K Nakai, Y Morimoto, T Arai, H Ito, M Kominami, H Matsuo, M Kikuchi
{"title":"Application of low-intensity ultraviolet irradiation to the treatment for pharmacological vasoconstriction via a percutaneous transluminal approach.","authors":"K Nakai, Y Morimoto, T Arai, H Ito, M Kominami, H Matsuo, M Kikuchi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We applied low-power ultraviolet (UV) laser irradiation via a thin flexible optical fiber to an in vivo model of vasospasm using an intravascular transluminal approach. The surgically exposed left femoral arteries of a rabbit were constricted by norepinephrine. A quartz fiber of 400 microm in diameter was introduced into the artery via the right common carotid artery through a 2.5F catheter. The femoral artery lumen was then irradiated with a helium-cadmium laser (wavelength 325 nm, output power 8 mW) through the fiber for 30 s. The UV irradiation increased the mean luminal diameter by 85% in comparison to the precontracted state, while the increase was only 45% in a sham operation. A histopathologic examination revealed no thermal damage and an intact internal elastic lamina. These results suggest that intravascular transluminal irradiation with a low-power UV laser may thus have potentially clinical applications to reverse acute arterial vasospasm.</p>","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"9 3","pages":"241-8"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21470986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A circle map model of human circadian rhythms.","authors":"H Sakai, M Nakao, M Yamamoto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Peculiar relationships between the sleep-wake cycle and temperature rhythm have been found during free-run situations, i.e. internal synchronization, internal desynchronization and phase trapping. The periods of both rhythms and the phase relationships between them could well characterize the above behavioral states. In this paper, firstly, our mathematical interpretations for them are proposed. According to these interpretations, a new circadian system model is developed. Our model consists of two circle maps, one for the dynamics of sleep-onset phase and the other wake-onset phase in reference to the temperature rhythm. The model dynamics is controlled mainly by the map for sleep-onsets which simultaneously determines behavior of wake-onsets. The model parameters are uniquely estimated based on the experimental results. The diverse behavior of the sleep-wake cycle associated with the synchronized and desynchronized states is suggested to be understood as bifurcation phenomena of the model dynamics. The bifurcation of the model dynamics is controlled by a single parameter, whose quantitative characteristics are investigated in detail. The results shown here could provide a novel framework to understand the human circadian rhythms systematically.</p>","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"9 1","pages":"75-92"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21223466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Accuracy verification of the photostereometric system KKN/1B developed for intraoperative measurement of knee movement immediately after total knee arthroplasty.","authors":"K Nishino, T Hayashi, Y Suzuki, Y Koga, G Omori","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The function and integrity of the knee joint following total knee arthroplasty (TKA) is determined at first by the design and implantation of the prosthesis, and later by the tension of soft tissues surrounding it. Accurate post-TKA motion data obtained intraoperatively could be used not only to optimize implantation techniques from a kinematic standpoint, but also to improve prosthetic design. We therefore developed a system specifically geared to photostereometric measurement of 6 d.o.f. knee motion. A total of eight LEDs are mounted on the prosthetic components in two sets of four by means of connecting measuring-bows. The positions of the LEDs are detected in three-dimensions by two sets of three linear CCD cameras, located bilaterally relative to the knee. The position and orientation of the femoral component relative to the tibial one are estimated from the positions of all LEDs in the sense of least-squares. Based upon results of various accuracy validation experiments performed after precise camera calibration, static overall accuracy and spatial resolution were considered to lie within 0.52 and 0.11 mm, respectively, at any point on the femoral articular surface.</p>","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"9 4","pages":"261-73"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21571049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Three-shell head model constructed from scalp geometry for electroencephalogram dipole localization.","authors":"H A Haque, T Musha, M Nakajima","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>One of the most sophisticated methods of dipole localization from (electroencephalograms) is based on a multi-compartment head model, which consists of the scalp, skull, cerebrospinal fluid (CSF) and brain cortex. The CSF layer in normal subjects is thin and can be ignored in dipole localization to good approximation. This multi-shell model is called the SSB (scalp-skull-brain) head model. The SSB head model is constructed from magnetic resonance imaging (MRI) or X-ray computed tomography slices of the head. These image slices, however, are not easy to obtain. The present paper presents a simple method for constructing the SSB head model only from the geometrical shape of the scalp, which is easily measured with a three-dimensional digitizer. We have derived a relationship between the head structure and the geometry of the head from statistical analysis of MRI slices of 12 normal subjects. The average estimation errors of the outer and inner boundaries of the skull were 1.2 and 2.2 mm, respectively. The head model thus estimated is called the sSSB (statistical SSB) model.</p>","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"9 4","pages":"295-304"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21571052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K M Patil, M V Bhat, M M Bhatia, V B Narayanamurthy, R Parivalavan
{"title":"New on-line methods for analysis of walking foot pressures in diabetic neuropathy.","authors":"K M Patil, M V Bhat, M M Bhatia, V B Narayanamurthy, R Parivalavan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In this paper, studies are performed on a large number of diabetic patients belonging to different classes, using new on-line foot pressure parameters, i.e. normalized peak pressure (NPP) and pressure contact ratio (PCR), which include effects of the weight of the subject, velocity of walking and duration of high pressures in any region of the foot. A statistical study of the mean maximum value of these parameters in different plantar areas of the feet, for different classes of diabetic subjects, indicates distinguishing trends and hence could aid the clinician in better diagnosis and therapy planning. The NPP and PCR transforms calculated on-line (using specially developed software) help the clinician to quickly determine the heavily loaded foot areas that are potential sites of ulceration in insensitive feet and take the necessary action to prevent further damage to the foot sole.</p>","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"9 1","pages":"49-62"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21223464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Relation between intrinsic viscoelasticity and activation level of the human finger muscle during voluntary isometric contraction.","authors":"K Akazawa, R Okuno, H Kusumoto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The purpose of the present study was to isolate the length perturbation-evoked force attributed to intrinsic muscle viscoelasticity, and to investigate the relation between muscle viscoelasticity and the level of muscle activation during isometric contraction in five healthy male subjects. A small length perturbation (stretching or contraction) was applied to the flexor pollicis longus muscle while the subject maintained constant isometric force; the time courses of the length perturbation was found to be almost identical in all the experiments. The force (Fv) induced by the muscle viscoelasticity was calculated using the equation Fv = F - Fc - Fp over an interval of 35 ms after the onset of perturbation, where F is the measured force, Fc is the tonic isometric force before the onset of perturbation and Fp is the force at rest obtained from the same length perturbation. The force response attributed to the stretch reflex is not included during this interval. These experiments were repeated at varying levels of isometric force. An almost linear relationship was obtained between the muscle viscoelasticity-induced force and the tonic isometric force during both the stretching and contraction of the muscle, i.e. the intrinsic muscle viscoelasticity varied almost linearly with the level of isometric contraction.</p>","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"9 2","pages":"123-35"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21315182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A needle-type immunotherapeutic system incorporating laser light and platonin in combination with ethanol injection in the treatment of cancer growing in deep organs.","authors":"K Mito","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Platonin is a potent cell-activating agent and a photosensitizing dye characterized by a typical absorption peak at 590 nm. It has been already clarified that macrophage activity is enhanced synergistically by platonin administration together with laser light irradiation. This method is considered to be useful in cancer immunotherapy. In this study, a needle-type therapeutic system incorporating this method was applied for the therapy of a homogeneous tumor grafted onto mice. The tumor was strongly cicatrized by collagen fibers at an early stage of the treatment. A high T/B cell ratio of lymphocytes was observed in the peripheral blood of the treated mice. In addition, a high survival ratio was seen, especially in the group of concomitant therapy with ethanol injection (PEI method). It was determined that the induction of high immunopotentiation of mice was triggered by ethanol injection at an early stage. These results demonstrated that the system is reliable for the treatment of cancer in deep organs such as a liver, requiring no major surgical intervention.</p>","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"9 4","pages":"275-84"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21571050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The penetration characteristic of radio wave frequencies from oral cavities.","authors":"T Watanabe, K Kobayashi, M Nagao","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Recently many radio telemetry systems have been inserted into oral cavities and have been used to send data to receivers. Although various frequencies were used in those systems, there has been no report about the most effective penetrative frequency in the human body. In this study, we observed the penetration of radio waves from oral cavities and compared the efficiency of different frequencies. We selected 11 edentulous persons as subjects and the frequencies ranged from 1 to 150 MHz. Although the attenuation gradually increased with the increase of frequency in most cases, we observed that there were effective resonance-like frequencies in three subjects and the frequency differed from person to person. This phenomenon was only observed when receiving antennas were set beside the mouth and not observed when the antennas were set about 1 m away from subjects. Therefore, it is considered that this phenomenon was produced by the relationship between the transmitting antenna and the receiving antenna. This result suggested that there were effective resonance-like frequencies in the case of radiation from edentulous oral cavities.</p>","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"9 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21223461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Mishima, K Kawakami, T Hirai, Y Takubo, H Sakai, Y Nakano, S Muro, Y Oku, K Chin, M Ohi
{"title":"Respiratory impedance during positive expiratory airway pressure in patients with chronic obstructive pulmonary disease.","authors":"M Mishima, K Kawakami, T Hirai, Y Takubo, H Sakai, Y Nakano, S Muro, Y Oku, K Chin, M Ohi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of positive airway pressure (5.0 hPa) on airway impedance (Za) and tissue impedance (Zt) during the expiratory phase in chronic obstructive pulmonary disease (COPD) patients was evaluated using random noise oscillation and a body box method. The results were then compared with those obtained from normal subjects. In normal subjects, there was no significant difference between non-expiratory positive pressure (NPEP) and positive expiratory pressure (PEP) for the Zar (real part) and Zai (imaginary part) at 10 Hz (Zar NPEP: 2.14 +/- 0.76, PEP: 1.96 +/- 0.79; Zai NPEP: 1.42 +/- 0.66, PEP: 1.40 +/- 0.70 hPa l-1 s). However, in COPD patients, Zar decreased significantly and the Zai increased significantly during PEP as compared to the values during NPEP (Zar NPEP: 7.10 +/- 1.88, PEP: 5.97 +/- 1.67, P < 0.05; Zai NPEP: -4.10 +/- 2.27, PEP: -2.99 +/- 2.62 hPa l-1 s, P < 0.05). These results suggested that both central and peripheral airway resistance decreased during PEP in COPD patients. Tissue compliance (Ct) calculated from the Zt increased significantly during PEP as compared to during NPEP, in both normal subjects and in COPD patients (normal NPEP: 0.024 +/- 0.004, PEP: 0.021 +/- 0.003, P < 0.05; COPD NPEP: 0.024 +/- 0.004, PEP: 0.014 +/- 0.004 l hPa-1, P < 0.001). This may have been indicative of the stiffened chest wall during PEP.</p>","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"9 1","pages":"63-73"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21223465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A low-distortion filter method to reject muscle noise in multi-lead electrocardiogram systems.","authors":"D Wei, E Harasawa, H Hosaka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This paper proposes a low-distortion filter method for rejection of muscle noise in multilead electrocardiogram (ECG) systems. This approach combines low-pass filtering with a modified version of source consistency filtering. The low-pass filtering splits the raw ECG signal into a muscle-noise-free part and a muscle-noise-overlapping part. The modified source consistency filtering then extracts the signal components from the muscle-noise-overlapping part. The extracted signal components are restored to the muscle-noise-free part as the output. The performance of our method was verified with simulated and clinically recorded ECG signals. The simulated ECG signals were created from computer simulation using three-dimensional, realistically shaped heart and torso models. The ideal signals are superimposed with white noise to simulate muscle noise and with a low frequency sine wave to simulate baseline drift. For verification, our method was compared with Butterworth low-pass filters. The results show that our method can effectively reduce muscle noise with less distortion of the QRS wave than conventional low-pass filters.</p>","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"9 4","pages":"315-30"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21571054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}