K. Kamijo, T. Kiyuna, Y. Takaki, A. Kenmochi, T. Tanigawa, T. Yamazaki
{"title":"Integrated approach of an artificial neural network and numerical analysis to multiple equivalent current dipole source localization.","authors":"K. Kamijo, T. Kiyuna, Y. Takaki, A. Kenmochi, T. Tanigawa, T. Yamazaki","doi":"10.1163/156855700750265468","DOIUrl":"https://doi.org/10.1163/156855700750265468","url":null,"abstract":"The authors have developed a PC-based multichannel electroencephalogram (EEG) measurement and analysis system. This system enables us (1) to simultaneously record a maximum of 64 channels of EEG data, (2) to measure three-dimensional positions of the recording electrodes, (3) to rapidly and precisely localize equivalent current dipoles (ECDs) responsible for the EEG data, and (4) to superimpose the localization results on magnetic resonance images. A new neural network and numerical analysis (NNN) approach to ECD localization is described which integrates a feedforward artificial neural network (ANN) and a numerical optimization (Powell's hybrid) method. It was shown that the ANN method has the advantages of high-speed localization and noise robustness, because in this approach: (1) ECD parameters are immediately initialized from the recorded EEG data by the ANN and (2) ECD parameters are accurately refined by the hybrid method. Our multiple ECD localization method was applied to sensory evoked potentials and event-related potentials using the present system.","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"1 1","pages":"285-301"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81917036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Applications of fluorescence microscopy to studies of dental hard tissue.","authors":"H. Matsumoto, S. Kitamura, T. Araki","doi":"10.1163/156855700750265459","DOIUrl":"https://doi.org/10.1163/156855700750265459","url":null,"abstract":"In this review we describe applications of fluorescence microscopy to investigations of dental hard tissue. Many studies have shown that human teeth show autofluorescence and several applications of fluorescence microscopy have been reported, although the chemical nature of autofluorescence remains unknown. However, most applications are based on a static measurement mode, which has inherent limitations. These limitations can be overcome by the use of time-resolved fluorescence microscopy. Therefore, we attempted to combine ordinary and time-resolved fluorescence microscopy to study human dentine. Using stationary measurements, blue fluorescence with a peak of 440 +/- 10 nm and a width of approximately 100 nm was observed. Increases in fluorescence intensity were found to be dependent upon age and temperature, regardless of tooth type or gender. The results suggest that the aging mechanism for crown dentine differs from that for root dentine and that the observed increase in fluorescence intensity is partially due to a temperature-dependent physicochemical mechanism. We speculate that fluorescence microscopy will become a useful tool for analysis of dental hard tissue in several fields.","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"154 1","pages":"269-84"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74737159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Control of arterial partial pressure of oxygen in patients with respiratory abnormalities using an adaptive observer.","authors":"V. Kroumov, K. Yoshino","doi":"10.1163/156855700750265477","DOIUrl":"https://doi.org/10.1163/156855700750265477","url":null,"abstract":"A system for controlling the arterial partial pressure of oxygen in patients on long-term oxygen therapy is proposed. After performing a parameter estimation of the model of pulmonary system, an adaptive observer is applied to perform the control task. The observer considers the model uncertainties as disturbances and rejects their impact on the system. As a result of this, the quality of the control can be drastically improved. The presented simulation and experimental results show the effectiveness of the proposed scheme. The proposed control scheme is applicable without preliminary adjustment of the control parameters.","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"17 1","pages":"303-18"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87155623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Numerical simulation of the turbulent flow field distal to an aortic heart valve.","authors":"Y. Morsi, A. Ahmad, A. Hassan","doi":"10.1163/156855701750383150","DOIUrl":"https://doi.org/10.1163/156855701750383150","url":null,"abstract":"A numerical technique is described which simulates the turbulent flow through a aortic Jellyfish valve, for two volumetric flow rates of 15 and 26 l/min representing peak systole flow. The steady incompressible Navier-Stokes equations written in three-dimensional (3-D) format are solved iteratively using a computational fluid dynamics code (Bio-FL). The numerical results show that the flow at the edge of the membrane of the valve splits into two nearly symmetrical jets with similar phenomenological features. Moreover, the 3-D flow simulations indicate the existence of two vortices in the immediate vicinity of the valve ring. Although these vortices are attenuated rapidly downstream by diffusion, they can have an adverse effect on erythrocytes and active platelets. It is also shown that elevated shear stresses occur in the vicinity of the upstream surface of the open occluder. In general. the numerical predictions compare well with the experimental measurements made at various locations downstream of the valve. The locations and the values of maximum velocity and shear stress, as well as width and length of re-circulation regions, are correctly predicted.","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"96 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83404259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Automatic analysis and classification of surface electromyography.","authors":"F. Abou-Chadi, A. Nashar, M. Saad","doi":"10.1163/156855701750383169","DOIUrl":"https://doi.org/10.1163/156855701750383169","url":null,"abstract":"In this paper, parametric modeling of surface electromyography (EMG) algorithms that facilitates automatic SEMG feature extraction and artificial neural networks (ANN) are combined for providing an integrated system for the automatic analysis and diagnosis of myopathic disorders. Three paradigms of ANN were investigated: the multilayer backpropagation algorithm, the self-organizing feature map algorithm and a probabilistic neural network model. The performance of the three classifiers was compared with that of the old Fisher linear discriminant (FLD) classifiers. The results have shown that the three ANN models give higher performance. The percentage of correct classification reaches 90%. Poorer diagnostic performance was obtained from the FLD classifier. The system presented here indicates that surface EMG, when properly processed, can be used to provide the physician with a diagnostic assist device.","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"18 1","pages":"13-29"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87584169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ECG data reduction method for medical telemetry systems.","authors":"M. Kyoso, A. Uchiyama","doi":"10.1163/156855701316922306","DOIUrl":"https://doi.org/10.1163/156855701316922306","url":null,"abstract":"In current medical practice, all transmitters used for monitoring an ECG send data continuously. If transmission could be limited to only the ECG data that requires the attention of a technician, the likelihood of interference and power consumption would be reduced considerably. In this paper, we propose a new ECG telemetry system. The transmitter has a simple ECG analyzer and it only transmits data when abnormal waveforms are detected. As part of this system, we propose a simple algorithm to detect an abnormal ECG. The algorithm is composed of a baseline drift canceller (utilizing a moving average calculation), a waveform detector (using a modified second order derivative) and an ECG analyzer. In order to test the effectiveness and feasibility of the algorithm, computer simulations (with a MIT-BIH ECG database) and experiments (with microprocessor-based hardware) were performed. The results of the simulations show that the detection performance and data compression performance of the algorithm are adequate. The results of the experiment show that the algorithm even performs adequately when used with microprocessor-based hardware that is of limited size or limited power consumption.","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"98 1","pages":"131-152"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79267324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Bai, M. Nakamura, T. Nagamine, A. Ikeda, H. Shibasaki
{"title":"Blink artifact elimination in electroencephalographic records based on discrete cosine transform domain modeling.","authors":"O. Bai, M. Nakamura, T. Nagamine, A. Ikeda, H. Shibasaki","doi":"10.1163/15685570152772469","DOIUrl":"https://doi.org/10.1163/15685570152772469","url":null,"abstract":"A method for eliminating blink artifacts that contaminate electroencephalographic (EEG) records is introduced. The proposed method enables a direct estimation of blink artifacts without the use of the simultaneously recorded electroculargraphic (EOG) signal. The estimation of blink artifacts in the EEG was achieved by modeling in the discrete cosine transform (DCT) domain. The DCT coefficients of the blink artifact were sufficiently represented by a system transfer function with a low model order of 4. Two cases were investigated: one was blink artifact elimination for the background EEG and the other was for the somatosensory evoked potentials. The effectiveness of the proposed method was demonstrated in an experimental study based on actual EEG data of 11 healthy subjects. The simplicity and effectiveness of the proposed method suggest that blink artifact elimination using DCT domain modeling can possibly be applied in various areas of neuroscience for improving EEG quality.","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"10 1","pages":"191-206"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75234492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Gopalakrishna Prabhu, K. Mothiram Patil, S. Srinivasan
{"title":"A new method of analysis of standing foot pressure images for detection of the plantar ulcers in early-stage diabetic neuropathy.","authors":"K. Gopalakrishna Prabhu, K. Mothiram Patil, S. Srinivasan","doi":"10.1163/156855701750383178","DOIUrl":"https://doi.org/10.1163/156855701750383178","url":null,"abstract":"In this paper, studies are performed on a large number of diabetic patients belonging to different levels of plantar sensation loss, by analyzing the standing foot pressure images in the frequency domain. A new parameter, the power ratio (PR, the ratio of high frequency power to the total power in an image), is used to distinguish between foot pressure image patterns of diabetic neuropathic subjects (at different levels of sensation loss) and those of normal feet. The foot areas of the diabetic subjects are scanned in 10 specified areas using Semmes Weinstein's nylon monofilaments to quantify the diabetic neuropathy. A statistical study of the mean values of this parameter in different plantar areas of the feet for different levels of diabetic neuropathy indicates distinguishing trends. The result could help in the early detection of low-level sensation loss by establishing the threshold of the PR in a particular area above which there could be the possibility of plantar ulcer formation. This information could be utilized by orthopedic surgeons to devise early corrective methods to protect the feet from further damage due to plantar ulcers.","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"28 6","pages":"31-43"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72615374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Okada, S. Hando, M. Teranishi, Y. Matsumoto, I. Fukumoto
{"title":"Analysis of pathological tremors using the autoregression model.","authors":"K. Okada, S. Hando, M. Teranishi, Y. Matsumoto, I. Fukumoto","doi":"10.1163/15685570152772487","DOIUrl":"https://doi.org/10.1163/15685570152772487","url":null,"abstract":"The usefulness of analysis of acceleration data using an autoregression model (AR) for differential diagnosis of Parkinson's disease and other diseases with tremors was investigated. The order of the AR model used in this study was 7, in accordance with Akaike's final prediction error criterion. The subjects included 19 patients with Parkinson's disease; 21 patients with essential tremor, which mainly appears in old people, as well as Parkinson's disease; and 13 healthy old people as a control group. The results of analysis of acceleration data showed that the first prediction coefficient, just as the main tremor frequency, was a useful parameter for differentiating patients in the Parkinson's disease patient group and essential tremor patient group. The seventh prediction coefficient was found to be a useful parameter for distinguishing pathological tremors observed in Parkinson's disease and essential tremor disease from physiological tremors observed in healthy people. Although the usefulness of other prediction coefficients for differential diagnosis of Parkinson's disease and other diseases with tremors has not yet been clarified, the results of this study showed that information obtained from AR model parameters in addition to information on main tremor frequency is useful for the diagnosis of Parkinson's disease.","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"38 1","pages":"221-35"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77319394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Bab, K. Ueda, A. Kuba, E. Kohda, N. Shiraga, T. Sanmiya
{"title":"Development of a subject-standing-type cone-beam computed tomography for chest and orthopedic imaging.","authors":"R. Bab, K. Ueda, A. Kuba, E. Kohda, N. Shiraga, T. Sanmiya","doi":"10.1163/15685570152772450","DOIUrl":"https://doi.org/10.1163/15685570152772450","url":null,"abstract":"A subject-standing-type cone-beam computed tomography (CT) with high spatial resolution has been developed as a new three-dimensional imaging modality for subjects standing or sitting naturally on a turntable. A 16-in. X-ray image intensifier and charge coupled device camera acquires a 12-bit 5122-pixel projection at 60 f/s and the rotation period is 4.8 or 9.6 s for 288 or 576 projections, respectively. To reduce image noise, the system controls the X-ray pulse duration and iris-opening area through real-time analysis of the projection image. To improve CT accuracy and eliminate artifacts, the veiling glare of the image intensifier and scattered X-rays are corrected. Human chest and orthopedic studies with about 50 patients were conducted. Three-dimensional images with a spherical field of view with a diameter of 21-25 cm, 0.4- to 0.5-mm voxels and a 512(3) matrix were obtained. In coronal, sagittal and volume rendering images, the surface of arthrosis was visualized smoothly with a resolution higher than that of conventional CT. In the case of gonarthrosis, narrowing of the clearance at the surface of arthrosis was visualized clearly under body-weight burdening, which would be difficult if the subject was lying down.","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"68 1","pages":"177-89"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85795089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}