Al-Azhar Assiut Medical Journal最新文献_第3页

Specular microscopic changes of corneal endothelial cells after phacoemulsification in patients with pseudoexfoliation 假剥脱患者超声乳化术后角膜内皮细胞的镜下变化

Al-Azhar Assiut Medical Journal Pub Date : 2022-10-01 DOI: 10.4103/azmj.azmj_128_21

H. Yousef, Ibrahim Amer, Shymaa A. Thabet

{"title":"Specular microscopic changes of corneal endothelial cells after phacoemulsification in patients with pseudoexfoliation","authors":"H. Yousef, Ibrahim Amer, Shymaa A. Thabet","doi":"10.4103/azmj.azmj_128_21","DOIUrl":"https://doi.org/10.4103/azmj.azmj_128_21","url":null,"abstract":"Background and aim Pseudoexfoliation (PEX) syndrome is an age-related ocular disorder that is known to be linked with early development of cataract. Phacoemulsification, a cataract surgery, is thought to carry higher risk of complication in patients with PEX. This study aimed to evaluate the corneal endothelial cell changes before and after phacoemulsification in pseudoexfoliative patients relative to healthy adults. Patients and methods In total, 100 eyes of 100 patients were enrolled in this prospective nonrandomized study who were divided into two groups (PEX and non-PEX patients). All participants were subjected to ocular examination with specular microscopy before and after phacoemulsification. Data for corneal endothelial cell density (ECD), coefficient of variation (CV), and hexagonal cells were recorded before operation and at 1 week, 1 month, and 6 months postoperative. Results No significant difference was detected between the two studied groups regarding ECD, CV, and hexagonality either preoperatively or postoperatively at 1 week, 1 month, and 6 months. However, a significant difference between preoperative and postoperative data of ECD, CV, and hexagonality was detected in each group. Conclusion Despite the previous conviction that phacoemulsification surgery carries more risks in eyes with PEX, the results of this study prove that phacoemulsification is a safe choice in these eyes without a higher rate of postoperative complications.","PeriodicalId":7711,"journal":{"name":"Al-Azhar Assiut Medical Journal","volume":"20 1","pages":"314 - 318"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44536501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of budesonide inhalation in treatment of meconium-aspiration syndrome 布地奈德吸入治疗胎粪吸入综合征的作用

Al-Azhar Assiut Medical Journal Pub Date : 2022-04-01 DOI: 10.4103/AZMJ.AZMJ_10_20

Zainab H. Ahmed, Amira Mohamed, Mona Abdelmeguid

{"title":"Role of budesonide inhalation in treatment of meconium-aspiration syndrome","authors":"Zainab H. Ahmed, Amira Mohamed, Mona Abdelmeguid","doi":"10.4103/AZMJ.AZMJ_10_20","DOIUrl":"https://doi.org/10.4103/AZMJ.AZMJ_10_20","url":null,"abstract":"Background and aim Meconium-aspiration syndrome (MAS) is a common cause of respiratory distress. MAS is a serious disease that affects neonates born through meconium-stained amniotic fluid. The pathophysiology of MAS is multifactorial, inflammation has an important role in MAS, so anti-inflammatory drugs like corticosteroids may be effective in the treatment of MAS. Budesonide is a nonhalogenated glucocorticoid that can reduce vascular permeability, inhibit secretion of mucus, relieve edema and spasm, and help pulmonary ventilation. In this study we aimed to find out the effect of early nebulized budesonide in the treatment of MAS. Patients and methods This was a prospective study conducted during the period from October 2017 to July 2018 at El-Minia General Hospital and Al-Azhar University Hospital, Assiut. Intervention: budesonide inhalation in a dose of 50 mg every 12 h till clinical recovery, whichever was earlier. Results The present study revealed that nebulized budesonide improves the clinical outcome of newborns with MAS in terms of lowering the duration of O2 dependency, duration of respiratory distress, duration of hospital stay, duration of radiograph clearance, time for full feeding (P<0.001), and thus early discharge from the NICU. Conclusion Early nebulized budesonide is effective in treating MAS and has high safety with almost no short-term complications.","PeriodicalId":7711,"journal":{"name":"Al-Azhar Assiut Medical Journal","volume":"20 1","pages":"197 - 202"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42446114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Efficacy, safety, and predictors of response to infliximab therapy for ulcerative colitis 英夫利昔单抗治疗溃疡性结肠炎的疗效、安全性和预测因素

Al-Azhar Assiut Medical Journal Pub Date : 2022-04-01 DOI: 10.4103/azmj.azmj_14_21

Mohamed Fawaz, K. Eid, Mohamed Mohamed

{"title":"Efficacy, safety, and predictors of response to infliximab therapy for ulcerative colitis","authors":"Mohamed Fawaz, K. Eid, Mohamed Mohamed","doi":"10.4103/azmj.azmj_14_21","DOIUrl":"https://doi.org/10.4103/azmj.azmj_14_21","url":null,"abstract":"Background Using infliximab (IFX), an antitumor necrosis factors antibody, has dramatically increased therapeutic choices for ulcerative colitis (UC). This study assessed IFX therapy’s efficacy, safety, and action predictor variables for UC. Patients and methods This prospective interventional study was done on 50 patients with UC. Patients underwent colonoscopy, biopsy, complete blood count, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) before start of IFX and after 8 weeks. Patients started 5 mg/kg IFX infusion at 0, 2, and 6 weeks and then every eight weeks. After 6 months, cases were subjected to colonoscopy, biopsy, CRP, complete blood count, and ESR to assess IFX therapy. Results After therapy, hemoglobin and inactive UC cases (90%) increased significantly and white blood cell, ESR, and CRP decreased significantly than before treatment, without significant difference in platelet count. IFX treatment was associated with improvement in 90% of cases. There was a significant relation between improvement and colonoscopy, histopathology finding, and CRP after treatment (P<0.001) as the majority of cases had inactive UC, UC chronic phase with mild inflammation, and negative CRP after therapy. There was a nonsignificant relation between improvement and disease extension and severity (mayo clinic score) after the period. Conclusions Active UC cases treated by IFX had a better mucosal healing and clinical responses, corrected of anemia and thrombocytopenia and normalized acute-phase reaction.","PeriodicalId":7711,"journal":{"name":"Al-Azhar Assiut Medical Journal","volume":"20 1","pages":"177 - 184"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42050004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence of cerebral microembolization in patients with nonvalvular atrial fibrillation using transcranial Doppler 经颅多普勒分析非瓣膜性房颤患者脑微栓塞的发生率

Al-Azhar Assiut Medical Journal Pub Date : 2022-04-01 DOI: 10.4103/azmj.azmj_141_21

Hamouda El-Bahnasy, M. Zaki

{"title":"Incidence of cerebral microembolization in patients with nonvalvular atrial fibrillation using transcranial Doppler","authors":"Hamouda El-Bahnasy, M. Zaki","doi":"10.4103/azmj.azmj_141_21","DOIUrl":"https://doi.org/10.4103/azmj.azmj_141_21","url":null,"abstract":"Background and aim Atrial fibrillation (AF)-related stroke represented more than 79% of all strokes of cardiogenic origin. AF is the crucial factor of cardiogenic stroke. AF-related stroke is manifested with severe clinical manifestation, significant disability, high mortality, and easier relapse. The incidence of mortality is twice as high as non-AF-related stroke. The AF type is usually of nonvalvular origin. The current work is aiming to determine the incidence of cerebral microembolization in nonvalvular AF patients. Patients and methods The current study was a prospective study of two groups of individuals: control and nonvalvular asymptomatic AF cardiac condition, hypertension, age, diabetes, sex, and stroke (CHADS) score 2 or more. Patients were collected from the cardiology clinic and department (Al-Azhar University Hospital, New Damietta, Egypt). Patients were submitted to history taking, clinical assessment, echocardiography, and transcranial Doppler ultrasonography, and microembolic signal detection and count. Also, the transcranial Doppler was used to monitor both middle cerebral arteries. Results There was a statistically significant difference between the control and study groups in relation to the number of microembolic signals. Signals of microembolizations were detected in eight cases (all were in the study group). There was a positive correlation between embolic signals and patient age (r=0.424, P=0.020) and there was a significant association with female sex. In addition, there was a positive correlation between embolic signals and left-atrium dimension (r=0.502). Regarding correlation, there was a negative interaction between embolic signals and anticoagulation use (r=−0.413, P=0.023). Conclusion Asymptomatic embolic signals occur in patients with nonvalvular AF who are not being treated with anticoagulants at a significantly greater frequency than in age-matched controls.","PeriodicalId":7711,"journal":{"name":"Al-Azhar Assiut Medical Journal","volume":"20 1","pages":"211 - 217"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42701010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Diffusion-weighted image versus contrast-enhanced kinetic curves: which is more valuable in assessment of breast cancer? 弥散加权图像与增强动力学曲线:哪个在乳腺癌评估中更有价值?

Al-Azhar Assiut Medical Journal Pub Date : 2022-04-01 DOI: 10.4103/AZMJ.AZMJ_138_20

Salma Abokhozayem, Hosnia Mohammed, Sally Osama

{"title":"Diffusion-weighted image versus contrast-enhanced kinetic curves: which is more valuable in assessment of breast cancer?","authors":"Salma Abokhozayem, Hosnia Mohammed, Sally Osama","doi":"10.4103/AZMJ.AZMJ_138_20","DOIUrl":"https://doi.org/10.4103/AZMJ.AZMJ_138_20","url":null,"abstract":"Background and aim Noninvasive radiological techniques such as dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted imaging (DWI) can help distinguish between malignant and benign lesions of the breast. The current study was conducted to evaluate the diagnostic values of DCE-MRI and DWI in differentiation between benign and malignant breast lesions. Patients and methods This study was conducted on 30 patients with 32 lesions during the period from June 2019 to May 2020 at the Radiology Department and approved by the Ethics Committee. DCE-MRI and DWI were acquired for each patient using a 1.5 T machine with breast coils. Histopathological results were collected as a gold standard of the study. Results Of 32 lesions, histopathology revealed that 22 (68.75%) lesions were malignant and 10 (31.25%) lesions were benign. Mean apparent diffusion coefficient (ADC) of benign lesions was 1.25±0.56×10−3 mm2/s, which was significantly higher than those of malignant lesions (0.93±0.42×10−3 mm2/s). DWI-MRI had high sensitivity, specificity, positive predictive value, negative predictive value, and accuracy in distinguishing benign from malignant lesions (90.9, 70, 86.96, 77.78, and 84.38%, respectively). However, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of DCE-MRI were 95.5, 80, 91.3, 88.9, and 90.6%, respectively. Conclusion Compared with DWI, DCE-MRI has a higher sensitivity and specificity for distinguishing between benign and malignant lesions of the breast. Diffusion-weighted MRI provides quantitative assessment of benign and malignant lesions of the breast by measuring the ADC values.","PeriodicalId":7711,"journal":{"name":"Al-Azhar Assiut Medical Journal","volume":"20 1","pages":"163 - 171"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45810682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of inadequate weight loss after laparoscopic sleeve gastrectomy 腹腔镜袖式胃切除术后体重减轻不足的预测因素

Al-Azhar Assiut Medical Journal Pub Date : 2022-04-01 DOI: 10.4103/azmj.azmj_131_21

Osama Almezaien

{"title":"Predictors of inadequate weight loss after laparoscopic sleeve gastrectomy","authors":"Osama Almezaien","doi":"10.4103/azmj.azmj_131_21","DOIUrl":"https://doi.org/10.4103/azmj.azmj_131_21","url":null,"abstract":"Background and aim Laparoscopic sleeve gastrectomy (LSG) has become a popular procedure in the bariatric field in Egypt. However, little is known regarding the prevalence and risk factors of inadequate weight loss (IWL) following this procedure. Thus, we conducted this study to estimate the prevalence of IWL and its predictors after LSG. Patients and methods The data of consecutive 118 obese adults who underwent LSG were reviewed. The collected data included preoperative and intraoperative variables. Our primary outcome was to estimate the prevalence of IWL or failure after LSG (percent of excess weight loss <50), while the secondary outcomes included identifying risk factors or predictors for this unsatisfactory outcome. Results Failure was encountered in 34 patients out of the included 118 cases. Therefore, the prevalence of failure was 28.81%. Older age and higher basal BMI were associated with failure. Sex distribution was comparable between success and failure groups. Obesity-related comorbidities showed no significant difference between the same groups, apart from obstructive sleep apnea, which showed a significant rise in the failure group. Additionally, operative time, bougie size, and distance from pylorus did not show any significant differences between the two groups. Conclusion Older age, higher basal BMI, obstructive sleep apnea, increased number of obesity-related comorbidities, and previous gastric balloon are significant risk factors for IWL following LSG. Another bariatric procedure (mainly malabsorptive) should be offered for these high-risk groups.","PeriodicalId":7711,"journal":{"name":"Al-Azhar Assiut Medical Journal","volume":"20 1","pages":"225 - 231"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43128001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effect of cesarean section on breastfeeding at the age of 6 months 剖宫产对6月龄母乳喂养的影响

Al-Azhar Assiut Medical Journal Pub Date : 2022-04-01 DOI: 10.4103/azmj.azmj_93_21

Mamdouh Ibrahim, M. Khashaba, A. El-Gilany, T. Barakat

{"title":"Effect of cesarean section on breastfeeding at the age of 6 months","authors":"Mamdouh Ibrahim, M. Khashaba, A. El-Gilany, T. Barakat","doi":"10.4103/azmj.azmj_93_21","DOIUrl":"https://doi.org/10.4103/azmj.azmj_93_21","url":null,"abstract":"Background and aim Milk from a mother’s breast is the most suitable nutrient source for healthy growth and development of infants. Cesarean section (CS) is one of the factors that affect breastfeeding. This study aimed to show the effect of CS on breastfeeding at the age of 6 months. Patients and methods This was a retrospective cohort study conducted in primary health care centers of Sherbin District during a period of 1 year from December 2018 to December 2019. Each mother underwent full history taking and assessment of breastfeeding state regarding the following parameters: time of initiation of breastfeeding, no prelacteal feeding practice, exclusive breastfeeding (EBF), and breastfeeding performance index (BFPI). Results Time of initiation of breastfeeding, no prelacteal feeding practice, EBF, and BFPI are significantly higher in normal vaginal delivery than CS, with P values of 0.043, 0.028, 0.001, and less than or equal to 0.001, respectively. CS group is more likely to be younger and primiparous than the vaginal group. EBF was more evident among housewives, previously breastfed mothers, and mothers delivered vaginally than the CS group. Suckling before 1 h is more common among older mothers (>30 years of age), multiparous mothers, and previously breastfed mothers. Labor in a nonprivate place and CS were found to have a 30% more incidence of suckling after 1 h. No prelacteal feeding practice is more commonly seen among older mothers, multiparous, previously breastfed mothers, and mothers delivered vaginally than the CS group. Previously breastfed mothers and mothers delivered vaginally are more likely to have high BFPI. Conclusions CS is a negatively associated with EBF, early breastfeeding start, no prelacteal feeding practice, and BFPI.","PeriodicalId":7711,"journal":{"name":"Al-Azhar Assiut Medical Journal","volume":"20 1","pages":"218 - 224"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45777190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of blended learning in ophthalmology for undergraduates during coronavirus disease 2019 pandemic 2019冠状病毒病疫情期间本科生眼科混合学习分析

Al-Azhar Assiut Medical Journal Pub Date : 2022-04-01 DOI: 10.4103/azmj.azmj_136_21

Mostafa A Mohammed

{"title":"Analysis of blended learning in ophthalmology for undergraduates during coronavirus disease 2019 pandemic","authors":"Mostafa A Mohammed","doi":"10.4103/azmj.azmj_136_21","DOIUrl":"https://doi.org/10.4103/azmj.azmj_136_21","url":null,"abstract":"Background and aim Online and blended learning (BL) are widely adopted by colleges during coronavirus disease 2019 (COVID-19) pandemic. This study aimed to analyze BL tools that were applied in integrated ophthalmology curriculum for medical students during the COVID-19 pandemic. Patients and methods Subjective analysis was done using the Google platform survey. In all, 230 third-level medical students at Al-Azhar Faculty of Medicine responded to 19 Likert scale questionnaires at the end of the ophthalmology course. Statistical Package for the Social Sciences program, version 24 was used to measure statistical differences of students’ responses from neutrality. Results Students’ responses suggested that lecturers used effective instructional tools and explained course topics clearly, but 6 weeks for ophthalmology curriculum in association with other medical courses were exhausting for students. Virtual case-based learning can substitute practical real patients’ dependent learning for undergraduates during the COVID-19 pandemic, and using of more animations, simulations, and videos can improve clinical learning. Interaction between instructors and students was essential for better understanding and solving any educational problems. Microsoft teams was easy for studying and for conducting the examination. Most students reported that BL is more useful than only face-to-face traditional learning as BL helped them to improve thinking and selves’ confidence, and they can study at any time at home comfortably but they met some technical problems related to internet connection and electronic applications. Conclusion BL has valuable advantages over traditional only face-to-face methods and is effective in the absence of practical real patients’ dependent learning for undergraduates during the COVID-19 pandemic.","PeriodicalId":7711,"journal":{"name":"Al-Azhar Assiut Medical Journal","volume":"20 1","pages":"172 - 176"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41927054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of bullying behavior and its risk factors among primary school students in Sohag Governorate 索哈格省小学生欺凌行为及其危险因素研究

Al-Azhar Assiut Medical Journal Pub Date : 2022-04-01 DOI: 10.4103/azmj.azmj_28_21

N. Metwaly, I. Shaaban, M. Ali

{"title":"Study of bullying behavior and its risk factors among primary school students in Sohag Governorate","authors":"N. Metwaly, I. Shaaban, M. Ali","doi":"10.4103/azmj.azmj_28_21","DOIUrl":"https://doi.org/10.4103/azmj.azmj_28_21","url":null,"abstract":"Background and aim Bullying is one of the most serious problems that children face in the education system. Several other studies have found that bullying represents a standard problem in schools worldwide. This study aims to assess the incidence of school bullying as well as its suspected risk factors among primary school students. Patients and methods The study included 280 primary school students (146 males and 134 females) aged from 10 to 12 years old in the first stage of the study for screening for bullying behavior. A self-administered questionnaire was used to collect data about the bullying behavior among the selected students. The questionnaire was adopted from the validated Arabic version of Bullying Behavior Scale for children and adolescents. Results The incidence of significant bullying among the included students was found to be 12.5%, with males showing higher degrees of bullying. There was a significant association between involvement of the student in the bullying behavior and the risk factors such as student exposure to frequent punishment and negative attitude by the teacher, lack of acceptance from colleagues, and exposure to previous bullying. Conclusion Male students in primary schools showing higher degrees of bullying with significant association were found between bullying behavior and its risk factors.","PeriodicalId":7711,"journal":{"name":"Al-Azhar Assiut Medical Journal","volume":"20 1","pages":"185 - 189"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48824004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relation between Demodex colonization and manifestations of meibomian-gland dysfunction 蠕形螨定植与睑板腺功能障碍表现的关系

Al-Azhar Assiut Medical Journal Pub Date : 2022-04-01 DOI: 10.4103/azmj.azmj_138_21

Shorouk Mohammed, T. Mostafa, Rehab M. Kamel, Walaa A El Kholy

{"title":"The relation between Demodex colonization and manifestations of meibomian-gland dysfunction","authors":"Shorouk Mohammed, T. Mostafa, Rehab M. Kamel, Walaa A El Kholy","doi":"10.4103/azmj.azmj_138_21","DOIUrl":"https://doi.org/10.4103/azmj.azmj_138_21","url":null,"abstract":"Background and aim Meibomian-gland dysfunction (MGD) is a very common disease we face every day in the clinic. It is the essential cause of evaporative dry eye. It is a chronic, diffuse disorder of the meibomian glands, distinguished by terminal-duct obstruction and/or qualitative/quantitative variations in glandular secretion. It may result in alteration of the tear film, manifestations of eye irritation, clinically evident inflammation, and also ocular-surface disease (OSD). The aim of the study was to relate Demodex colonization to MGD. Patients and methods This study included 76 eyes divided into two groups, group A (patients’ group) included 38 eyes with MGD, group B (control group) included 38 eyes with normal lid margin. Both groups were subjected to history taking, MGD evaluation by MGD grading, fluorescein breakup time, OSD index, Schirmer-1 test, and lash sampling. The lashes sampled were examined for Demodex colonization by light microscopy. Results There was a statistically significant difference in Demodex colonization between the patients’ group 16 (42.1%) eyes and the control group four (10.5%)eyes. We noticed predominance of female sex in the MGD patients’ group (84.2%). There was a statistically significant difference between the two groups regarding fluorescein breakup time, OSD index, and Schirmer-1 test with P value less than 0.001. Conclusion Demodex colonization is incriminated as an important cause of MGD and OSD. Our study suggests that treating Demodex is crucial in MGD patients.","PeriodicalId":7711,"journal":{"name":"Al-Azhar Assiut Medical Journal","volume":"20 1","pages":"190 - 196"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46427653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0