{"title":"Toxicity in a water column following the stratification of a cyanobacterial population development in a calm lake.","authors":"A. P. Belov, J. Giles, R. Wiltshire","doi":"10.1093/IMAMMB/16.1.93","DOIUrl":"https://doi.org/10.1093/IMAMMB/16.1.93","url":null,"abstract":"Cyanobacteria, including the genera Anabaena, Aphanizomenon, Microcystis, and Oscillatoria, are known to release or have the potential to release phycotoxins into the water. Indeed, there are documented cases of both animal and human intoxication. Data obtained from field observations and laboratory experiments demonstrate a correlation between the development of the cyanobacterial population and the level of phycotoxin present in the water, though it should be noted that not all cyanobacterial blooms are toxic. The development of cyanobacterial populations is described by a dynamical model which accounts for factors that include algal growth, degradation, and light-driven buoyancy under the assumption of an isothermal, calm, and nutrient-abundant lake. A semiempirical mathematical model for water-column toxicity is developed and is used in conjunction with an improved result for the density of the cyanobacteria population obtained from the dynamical model. Light transfer through the water column, light absorption, the implication of the differentiated attenuation of light by the water, and its diurnal effect on the cyanobacteria population is considered. The result of which is a plausible description of the seasonal development of cyanobacteria populations and of the toxicity within the water body.","PeriodicalId":77168,"journal":{"name":"IMA journal of mathematics applied in medicine and biology","volume":"16 1 1","pages":"93-110"},"PeriodicalIF":0.0,"publicationDate":"1999-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/IMAMMB/16.1.93","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61178592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Toxicity in a water column following the stratification of a cyanobacterial population development in a calm lake.","authors":"A P Belov, J D Giles, R J Wiltshire","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cyanobacteria, including the genera Anabaena, Aphanizomenon, Microcystis, and Oscillatoria, are known to release or have the potential to release phycotoxins into the water. Indeed, there are documented cases of both animal and human intoxication. Data obtained from field observations and laboratory experiments demonstrate a correlation between the development of the cyanobacterial population and the level of phycotoxin present in the water, though it should be noted that not all cyanobacterial blooms are toxic. The development of cyanobacterial populations is described by a dynamical model which accounts for factors that include algal growth, degradation, and light-driven buoyancy under the assumption of an isothermal, calm, and nutrient-abundant lake. A semiempirical mathematical model for water-column toxicity is developed and is used in conjunction with an improved result for the density of the cyanobacteria population obtained from the dynamical model. Light transfer through the water column, light absorption, the implication of the differentiated attenuation of light by the water, and its diurnal effect on the cyanobacteria population is considered. The result of which is a plausible description of the seasonal development of cyanobacteria populations and of the toxicity within the water body.</p>","PeriodicalId":77168,"journal":{"name":"IMA journal of mathematics applied in medicine and biology","volume":"16 1","pages":"93-110"},"PeriodicalIF":0.0,"publicationDate":"1999-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21204780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A mathematical analysis of the spread of HIV/AIDS in Japan.","authors":"M. Kakehashi","doi":"10.1093/IMAMMB16.1.111","DOIUrl":"https://doi.org/10.1093/IMAMMB16.1.111","url":null,"abstract":"The spread of HIV/AIDS in Japan was analysed using a mathematical model incorporating pair formations between adults and sexual contacts with commercial sex workers. The parameters involved in the model were carefully specified as realistically as possible to the actual situation in Japan. Plausible ranges were assigned to those parameters for which values are not known precisely. The model was used to simulate the effect of HIV infected commercial sex workers introduced into a population without HIV. It was shown that the model could generate different scenarios, an explosive infection or a temporal spread, according to different settings of the parameters. Then the condition for occasional introduction of HIV infected commercial sex workers to be able to cause an explosive spread of HIV infection was analysed. This condition was summarized in terms of the critical transmission probability so that we could easily evaluate the degree of the risk. For some unclear parameters, sensitivity to the critical transmission probability was calculated. We also calculated a plausible range of the critical transmission probability using the Latin hypercube sampling method where the parameters were distributed on the plausible ranges. According to the analyses of the model it is concluded that the actual situation of HIV spread in Japan should lie very near the critical point that determines whether the explosive HIV spread actually takes place. This also suggests that effective action taken immediately could be useful to prevent explosive HIV infection in Japan.","PeriodicalId":77168,"journal":{"name":"IMA journal of mathematics applied in medicine and biology","volume":"15 4 1","pages":"299-311"},"PeriodicalIF":0.0,"publicationDate":"1999-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61183345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Delay effect in a model for virus replication.","authors":"Judy Tam","doi":"10.1093/IMAMMB/16.1.29","DOIUrl":"https://doi.org/10.1093/IMAMMB/16.1.29","url":null,"abstract":"As biology becomes more quantitative, it appears that the increasing use of mathematics in this area is inevitable. In 1996, Nowak & Bangham (1996, Science 272, 74-79) proposed three mathematical models to explore the relation between antiviral immune responses, virus load, and virus diversity. In this paper we investigate the delay effect in a model which considers the interaction between a replicating virus and host cells. We assume that there is a finite time lag between infection of a cell and the emission of viral particles. Even with the introduction of this delay, the steady states of the model--as suggested by Nowak & Bangham--remain stable. The result also gives a condition for how the parameter values should be chosen when analysing clinical data so that the model remains tenable.","PeriodicalId":77168,"journal":{"name":"IMA journal of mathematics applied in medicine and biology","volume":"100 1","pages":"29-37"},"PeriodicalIF":0.0,"publicationDate":"1999-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/IMAMMB/16.1.29","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61178789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Modelling and simulation of chemotherapy of haematological and gynaecological cancers.","authors":"F K Nani, M N Oğuztöreli","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In this paper elaborate mathematical models and investigative computer simulations for the chemotherapy of haematological and gynaecological cancers are presented. The pharmacodynamics of the actions of the antineoplastic drugs are described by multicompartmental models with the associated model equations taking into account the drug dosage, type of delivery, route of delivery, the intercompartmental drug-transition constants, degradation parameters, and leakage coefficients. The cell-cycle phase-specific six-compartmental cytokinetic tumour growth model presented here incorporates the cell-cycle phase residence time, time lags associated with drug-induced cell-kill, or progression delays due to repair of cell damage. Investigative computer simulations are performed depicting the effects of cell-cycle phase-specific antineoplastic drugs on haematological and gynaecological cancer cells. The computer simulations are performed under various clinically plausible parametric configurations to elucidate the effects of certain critical variables such as tumour cell burden, mode of antineoplastic drug delivery, tumour cell loss and cell-cycle cytokinetic parameters.</p>","PeriodicalId":77168,"journal":{"name":"IMA journal of mathematics applied in medicine and biology","volume":"16 1","pages":"39-91"},"PeriodicalIF":0.0,"publicationDate":"1999-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21205182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dynamics of Japanese encephalitis--a study in mathematical epidemiology.","authors":"A. Ghosh, P. Tapaswi","doi":"10.1093/IMAMMB/16.1.1","DOIUrl":"https://doi.org/10.1093/IMAMMB/16.1.1","url":null,"abstract":"An S-->I-->R-->S (susceptible-infective-recovered-susceptible) epidemiological model coupling the dynamics of the spread of Japanese encephalitis (JE) in two populations, human and reservoir animals (pigs, cattle, equines, birds, etc.) through a vector population (a particular species of mosquitos, Culex vishnui, Culex tritaeniorhynchus, etc.) is discussed. We assume that there is a constant recruitment rate of the susceptibles into both the populations, whereas the death rates are proportional to the population sizes, which are hence variables. We also assume that the human population is regulated by the disease. Conditions for the existence of a unique endemic equilibrium were found, and the endemicity of the disease is discussed. The threshold values determine whether the disease dies out or approaches an endemic equilibrium. The persistence of disease and disease-related death can lead to a new equilibrium population size. The criteria for eradication of the disease have been worked out. The analytical results corresponding to the solutions of our system are verified by numerical analysis and computer simulation. The dynamics of disease transmission of JE during 1948-1956 in Japan were also investigated with the help of available data.","PeriodicalId":77168,"journal":{"name":"IMA journal of mathematics applied in medicine and biology","volume":"16 1 1","pages":"1-27"},"PeriodicalIF":0.0,"publicationDate":"1999-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/IMAMMB/16.1.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61178332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Estimating vaccine coverage by using computer algebra.","authors":"Doris Altmann, K. Altmann","doi":"10.1093/IMAMMB/17.2.137","DOIUrl":"https://doi.org/10.1093/IMAMMB/17.2.137","url":null,"abstract":"The approach of N Gay for estimating the coverage of a multivalent vaccine from antibody prevalence data in certain age cohorts is complemented by using computer aided elimination theory of variables. Hereby, Gay's usage of numerical approximation can be replaced by exact formulae which are surprisingly nice, too.","PeriodicalId":77168,"journal":{"name":"IMA journal of mathematics applied in medicine and biology","volume":"28 1","pages":"137-46"},"PeriodicalIF":0.0,"publicationDate":"1998-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/IMAMMB/17.2.137","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61180465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stability analysis of the FitzHugh-Nagumo differential equations driven by impulses: applied to the electrical firing of magnocellular neurons.","authors":"A. Milne, Z. Chalabi","doi":"10.1093/imammb/15.4.367","DOIUrl":"https://doi.org/10.1093/imammb/15.4.367","url":null,"abstract":"A stability analysis is carried out for a mathematical model which describes the electrical firing of a single vasopressin neuron. The model used in a FitzHugh-Nagumo-type system which is driven by impulses. The analysis is based on recent developments in the stability theory of impulsive differential equations. Conditions are derived under which the system of differential equations is stable at two of its equilibrium points. Biologically this bistability represents the cell alternating between periods of electrical activity and silence. The conditions for stability are specified in terms of the amplitude and frequency of the impulses perturbing the system. Both stochastic and deterministic impulses are considered.","PeriodicalId":77168,"journal":{"name":"IMA journal of mathematics applied in medicine and biology","volume":"15 4 1","pages":"367-85"},"PeriodicalIF":0.0,"publicationDate":"1998-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/imammb/15.4.367","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61178284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Crooke, J. D. Head, John J. Marini, J. Hotchkiss
{"title":"Patient-ventilator interaction: a general model for nonpassive mechanical ventilation.","authors":"P. Crooke, J. D. Head, John J. Marini, J. Hotchkiss","doi":"10.1093/IMAMMB/15.4.321","DOIUrl":"https://doi.org/10.1093/IMAMMB/15.4.321","url":null,"abstract":"A general mathematical model for the dynamic behaviour of a single-compartment respiratory system in response to an arbitrary applied inspiratory airway pressure and arbitrary respiratory muscle activity is investigated. The model is used to compute explicit expressions for ventilation and pressure variables of clinical interest for clinician-selected and impedance-determined inputs. The outcome variables include tidal volume, end-expiratory pressure, minute ventilation, mean alveolar pressure, average pleural pressure, as well as the work performed by the ventilator and the respiratory muscles. It is also demonstrated that under suitable conditions, there is a flow reversal that can occur during inspiration.","PeriodicalId":77168,"journal":{"name":"IMA journal of mathematics applied in medicine and biology","volume":"15 4 1","pages":"321-37"},"PeriodicalIF":0.0,"publicationDate":"1998-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/IMAMMB/15.4.321","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61178169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stability analysis of the FitzHugh-Nagumo differential equations driven by impulses: applied to the electrical firing of magnocellular neurons.","authors":"A E Milne, Z S Chalabi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A stability analysis is carried out for a mathematical model which describes the electrical firing of a single vasopressin neuron. The model used in a FitzHugh-Nagumo-type system which is driven by impulses. The analysis is based on recent developments in the stability theory of impulsive differential equations. Conditions are derived under which the system of differential equations is stable at two of its equilibrium points. Biologically this bistability represents the cell alternating between periods of electrical activity and silence. The conditions for stability are specified in terms of the amplitude and frequency of the impulses perturbing the system. Both stochastic and deterministic impulses are considered.</p>","PeriodicalId":77168,"journal":{"name":"IMA journal of mathematics applied in medicine and biology","volume":"15 4","pages":"367-85"},"PeriodicalIF":0.0,"publicationDate":"1998-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20857131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}