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Epilepsy research. Supplement最新文献

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Substantia nigra GABA receptors can mediate anticonvulsant or proconvulsant effects. 黑质GABA受体可介导抗惊厥或前惊厥作用。
Epilepsy research. Supplement Pub Date : 1996-01-01
S L Moshé, D S Garant
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引用次数: 0
Possible mechanisms of seizure-related cell damage in the dentate hilus. 齿状门癫痫相关细胞损伤的可能机制。
Epilepsy research. Supplement Pub Date : 1996-01-01
P A Schwartzkroin, P S Buckmaster, B W Strowbridge, D D Kunkel, J Owens, J Pokorný
{"title":"Possible mechanisms of seizure-related cell damage in the dentate hilus.","authors":"P A Schwartzkroin, P S Buckmaster, B W Strowbridge, D D Kunkel, J Owens, J Pokorný","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77115,"journal":{"name":"Epilepsy research. Supplement","volume":"12 ","pages":"317-24"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20241950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seizure-induced molecular changes, sprouting and synaptogenesis of hippocampal mossy fibers. 癫痫诱导海马苔藓纤维的分子变化、发芽和突触发生。
Epilepsy research. Supplement Pub Date : 1996-01-01
H Pollard, K Bugra, M Khrestchatisky, A Represa, Y Ben-Ari
{"title":"Seizure-induced molecular changes, sprouting and synaptogenesis of hippocampal mossy fibers.","authors":"H Pollard, K Bugra, M Khrestchatisky, A Represa, Y Ben-Ari","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77115,"journal":{"name":"Epilepsy research. Supplement","volume":"12 ","pages":"355-63"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20241954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The relationship between seizures and damage in the maturing brain. 癫痫发作与成熟大脑损伤之间的关系。
Epilepsy research. Supplement Pub Date : 1996-01-01
E F Sperber
{"title":"The relationship between seizures and damage in the maturing brain.","authors":"E F Sperber","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77115,"journal":{"name":"Epilepsy research. Supplement","volume":"12 ","pages":"365-76"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20241955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe seizures in young children are associated with hippocampal neuron losses and aberrant mossy fiber sprouting during fascia dentata postnatal development. 幼儿严重癫痫发作与出生后牙筋膜发育过程中海马神经元丢失和苔藓纤维异常萌发有关。
Epilepsy research. Supplement Pub Date : 1996-01-01
G W Mathern, J P Leite, J K Pretorius, B Quinn, W J Peacock, T L Babb
{"title":"Severe seizures in young children are associated with hippocampal neuron losses and aberrant mossy fiber sprouting during fascia dentata postnatal development.","authors":"G W Mathern, J P Leite, J K Pretorius, B Quinn, W J Peacock, T L Babb","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77115,"journal":{"name":"Epilepsy research. Supplement","volume":"12 ","pages":"33-43"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20244070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NMDA and non-NMDA synaptic currents in rat neocortex during early postnatal development. 出生后早期大鼠新皮层的NMDA和非NMDA突触电流。
Epilepsy research. Supplement Pub Date : 1996-01-01
J J Hablitz, E C Burgard
{"title":"NMDA and non-NMDA synaptic currents in rat neocortex during early postnatal development.","authors":"J J Hablitz, E C Burgard","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77115,"journal":{"name":"Epilepsy research. Supplement","volume":"12 ","pages":"45-52"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20244071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genomic structure, sequence, and physiological expression of mKv 1.5, a mouse potassium channel gene. 小鼠钾通道基因mKv 1.5的基因组结构、序列和生理表达。
Epilepsy research. Supplement Pub Date : 1996-01-01
V A Street, W F Hopkins, B L Tempel
{"title":"Genomic structure, sequence, and physiological expression of mKv 1.5, a mouse potassium channel gene.","authors":"V A Street, W F Hopkins, B L Tempel","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77115,"journal":{"name":"Epilepsy research. Supplement","volume":"12 ","pages":"165-75"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20244084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of rational polypharmacy to treat epilepsy. 合理综合用药治疗癫痫的应用。
Epilepsy research. Supplement Pub Date : 1996-01-01
J A Ferrendelli
{"title":"Use of rational polypharmacy to treat epilepsy.","authors":"J A Ferrendelli","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77115,"journal":{"name":"Epilepsy research. Supplement","volume":"11 ","pages":"239-43"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20234875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Definition of rational antiepileptic polypharmacy. 合理抗癫痫复方药的定义。
Epilepsy research. Supplement Pub Date : 1996-01-01
B J Wilder, R W Homan
{"title":"Definition of rational antiepileptic polypharmacy.","authors":"B J Wilder,&nbsp;R W Homan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Rational polypharmacy is in its earliest stages of development and will require substantial additional development to realize its full potential. Indeed, despite the powerful appeal of the concept, clinical proof is not yet available that RP is superior to monotherapy. Important questions need to be addressed: 1. Will RP control seizures more effectively than monotherapy? 2. What data are needed to develop RP for a specific patient? 3. Will RP be cost effective? 4. Can RP be developed which will treat or prevent epilepsy while controlling seizures? Possible approaches to these questions could include: 1. The development of a data base for prospective use to monitor patients being treated at Epilepsy Centers using RP principles. 2. Use the data obtained from the above to construct more specific studies to compare identified combination therapies with monotherapy. 3. Prospectively compare in a placebo controlled, blinded study, the effect of the combination of an anti-ictal medication and a laboratory proven antiepileptic drug for prevention of the development of epilepsy in an at risk population such as head trauma or stroke.</p>","PeriodicalId":77115,"journal":{"name":"Epilepsy research. Supplement","volume":"11 ","pages":"253-8"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20234877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is there a mechanistic basis for rational polypharmacy? 合理的多药疗法有机制基础吗?
Epilepsy research. Supplement Pub Date : 1996-01-01
R L Macdonald
{"title":"Is there a mechanistic basis for rational polypharmacy?","authors":"R L Macdonald","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Established antiepileptic drugs (AEDs) decrease membrane excitability by interacting with neurotransmitter receptors or ion channels. AEDs developed prior to 1980 appear to act on sodium channels. gamma-amino butyric acid type A (GABAA) receptors (GABARs) or calcium channels. Benzodiazepines and barbiturates enhance GABAR-mediated inhibition. Phenytion, carbamazepine and possibly sodium valproate decrease high-frequency repetitive firing of action potentials by enhancing sodium channel inactivation. Ethosuximide and sodium valproate reduce a low threshold (T-type) calcium channel current. The mechanisms of action of the new AEDs are not fully established. Gabapentin binds to a high affinity site on neuronal membranes in a restricted regional distribution of the central nervous system. This binding site may be related to a possible active transport process of gabapentin into neurons; however, this has not been proven and the mechanism of action of gabapentin remains uncertain. Lamotrigine decreases sustained high-frequency repetitive firing of voltage-dependent sodium actin potentials that may result in a preferential decreased release of presynaptic glutamate. Oxcarbazepine's mechanism of action is not known; however, its similarity in structure and clinical efficacy to that of carbamazepine suggests that its mechanism of action may involve inhibition of sustained high-frequency repetitive firing of voltage-dependent sodium action potentials. Vigabatrin irreversibly inhibits GABA transaminase, the enzyme that degrades GABA, thereby producing greater available pools of presynaptic GABA for release in central synapses. Increased activity of GABA at postsynaptic receptors may underlie the clinical efficacy of vigabatrin. The potential mechanistic bases for rational polypharmacy are reviewed.</p>","PeriodicalId":77115,"journal":{"name":"Epilepsy research. Supplement","volume":"11 ","pages":"79-93"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20236361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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