Hematologic pathology最新文献_第10页

Hematopoietic growth factor receptors. 造血生长因子受体。

Hematologic pathology Pub Date : 1991-01-01

G Krystal, M Alai, R L Cutler, H Dickeson, A L Mui, A W Wognum

引用次数: 0

Interleukin-2: basic biology and therapeutic use. 白细胞介素-2:基础生物学和治疗用途。

Hematologic pathology Pub Date : 1991-01-01

T M Williams, K R Fox, J A Kant

引用次数: 0

Different patterns of chromosome and molecular breakage in classic Ph1 chronic myelogenous leukemia (CML) and variant Ph1 CML. 经典Ph1型慢性粒细胞白血病(CML)和变异Ph1型慢性粒细胞白血病(CML)染色体和分子断裂的不同模式。

Hematologic pathology Pub Date : 1991-01-01

P Koduru, J C Goh, S L Allen, L Karp, H Jasti, L C DeMarco, S M Lichtman

{"title":"Different patterns of chromosome and molecular breakage in classic Ph1 chronic myelogenous leukemia (CML) and variant Ph1 CML.","authors":"P Koduru, J C Goh, S L Allen, L Karp, H Jasti, L C DeMarco, S M Lichtman","doi":"","DOIUrl":"","url":null,"abstract":"Variant translocations involving either chromosome 9, chromosome 22, or both with other chromosomes have been reported in about 8% of chronic myelogenous leukemia (CML) patients. In the 22 Ph+ patients studied in our laboratory, two showed variant translocations: t(9;22;11) (q34;q11;q13), and t(9;11) (q34;q11). We compared the pattern of involvement of different chromosomes (and bands) in secondary structural changes in CMLs carrying the t(9;22) (q34;q11) and in the variant translocations. Analysis showed significant differences in the pattern of involvement of different chromosomes and chromosome sites in the secondary structural changes in classic CMLs. This study, thus identifies nonrandomly involved chromosome sites that may be targeted for detailed molecular analysis to obtain an understanding of their role in disease progression. In the variant translocations chromosomes and chromosome bands were nonrandomly involved. Breakpoint cluster region (bcr) of the BCR gene was found to be rearranged in our two cases. We compared the location of molecular breaks within the bcr in classic and variant translocations. We found that translocation breaks occurred more frequently in the 5' region, and less frequently in the 3' region of bcr in variant translocations as compared with classic translocations. The significance of these findings in the etiology of CML is discussed.","PeriodicalId":77160,"journal":{"name":"Hematologic pathology","volume":"5 2","pages":"57-66"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13054267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atypical pattern of light chain gene rearrangement in hairy cell leukemia. 毛细胞白血病轻链基因重排的非典型模式。

Hematologic pathology Pub Date : 1991-01-01

F Narni, M T Mariano, L Moretti, A Colò, G Montagnani, M Grantini, A Donelli, U Torelli

引用次数: 0

Models of S-phase determination in lymphomas from flow cytometric DNA content histograms: comparison with the bromodeoxyuridine labeling index. 流式细胞DNA含量直方图测定淋巴瘤s期的模型:与溴脱氧尿苷标记指数的比较。

Hematologic pathology Pub Date : 1991-01-01

P Beauregard, T E Witzig, P J Kurtin, P R Greipp, M J Stenson, J A Katzmann, T M Habermann, H S Wieand

{"title":"Models of S-phase determination in lymphomas from flow cytometric DNA content histograms: comparison with the bromodeoxyuridine labeling index.","authors":"P Beauregard, T E Witzig, P J Kurtin, P R Greipp, M J Stenson, J A Katzmann, T M Habermann, H S Wieand","doi":"","DOIUrl":"","url":null,"abstract":"The estimated S-phase fraction (%S) of non-Hodgkin's lymphomas has been demonstrated to be of prognostic value. The %S can be determined by labeling index (LI) techniques or by various mathematical models applied to DNA content histograms. We performed DNA content analysis and a slide-based bromodeoxyuridine immunofluorescence LI on split samples from 117 biopsy specimens suspicious for lymphoma. The LI was compared with the %S determined by two computer models (rectangular and polynomial) with and without debris subtraction, and a manual gates computer model. In the 93 DNA diploid cases, the rectangular models had the highest correlation with the LI (R = 0.88). In the 24 aneuploid cases, the manual gates model was the most useful because of a high correlation with the LI (R = 0.70) and its ability to be used in most cases (23/24). The polynomial models had limited usefulness because they generally gave a higher %S than the LI and could be fitted in less than half of the DNA aneuploid histograms. These results suggest that in situations where the LI is not possible, an accurate %S estimate can usually be obtained with either a rectangular or manual gates model.","PeriodicalId":77160,"journal":{"name":"Hematologic pathology","volume":"5 4","pages":"177-83"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12956830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Induction of non-MHC-restricted cytotoxicity in a patient with pure red cell aplasia: functional relevance to antigen-specific cytotoxic T cells. 在纯红细胞发育不全患者中诱导非mhc限制性细胞毒性:与抗原特异性细胞毒性T细胞的功能相关性

Hematologic pathology Pub Date : 1991-01-01

K Morikawa, F Oseko, J Hara, S Morikawa

{"title":"Induction of non-MHC-restricted cytotoxicity in a patient with pure red cell aplasia: functional relevance to antigen-specific cytotoxic T cells.","authors":"K Morikawa, F Oseko, J Hara, S Morikawa","doi":"","DOIUrl":"","url":null,"abstract":"A functional analysis of an expanded T-cell subpopulation was studied in a patient with pure red cell aplasia who had no evidence of malignancy. In the time of an aggravation of the anemia, an expanded population of large granular lymphocytes (LGL) with T-cell receptor (TCR) alpha beta +CD3+CD8+ phenotype was noted, which reverted to normal with remission. These T cells displayed a polyclonal pattern in DNA analysis. Functionally, the T cells, with suppressor/cytotoxic phenotype exhibited normal capabilities for transducing the signals of the proliferative response, and of interleukin-2R (IL-2R) expression and IL-2 production via the TCR-CD3 complex structure. While they suppressed erythroid colony formation in vitro, neither non-major histocompatibility complex-restricted cytotoxic activity, cytotoxic T-cell activity, nor suppressive activity for immunoglobulin synthesis by B cells was detected. Pretreatment by anti-CD3 or anti-T-cell receptor antibody generated cytotoxicity for FcR+ target cells in the patient cells, but no such augmentation was found with other monoclonal antibodies of FcR- target cells. These findings indicated that the expanded T cells are functionally relevant to antigen-specific cytotoxic T lymphocytes.","PeriodicalId":77160,"journal":{"name":"Hematologic pathology","volume":"5 3","pages":"125-38"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13117721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vascular endothelial cells and hematopoiesis: regulation of gene expression in human vascular endothelial cells. 血管内皮细胞与造血:人血管内皮细胞基因表达的调控。

Hematologic pathology Pub Date : 1991-01-01

G C Bagby, M C Heinrich

{"title":"Vascular endothelial cells and hematopoiesis: regulation of gene expression in human vascular endothelial cells.","authors":"G C Bagby, M C Heinrich","doi":"","DOIUrl":"","url":null,"abstract":"Vascular endothelial cells do not constitutively produce significant quantities of hematopoietic growth factors, interleukins, or adhesion molecules, but they can be induced to do so by a variety of stimuli including the inductive cytokines, interleukin-1 (IL-1), and tumor necrosis factor-alpha, as well as phorbol esters, bacterial proteins, endotoxin, certain viruses, and modified low-density lipoproteins. Recently, some groups have begun to investigate the molecular mechanism by which expression of these genes is regulated. Because induced expression of the gene products is always prefaced by an increase in mRNA the focus of attention has been largely upon the mechanisms involved in the process of transcript accumulation. Certain inducing agents drive transcription of these genes, others may induce both transcription and transcript stability. In the case of the inducing factor IL-1, it was recently demonstrated that accumulation of G-CSF, GM-CSF, and interleukin-1 beta mRNAs induced in vascular endothelial cells occurs as a result of transcript stabilization. Based on preliminary studies in a cell-free system, it is proposed that the inductive capacity of interleukin-1 results, at least in part, from its capacity to activate cytoplasmic inhibitors of selective ribonucleases and hypothesize that this may be a mechanism that has been conserved throughout evolution. Because other inducing agents also incite IL-1 gene expression, transcript stabilization may be a common ingredient of most inductive stimuli.","PeriodicalId":77160,"journal":{"name":"Hematologic pathology","volume":"5 3","pages":"93-9"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13117722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Loss of genetic material from the short arm of chromosome 12 is a frequent secondary abnormality in non-Hodgkin's lymphoma. 12号染色体短臂遗传物质缺失是非霍奇金淋巴瘤常见的继发性异常。

Hematologic pathology Pub Date : 1991-01-01

P Jonveaux, M Le Coniat, J Derré, D Vecchione, R Berger

引用次数: 0

Role of humoral and cellular factors on the growth of blast progenitors of acute myeloblastic leukemia in serum-free culture. 体液和细胞因子在无血清培养急性髓母细胞白血病细胞祖细胞生长中的作用。

Hematologic pathology Pub Date : 1990-01-01

Y Maruyama, S Tohda, K Nagata, T Suzuki, I Murohashi, N Nara

引用次数: 0

Angioimmunoblastic lymphadenopathy with trisomy 3: the cells of the malignant clone are T cells. 血管免疫母细胞淋巴结病伴3三体:恶性克隆细胞为T细胞。

Hematologic pathology Pub Date : 1990-01-01

B Schlegelberger, I Nölle, A C Feller, E Bauer, W Grote

引用次数: 0