Diabetes research (Edinburgh, Scotland)最新文献

ASSOCIATION OF TOTAL AND DIFFERENTIAL WHITE BLOOD CELL COUNTS TO DEVELOPMENT OF TYPE 2 DIABETES IN MEXICAN AMERICANS IN CAMERON COUNTY HISPANIC COHORT. 卡梅伦县西班牙裔队列中的墨西哥裔美国人白细胞总数和差值与 2 型糖尿病发病的关系。

Diabetes research (Edinburgh, Scotland) Pub Date : 2015-01-01 Epub Date: 2015-09-23 DOI: 10.17140/DROJ-1-117

Kristina P Vatcheva, Susan P Fisher-Hoch, Mohammad H Rahbar, MinJae Lee, Rene L Olvera, Joseph B Mccormick

{"title":"ASSOCIATION OF TOTAL AND DIFFERENTIAL WHITE BLOOD CELL COUNTS TO DEVELOPMENT OF TYPE 2 DIABETES IN MEXICAN AMERICANS IN CAMERON COUNTY HISPANIC COHORT.","authors":"Kristina P Vatcheva, Susan P Fisher-Hoch, Mohammad H Rahbar, MinJae Lee, Rene L Olvera, Joseph B Mccormick","doi":"10.17140/DROJ-1-117","DOIUrl":"10.17140/DROJ-1-117","url":null,"abstract":"Objective: To evaluate the relationship between total and differential White Blood Cell (WBC) counts with time to transition to type 2 diabetes in Mexican Americans using prospective data from the Cameron County Hispanic Cohort (CCHC).Results: Multivariable Cox proportional hazards regression models revealed that obese Mexican-American cohort participants whose total WBC or granulocyte count increased over time had 1.39 and 1.35 times higher risk respectively of transition to type 2 diabetes when compared to overweight participants. The granulocyte or total WBC count in participants with BMI≥35 were significant risk factors for transition to type 2 diabetes.Conclusions: Increased total WBC and WBC differential counts, particularly lymphocytes and granulocytes, are associated with risk of transition to type 2 diabetes in obese Mexican Americans, after adjusting for other potential confounders. Screening and monitoring the WBC counts, including lymphocytes and granulocytes can help with monitoring potential transition to type 2 diabetes.","PeriodicalId":77108,"journal":{"name":"Diabetes research (Edinburgh, Scotland)","volume":"1 4","pages":"103-112"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141071965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel effect of selenium on streptozotocin-induced diabetic mice. 硒对链脲佐菌素诱导的糖尿病小鼠的新作用。

Diabetes research (Edinburgh, Scotland) Pub Date : 1994-01-01

R Ghosh, B Mukherjee, M Chatterjee

引用次数: 0

Feeding an isocaloric omega-3 fatty acid diet reduces the brush border membrane vesicle uptake of glucose in streptozotocin-diabetic rats. 喂食等热量ω -3脂肪酸饮食减少链脲佐菌素糖尿病大鼠的刷状边界膜泡对葡萄糖的摄取。

Diabetes research (Edinburgh, Scotland) Pub Date : 1994-01-01

J Love, G Mulvey, K Doring, M Keelan, M T Clandinin, A B Thomson

{"title":"Feeding an isocaloric omega-3 fatty acid diet reduces the brush border membrane vesicle uptake of glucose in streptozotocin-diabetic rats.","authors":"J Love, G Mulvey, K Doring, M Keelan, M T Clandinin, A B Thomson","doi":"","DOIUrl":"","url":null,"abstract":"Glucose uptake is increased into the intestine of diabetic rats, and this adaptation can be modified further by manipulation of the type of fatty acids in the triglycerides in the diet. Jejunal brush border membrane vesicles were used to examine the uptake of D-glucose into the jejunum of non-diabetic control and streptozotocin-diabetic rats fed for two weeks in isocaloric semisynthetic diet enriched with saturated fat (beef tallow) or polyunsaturated omega-3 fatty acids (fish oil). The time-course of uptake of 100 microM glucose demonstrated an overshoot which peaked at approximately 30 seconds and declined thereafter to an equilibrium plateau. In concentration studies, glucose uptake was greater into brush border membrane vesicles of diabetic as compared with control rats. The maximal transport rate (Vmax) was increased approximately 9-fold in diabetics as compared with control rats fed beef tallow (p < 0.05), and was increased approximately 6-fold in diabetic rats fed fish oil. In diabetic rats, feeding fish oil reduced the value of the Vmax by approximately 50% as compared with diabetic rats fed beef tallow. Thus, the enhanced glucose uptake into BBM vesicles of streptozotocin-diabetic rats can be partially corrected by feeding an isocaloric semisynthetic diet enriched with polyunsaturated omega-3 fish oils.","PeriodicalId":77108,"journal":{"name":"Diabetes research (Edinburgh, Scotland)","volume":"25 2","pages":"65-75"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18652246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acceptability of capillary blood glucose testing with Companion 2 after intensive individual patient training. 患者个体强化训练后伴2毛细管血糖检测的可接受性。

Diabetes research (Edinburgh, Scotland) Pub Date : 1994-01-01

U M Kabadi, M Kabadi, K M O'Connell

{"title":"Acceptability of capillary blood glucose testing with Companion 2 after intensive individual patient training.","authors":"U M Kabadi, M Kabadi, K M O'Connell","doi":"","DOIUrl":"","url":null,"abstract":"This study determined the accuracy and precision of the MediSense Companion 2 Blood Glucose Monitoring System in the hands of newly trained patients, after individual training. 101 subjects attending a diabetes clinic at a Veterans Affairs Medical Center participated in the study. Subjects were individually trained in the use of the Companion 2 system. They performed 10 practice control solution tests prior to two capillary blood glucose tests. Venous blood was collected within 15 minutes for comparative laboratory analysis. The comparisons were performed by both the linear regression and the total Grid analysis. The correlation between the first capillary blood glucose test results and the laboratory values was highly significant (r = 0.94, p = 0.0001). Total Error Analysis also revealed that the Systematic Error (SE), Random Error (RE) and Total Error (TE) were all well within the acceptable norms at two glucose levels of 5.5 mmol/(100 mg/dL) and 11.1 mmol/L (200 mg/dL); (SE < 15%, RE < 10% and TE < 15%). Therefore, this study demonstrates that Companion 2 provides precise and accurate values during capillary blood glucose testing by newly trained subjects following intensive individual training.","PeriodicalId":77108,"journal":{"name":"Diabetes research (Edinburgh, Scotland)","volume":"26 1","pages":"25-32"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18670011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma disappearance and distribution volume of polyfructosan in type 1 (insulin-dependent) diabetes mellitus. 1型(胰岛素依赖型)糖尿病多果糖糖的血浆消失和分布体积。

Diabetes research (Edinburgh, Scotland) Pub Date : 1994-01-01

L Bent-Hansen

{"title":"Plasma disappearance and distribution volume of polyfructosan in type 1 (insulin-dependent) diabetes mellitus.","authors":"L Bent-Hansen","doi":"","DOIUrl":"","url":null,"abstract":"The simultaneous plasma disappearance curves of the extracellular marker polyfructosan and 125I-fibrinogen were recorded for 3 h in 24 male long-term diabetic patients. Eight normal subjects served as a control group. The patients were divided into three groups according to their urinary albumin excretion: Group 1 had normal albumin excretion (< 30 mg/24 h), Group 2 had microalbuminuria (30-300 mg/24 h), and Group 3 had clinical nephropathy (> 300 mg/24 h). Using fibrinogen as a plasma volume reference, the permeability surface product (PdS), the plasma clearance rate at 10 min C1(10), and the extracellular volume (ECV) were determined from the polyfructosan curves. Plasma volume was similar in all groups, and no differences were found between Group 1 and the control group. PdS was higher in the albuminuric groups, but barely to reach significant levels (p = 0.08-0.03), while C1(10) was significantly elevated (p < 0.01). The ECV was also significantly higher in these patients (p = 0.02-0.005), resulting in a marked decrease of the plasma volume to extravascular volume ratio. The results suggest a general degeneration of perivascular resistance components in diabetic microvascular complications, followed by secondary alterations of fluid balance, due to decreasing colloid osmotic counterpressure and eventually increasing transcapillary hydrostatic pressure.","PeriodicalId":77108,"journal":{"name":"Diabetes research (Edinburgh, Scotland)","volume":"25 3","pages":"121-8"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18676283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A monoclonal antibody based enzyme-linked immunosorbent assay for the determination of GAD65, the smaller isoform of glutamic acid decarboxylase. 一种基于单克隆抗体的酶联免疫吸附法测定谷氨酸脱羧酶的小异构体GAD65。

Diabetes research (Edinburgh, Scotland) Pub Date : 1994-01-01

J Hamann, J Hahmann, M Strebelow, B Ziegler, M Ziegler

引用次数: 0

The role of plasma, erythrocyte and platelet myo-inositol levels in the development of diabetic microangiopathy. 血浆、红细胞和血小板肌醇水平在糖尿病微血管病变发展中的作用。

Diabetes research (Edinburgh, Scotland) Pub Date : 1994-01-01

M Hacibekiroğlu, T Akçay

{"title":"The role of plasma, erythrocyte and platelet myo-inositol levels in the development of diabetic microangiopathy.","authors":"M Hacibekiroğlu, T Akçay","doi":"","DOIUrl":"","url":null,"abstract":"Unlabelled: In this study the plasma, erythrocyte, and platelet myo-inositol levels in 24 type I, 24 type II diabetics, and in 15 healthy controls were determined. The diabetics were devided into two groups with microangiopathy (n = 26) and without microangiopathy (n = 22). The plasma, erythrocyte, and platelet myo-inositol levels in the whole diabetic group and control subjects were as follows. Diabetic group: 46.5 +/- 39.8 mumol.l-1 23.3 +/- 19.8 nmol.ml-1, 2.6 +/- 2.8 nmol.ml-1 (10(5) cells)-1.Control group: 17.4 +/- 3.7 mumol.l-1, 12.2 +/- 5.2 nmol.ml-1, 1.5 +/- 0.9 nmol.ml-1 (10(5) cells)-1. The values of the diabetic group were significantly higher than the values of the control group (p < 0.01). In patients with HbA1c levels more than 9% plasma, erythrocyte, and platelet myo-inositol values were significantly higher than the values of the group with HbA1C levels less than 9% (p < 0.05, p < 0.05 and p < 0.01). In diabetics without complications plasma and erythrocyte myo-inositol levels were higher than the values of the control group (p < 0.01), whereas there was no significant difference between the platelet myo-inositol values. In diabetics with complication all these three values were higher than those of the control group (p < 0.01, p < 0.01, p < 0.01). The most profound increase in the plasma, erythrocyte, and platelet myo-inositol levels were seen in complicated diabetics with a diabetes duration of 6-10 years (p < 0.01). After 10 years duration the values declined. In the group without complication there was no difference according to the duration of diabetes.","PeriodicalId":77108,"journal":{"name":"Diabetes research (Edinburgh, Scotland)","volume":"25 4","pages":"173-9"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18651660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased susceptibility of LDL to in vitro oxidation in patients with insulin-dependent and non-insulin-dependent diabetes mellitus. 胰岛素依赖型和非胰岛素依赖型糖尿病患者LDL体外氧化易感性增加

Diabetes research (Edinburgh, Scotland) Pub Date : 1994-01-01

L Cominacini, U Garbin, A M Pastorino, A Fratta Pasini, M Campagnola, A De Santis, A Davoli, V Lo Cascio

{"title":"Increased susceptibility of LDL to in vitro oxidation in patients with insulin-dependent and non-insulin-dependent diabetes mellitus.","authors":"L Cominacini, U Garbin, A M Pastorino, A Fratta Pasini, M Campagnola, A De Santis, A Davoli, V Lo Cascio","doi":"","DOIUrl":"","url":null,"abstract":"The susceptibility of LDL to copper-catalyzed oxidation was evaluated in 24 patients with insulin-dependent and 16 patients with non-insulin-dependent diabetes mellitus, 14 abdominal and 14 gluteal-femoral obese women, 22 familial hypertriglyceridemic and 28 control subjects. Differences in the LDL susceptibilities were studied by measuring the changes of fluorescence intensity and expressed as lag-phase. The lag-phase was significantly shorter in patients with insulin-dependent, non-insulin-dependent diabetes mellitus, abdominal obesity and familial hypertriglyceridemic patients than in gluteal-femoral obese subjects and controls (p < 0.01). The shortest lag-phase was found in familial hypertriglyceridemic patients while intermediate values were found in insulin-dependent, non-insulin-dependent and abdominal obese patients who had only a slight increase in triglyceride values. Similarly the lowest value of the LDL cholesterol to protein ratio, as expression of LDL particle size, was found in familial hypertriglyceridemic patients (p < 0.01), while the patients with insulin-dependent, non-insulin-dependent diabetes mellitus and abdominal obesity had intermediate values. The ratio was found to be directly correlated with the length of the lag-phase (r = 0.87, p < 0.001). In spite of similar triglyceride and cholesterol to protein ratio values, however, the length of the lag-phase was significantly shorter in patients with insulin-dependent diabetes mellitus than in those with abdominal obesity. So it is concluded that the different susceptibility to oxidation found in the different groups of patients is only partially explained by plasma triglyceride values.","PeriodicalId":77108,"journal":{"name":"Diabetes research (Edinburgh, Scotland)","volume":"26 4","pages":"173-84"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18652288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevention of diabetes in BB/Wor rats by injection of peritoneal exudate cells cultured in the presence of transforming growth factor beta (TGF-beta) and islet cells. 通过注射转化生长因子β (tgf - β)和胰岛细胞培养的腹膜渗出细胞预防BB/Wor大鼠糖尿病。

Diabetes research (Edinburgh, Scotland) Pub Date : 1994-01-01

S B Koevary

{"title":"Prevention of diabetes in BB/Wor rats by injection of peritoneal exudate cells cultured in the presence of transforming growth factor beta (TGF-beta) and islet cells.","authors":"S B Koevary","doi":"","DOIUrl":"","url":null,"abstract":"Studies of ocular immunity showed that incubation of peritoneal exudate cells with antigen in the presence of aqueous humor containing TGF-beta, conferred upon them the ability to systemically inhibit antigen-specific cellular immunity when injected into naive recipients. Since cell mediated immunity has been implicated in the destruction of the islets of Langerhans in diabetes, it was theorized that injection of naive diabetes prone BB/W or rats with peritoneal exudate cells pre-cultured in the presence of islet antigen and TGF-beta might similarly inhibit their anti-islet immune reactions and prevent their development of diabetes. 34.2% (13 of 38) of experimental recipient diabetes prone rats developed diabetes while 78.4% (29 of 37; p < 0.0005 compared to experimentals), 72.2% (13 of 18; p < 0.03 compared to experimentals), 68.8% (11 of 16; p < 0.09 compared to experimentals), and 77.7% (7 of 9; p < 0.08 compared to experimentals) of controls receiving peritoneal exudate cells pre-cultured alone, with TGF-beta, with TGF-beta and pheochromocytoma (PC12) cells, or with islets + TGF-beta + anti-TGF-beta antibody, respectively, became diabetic. Experimental treatment did not markedly alter recipient spleen cell subsets, and spleen cells from protected rats did not confer disease protection when transferred into naive recipients. These data demonstrate that the above approach is efficacious and represents a unique strategy for preventing the development of autoimmune type I diabetes in an animal model.","PeriodicalId":77108,"journal":{"name":"Diabetes research (Edinburgh, Scotland)","volume":"27 1","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18652289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insulinotropic action of the D-glucosyl and 3-O-methyl-D-glucosyl monomethyl esters of succinic acid. 丁二酸d -葡萄糖基和3- o -甲基- d -葡萄糖基单甲基酯的胰岛素作用。

Diabetes research (Edinburgh, Scotland) Pub Date : 1994-01-01

W J Malaisse, T M Zhang, V Leclercq-Meyer, A Sener, F Björkling

引用次数: 0