Journal of neural transmission. General section最新文献_第10页

The effect of reserpine treatment in vivo upon L-dopa and amphetamine evoked dopamine and DOPAC efflux in vitro from the corpus striatum of male rats. 利血平对体内左旋多巴和安非他明的影响诱导雄性大鼠纹状体多巴胺和多巴胺外排。

Journal of neural transmission. General section Pub Date : 1994-01-01 DOI: 10.1007/BF01271567

D E Dluzen, B Liu

{"title":"The effect of reserpine treatment in vivo upon L-dopa and amphetamine evoked dopamine and DOPAC efflux in vitro from the corpus striatum of male rats.","authors":"D E Dluzen, B Liu","doi":"10.1007/BF01271567","DOIUrl":"https://doi.org/10.1007/BF01271567","url":null,"abstract":"In the present experiment we tested the effects of L-DOPA and amphetamine upon dopamine and DOPAC efflux in vitro from superfused corpus striatal tissue fragments of male rats who had been pretreated with reserpine. Male rats were treated with reserpine (5 mg/kg) or its vehicle at 24 hours prior to sacrifice and superfusion of the corpus striatum. Two different modes of L-DOPA (5 microM) and amphetamine (10 microM) stimulation, a brief 10-minute and a continuous 60-minute infusion, were tested for their ability to evoke striatal dopamine and DOPAC efflux. Depletion of monoamine storage capacity as achieved with reserpine significantly reduced the amount of basal dopamine and DOPAC released from superfused striatal tissue fragments of male rats. Although basal release rates were significantly reduced, the amount of dopamine and DOPAC released in response to in vitro L-DOPA infusions (10 or 60 minute infusions) was equivalent between reserpine and vehicle treated animals. In contrast, amphetamine stimulated DA release was significantly reduced in male rats treated with reserpine. For both L-DOPA and amphetamine, significantly greater amounts of dopamine were obtained with the 60- versus 10-minute infusion modes. These results demonstrate that the capacity for L-DOPA, but not amphetamine, to evoke dopamine efflux is unaltered under conditions when monoamine storage ability is diminished.","PeriodicalId":77215,"journal":{"name":"Journal of neural transmission. General section","volume":"95 3","pages":"209-22"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01271567","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18863902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Effects of nefiracetam on deficits in active avoidance response and hippocampal cholinergic and monoaminergic dysfunctions induced by AF64A in mice. 奈非拉西坦对AF64A诱导小鼠主动回避反应缺陷及海马胆碱能和单胺能功能障碍的影响。

Journal of neural transmission. General section Pub Date : 1994-01-01 DOI: 10.1007/BF01271565

E Abe, S Murai, H Saito, Y Masuda, Y Takasu, T Shiotani, H Tachizawa, T Itoh

{"title":"Effects of nefiracetam on deficits in active avoidance response and hippocampal cholinergic and monoaminergic dysfunctions induced by AF64A in mice.","authors":"E Abe, S Murai, H Saito, Y Masuda, Y Takasu, T Shiotani, H Tachizawa, T Itoh","doi":"10.1007/BF01271565","DOIUrl":"https://doi.org/10.1007/BF01271565","url":null,"abstract":"The effects of nefiracetam [DM-9384; N-(2,6-dimethyl-phenyl)-2-(2-oxo-pyrrolidinyl)acetamide] and of phosphatidylcholine on a step-up active avoidance response, locomotor activities and regional brain cholinergic and monoaminergic neurotransmitters in AF64A-treated mice were investigated. Intracerebroventricular (i.c.v.) injection of AF64A (ethylcholine mustard aziridinium ion; 8 nmol/ventricle) impaired acquisition and retention of the avoidance task, and increased vertical and horizontal locomotor activities. Regional levels of acetylcholine, noradrenaline, 3-methoxy-4-hydroxyphenylglycol (MHPG), 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were significantly decreased and homovanillic acid (HVA) levels were increased in the hippocampus but not in the septum, cerebral cortex or striatum of AF64A-treated animals. Administration of nefiracetam (3 mg/kg, p.o.) twice daily for 9 days to AF64A-treated animals ameliorated the deficit in active avoidance response in addition to attenuating the increase in locomotor activities. In parallel with these behavioural effects, nefiracetam reversed AF64A-induced alterations in the hippocampal profiles of cholinergic and monoaminergic neurotransmitters and their metabolites. In contrast, administration of phosphatidylcholine (30 mg/kg, p.o.) twice daily for 9 days had no significant effect on the deficit in active avoidance response, despite significantly reversing the decrease in acetylcholine levels in the hippocampus. These results indicate that the effects of nefiracetam on AF64A-induced behavioural deficits are probably due to its ability to facilitate both cholinergic and monoaminergic neurotransmitter systems.","PeriodicalId":77215,"journal":{"name":"Journal of neural transmission. General section","volume":"95 3","pages":"179-93"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01271565","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18866011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Iodine-123-IBZM-SPECT: studies in 15 patients with pituitary tumors. 碘123- ibzm - spect: 15例垂体肿瘤的研究。

Journal of neural transmission. General section Pub Date : 1994-01-01 DOI: 10.1007/BF02336144

W Pirker, T Brücke, M Riedl, M Clodi, A Luger, S Asenbaum, I Podreka, L Deecke

引用次数: 6

Comparison of the subregional distributions of the monoamine vesicular transporter and dopamine uptake complex in the rat striatum and changes during aging. 大鼠纹状体单胺泡转运体和多巴胺摄取复合物的分区域分布及其随年龄变化的比较。

Journal of neural transmission. General section Pub Date : 1994-01-01 DOI: 10.1007/BF01277946

I Leroux-Nicollet, J Costentin

{"title":"Comparison of the subregional distributions of the monoamine vesicular transporter and dopamine uptake complex in the rat striatum and changes during aging.","authors":"I Leroux-Nicollet, J Costentin","doi":"10.1007/BF01277946","DOIUrl":"https://doi.org/10.1007/BF01277946","url":null,"abstract":"We have studied the heterogeneous distribution of the vesicular monoamine transporter, labelled with 3H dihydrotetrabenazine (3H TBZOH) and the dopamine uptake complex, labelled with 3H GBR12783 in the rat striatum. The ratio TBZOH/GBR12783 was higher in the anterior part of the striatum than in the caudal part. This discrepancy could not be explained by the contribution of serotoninergic innervation to 3H TBZOH binding, since the ratio TBZOH/citalopram was also higher in the anterior striatum than in the caudal striatum. The monoamine vesicular transporter and the dopamine uptake complex were more abundant in the lateral regions than in the regions situated near the midline. In the caudal striatum, the ventral part was richer in vesicular transporter than the dorsal part. In aged rats (30 months), a significant decrease in the density of both transporters was noticed in the middle part of the striatum. In the anterior part of the striatum, the ratio TBZOH/GBR12783 was elevated in aged rats compared to adult ones. This could participate in a functional adaptation of the partially diminished population of dopaminergic neurons during aging.","PeriodicalId":77215,"journal":{"name":"Journal of neural transmission. General section","volume":"97 2","pages":"93-106"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01277946","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18871459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Insulin-like growth factor-1 receptors in human spinal cord: changes in amyotrophic lateral sclerosis. 人脊髓中的胰岛素样生长因子-1受体:肌萎缩性侧索硬化症的变化。

Journal of neural transmission. General section Pub Date : 1994-01-01 DOI: 10.1007/BF01277964

A Adem, J Ekblom, P G Gillberg, S S Jossan, A Höög, B Winblad, S M Aquilonius, L H Wang, V Sara

{"title":"Insulin-like growth factor-1 receptors in human spinal cord: changes in amyotrophic lateral sclerosis.","authors":"A Adem, J Ekblom, P G Gillberg, S S Jossan, A Höög, B Winblad, S M Aquilonius, L H Wang, V Sara","doi":"10.1007/BF01277964","DOIUrl":"https://doi.org/10.1007/BF01277964","url":null,"abstract":"Neurotrophic factors are important for neuronal survival and maintenance in the adult nervous system. The regional distribution of insulin-like growth factor-1 (IGF-1) receptors in human spinal cords from controls and amyotrophic lateral sclerosis (ALS) patients was studied by immunohistochemistry and quantitative autoradiography. When comparing 125I-IGF-1 binding in the different spinal levels of normal spinal cord the same distribution pattern was found in which the binding was highest in the central canal > dorsal horn > ventral horn > white matter. In the ALS cases although a general upregulation of IGF-1 receptors was observed throughout the spinal cord, significant increases were observed in the cervical and sacral segments compared to controls. IGF-1 receptor immunoreactivity showed a similar pattern to that for 125I-IGF-1 binding, with immunoreactivity being found in the gray matter of the spinal cord and enhanced immunoreactivity occuring in ALS patients compared to controls. In agreement with the distribution of IGF-1 receptors, IGF-1 immunoreactivity was found within the gray matter of the spinal cord. The cartography of IGF-1 receptors in the normal spinal cord as well as the change of these receptors in diseased spinal cord may be of importance in future treatment strategies of ALS.","PeriodicalId":77215,"journal":{"name":"Journal of neural transmission. General section","volume":"97 1","pages":"73-84"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01277964","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18884829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 38

Effects of D-cycloserine and (+)-HA-966 on the locomotor stimulation induced by NMDA antagonists and clonidine in monoamine-depleted mice. d -环丝氨酸和(+)-HA-966对NMDA拮抗剂和可乐定诱导的单胺衰竭小鼠运动刺激的影响。

Journal of neural transmission. General section Pub Date : 1994-01-01 DOI: 10.1007/BF01271568

M L Carlsson, G Engberg, A Carlsson

{"title":"Effects of D-cycloserine and (+)-HA-966 on the locomotor stimulation induced by NMDA antagonists and clonidine in monoamine-depleted mice.","authors":"M L Carlsson, G Engberg, A Carlsson","doi":"10.1007/BF01271568","DOIUrl":"https://doi.org/10.1007/BF01271568","url":null,"abstract":"We have previously observed that an N-methyl-D-aspartate (NMDA) antagonist in combination with the alpha 2-adrenoceptor agonist clonidine produces a marked locomotor stimulation in monoamine-depleted mice. In this paper we report on how the partial glycine agonists D-cycloserine (high intrinsic activity) and (+)-HA-966 [(+)-3-amino-1-hydroxypyrrolid-2-one; low intrinsic activity] affect this response; the interaction with both an uncompetitive and a competitive NMDA antagonist was investigated. (+)-HA-966 was found to counteract the locomotor stimulation produced by clonidine combined with either an uncompetitive (MK-801 = dizocilpine) or a competitive [D-CPPene = 3-(2-carboxypiperazine-4-yl)-1-propenyl-1-phosphonic acid] NMDA antagonist. D-cycloserine potentiated the locomotor stimulation produced by either NMDA antagonist combined with clonidine, although statistical significance was achieved only in the case of MK-801. If the present hyperactivity model has any relevance for psychosis the prediction based on the present results would be that d-cycloserine, contrary to current hopes, might not be so effective in schizophrenia, whereas (+)-HA-966 might be an interesting candidate.","PeriodicalId":77215,"journal":{"name":"Journal of neural transmission. General section","volume":"95 3","pages":"223-33"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01271568","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18863903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

The antigonadotrophic effect of melatonin in Syrian hamsters is modulated by prostaglandin. 褪黑素在叙利亚仓鼠中的抗促性腺激素作用是由前列腺素调节的。

Journal of neural transmission. General section Pub Date : 1994-01-01 DOI: 10.1007/BF01271564

I Nir, U Schmidt, N Zilber

引用次数: 0

Trypanosoma cruzi infection in rats induced early lesion of the heart noradrenergic nerve terminals by a complement-independent mechanism. 克氏锥虫感染引起大鼠心脏去甲肾上腺素能神经末梢的早期病变，其机制不依赖于补体。

Journal of neural transmission. General section Pub Date : 1994-01-01 DOI: 10.1007/BF01277950

C R Machado, D A de Oliveira, M J Magalhaes, E M Carvalho, F J Ramalho-Pinto

引用次数: 7

Tiagabine inhibits haloperidol-induced oral dyskinesias in rats. 替加滨抑制氟哌啶醇引起的大鼠口腔运动障碍。

Journal of neural transmission. General section Pub Date : 1994-01-01 DOI: 10.1007/BF01283031

X M Gao, T Kakigi, M B Friedman, C A Tamminga

{"title":"Tiagabine inhibits haloperidol-induced oral dyskinesias in rats.","authors":"X M Gao, T Kakigi, M B Friedman, C A Tamminga","doi":"10.1007/BF01283031","DOIUrl":"https://doi.org/10.1007/BF01283031","url":null,"abstract":"Chronic administration of haloperidol to male Sprague Dawley rats for 6 months at a dosage of 1.5 mg/kg/day produces oral dyskinesias in a significant percent of the treated group. This has been used as an animal model of tardive dyskinesia in several laboratories, because the rat movements display characteristics reminiscent of the human dyskinetic condition. Previously, we have reported a reduction in these haloperidol-induced oral dyskinesias with the coadministration of a direct acting GABA agonist progabide. Here, we have tested an indirect acting GABA agonist, tiagabine, coadministered with haloperidol, for its effect on the oral dyskinesias. At a dosage of 75 mg/kg/day tiagabine significantly inhibited the onset of vacuous chewing movements (VCMs), decreasing the average movement severity from 11.2 +/- 2.0 to 4.4 +/- 1.4, compared with a placebo rate of 1.3 +/- 0.5 (VCMs/5 min). These data support the proposition that an effective, potent GABAmimetic coadministered with haloperidol, will block the onset of rat oral dyskinesias. This conclusion has important implications for the treatment and prevention of tardive dyskinesia in humans.","PeriodicalId":77215,"journal":{"name":"Journal of neural transmission. General section","volume":"95 1","pages":"63-9"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01283031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18856977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Bilateral reciprocal organisation in man: focus on IA interneurone. 人的双边互惠组织:聚焦于IA间神经元。

Journal of neural transmission. General section Pub Date : 1994-01-01 DOI: 10.1007/BF01277926

M Sabatino, P Sardo, G Ferraro, G Caravaglios, V La Grutta

引用次数: 11