用次数: 12

Predictors of functional outcome in elderly patients undergoing posterior lumbar spine surgery. 老年腰椎后路手术患者功能预后的预测因素。

Journal of spinal disorders Pub Date : 2001-12-01 DOI: 10.1097/00002517-200112000-00011

Fengyu Zheng, H. Sandhu, F. Cammisa, F. Girardi, Safdar N. Khan

引用次数: 31

Profiles of the cervical, thoracic, and lumbosacral spine in children and adolescents with lumbosacral spondylolisthesis. 儿童和青少年腰骶椎滑脱的颈椎、胸椎和腰骶脊柱的概况。

Journal of spinal disorders Pub Date : 2001-12-01 DOI: 10.1097/00002517-200112000-00001

R. Loder

{"title":"Profiles of the cervical, thoracic, and lumbosacral spine in children and adolescents with lumbosacral spondylolisthesis.","authors":"R. Loder","doi":"10.1097/00002517-200112000-00001","DOIUrl":"https://doi.org/10.1097/00002517-200112000-00001","url":null,"abstract":"The sagittal and frontal profiles of the entire spine are poorly studied in lumbosacral spondylolisthesis. It was the purpose of this study to further investigate these profiles. Standing posterior-anterior and lateral radiographs in 24 children with lumbosacral spondylolisthesis were reviewed (18 isthmic, 6 congenital). Cervical lordosis, lumbar lordosis, thoracic kyphosis, sagittal vertebral axis, sacral inclination, slip magnitude, slip angle, and sagittal rotation were measured. Cobb magnitude, Risser sign, curve location, and direction were noted for those with scoliosis. Relationships between sagittal variables were explored (Pearson correlation). The average age of patients was 14.7 +/- 2.5 years, slip magnitude was 38 +/- 38%, slip angle was 5 +/- 31 degrees, sagittal rotation was -6 +/- 31 degrees, thoracic kyphosis was 29 +/- 16 degrees, cervical lordosis was -1 +/- 12 degrees, and lumbar lordosis was 62 +/- 22 degrees. Correlations were noted between thoracic kyphosis and sacral inclination, percent slip, slip angle, and sagittal rotation. Sacral inclination decreased as the slip increased. Scoliosis was present in 10 children, with an average curve of 19 +/- 6 degrees. Thoracic kyphosis was less in those with scoliosis (21 +/- 25 degrees versus 33 +/- 25 degrees, p = 0.033). In children with lumbosacral spondylolisthesis, the sacrum becomes more vertical as the slip worsens. As the sacrum becomes more vertical, the thoracic spine becomes more lordotic, which is likely an adaptive mechanism used by the body to maintain forward visual gaze.","PeriodicalId":77226,"journal":{"name":"Journal of spinal disorders","volume":"14 6 1","pages":"465-71"},"PeriodicalIF":0.0,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00002517-200112000-00001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61370383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Neurogenic thoracic outlet syndrome in whiplash injury. 颈扭伤损伤中的神经源性胸廓出口综合征。

Journal of spinal disorders Pub Date : 2001-12-01 DOI: 10.1097/00002517-200112000-00004

Y. Kai, M. Oyama, S. Kurose, T. Inadome, Y. Oketani, Y. Masuda

引用次数: 54

Follow-up study of conservative treatment for atlantoaxial rotatory displacement. 寰枢椎旋转移位保守治疗的随访研究。

Journal of spinal disorders Pub Date : 2001-12-01 DOI: 10.1097/00002517-200112000-00005

H. Mihara, K. Onari, M. Hachiya, Atsushi Toguchi, Katsuhisa Yamada

引用次数: 36

Anterior/posterior lumbar fusion versus transforaminal lumbar interbody fusion: analysis of complications and predictive factors. 前/后路腰椎融合术与经椎间孔腰椎椎间融合术:并发症及预测因素分析

Journal of spinal disorders Pub Date : 2001-12-01 DOI: 10.1097/00002517-200112000-00013

H. Hee, F. Castro, M. Majd, R. Holt, Leann Myers

{"title":"Anterior/posterior lumbar fusion versus transforaminal lumbar interbody fusion: analysis of complications and predictive factors.","authors":"H. Hee, F. Castro, M. Majd, R. Holt, Leann Myers","doi":"10.1097/00002517-200112000-00013","DOIUrl":"https://doi.org/10.1097/00002517-200112000-00013","url":null,"abstract":"No previous study has compared the complications between anterior/posterior and transforaminal interbody fusions. We performed a retrospective analysis of 164 patients to compare the complications and associated predictive factors of the two techniques of circumferential lumbar fusion. Fifty-three had same-day anterior/posterior fusion (group 1), and 111 had transforaminal interbody fusion (group 2). Mean operating time (p < 0.0001) and hospital stay (p < 0.0001) was significantly longer for group 1 patients. Average blood loss was greater for group 1 patients (p < 0.01). Higher complication rates were found in group 1 patients (p < 0.004). Wound infection occurred more frequently in patients with adjunctive treatment (p < 0.04). Hospital stay was an independent predictor of complications in both groups. In group 1, body mass index was independently associated with complications. In group 2, both hospital stay and adjunctive treatment were predictive of complications. Transforaminal lumbar interbody fusion is the preferred technique because it is associated with shorter operating time, less blood loss, shorter hospital stay, and lower incidence of complications.","PeriodicalId":77226,"journal":{"name":"Journal of spinal disorders","volume":"14 6 1","pages":"533-40"},"PeriodicalIF":0.0,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00002517-200112000-00013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61370608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 190