American family physician最新文献

Systemic Sclerosis: Evaluation and Treatment. 系统性硬化症：评估和治疗。

IF 3.5 3区医学

American family physician Pub Date : 2026-04-01

Winfred Frazier, Courtney Goettel, Parul Chaudhri

{"title":"Systemic Sclerosis: Evaluation and Treatment.","authors":"Winfred Frazier, Courtney Goettel, Parul Chaudhri","doi":"","DOIUrl":"","url":null,"abstract":"Systemic sclerosis is a rare autoimmune connective tissue disease characterized by progressive fibrosis of the skin and internal organs, vasculopathy, and the presence of specific autoantibodies. Despite its low prevalence, systemic sclerosis is associated with high morbidity. Early features often include Raynaud phenomenon, hand edema, and fatigue. Diagnosis requires a comprehensive approach, including clinical assessment, laboratory evaluation, imaging, and pulmonary function testing. The American College of Rheumatology and European Alliance of Associations for Rheumatology (formerly the European League Against Rheumatism) provide classification criteria and updated treatment recommendations. Management focuses on addressing eight disease domains: Raynaud phenomenon, digital ulcers, pulmonary artery hypertension, interstitial lung disease, renal crisis, gastrointestinal involvement, skin fibrosis, and musculoskeletal involvement. Vasodilator therapy is first-line treatment for Raynaud phenomenon, whereas phosphodiesterase-5 inhibitors and intravenous iloprost are used to treat digital ulcers. Combination therapy with phosphodiesterase-5 inhibitors and endothelin receptor antagonists is first-line treatment for pulmonary artery hypertension. Mycophenolate mofetil is the preferred treatment for interstitial lung disease.","PeriodicalId":7713,"journal":{"name":"American family physician","volume":"113 4","pages":"349-357"},"PeriodicalIF":3.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating Drinking Water Safety Into Routine Practice. 将饮水安全纳入日常实践。

IF 3.5 3区医学

American family physician Pub Date : 2026-04-01

Dominika Jegen

引用次数: 0

Elinzanetant Is Effective for Vasomotor Symptoms Caused by Endocrine Therapy for Breast Cancer. 依兰那坦对乳腺癌内分泌治疗引起的血管舒缩症状有效。

IF 3.5 3区医学

American family physician Pub Date : 2026-04-01

Mark H Ebell

引用次数: 0

Fall Prevention: Interventions for Older Adults in Care Facilities. 预防跌倒：护理机构中老年人的干预措施。

IF 3.5 3区医学

American family physician Pub Date : 2026-04-01

Dongsheng Jiang, Juan Qiu

引用次数: 0

Diary of a Family Physician. 《一个家庭医生的日记》

IF 3.5 3区医学

American family physician Pub Date : 2026-04-01

Llewellyn Mensah, Vikash Pernenkil

引用次数: 0

Corrections. 修正。

IF 3.5 3区医学

American family physician Pub Date : 2026-04-01

引用次数: 0

Mirtazapine and Amitriptyline Are Modestly Effective for Short-Term Improvement of Insomnia in Adults. 米氮平和阿米替林对短期改善成人失眠有中等效果。

IF 3.5 3区医学

American family physician Pub Date : 2026-04-01

Henry C Barry

引用次数: 0

Nail Abnormality With Vertical Streaks. 指甲异常与垂直条纹。

IF 3.5 3区医学

American family physician Pub Date : 2026-04-01

Courtney Humphrey, Lydia Bothwell

引用次数: 0

Corrections. 修正。

IF 3.5 3区医学

American family physician Pub Date : 2026-04-01

引用次数: 0

Heat-Related Illnesses. 热疾病。

IF 3.5 3区医学

American family physician Pub Date : 2026-04-01

Robert L Gauer, Ryan McNutt, Kevon Bryan

{"title":"Heat-Related Illnesses.","authors":"Robert L Gauer, Ryan McNutt, Kevon Bryan","doi":"","DOIUrl":"","url":null,"abstract":"Heat-related illnesses encompass a spectrum of disorders resulting from exposure to high temperatures and the body's inability to efficiently dissipate heat. These syndromes range from mild illnesses, such as heat edema, heat rash, and heat cramps, to more concerning manifestations such as exercise-associated collapse, heat exhaustion, and exertional rhabdomyolysis. The most severe and potentially life-threatening heat-related illnesses include exercise collapse associated with sickle cell trait, severe exercise-associated hyponatremia, and heat stroke. Common risk factors of heat-related illness are physical activity in high ambient temperatures, behavioral factors, lack of acclimatization, deconditioning, recent illness, inadequate hydration, predisposing medical conditions, use of certain drugs and supplements, and excessive clothing or equipment. Treatment of mild heat-related illness includes cessation of activity, removal of the patient from high temperatures, and oral hydration. Symptoms of heat exhaustion are nonspecific and may include the inability to continue physical activity, weakness, fatigue, headache, nausea, and vomiting. Management includes rest, hydration, and basic cooling measures. Heat stroke is a medical emergency requiring immersion in ice-cold water within 30 minutes to prevent significant morbidity and mortality. Diagnosis of severe exercise-associated hyponatremia and exercise collapse associated with sickle cell trait require a high index of suspicion because they can mimic heat stroke but require different treatments. Heat-related illnesses are largely preventable with proper acclimatization, adequate hydration, avoidance of physical activity in extreme temperatures, and promotion of population-based intervention programs, particularly during anticipated heat waves.","PeriodicalId":7713,"journal":{"name":"American family physician","volume":"113 4","pages":"369-381"},"PeriodicalIF":3.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0