Heart and vessels. Supplement最新文献_第4页

Introductory remarks for this special issue on Takayasu arteritis. 本特刊关于高须动脉炎的导言。

Heart and vessels. Supplement Pub Date : 1992-01-01 DOI: 10.1007/BF01744536

F Numano

引用次数: 17

Detrimental effects of beta-adrenergic stimulation on beta-adrenoceptors and microtubules in the heart. -肾上腺素能刺激对-肾上腺素受体和心脏微管的有害影响。

Heart and vessels. Supplement Pub Date : 1991-01-01 DOI: 10.1007/BF01752531

M Hori, Y Koretsune, H Sato, T Kagiya, A Kitabatake, T Kamada

引用次数: 2

The effect of beta-adrenergic blockade in dilated cardiomyopathy--a questionnaire study in Japan. -肾上腺素能阻断在扩张型心肌病中的作用——日本的一项问卷研究。

Heart and vessels. Supplement Pub Date : 1991-01-01 DOI: 10.1007/BF01752530

A Matsumori, M Tominaga, S Handa, Y Fukuchi, A Kitabatake, H Matsuo, S Matsuo, J Mihune, T Nakano, S Nobuoka

{"title":"The effect of beta-adrenergic blockade in dilated cardiomyopathy--a questionnaire study in Japan.","authors":"A Matsumori, M Tominaga, S Handa, Y Fukuchi, A Kitabatake, H Matsuo, S Matsuo, J Mihune, T Nakano, S Nobuoka","doi":"10.1007/BF01752530","DOIUrl":"https://doi.org/10.1007/BF01752530","url":null,"abstract":"The effect of beta-blockade in dilated cardiomyopathy was studied by a questionnaire survey. Thirty-three cases were monitored in whom metoprolol (22 patients, 35.9 +/- 20.4 mg, mean +/- SD), propranolol (four patients, 26.3 +/- 7.5 mg), or other beta-blockers (seven patients) were administered. Four patients died, but no direct relationship was found between administration of beta-blocker and death. The NYHA functional class improved significantly. The mean heart rate decreased from 96/min to 77/min (P less than 0.01). The mean cardiothoracic ratio decreased from 55.6% to 52.1% (P less than 0.01). The mean ejection fraction of the left ventricle measured by echocardiogram increased from 30.4% to 36.9% (P less than 0.01). Exercise tolerance in the treadmill test improved significantly. There was no change in blood pressure, nor were there arrhythmias seen on Holter electrocardiograms. In two patients, congestive heart failure deteriorated after administration of beta-blockers. It is concluded that beta-adrenergic blockade has a beneficial effect in most of the patients with dilated cardiomyopathy.","PeriodicalId":77157,"journal":{"name":"Heart and vessels. Supplement","volume":"6 ","pages":"6-10"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01752530","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12852947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapy of idiopathic dilated cardiomyopathy with chronic beta-adrenergic blockade. 慢性肾上腺素能阻滞剂治疗特发性扩张型心肌病。

Heart and vessels. Supplement Pub Date : 1991-01-01 DOI: 10.1007/BF01752533

E M Gilbert, J B O'Connell, M R Bristow

引用次数: 3

Beta-adrenergic blockade in dilated cardiomyopathy, ischemic cardiomyopathy, and other secondary cardiomyopathies. 扩张型心肌病、缺血性心肌病和其他继发性心肌病的β -肾上腺素能阻断治疗。

Heart and vessels. Supplement Pub Date : 1991-01-01 DOI: 10.1007/BF01752532

F Waagstein

{"title":"Beta-adrenergic blockade in dilated cardiomyopathy, ischemic cardiomyopathy, and other secondary cardiomyopathies.","authors":"F Waagstein","doi":"10.1007/BF01752532","DOIUrl":"https://doi.org/10.1007/BF01752532","url":null,"abstract":"Beta-blockers were initially given to patients with chronic heart failure due to ischemic heart disease and resting tachycardia. The prompt effect on severe backward heart failure was directly associated with an immediate fall in heart rate. This observation led to long-term administration to patients with idiopathic dilated cardiomyopathy and, later, to patients with ischemic cardiomyopathy and secondary cardiomyopathies as well. Due to marked down-regulation of beta receptors, patients with heart failure are extremely sensitive to beta blockade. A test dose of metoprolol 5 mg b.i.d. for 2 days is recommended to select patients for long-term beta-blockade, followed by careful titration with increment in dose over 6 weeks. One important effect of beta-blockade in the early phase of treatment is a reduction in the myocardial energy demand early after the onset of long-term treatment. After 1 month of treatment with beta-blockers, marked improvement of diastolic function is observed. This effect might be attributed to inhibition of calcium overload. After 3 months of treatment, an increase in ejection fraction can be observed, which might be attributed to upregulation of beta receptors. The withdrawal of long-term treatment was followed by a deterioration of heart function in 61% of patients and improvement was seen after reinstitution of beta-blockade. There was an increase in cardiac index and stroke work index at rest as well as during supine exercise. A marked fall in left ventricular filling pressure at rest and unchanged filling pressure during supine exercise was noted, while exercise capacity increased by 25%. A similar pattern was seen in patients with ischemic cardiomyopathies and other secondary cardiomyopathies. However, the increase in ejection fraction in the ischemic cardiomyopathy group was lower (0.06) compared to the groups with dilated cardiomyopathy and other secondary cardiomyopathies (0.18).","PeriodicalId":77157,"journal":{"name":"Heart and vessels. Supplement","volume":"6 ","pages":"18-28"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01752532","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12852944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

The role of G-proteins in transduction of the beta-adrenergic response in heart failure. g蛋白在心力衰竭β -肾上腺素能反应转导中的作用。

Heart and vessels. Supplement Pub Date : 1991-01-01 DOI: 10.1007/BF01752529

L A Ransnäs

引用次数: 1

Relation between myocardial histological changes and ventricular tachycardia in cardiomyopathy: a study by 24-hour ECG-monitoring and endomyocardial biopsy. 心肌病心肌组织学改变与室性心动过速的关系:24小时心电图监测和心内膜活检的研究。

Heart and vessels. Supplement Pub Date : 1990-01-01

I Segawa, T Suzuki, M Kato, A Tashiro, R Satodate